Drug Development

ST3GAL1 drives colorectal cancer metastasis by mediating NRF2-induced activation of the integrin-α6β4 signaling pathway via sialylation modification.

Journal of translational medicine 2026-Mar-28

Yang Yang, Bao Simeng, Xing Qingyang, Ren Yupeng

Abstract

Key Findings

ST3GAL1 promotes colorectal cancer metastasis.
ST3GAL1 mediates NRF2-induced activation of the integrin-α6β4 signaling pathway.
The mechanism involves sialylation modification.

Clinical Significance

Targeting ST3GAL1 or the NRF2-integrin-α6β4 signaling axis may offer novel therapeutic strategies to inhibit colorectal cancer metastasis.

Citation

Yang Yang, Bao Simeng, Xing Qingyanget al.. ST3GAL1 drives colorectal cancer metastasis by mediating NRF2-induced activation of the integrin-α6β4 signaling pathway via sialylation modification. Journal of translational medicine. 2026-Mar-28.

DOI: 10.1186/s12967-026-08025-0