New insights into crosstalk between Nrf2 pathway and ferroptosis in lung disease

Abstract

Ferroptosis is a distinctive process of cellular demise linked to amino acid metabolism, lipid oxidation, and iron oxidation. The ferroptosis cascade genes are among the regulatory targets of NRF2. This review provides new insights from recent discoveries involving modulation of Nrf2 and ferroptosis in lung diseases.

Key Findings

• NRF2 is a master regulator of ferroptosis cascade genes in lung disease
• NRF2 hyperactivation in lung cancer impedes ferroptosis
• Key targets identified: GPX4, SLC7A11, FSP1, HO-1, ferritin
• NRF2 inhibitors can enhance ferroptosis-inducing agent sensitivity

Clinical Significance

Citation

Chen, Y. et al. (2024). Nrf2 pathway and ferroptosis in lung disease. Cell Death & Disease.