Targeting epigenetic and post-translational modifications of NRF2: key regulatory factors in disease treatment

Abstract

NRF2 is regulated through post-translational modifications (PTMs) and epigenetic alterations. PTMs including phosphorylation, ubiquitination, and acetylation modulate NRF2's stability, activity, and localization. Epigenetic modifications including DNA methylation, histone modifications, and non-coding RNAs regulate NRF2 expression.

Key Findings

• NRF2 stability controlled by phosphorylation, ubiquitination, acetylation
• Epigenetic modifications regulate NRF2 expression
• DNA methylation of NRF2 promoter represses expression
• Roadmap for PTM-targeted NRF2 therapies

Clinical Significance

Citation

Yang, X. et al. (2025). Epigenetic and PTM modifications of NRF2. Cell Death Discovery.