Ferroptosis

Paclitaxel induces neurotoxicity via activating ferroptosis by suppressing Nrf2/SLC7A11/GSH/GPX4 signaling.

Acta biochimica et biophysica Sinica 2026-Apr-25

Yu Jiaqi, Xu Weifeng, Liu Dongmeng, Feng Xiaoli, Zheng Chenglong, Li Xiaodan, Bao Jiaolin, Luo Sulan, Ding Ren-Bo

Abstract

Key Findings

Paclitaxel induces neurotoxicity by activating ferroptosis.
The mechanism involves suppression of the Nrf2/SLC7A11/GSH/GPX4 signaling pathway.
Inhibition of this pathway leads to increased oxidative damage contributing to neurotoxicity.

Clinical Significance

Understanding that paclitaxel induces neurotoxicity via ferroptosis through suppression of Nrf2 signaling provides potential targets for mitigating side effects in patients undergoing chemotherapy.

Citation

Yu Jiaqi, Xu Weifeng, Liu Dongmenget al.. Paclitaxel induces neurotoxicity via activating ferroptosis by suppressing Nrf2/SLC7A11/GSH/GPX4 signaling. Acta biochimica et biophysica Sinica. 2026-Apr-25.

DOI: 10.3724/abbs.2026068