Clinical Trials & Research

English: Graph of Nrf2 publications (pubmed se...

English: Graph of Nrf2 publications (pubmed search) by year (Photo credit: Wikipedia)

There are currently over 2300 articles (peer reviewed clinical reviews and studies) on Pubmed.gov on the topic of NRF2 Activation.

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How to tell whether a NRF2 product is valid and has the backing of science.

There are a ton of companies claiming they have scientific studies showing that their products are NRF2 Activators. Go to Pubmed.gov and type in the name of their product say “AgeLoc”, “Vivix”, “NRF2 Activator” or “Protandim”. Basically the only ones at the time of writing this article with peer reviewed studies is Protandim (14 Studies) and according to the company has 21 Universities and medical institutions studying the product. Biogen’s Tecfidera has now been approved by the FDA and has two published clinical trials for its multiple sclerosis treatment.

Pubmed is a website operated by the National Institute of Health (NIH).  PubMed comprises over 21 million citations for biomedical literature from MEDLINE, life science journals, and online books. PubMed citations and abstracts include the fields of biomedicine and health, covering portions of the life sciences, behavioral sciences, chemical sciences, and bioengineering. PubMed also provides access to additional relevant web sites and links to the other NCBI molecular biology resources.

Last 200 NRF-2 Studies published on Pubmed

A Perspective on Dietary Phytochemicals and Cancer Chemoprevention: Oxidative Stress, Nrf2, and Epigenomics.

Decline in DJ-1 and decreased nuclear translocation of Nrf2 in Fuchs endothelial corneal dystrophy.

Protective effects of erythropoietin on cirrhotic cardiomyopathy in rats.

Heme Oxygenase-1, Oxidation, Inflammation, and Atherosclerosis.

A promoter polymorphism in the Per3 gene is associated with alcohol and stress response.

Cre-mediated stress affects sirtuin expression levels, peroxisome biogenesis and metabolism, antioxidant and proinflammatory signaling pathways.

Sex differences in the response of the alveolar macrophage proteome to treatment with exogenous surfactant protein-A.

Role of Nrf2 in protection against triptolide-induced toxicity in rat kidney cells.

The Nrf2 -antioxidant response element pathway: a target for regulating energy metabolism.

Analysis of the role of Nrf2 in the expression of liver proteins in mice using two-dimensional gel-based proteomics.

Therapeutic approach to neurodegenerative diseases by medical gases: focusing on redox signaling and related antioxidant enzymes.

NRF2 and cancer: the good, the bad and the importance of context.

Effect of Graded Nrf2 Activation on Phase-I and -II Drug Metabolizing Enzymes and Transporters in Mouse Liver.

Major differences among chemopreventive organoselenocompounds in the sustained elevation of cytoprotective genes.

The enhancement of phase 2 enzyme activities by sodium butyrate in normal intestinal epithelial cells is associated with Nrf2 and p53.

[The effects of Nrf2 gene expression induced by RU486 at different doses on A549 cell damage induced by paraquat].

Leukocyte Nurr1 as peripheral biomarker of early-life environmental exposure to permethrin insecticide.

[Effect of danshensu on redox state and relevant nuclear transcription factors in non-small cell lung cancer A549 cells].

Cisplatin-induced chemoresistance in colon cancer cells involves FXR-dependent and FXR-independent up-regulation of ABC proteins.

Update on the pathogenesis of complex regional pain syndrome: Role of oxidative stress.

Identification and Functional Studies of a New Nrf2 partner IQGAP1: A critical role in the stability and transactivation of Nrf2.

Decreased Lectin-Like Oxidized LDL Receptor 1 (LOX-1) and Low Nrf2 Activation in Placenta Are Involved in Preeclampsia.

The Effects of Chromium Picolinate and Chromium Histidinate Administration on NF-κB and Nrf2 /HO-1 Pathway in the Brain of Diabetic Rats.

Nrf2 redirects glucose and glutamine into anabolic pathways in metabolic reprogramming.

S-allyl cysteine protects against 6-hydroxydopamine-induced neurotoxicity in the rat striatum: Involvement of Nrf2 transcription factor activation and modulation of signaling kinase cascades.

Pharmacodynamics of Ginsenosides: Antioxidant Activities, Activation of Nrf2 and Potential Synergistic Effects of Combinations.

The keap1- nrf2 cell defense pathway – a promising therapeutic target?

Antioxidant sulforaphane and sensitizer trinitrobenzene sulfonate induce carboxylesterase-1 through a novel element transactivated by nuclear factor-E2 related factor-2.

Fumarate hydratase inactivation in renal tumors: HIF1α, NRF2 and “cryptic targets” of transcription factors.

MRP3 gene expression correlates with NRF2 mutations in lung squamous cell carcinomas.

6-shogaol-rich extract from ginger up-regulates the antioxidant defense systems in cells and mice.

Resveratrol Enhances Solar UV-Induced Responses in Normal Human Epidermal Keratinocytes.

Nrf2 protects against diquat-induced liver and lung injury.

Oxidative stress induced by potassium bromate exposure results in altered tight junction protein expression in renal proximal tubule cells.

Physiological functions of GPx2 and its role in inflammation-triggered carcinogenesis.

Keap1- Nrf2 Signaling: A Target for Cancer Prevention by Sulforaphane.

Chemoprotection Against Cancer by Isothiocyanates: A Focus on the Animal Models and the Protective Mechanisms.

The gamma secretase inhibitor MRK-003 attenuates pancreatic cancer growth in preclinical models.

Structural and functional characterization of Nrf2 degradation by the GSK-3/β-TrCP axis.

Mithramycin Represses Basal and Cigarette Smoke-Induced Expression of ABCG2 and Inhibits Stem Cell Signaling in Lung and Esophageal Cancer Cells.

Nrf2 -ARE pathway regulates induction of Sestrin-2 expression.

Isolation, identification, and biological evaluation of Nrf2 -ARE activator from the leaves of green perilla (perilla frutescens var. crispa f. viridis).

Targeting Nrf2 -mediated gene transcription by extremely potent synthetic triterpenoids attenuate dopaminergic neurotoxicity in the MPTP- mouse model of Parkinson’s disease.

Keap1: One stone kills three birds Nrf2, IKKβ and Bcl-2/Bcl-xL.

The neuroprotective effects of milk fat globule-EGF factor 8 against oligomeric amyloid ß toxicity.

The Nrf2 -ARE Pathway: A Valuable Therapeutic Target for the Treatment of Neurodegenerative Diseases.

AP-1 Regulation of Murine Aldehyde Dehydrogenase 1a1.

Perk-dependent repression of miR-106b-25 cluster is required for ER stress-induced apoptosis.

Calcineurin expression and activity is regulated by the intracellular redox status and under hypertension in human neutrophils.

[The effect of transcription factor KLF2 in expression of gamma-GCS depend on regulation by Nrf2 in lung of rats with chronic obstructive pulmonary disease].

SERPINA3K Protects against Oxidative Stress via Modulating ROS Generation/Degradation and KEAP1- NRF2 Pathway in the Corneal Epithelium.

Recombinant adenovirus Ad-RUNrf2 reduces paraquat-induced A549 injury.

Phenylpropanoid glycosides from plant cell cultures induce heme oxygenase 1 gene expression in a human keratinocyte cell line by affecting the balance of NRF2 and BACH1 transcription factors.

Catalase Prevents Maternal Diabetes-Induced Perinatal Programming via the Nrf2 -HO-1 Defense System.

Anti-fibrotic effects of L-2-oxothiazolidine-4-carboxylic acid via modulation of nuclear factor erythroid 2-related factor 2 in rats.

Validation of the multiple sensor mechanism of the Keap1- Nrf2 system.

[Effect of ulinastatin on oxidative stress and nuclear factor E2-related factor 2 expression in the lung tissues of acute hydrogen sulfide intoxicated rats].

17β-Estradiol regulates the expression of antioxidant enzymes in myocardial cells by increasing Nrf2 translocation.

Oxidative stress fuels Trypanosoma cruzi infection in mice.

Induction of apoptosis and autophagy by sodium selenite in A549 human lung carcinoma cells through generation of reactive oxygen species.

Activation of nuclear factor erythroid 2-related factor 2 and PPARγ plays a role in the genistein-mediated attenuation of oxidative stress-induced endothelial cell injury.

Standardized extract of Bacopa monniera (BESEB CDRI-08) attenuates contextual associative learning deficits in the aging rat’s brain induced by D-galactose.

Gene expression analysis of toxicological pathways in TM3 leydig cell lines treated with Ethane dimethanesulfonate.

Interferon-beta-1b-induced short- and long-term signatures of treatment activity in multiple sclerosis.

Silymarin suppresses hepatic stellate cell activation in a dietary rat model of non-alcoholic steatohepatitis: Αnalysis of isolated hepatic stellate cells.

Antioxidant effect of silymarin on paraquat-induced human lung adenocarcinoma A549 cell line.

Inhibition of Phosphorylation of JNK Suppresses Aβ-Induced ER Stress and Upregulates Prosurvival Mitochondrial Proteins in Rat Hippocampus.

Aldehyde oxidase 1 gene is regulated by Nrf2 pathway.

Curcumin restores Nrf2 levels and prevents quinolinic acid-induced neurotoxicity.

Catechin protects against ketoprofen-induced oxidative damage of the gastric mucosa by up-regulating Nrf2 in vitro and in vivo.

Nrf2 nuclear translocation induces myofibroblastic dedifferentiation in idiopathic pulmonary fibrosis.

Insulin-Like Growth Factor-1 Inhibits 6-Hydroxydopamine-Mediated Endoplasmic Reticulum Stress-Induced Apoptosis via Regulation of Heme Oxygenase-1 and Nrf2 Expression in PC12 Cells.

The predicted molecular weight of Nrf2: It is what it is not.

Antioxidants in kidney diseases: the impact of bardoxolone methyl.

Proteostasis, an Emerging Therapeutic Paradigm for Managing Inflammatory Airway Stress Disease.

Cigarette smoke-induced proteostasis imbalance in obstructive lung diseases.

Genetic ablation of nrf2 /antioxidant response pathway in alexander disease mice reduces hippocampal gliosis but does not impact survival.

NFE2L2 Pathway Polymorphisms and Lung Function Decline in Chronic Obstructive Pulmonary Disease.

Activation of genes involved in xenobiotic metabolism is a shared signature of mouse models with extended lifespan.

Ginsenoside Rb1 Attenuates Intestinal Ischemia Reperfusion Induced Renal Injury by Activating Nrf2 /ARE Pathway.

Implication of Nrf2 and ATF4 in differential induction of CHOP by proteasome inhibition in thyroid cancer cells.

HGF-mediated inhibition of oxidative stress by 8-nitro-cGMP in high glucose-treated rat mesangial cells.

(1)H, (15)N and (13)C backbone resonance assignments of the Kelch domain of mouse Keap1.

Liver tumor promoting effect of omeprazole in rats and its possible mechanism of action.

Nrf2: Friend and Foe in Preventing Cigarette Smoking-Dependent Lung Disease.

The antioxidant mechanisms underlying the aged garlic extract- and s-allylcysteine-induced protection.

Phytochemical Activation of Nrf2 Protects Human Coronary Artery Endothelial Cells against an Oxidative Challenge.

Regulatory role of KEAP1 and NRF2 in PPARγ expression and chemoresistance in human non-small-cell lung carcinoma cells.

An effective strategy for increasing the radiosensitivity of Human lung Cancer cells by blocking Nrf2 -dependent antioxidant responses.

NAD(P)H:quinone oxidoreductase 1 activity reduces hypertrophy in 3T3-L1 adipocytes.

Induction of heme oxygenase-1 by chamomile protects murine macrophages against oxidative stress.

Promoter demethylation of Keap1 gene in human diabetic cataractous lenses.

Nrf2 as a converging node for cellular signaling pathways of gasotransmitters.

Nrf2 activation prevents cadmium-induced acute liver injury.

Activation of Nrf2 Is Required for Up-Regulation of the π Class of Glutathione S-Transferase in Rat Primary Hepatocytes with l-Methionine Starvation.

Nrf2 protects human alveolar epithelial cells against injury induced by influenza A virus.

SHPS-1 deficiency induces robust neuroprotection against experimental stroke by attenuating oxidative stress.

Expression of heme oxygenase-1 in response to proteasomal inhibition.

Analysis of nrf2 -mediated transcriptional induction of antioxidant response in early embryos.

Polymorphisms in the transcription factor NRF2 and forearm vasodilator responses in humans.

Structural influence of isothiocyanates on expression of cytochrome P450, phase II enzymes, and activation of Nrf2 in primary rat hepatocytes.

Pharmacologic Induction of Heme Oxygenase-1 Plays a Protective Role in Diabetic Retinopathy in Rats.

Targeting signaling pathways in glomerular diseases.

Putting the parts together: Combining in vitro methods to test for skin sensitizing potentials.

Highly Potent Activation of Nrf2 by Topical Tricyclic Bis(Cyano Enone): Implications for Protection against UV Radiation during Thiopurine Therapy.

Unique structure and regulation of the nematode detoxification gene regulator, SKN-1: implications to understanding and controlling drug resistance.

A combination of lipoic acid plus coenzyme Q10 induces PGC1α, a master switch of energy metabolism, improves stress response, and increases cellular glutathione levels in cultured C2C12 skeletal muscle cells.

The yin and yang of nrf2 -regulated selenoproteins in carcinogenesis.

Hormonal and Chemical Regulation of Paraoxonases in Mice.

Thyroid hormone-induced cytosol-to-nuclear translocation of rat liver Nrf2 is dependent on Kupffer cell functioning.

Elevated Hepatic Iron Activates NF-E2-Related Factor 2 (NRF2) Regulated Pathway in a Dietary Iron Overload Mouse Model.

Genetic variation in the Nrf2 promoter associates with defective spermatogenesis in humans.

Curcumin attenuates Nrf2 signaling defect, oxidative stress in muscle and glucose intolerance in high fat diet-fed mice.

Prevention of diabetic complications by activation of Nrf2: diabetic cardiomyopathy and nephropathy.

The NRF2 -related interactome and regulome contain multifunctional proteins and fine-tuned autoregulatory loops.

Dietary modulation of the biotransformation and genotoxicity of aflatoxin B(1).

A Phase I First-in-Human Trial of Bardoxolone Methyl in Patients with Advanced Solid Tumors and Lymphomas.

Decreased oxidative stress during glycolytic inhibition enables maintenance of ATP production and astrocytic survival.

Anti-malarial drug artesunate ameliorates oxidative lung damage in experimental allergic asthma.

The Evolving Role of the Aryl Hydrocarbon Receptor (AHR) in the Normophysiology of Hematopoiesis.

Attenuation of insulin resistance, metabolic syndrome and hepatic oxidative stress by resveratrol in fructose-fed rats.

Role of Nrf2 in preventing ethanol-induced oxidative stress and lipid accumulation.

Bortezomib induces heme oxygenase-1 expression in multiple myeloma.

Increased NRF2 gene (NFE2L2) copy number correlates with mutations in lung squamous cell carcinomas.

Cadmium-Induced Proteome Remodeling Regulated by Spc1/Sty1 and Zip1 in Fission Yeast.

Eriodictyol protects against H(2)O(2)-induced neuron-like PC12 cell death through activation of Nrf2 /ARE signaling pathway.

Functional dissection of Nrf2 -dependent phase II genes in vascular inflammation and endotoxic injury using Keap1 siRNA.

Thioredoxin Reductase Inhibition Elicits Nrf2 -Mediated Responses in Clara Cells: Implications for Oxidant-Induced Lung Injury.

Suppression of the Nrf2 -dependent antioxidant response by glucocorticoids and 11β-HSD1-mediated glucocorticoid activation in hepatic cells.

Extracellular DNA oxidation stimulates activation of NRF2 and reduces the production of ROS in human mesenchymal stem cells.

Drug resistance associates with activation of Nrf2 in MCF-7/DOX cells, and wogonin reverses it by down-regulating Nrf2 -mediated cellular defense response.

Altered manganese homeostasis: Implications for BLI-3-dependent dopaminergic neurodegeneration and SKN-1 protection in C. elegans.

Dysregulated expression of fatty acid oxidation enzymes and iron-regulatory genes in livers of Nrf2 -null mice.

Phase II Trial of Vorinostat With Idarubicin and Cytarabine for Patients With Newly Diagnosed Acute Myelogenous Leukemia or Myelodysplastic Syndrome.

How a calculated oxidative stress can yield multiple therapeutic effects.

Anti-inflammatory Effect of a Cell-Penetrating Peptide Targeting the Nrf2 /Keap1 Interaction.

Identification of novel NRF2 -regulated genes by ChIP-Seq: influence on retinoid X receptor alpha.

Effects of aging and methionine restriction applied at old age on ROS generation and oxidative damage in rat liver mitochondria.

Chemically induced oxidative stress increases polyamine levels by activating the transcription of ornithine decarboxylase and spermidine/spermine-N(1)-acetyltransferase in human hepatoma HUH7 cells.

Glucosinolates and isothiocyanates in health and disease.

Neuroprotective Effects of Dehydroglyasperin C through Activation of Heme Oxygenase-1 in Mouse Hippocampal Cells.

Crosstalk between Nrf2 and the proteasome: Therapeutic potential of Nrf2 inducers in vascular disease and aging.

Development of a Cell-Based High Throughput Luciferase Enzyme Fragment Complementation Assay to Identify Nuclear-Factor-E2-Related Transcription Factor 2 Activators.

Protective effects of isothiocyanates on blood-CSF barrier disruption induced by oxidative stress.

Stress Resistance in the Naked Mole-Rat: The Bare Essentials – A Mini-Review.

Transcript profiling identifies dynamic gene expression patterns and an important role for Nrf2 /Keap1 pathway in the developing mouse esophagus.

Santamarin, a sesquiterpene lactone isolated from Saussurea lappa, represses LPS-induced inflammatory responses via expression of heme oxygenase-1 in murine macrophage cells.

Upregulation of haeme oxygenase-1 by zinc in HCT-116 cells.

Effects of phytochemicals sulforaphane on uridine diphosphate-glucuronosyltransferase expression as well as cell-cycle arrest and apoptosis in human colon cancer Caco-2 cells.

Does Nrf2 Contribute to p53-Mediated Control of Cell Survival and Death?

Modulation of experimental herpes encephalitis-associated neurotoxicity through sulforaphane treatment.

Mechanism of chemical activation of Nrf2.

Anti-inflammatory effects of Amomum compactum on RAW 264.7 cells via induction of heme oxygenase-1.

Ethanol induction of CYP2A5: role of CYP2E1-ROS- Nrf2 pathway.

Inhibition of 6-hydroxydopamine-induced endoplasmic reticulum stress by sulforaphane through the activation of Nrf2 nuclear translocation.

Experimental therapeutics of Nrf2 as a target for prevention of bacterial exacerbations in COPD.

Small Molecule Modulators of Keap1- Nrf2 -ARE Pathway as Potential Preventive and Therapeutic Agents.

Effects of a Water-Soluble Curcumin Protein Conjugate vs. Pure Curcumin in a Diabetic Model of Erectile Dysfunction.

Caveolin-1 Inhibits Expression of Antioxidant Enzymes through Direct Interaction with Nuclear Erythroid 2 p45-related Factor-2 (Nrf2).

Silver nanoparticles-mediated G2/M cycle arrest of renal epithelial cells is associated with NRF2 -GSH signaling.

Induction of lung glutathione and glutamylcysteine ligase by 1,4-phenylenebis(methylene)selenocyanate and its glutathione conjugate: Role of nuclear factor-erythroid 2-related factor 2.

The effects of chromium(VI) on the thioredoxin system: Implications for redox regulation.

Thrombin induces heme oxygenase-1 expression in human synovial fibroblasts through protease-activated receptor signaling pathways.

Ellagic acid attenuates high-carbohydrate, high-fat diet-induced metabolic syndrome in rats.

Oxidative stress is involved in Dasatinib-induced apoptosis in rat primary hepatocytes.

Extremely low-frequency electromagnetic fields activate the antioxidant pathway Nrf2 in a Huntington’s disease-like rat model.

Quercetin ameliorates cardiovascular, hepatic, and metabolic changes in diet-induced metabolic syndrome in rats.

Allopurinol ameliorates thioacetamide-induced acute liver failure by regulating cellular redox-sensitive transcription factors in rats.

Mild hypothermia attenuates mitochondrial oxidative stress by protecting respiratory enzymes and upregulating MnSOD in a pig model of cardiac arrest.

Renal efflux transporter expression in pregnant mice with Type I diabetes.

PM10-induced hospital admissions for asthma and chronic obstructive pulmonary disease: the modifying effect of individual characteristics.

Ethanol-mediated regulation of cytochrome P450 2A6 expression in monocytes: role of oxidative stress-mediated PKC/MEK/ Nrf2 pathway.

GRP78 knockdown enhances apoptosis via the down-regulation of oxidative stress and Akt pathway after epirubicin treatment in colon cancer DLD-1 cells.

The absence of Nrf2 enhances NF-κB-dependent inflammation following scratch injury in mouse primary cultured astrocytes.

Mitochondrial dysfunction in antiphospholipid syndrome: implications in the pathogenesis of the disease and effects of coenzyme Q10 treatment.

Inhibition of Nuclear Factor Erythroid 2-Related Factor 2 Exacerbates HIV-1 gp120-Induced Oxidative and Inflammatory Response: Role in HIV Associated Neurocognitive Disorder.

Oxidative damage of lung and its protective mechanism in mice caused by long-term exposure to titanium dioxide nanoparticles.

Isothiocyanate-drug interactions in the human adenocarcinoma cell line Caco-2.

The role of Nrf2 and apoptotic signaling pathways in oroxylin A-mediated responses in HCT-116 colorectal adenocarcinoma cells and xenograft tumors.

Beta-adrenoceptor pathway enhances mitochondrial function in human neural stem cells via rotary cell culture system.

Extending healthy ageing: nutrient sensitive pathway and centenarian population.

LOSS of Mrp1 alters detoxification enzyme expression in a tissue- and hormonal-status-specific manner.

Glucose oxidase induces insulin resistance via influencing multiple targets in vitro and in vivo: The central role of oxidative stress.

Cap-independent Nrf2 translation is part of a lipoic acid-stimulated detoxification stress response.

Ethyl pyruvate-mediated Nrf2 activation and hemeoxygenase 1 induction in astrocytes confer protective effects via autocrine and paracrine mechanisms.

EGCG protects endothelial cells against PCB 126-induced inflammation through inhibition of AhR and induction of Nrf2 -regulated genes.

Involvement of redox-signalling in endogenous hydrogen sulfide production.

Intracellular signaling pathways modulated by phenolic compounds: application for new anti-inflammatory drugs discovery.

α-Synuclein expression and Nrf2 deficiency cooperate to aggravate protein aggregation, neuronal death and inflammation in early-stage Parkinson’s disease.

Low glucose under hypoxic conditions induces unfolded protein response and produces reactive oxygen species in lens epithelial cells.

Perspectives on the Development of Antioxidant Antiepileptogenic Agents.

Curcumin enhances non-opsonic phagocytosis of Plasmodium falciparum through up-regulation of CD36 surface expression on monocytes/macrophages.

Chamomile Confers Protection against Hydrogen Peroxide-Induced Toxicity through Activation of Nrf2 -Mediated Defense Response.

Malabaricone C inhibits PDGF-induced proliferation and migration of aortic smooth muscle cells through induction of heme oxygenase-1.

A versatile ΦC31 based reporter system for measuring AP-1 and Nrf2 signaling in Drosophila and in tissue culture.

DEP induction of ROS in capillary-like endothelial tubes leads to VEGF-A expression.

Heme oxygenase-1 induction and organic nitrate therapy: beneficial effects on endothelial dysfunction, nitrate tolerance, and vascular oxidative stress.

Proton pump inhibitors suppress iNOS-dependent DNA damage in Barrett’s esophagus by increasing Mn-SOD expression.

How does the macula protect itself from oxidative stress?

Function and regulation of the Cyp2a5/CYP2A6 genes in response to toxic insults in the liver.

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