Oxidative Stress

6-Hydroxyflavone Attenuates Inflammatory Osteolysis by Inhibiting Osteoclast Activation via the Nrf2 and Calcium Signaling Pathways.

Inflammation 2026-Apr-10

Qian Kun, Lu Qizhen, Wang Weiyi, Lu Qige, Dai Shenghong, Fu Chuanyun, Sun Shui

Abstract

Key Findings

6-Hydroxyflavone reduces inflammatory osteolysis by inhibiting osteoclast activation.
The inhibitory effect is mediated through activation of the Nrf2 signaling pathway.
Calcium signaling pathways also play a role in the mechanism of action.

Clinical Significance

6-Hydroxyflavone may serve as a potential therapeutic agent for preventing bone loss in inflammatory conditions by targeting oxidative stress and calcium signaling pathways.

Citation

Qian Kun, Lu Qizhen, Wang Weiyiet al.. 6-Hydroxyflavone Attenuates Inflammatory Osteolysis by Inhibiting Osteoclast Activation via the Nrf2 and Calcium Signaling Pathways. Inflammation. 2026-Apr-10.

DOI: 10.1007/s10753-026-02500-y