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Mas receptor activation regulates the functional phenotype of myocardial macrophages through the Akt/Nrf2 signaling pathway to alleviate sepsis-induced cardiomyopathy.

Journal of translational medicine

Abstract

Key Findings

  • Mas receptor activation modulates the phenotype of myocardial macrophages.
  • This modulation occurs through the Akt/Nrf2 signaling pathway.
  • Activation of this pathway alleviates sepsis-induced cardiomyopathy.

Clinical Significance

Targeting the Mas receptor and the Akt/Nrf2 pathway may offer a therapeutic strategy to reduce cardiac dysfunction in patients with sepsis-induced cardiomyopathy.

Citation

Chen Xin-Sen, Shao Meng, Ge Hua-Junet al.. Mas receptor activation regulates the functional phenotype of myocardial macrophages through the Akt/Nrf2 signaling pathway to alleviate sepsis-induced cardiomyopathy. Journal of translational medicine. 2026-Apr-24.

DOI: 10.1186/s12967-026-08171-5