Oxidative Stress
Gnetum montanum extract attenuates lipopolysaccharide induced acute lung inflammation through Nrf2 and heme oxygenase 1 mediated redox modulation in macrophages.
Scientific reports 2026-Apr-24
Pham Duc-Vinh, Tran Hong-Linh, Nguyen Thu-Hang, Bui Hong-Nhung, Nguyen Hai-Nam, Le Thanh Nguyen, Pham Thi Hien, Nguyen Thuy-Duong
Abstract
Key Findings
- Gnetum montanum extract reduces acute lung inflammation induced by lipopolysaccharide.
- The anti-inflammatory effect is mediated through activation of Nrf2 and heme oxygenase 1 pathways.
- Redox modulation in macrophages plays a key role in the extract's protective effects.
Clinical Significance
This study suggests that Gnetum montanum extract could be a potential therapeutic agent for treating acute lung inflammation by targeting oxidative stress pathways.
Citation
Pham Duc-Vinh, Tran Hong-Linh, Nguyen Thu-Hanget al.. Gnetum montanum extract attenuates lipopolysaccharide induced acute lung inflammation through Nrf2 and heme oxygenase 1 mediated redox modulation in macrophages. Scientific reports. 2026-Apr-24.
DOI: 10.1038/s41598-026-50370-z