Drug Development

Context-dependent NRF2 signaling in cancer: mechanisms and precision modulation.

Molecular biology reports 2026-Apr-25

Cong Ling-Lan, Dai Xue-Ling, Liu Xiu-Jun, Sun Ya-Xuan

Abstract

Key Findings

NRF2 signaling exhibits context-dependent roles in cancer progression and therapy resistance.
Mechanistic insights reveal how NRF2 modulates antioxidant responses and metabolic pathways in tumor cells.
Precision modulation of NRF2 pathways offers potential for targeted cancer therapies.

Clinical Significance

Understanding the context-dependent roles of NRF2 in cancer enables the development of precision drugs that can modulate NRF2 signaling to improve therapeutic outcomes and overcome resistance.

Citation

Cong Ling-Lan, Dai Xue-Ling, Liu Xiu-Junet al.. Context-dependent NRF2 signaling in cancer: mechanisms and precision modulation. Molecular biology reports. 2026-Apr-25.

DOI: 10.1007/s11033-026-11849-0