There are currently over 2300 articles (peer reviewed clinical reviews and studies) on Pubmed.gov on the topic of NRF2 Activation. There are a ton of companies claiming they have scientific studies showing that their products are NRF2 Activators. Go to Pubmed.gov and type in the name of their product. Pubmed is a website operated by the National Institute of Health (NIH). PubMed comprises over 21 million citations for biomedical literature from MEDLINE, life science journals, and online books. PubMed citations and abstracts include the fields of biomedicine and health, covering portions of the life sciences, behavioral sciences, chemical sciences, and bioengineering. PubMed also provides access to additional relevant web sites and links to the other NCBI molecular biology resources. Last 200 NRF-2 Studies published on Pubmed
Interaction of Nrf2 with dimeric STAT3 induces IL-23 expression: Implications for breast cancer progression. (2021) Cancer Lett. 500, 147-160 Pubmed Cancer Lett
Chondrocyte ferroptosis contribute to the progression of osteoarthritis. (2021) J Orthop Translat. 27, 33-43 Pubmed J Orthop Translat PMC Article
Construction of Lycetin Nanocarriers and Its Effect on the Proliferation and Apoptosis of Hepatocellular Carcinoma Cells by Regulating Nuclear Factor E2 Related Factor/Antioxidant Response Element Pathway. (2021) J Nanosci Nanotechnol. 21, 1054-1060 Pubmed J Nanosci Nanotechnol
Corrigendum to: "Protective effect of Shaoyao decoction against colorectal cancer via the Keap1-Nrf2-ARE signaling pathway", [J. Ethnopharmacol. 241 (2019) 111981]. (2021) J Ethnopharmacol. 266, 113532 Pubmed J Ethnopharmacol
Role of pyroptosis in spinal cord injury and its therapeutic implications. (2021) J Adv Res. 28, 97-109 Pubmed J Adv Res PMC Article
Trigonelline inhibits Nrf2 via EGFR signalling pathway and augments efficacy of Cisplatin and Etoposide in NSCLC cells. (2021) Toxicol In Vitro. 70, 105038 Pubmed Toxicol In Vitro
miR‑126 overexpression attenuates oxygen‑glucose deprivation/reperfusion injury by inhibiting oxidative stress and inflammatory response via the activation of SIRT1/Nrf2 signaling pathway in human umbilical vein endothelial cells. (2021) Mol Med Rep. 23, Pubmed Mol Med Rep PMC Article
MicroRNA-mediated autophagy regulation in cancer therapy: The role in chemoresistance/chemosensitivity. (2021) Eur J Pharmacol. 892, 173660 Pubmed Eur J Pharmacol
Neuroprotective effect of emodin against Alzheimer's disease via Nrf2 signaling in U251 cells and APP/PS1 mice. (2021) Mol Med Rep. 23, Pubmed Mol Med Rep PMC Article
S-allylcysteine induces cytotoxic effects in two human lung cancer cell lines via induction of oxidative damage, downregulation of Nrf2 and NF-κB, and apoptosis. (2021) Anticancer Drugs. 32, 117-126 Pubmed Anticancer Drugs
Sustained high expression of NRF2 and its target genes induces dysregulation of cellular proliferation and apoptosis is associated with arsenite-induced malignant transformation of human bronchial epithelial cells. (2021) Sci Total Environ. 756, 143840 Pubmed Sci Total Environ
Carnosic acid depends on glutathione to promote mitochondrial protection in methylglyoxal-exposed SH-SY5Y cells. (2021) Metab Brain Dis. Pubmed Metab Brain Dis
7β-(3-Ethyl--crotonoyloxy)-1α-(2-methylbutyryloxy)-3,14-dehydro- Notonipetranone Attenuates Neuropathic Pain by Suppressing Oxidative Stress, Inflammatory and Pro-Apoptotic Protein Expressions. (2021) Molecules. 26, Pubmed Molecules PMC Article
Germacrone alleviates neurological deficits following traumatic brain injury by modulating neuroinflammation and oxidative stress. (2021) BMC Complement Med Ther. 21, 6 Pubmed BMC Complement Med Ther PMC Article
Corrigendum to "Abrus agglutinin inhibits oral carcinogenesis through inactivation of NRF2 signaling pathway" [Int J Biol Macromol. 2020; 155:1123-1132.]. (2021) Int J Biol Macromol. Pubmed Int J Biol Macromol
Identification of a subset of immunosuppressive P2RX1-negative neutrophils in pancreatic cancer liver metastasis. (2021) Nat Commun. 12, 174 Pubmed Nat Commun
Physalin B ameliorates nonalcoholic steatohepatitis by stimulating autophagy and NRF2 activation mediated improvement in oxidative stress. (2021) Free Radic Biol Med. 164, 1-12 Pubmed Free Radic Biol Med
MOAP-1-mediated dissociation of p62/SQSTM1 bodies releases Keap1 and suppresses Nrf2 signaling. (2021) EMBO Rep. e50854 Pubmed EMBO Rep PMC Article
Modulatory effect of Tagetes erecta flowers essential oils via Nrf2/HO-1/NF-κB/p65 axis mediated suppression of N-methyl-N'nitro-N-nitroguanidine (MNNG) induced gastric cancer in rats. (2021) Mol Cell Biochem. Pubmed Mol Cell Biochem
Nrf2 overexpression increases risk of high tumor mutation burden in acute myeloid leukemia by inhibiting MSH2. (2021) Cell Death Dis. 12, 20 Pubmed Cell Death Dis PMC Article
Ginkgetin derived from Ginkgo biloba leaves enhances the therapeutic effect of cisplatin via ferroptosis-mediated disruption of the Nrf2/HO-1 axis in EGFR wild-type non-small-cell lung cancer. (2021) Phytomedicine. 80, 153370 Pubmed Phytomedicine
COVID-19: A Case for Inhibiting NLRP3 Inflammasome, Suppression of Inflammation with Curcumin?. (2021) Basic Clin Pharmacol Toxicol. 128, 37-45 Pubmed Basic Clin Pharmacol Toxicol
Exome of Radiation-induced Rat Mammary Carcinoma Shows Copy-number Losses and Mutations in Human-relevant Cancer Genes. (2021) Anticancer Res. 41, 55-70 Pubmed Anticancer Res
Mangiferin prevents the impairment of mitochondrial dynamics and an increase in oxidative stress caused by excessive fluoride in SH-SY5Y cells. (2021) J Biochem Mol Toxicol. e22705 Pubmed J Biochem Mol Toxicol
Aloin protects mice from diet-induced non-alcoholic steatohepatitis activation of Nrf2/HO-1 signaling. (2021) Food Funct. Pubmed Food Funct
The Isothiocyanate Sulforaphane Depends on the Nrf2/γ-GCL/GSH Axis to Prevent Mitochondrial Dysfunction in Cells Exposed to Methylglyoxal. (2021) Neurochem Res. Pubmed Neurochem Res
MiniPDX-guided postoperative anticancer treatment can effectively prolong the survival of patients with hepatocellular carcinoma. (2021) Cancer Chemother Pharmacol. 87, 125-134 Pubmed Cancer Chemother Pharmacol
Curcumin ameliorates mercuric chloride-induced liver injury via modulating cytochrome P450 signaling and Nrf2/HO-1 pathway. (2021) Ecotoxicol Environ Saf. 208, 111426 Pubmed Ecotoxicol Environ Saf
Different Modulatory Effects of Four Methicillin-Resistant Clones on MG-63 Osteoblast-Like Cells. (2021) Biomolecules. 11, Pubmed Biomolecules
Polysaccharides extracted from Rheum tanguticum ameliorate radiation-induced enteritis via activation of Nrf2/HO-1. (2021) J Radiat Res. 62, 46-57 Pubmed J Radiat Res PMC Article
INHIBITION OF THE NRF2/KEAP1 AXIS: A PROMISING THERAPEUTIC STRATEGY TO ALTER REDOX BALANCE OF CANCER CELLS. (2021) Antioxid Redox Signal. Pubmed Antioxid Redox Signal
Overcoming hypoxia-induced resistance of pancreatic and lung tumor cells by disrupting the PERK-NRF2-HIF-axis. (2021) Cell Death Dis. 12, 82 Pubmed Cell Death Dis
Loss of Tid1/DNAJA3 Co-Chaperone Promotes Progression and Recurrence of Hepatocellular Carcinoma after Surgical Resection: A Novel Model to Stratify Risk of Recurrence. (2021) Cancers (Basel). 13, Pubmed Cancers (Basel) PMC Article
Mechanistic Analysis of an Extracellular Signal-Regulated Kinase 2-Interacting Compound that Inhibits Mutant BRAF-Expressing Melanoma Cells by Inducing Oxidative Stress. (2021) J Pharmacol Exp Ther. 376, 84-97 Pubmed J Pharmacol Exp Ther
Harnessing the Co-vulnerabilities of Amino Acid-Restricted Cancers. (2021) Cell Metab. 33, 9-20 Pubmed Cell Metab
Non-canonical Glutamate-Cysteine Ligase Activity Protects against Ferroptosis. (2021) Cell Metab. 33, 174-189.e7 Pubmed Cell Metab
Kaempferol inhibits Nrf2 signalling pathway via downregulation of Nrf2 mRNA and induces apoptosis in NSCLC cells. (2021) Arch Biochem Biophys. 697, 108700 Pubmed Arch Biochem Biophys
Vitamin D exerts neuroprotection via SIRT1/nrf-2/ NF-kB signaling pathways against D-galactose-induced memory impairment in adult mice. (2021) Neurochem Int. 142, 104893 Pubmed Neurochem Int
Implications of hydrogen sulfide in liver pathophysiology: Mechanistic insights and therapeutic potential. (2021) J Adv Res. 27, 127-135 Pubmed J Adv Res PMC Article
Exacerbation of Coagulation and Cardiac Injury in Rats with Cisplatin-Induced Nephrotoxicity Following Intratracheal Instillation of Cerium Oxide Nanoparticles. (2021) Cell Physiol Biochem. 55, 1-16 Pubmed Cell Physiol Biochem
Vinpocetine ameliorates L-arginine induced acute pancreatitis via Sirt1/Nrf2/TNF pathway and inhibition of oxidative stress, inflammation, and apoptosis. (2021) Biomed Pharmacother. 133, 110976 Pubmed Biomed Pharmacother
β-hydroxybutyrate does not alter the effects of glucose deprivation on breast cancer cells. (2021) Oncol Lett. 21, 65 Pubmed Oncol Lett PMC Article
Phase 1 Trial of MLN0128 (Sapanisertib) and CB-839 HCl (Telaglenastat) in Patients With Advanced NSCLC (NCI 10327): Rationale and Study Design. (2021) Clin Lung Cancer. 22, 67-70 Pubmed Clin Lung Cancer
RNA-seq reveals novel cancer-selective and disease subtype-independent mechanistic targets of withaferin A in human breast cancer cells. (2021) Mol Carcinog. 60, 3-14 Pubmed Mol Carcinog PMC Article
Heavy metal associated health hazards: An interplay of oxidative stress and signal transduction. (2021) Chemosphere. 262, 128350 Pubmed Chemosphere
Inhibitory effects of nodakenin on inflammation and cell death in lipopolysaccharide-induced liver injury mice. (2021) Phytomedicine. 81, 153411 Pubmed Phytomedicine
The main bioactive compounds of Scutellaria baicalensis Georgi. for alleviation of inflammatory cytokines: A comprehensive review. (2021) Biomed Pharmacother. 133, 110917 Pubmed Biomed Pharmacother
Atractylenolides, essential components of Atractylodes-based traditional herbal medicines: Antioxidant, anti-inflammatory and anticancer properties. (2021) Eur J Pharmacol. 891, 173735 Pubmed Eur J Pharmacol
Maltol inhibits the progression of osteoarthritis the nuclear factor-erythroid 2-related factor-2/heme oxygenase-1 signal pathway and . (2021) Food Funct. Pubmed Food Funct
Sex-, Age-, and Race/Ethnicity-Dependent Variations in Drug-Processing and NRF2-Regulated Genes in Human Livers. (2021) Drug Metab Dispos. 49, 111-119 Pubmed Drug Metab Dispos
Tavarua Deoxyriboside A and Jasplakinolide as Potential Neuroprotective Agents: Effects on Cellular Models of Oxidative Stress and Neuroinflammation. (2021) ACS Chem Neurosci. 12, 150-162 Pubmed ACS Chem Neurosci
PP04 Ameliorates High-Fat Diet-Induced Hyperlipidemia by Regulating Lipid Metabolism in C57BL/6N Mice. (2020) J Agric Food Chem. 68, 15154-15163 Pubmed J Agric Food Chem
1-Bromopropane-induced apoptosis in OVCAR-3 cells via oxidative stress and inactivation of Nrf2. (2020) Toxicol Ind Health. 748233720979427 Pubmed Toxicol Ind Health
Glutamine pretreatment protects bovine mammary epithelial cells from inflammation and oxidative stress induced by γ-d-glutamyl-meso-diaminopimelic acid (iE-DAP). (2020) J Dairy Sci. Pubmed J Dairy Sci
[6]-Gingerol impedes 7,12-dimethylbenz(a)anthracene-induced inflammation and cell proliferation-associated hamster buccal pouch carcinogenesis through modulating Nrf2 signaling events. (2020) J Biochem Mol Toxicol. e22689 Pubmed J Biochem Mol Toxicol
Nrf2-A Molecular Target for Sepsis Patients in Critical Care. (2020) Biomolecules. 10, Pubmed Biomolecules PMC Article
Biochemical study on the protective effect of curcumin on acetaminophen and gamma-irradiation induced hepatic toxicity in rats. (2020) Environ Toxicol. Pubmed Environ Toxicol
Hydrogen Sulfide and Carnosine: Modulation of Oxidative Stress and Inflammation in Kidney and Brain Axis. (2020) Antioxidants (Basel). 9, Pubmed Antioxidants (Basel) PMC Article
Puerarin induces apoptosis in prostate cancer cells via inactivation of the Keap1/Nrf2/ARE signaling pathway. (2020) Bioengineered. Pubmed Bioengineered
Dietary taurine modulates hepatic oxidative status, ER stress and inflammation in juvenile turbot (Scophthalmus maximus L.) fed high carbohydrate diets. (2020) Fish Shellfish Immunol. 109, 1-11 Pubmed Fish Shellfish Immunol
Particulate Matter-Induced Inflammation/Oxidative Stress in Macrophages: Fucosterol from as a Potent Protector, Activated via NF-κB/MAPK Pathways and Nrf2/HO-1 Involvement. (2020) Mar Drugs. 18, Pubmed Mar Drugs PMC Article
Sulforaphane ameliorates ethanol plus carbon tetrachloride-induced liver fibrosis in mice through the Nrf2-mediated antioxidant response and acetaldehyde metabolization with inhibition of the LPS/TLR4 signaling pathway. (2020) J Nutr Biochem. 89, 108573 Pubmed J Nutr Biochem
LC-MS characterized methanolic extract of zanthoxylum armatum possess anti-breast cancer activity through Nrf2-Keap1 pathway: An in-silico, in-vitro and in-vivo evaluation. (2020) J Ethnopharmacol. 269, 113758 Pubmed J Ethnopharmacol
The KEAP1-NRF2 System as a Molecular Target of Cancer Treatment. (2020) Cancers (Basel). 13, Pubmed Cancers (Basel) PMC Article
Myricetin: A review of the most recent research. (2020) Biomed Pharmacother. 134, 111017 Pubmed Biomed Pharmacother
Polygalacin D suppresses esophageal squamous cell carcinoma growth and metastasis through regulating miR-142-5p/Nrf2 axis. (2020) Free Radic Biol Med. 164, 58-75 Pubmed Free Radic Biol Med
Nrf2-induced miR-23a-27a-24-2 cluster modulates damage repair of intestinal mucosa by targeting the Bach1/HO-1 axis in inflammatory bowel diseases. (2020) Free Radic Biol Med. 163, 1-9 Pubmed Free Radic Biol Med
Hybrid E/M Phenotype(s) and Stemness: A Mechanistic Connection Embedded in Network Topology. (2020) J Clin Med. 10, Pubmed J Clin Med PMC Article
The Effect of Novel Oleanolic Acid Oximes Conjugated with Indomethacin on the Nrf2-ARE And NF-κB Signaling Pathways in Normal Hepatocytes and Human Hepatocellular Cancer Cells. (2020) Pharmaceuticals (Basel). 14, Pubmed Pharmaceuticals (Basel)
Anti-Viral Potential and Modulation of Nrf2 by Curcumin: Pharmacological Implications. (2020) Antioxidants (Basel). 9, Pubmed Antioxidants (Basel) PMC Article
Dissecting molecular mechanisms underlying HO-induced apoptosis of mouse bone marrow mesenchymal stem cell: role of Mst1 inhibition. (2020) Stem Cell Res Ther. 11, 526 Pubmed Stem Cell Res Ther PMC Article
NRF2 Regulation by Noncoding RNAs in Cancers: The Present Knowledge and the Way Forward. (2020) Cancers (Basel). 12, Pubmed Cancers (Basel) PMC Article
Metabolomic and Transcriptomic Analysis of MCF-7 Cells Exposed to 23 Chemicals at Human-Relevant Levels: Estimation of Individual Chemical Contribution to Effects. (2020) Environ Health Perspect. 128, 127008 Pubmed Environ Health Perspect PMC Article
Revealing Temozolomide Resistance Mechanisms via Genome-Wide CRISPR Libraries. (2020) Cells. 9, Pubmed Cells PMC Article
Enhancer-bound Nrf2 licenses HIF-1α transcription under hypoxia to promote cisplatin resistance in hepatocellular carcinoma cells. (2020) Aging (Albany NY). 12, Pubmed Aging (Albany NY)
Vicenin-2 inhibits the Helicobacterium pylori infection associated gastric carcinogenic events through modulation of PI3K/AKT and Nrf2 signaling in GES-1 cells. (2020) J Biochem Mol Toxicol. e22680 Pubmed J Biochem Mol Toxicol
Fruit Has Anti-Inflammatory Effect and Induces Osteogenic Differentiation by Regulating Nrf2/HO-1 Signaling Pathway in In Vitro and In Vivo Models of Periodontitis. (2020) Antioxidants (Basel). 9, Pubmed Antioxidants (Basel) PMC Article
Ziziphus spina-christi leaf extract mitigates mercuric chloride-induced cortical damage in rats. (2020) Comb Chem High Throughput Screen. Pubmed Comb Chem High Throughput Screen
NRF2 and the Ambiguous Consequences of Its Activation during Initiation and the Subsequent Stages of Tumourigenesis. (2020) Cancers (Basel). 12, Pubmed Cancers (Basel) PMC Article
A comprehensive understanding about the pharmacological effect of diallyl disulfide other than its anti-carcinogenic activities. (2020) Eur J Pharmacol. 893, 173803 Pubmed Eur J Pharmacol
ROS‑mediated hypomethylation of PRDX5 promotes STAT3 binding and activates the Nrf2 signaling pathway in NSCLC. (2020) Int J Mol Med. Pubmed Int J Mol Med
LKB1 mutations in NSCLC are associated with KEAP1/NRF2-dependent radiotherapy resistance targetable by glutaminase inhibition. (2020) Clin Cancer Res. Pubmed Clin Cancer Res
Melatonin reverses cognitive deficits in streptozotocin-induced type 1 diabetes in the rat through attenuation of oxidative stress and inflammation. (2020) J Chem Neuroanat. 112, 101902 Pubmed J Chem Neuroanat
Dietary Ferulic Acid Supplementation Improves Antioxidant Capacity and Lipid Metabolism in Weaned Piglets. (2020) Nutrients. 12, Pubmed Nutrients PMC Article
n-BuOH extract of Bletilla striata exerts chemopreventive effects on lung against SiO nanoparticles through activation of Nrf2 pathway. (2020) Phytomedicine. 82, 153445 Pubmed Phytomedicine
Identifying Clear Cell Renal Cell Carcinoma Coexpression Networks Associated with Opioid Signaling and Survival. (2020) Cancer Res. Pubmed Cancer Res
High Expression of NRF2 Is Associated with Increased Tumor-Infiltrating Lymphocytes and Cancer Immunity in ER-Positive/HER2-Negative Breast Cancer. (2020) Cancers (Basel). 12, Pubmed Cancers (Basel) PMC Article
Andrographolide, an Anti-Inflammatory Multitarget Drug: All Roads Lead to Cellular Metabolism. (2020) Molecules. 26, Pubmed Molecules PMC Article
3D Culture Models with CRISPR Screens Reveal Hyperactive NRF2 as a Prerequisite for Spheroid Formation via Regulation of Proliferation and Ferroptosis. (2020) Mol Cell. 80, 828-844.e6 Pubmed Mol Cell PMC Article
NRF2 level is negatively correlated with TGF-β1-induced lung cancer motility and migration via NOX4-ROS signaling. (2020) Arch Pharm Res. 43, 1297-1310 Pubmed Arch Pharm Res
SUMO Wrestles with Mitophagy to Extend Lifespan. (2020) Rejuvenation Res. 23, 527-532 Pubmed Rejuvenation Res
Netrin-1 protects the SH-SY5Y cells against amyloid beta neurotoxicity through NF-κB/Nrf2 dependent mechanism. (2020) Mol Biol Rep. 47, 9271-9277 Pubmed Mol Biol Rep
Glyoxalase 1 expression analysis by immunohistochemistry in breast cancer. (2020) Pathol Res Pract. 216, 153257 Pubmed Pathol Res Pract
Biochanin A alleviates gingival inflammation and alveolar bone loss in rats with experimental periodontitis. (2020) Exp Ther Med. 20, 251 Pubmed Exp Ther Med PMC Article
Oxidative stress associated metabolic adaptations regulate radioresistance in human lung cancer cells. (2020) J Photochem Photobiol B. 213, 112080 Pubmed J Photochem Photobiol B
The anti-inflammatory potential of protein-bound anthocyanin compounds from purple sweet potato in LPS-induced RAW264.7 macrophages. (2020) Food Res Int. 137, 109647 Pubmed Food Res Int
The Unfolded Protein and Integrated Stress Response in Melanoma and Vitiligo. (2020) Pigment Cell Melanoma Res. Pubmed Pigment Cell Melanoma Res
The therapeutic value of XL388 in human glioma cells. (2020) Aging (Albany NY). 12, 22550-22563 Pubmed Aging (Albany NY) PMC Article
Cellular Nrf2 Levels Determine Cell Fate during Chemical Carcinogenesis in Esophageal Epithelium. (2020) Mol Cell Biol. Pubmed Mol Cell Biol
Free Radicals as a Double-Edged Sword: The Cancer Preventive and Therapeutic Roles of Curcumin. (2020) Molecules. 25, Pubmed Molecules PMC Article
Preconditioning the immature lung with enhanced Nrf2 activity protects against oxidant-induced hypoalveolarization in mice. (2020) Sci Rep. 10, 19034 Pubmed Sci Rep PMC Article
ADAMTS13 inhibits oxidative stress and ameliorates progressive chronic kidney disease following ischaemia/reperfusion injury. (2020) Acta Physiol (Oxf). e13586 Pubmed Acta Physiol (Oxf)
Ameliorative Effects of Quercetin and Metformin and Their Combination Against Experimental Endometriosis in Rats. (2020) Reprod Sci. Pubmed Reprod Sci
Pan-Cancer Multiomics Analysis of TC2N Gene Suggests its Important Role(s) in Tumourigenesis of Many Cancers. (2020) Asian Pac J Cancer Prev. 21, 3199-3209 Pubmed Asian Pac J Cancer Prev
Sophoricoside attenuates lipopolysaccharide-induced acute lung injury by activating the AMPK/Nrf2 signaling axis. (2020) Int Immunopharmacol. 107187 Pubmed Int Immunopharmacol
Amlodipine alleviates cisplatin-induced nephrotoxicity in rats through gamma-glutamyl transpeptidase (GGT) enzyme inhibition, associated with regulation of Nrf2/HO-1, MAPK/NF-κB, and Bax/Bcl-2 signaling. (2020) Saudi Pharm J. 28, 1317-1325 Pubmed Saudi Pharm J PMC Article
NRF2-dependent bioactivation of mitomycin C as a novel strategy to target KEAP1-NRF2 pathway activation in human cancer. (2020) Mol Cell Biol. Pubmed Mol Cell Biol
The NRF2, Thioredoxin, and Glutathione System in Tumorigenesis and Anticancer Therapies. (2020) Antioxidants (Basel). 9, Pubmed Antioxidants (Basel) PMC Article
Dihydroartemisinin administration improves the effectiveness of 5-aminolevulinic acid-mediated photodynamic therapy for the treatment of high-risk human papillomavirus infection. (2020) Photodiagnosis Photodyn Ther. 102078 Pubmed Photodiagnosis Photodyn Ther
Olive Leaf Extract, from L., Reduces Palmitate-Induced Inflammation via Regulation of Murine Macrophages Polarization. (2020) Nutrients. 12, Pubmed Nutrients PMC Article
Mitochondrial Protection and Anti-inflammatory Effects Induced by Emodin in the Human Neuroblastoma SH-SY5Y Cells Exposed to Hydrogen Peroxide: Involvement of the AMPK/Nrf2 Signaling Pathway. (2020) Neurochem Res. Pubmed Neurochem Res
An Overview of Nrf2 Signaling Pathway and Its Role in Inflammation. (2020) Molecules. 25, Pubmed Molecules PMC Article
Enhancer remodeling promotes tumor-initiating activity in NRF2-activated non-small cell lung cancers. (2020) Nat Commun. 11, 5911 Pubmed Nat Commun PMC Article
Allyl Isothiocyanate Protects Acetaminophen-Induced Liver Injury via NRF2 Activation by Decreasing Spontaneous Degradation in Hepatocyte. (2020) Nutrients. 12, Pubmed Nutrients PMC Article
The Keap1/Nrf2 Signaling Pathway in the Thyroid-2020 Update. (2020) Antioxidants (Basel). 9, Pubmed Antioxidants (Basel) PMC Article
Mechanism underlying the effect of SO2-induced oxidation on human skin keratinocytes. (2020) Medicine (Baltimore). 99, e23152 Pubmed Medicine (Baltimore) PMC Article
Application of the in vivo oxidative stress reporter Hmox1 as mechanistic biomarker of arsenic toxicity. (2020) Environ Pollut. 116053 Pubmed Environ Pollut
Role of the KEAP1-NRF2 Axis in Renal Cell Carcinoma. (2020) Cancers (Basel). 12, Pubmed Cancers (Basel) PMC Article
Tackling Chronic Inflammation with Withanolide Phytochemicals-A Withaferin a Perspective. (2020) Antioxidants (Basel). 9, Pubmed Antioxidants (Basel) PMC Article
Diosmetin alleviates acute kidney injury by promoting the TUG1/Nrf2/HO-1 pathway in sepsis rats. (2020) Int Immunopharmacol. 88, 106965 Pubmed Int Immunopharmacol
NQO1 promotes an aggressive phenotype in hepatocellular carcinoma via amplifying ERK-NRF2 signaling. (2020) Cancer Sci. Pubmed Cancer Sci
The extract of Gnaphalium affine D. Don protects against HO-induced apoptosis by targeting PI3K/AKT/GSK-3β signaling pathway in cardiomyocytes. (2020) J Ethnopharmacol. 113579 Pubmed J Ethnopharmacol
Particulate Matter (PM) from Biomass Combustion Induces an Anti-Oxidative Response and Cancer Drug Resistance in Human Bronchial Epithelial BEAS-2B Cells. (2020) Int J Environ Res Public Health. 17, Pubmed Int J Environ Res Public Health PMC Article
p62-Nrf2-p62 Mitophagy Regulatory Loop as a Target for Preventive Therapy of Neurodegenerative Diseases. (2020) Brain Sci. 10, Pubmed Brain Sci PMC Article
MicroRNA-200a represses myocardial infarction-related cell death and inflammation by targeting the Keap1/Nrf2 and β-catenin pathways. (2020) Hellenic J Cardiol. Pubmed Hellenic J Cardiol
Protective Effects of Curcumin Against Paclitaxel-Induced Spinal Cord and Sciatic Nerve Injuries in Rats. (2020) Neurochem Res. Pubmed Neurochem Res
Tim-3 deteriorates neuroinflammatory and neurocyte apoptosis after subarachnoid hemorrhage through the Nrf2/HMGB1 signaling pathway in rats. (2020) Aging (Albany NY). 12, 21161-21185 Pubmed Aging (Albany NY) PMC Article
Sesaminol prevents Parkinson's disease by activating the Nrf2-ARE signaling pathway. (2020) Heliyon. 6, e05342 Pubmed Heliyon PMC Article
The phytoprotective agent sulforaphane prevents inflammatory degenerative diseases and age-related pathologies via Nrf2-mediated hormesis. (2020) Pharmacol Res. 105283 Pubmed Pharmacol Res
NRF2 dependent stress defence in tumor antioxidant control and immune evasion. (2020) Pigment Cell Melanoma Res. Pubmed Pigment Cell Melanoma Res
Reductive stress promotes protein aggregation and impairs neurogenesis. (2020) Redox Biol. 37, 101739 Pubmed Redox Biol PMC Article
The Nrf2 in the pathophysiology of the intestine: Molecular mechanisms and therapeutic implications for inflammatory bowel diseases. (2020) Pharmacol Res. 105243 Pubmed Pharmacol Res
Keap1 inhibition sensitizes head and neck squamous cell carcinoma cells to ionizing radiation via impaired non-homologous end joining and induced autophagy. (2020) Cell Death Dis. 11, 887 Pubmed Cell Death Dis PMC Article
Chemopreventive Potential of Caryophyllane Sesquiterpenes: An Overview of Preliminary Evidence. (2020) Cancers (Basel). 12, Pubmed Cancers (Basel) PMC Article
Dimethyl fumarate reduces TNF and Plasmodium falciparum induced brain endothelium activation in vitro. (2020) Malar J. 19, 376 Pubmed Malar J PMC Article
Dissecting the Crosstalk between NRF2 Signaling and Metabolic Processes in Cancer. (2020) Cancers (Basel). 12, Pubmed Cancers (Basel) PMC Article
Molecular changes associated with the anticancer effect of sulforaphane against Ehrlich solid tumour in mice. (2020) J Biochem Mol Toxicol. e22655 Pubmed J Biochem Mol Toxicol
Nrf2 Lowers the Risk of Lung Injury via Modulating the Airway Innate Immune Response Induced by Diesel Exhaust in Mice. (2020) Biomedicines. 8, Pubmed Biomedicines PMC Article
Prognostic Significance of Oxidation Pathway Mutations in Recurrent Laryngeal Squamous Cell Carcinoma. (2020) Cancers (Basel). 12, Pubmed Cancers (Basel) PMC Article
A Critical Review of the Abilities, Determinants, and Possible Molecular Mechanisms of Seaweed Polysaccharides Antioxidants. (2020) Int J Mol Sci. 21, Pubmed Int J Mol Sci PMC Article
Identification, Characterization, and Mutational Analysis of a Probable KEAP1 Ortholog in Rice ( L.). (2020) Plants (Basel). 9, Pubmed Plants (Basel) PMC Article
Protective effects of natural compounds against oxidative stress in ischemic diseases and cancers via activating the Nrf2 signaling pathway: A mini review. (2020) J Biochem Mol Toxicol. e22658 Pubmed J Biochem Mol Toxicol
Protective effects of irigenin against 1-methyl-4-phenylpyridinium-induced neurotoxicity through regulating the Keap1/Nrf2 pathway. (2020) Phytother Res. Pubmed Phytother Res
Ameliorative Effect of Linalool in Cisplatin-Induced Nephrotoxicity: The Role of HMGB1/TLR4/NF-κB and Nrf2/HO1 Pathways. (2020) Biomolecules. 10, Pubmed Biomolecules PMC Article
ROS-Dependent ER Stress and Autophagy Mediate the Anti-Tumor Effects of Tributyltin (IV) Ferulate in Colon Cancer Cells. (2020) Int J Mol Sci. 21, Pubmed Int J Mol Sci PMC Article
Porphyromonas gingivalis infection alters Nrf2-Phase II enzymes and nitric oxide in primary human aortic endothelial cells. (2020) J Periodontol. Pubmed J Periodontol
Regulation of Canonical Oncogenic Signaling Pathways in Cancer via DNA Methylation. (2020) Cancers (Basel). 12, Pubmed Cancers (Basel) PMC Article
Protective Effects of Epigallocatechin Gallate (EGCG) on Endometrial, Breast, and Ovarian Cancers. (2020) Biomolecules. 10, Pubmed Biomolecules PMC Article
Pharmacological Effects of Salvianolic Acid B Against Oxidative Damage. (2020) Front Pharmacol. 11, 572373 Pubmed Front Pharmacol PMC Article
Nrf2 Mediates Metabolic Reprogramming in Non-Small Cell Lung Cancer. (2020) Front Oncol. 10, 578315 Pubmed Front Oncol PMC Article
Exploration the Mechanism of Doxorubicin-Induced Heart Failure in Rats by Integration of Proteomics and Metabolomics Data. (2020) Front Pharmacol. 11, 600561 Pubmed Front Pharmacol PMC Article
RASSF1A Enhances Chemosensitivity of NSCLC Cells Through Activating Autophagy by Regulating MAP1S to Inactivate Keap1-Nrf2 Pathway. (2021) Drug Des Devel Ther. 15, 21-35 Pubmed Drug Des Devel Ther PMC Article
Mild Oxidative Stress Reduces NRF2 SUMOylation to Promote // Mutant Lung Adenocarcinoma Cell Migration and Invasion. (2020) Oxid Med Cell Longev. 2020, 6240125 Pubmed Oxid Med Cell Longev PMC Article
NETO2 promotes esophageal cancer progression by inducing proliferation and metastasis via PI3K/AKT and ERK pathway. (2021) Int J Biol Sci. 17, 259-270 Pubmed Int J Biol Sci PMC Article
Toward Regulatory Effects of Curcumin on Transforming Growth Factor-Beta Across Different Diseases: A Review. (2020) Front Pharmacol. 11, 585413 Pubmed Front Pharmacol PMC Article
The Nrf2/PGC1 Pathway Regulates Antioxidant and Proteasomal Activity to Alter Cisplatin Sensitivity in Ovarian Cancer. (2020) Oxid Med Cell Longev. 2020, 4830418 Pubmed Oxid Med Cell Longev PMC Article
Primary Amine Modified Gold Nanodots Regulate Macrophage Function and Antioxidant Response: Potential Therapeutics Targeting of Nrf2. (2020) Int J Nanomedicine. 15, 8411-8426 Pubmed Int J Nanomedicine PMC Article
Daphnetin Attenuated Cisplatin-Induced Acute Nephrotoxicity With Enhancing Antitumor Activity of Cisplatin by Upregulating SIRT1/SIRT6-Nrf2 Pathway. (2020) Front Pharmacol. 11, 579178 Pubmed Front Pharmacol PMC Article
Chiauranib selectively inhibits colorectal cancer with wild-type by modulation of ROS through activating the p53 signaling pathway. (2020) Am J Cancer Res. 10, 3666-3685 Pubmed Am J Cancer Res PMC Article
Celecoxib Exerts Neuroprotective Effects in β-Amyloid-Treated SH-SY5Y Cells Through the Regulation of Heme Oxygenase-1: Novel Insights for an Old Drug. (2020) Front Cell Dev Biol. 8, 561179 Pubmed Front Cell Dev Biol PMC Article
The Protective Effects and Potential Mechanisms of : Focus on Anti-Inflammatory, Antioxidant, and Antiapoptotic Activities. (2020) Evid Based Complement Alternat Med. 2020, 8205983 Pubmed Evid Based Complement Alternat Med PMC Article
LncRNA MIR4435-2HG mediates cisplatin resistance in HCT116 cells by regulating Nrf2 and HO-1. (2020) PLoS One. 15, e0223035 Pubmed PLoS One PMC Article
LncRNA 1 Regulates miR-144-3p to Facilitate Epithelial-Mesenchymal Transition of Lens Epithelial Cells via the ROS/NRF2/Notch1/Snail Pathway. (2020) Oxid Med Cell Longev. 2020, 8184314 Pubmed Oxid Med Cell Longev PMC Article
Synergistic Carcinogenesis of HPV18 and MNNG in Het-1A Cells through p62-KEAP1-NRF2 and PI3K/AKT/mTOR Pathway. (2020) Oxid Med Cell Longev. 2020, 6352876 Pubmed Oxid Med Cell Longev PMC Article
Bixin Attenuates Experimental Autoimmune Encephalomyelitis by Suppressing TXNIP/NLRP3 Inflammasome Activity and Activating NRF2 Signaling. (2020) Front Immunol. 11, 593368 Pubmed Front Immunol PMC Article
Sinapic Acid Inhibits IL-1β-Induced Apoptosis and Catabolism in Nucleus Pulposus Cells and Ameliorates Intervertebral Disk Degeneration. (2020) J Inflamm Res. 13, 883-895 Pubmed J Inflamm Res PMC Article
Apigenin-Loaded Solid Lipid Nanoparticle Attenuates Diabetic Nephropathy Induced by Streptozotocin Nicotinamide Through Nrf2/HO-1/NF-kB Signalling Pathway. (2020) Int J Nanomedicine. 15, 9115-9124 Pubmed Int J Nanomedicine PMC Article
Targeting Epstein-Barr virus oncoprotein LMP1-mediated high oxidative stress suppresses EBV lytic reactivation and sensitizes tumors to radiation therapy. (2020) Theranostics. 10, 11921-11937 Pubmed Theranostics PMC Article
Mesenchymal Stem Cells Early Response to Low-Dose Ionizing Radiation. (2020) Front Cell Dev Biol. 8, 584497 Pubmed Front Cell Dev Biol PMC Article
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KRT-232 and navitoclax enhance trametinib's anti-Cancer activity in non-small cell lung cancer patient-derived xenografts with KRAS mutations. (2020) Am J Cancer Res. 10, 4464-4475 Pubmed Am J Cancer Res PMC Article
KSFY06 Prevents Inflammatory Response and Oxidative Stress in Acute Liver Injury Induced by D-Gal/LPS in Mice. (2021) Drug Des Devel Ther. 15, 37-50 Pubmed Drug Des Devel Ther PMC Article
Long-term transcriptomic and proteomic effects in Sprague Dawley rat thyroid and plasma after internal low dose 131I exposure. (2020) PLoS One. 15, e0244098 Pubmed PLoS One PMC Article
Honokiol Alleviates Methionine-Choline Deficient Diet-Induced Hepatic Steatosis and Oxidative Stress in C57BL/6 Mice by Regulating CFLAR-JNK Pathway. (2020) Oxid Med Cell Longev. 2020, 2313641 Pubmed Oxid Med Cell Longev PMC Article
NFE2L2 Is a Potential Prognostic Biomarker and Is Correlated with Immune Infiltration in Brain Lower Grade Glioma: A Pan-Cancer Analysis. (2020) Oxid Med Cell Longev. 2020, 3580719 Pubmed Oxid Med Cell Longev PMC Article
Ubiquitin-Like Modifier Activating Enzyme 1 as a Novel Diagnostic and Prognostic Indicator That Correlates With Ferroptosis and the Malignant Phenotypes of Liver Cancer Cells. (2020) Front Oncol. 10, 592413 Pubmed Front Oncol PMC Article
A Novel STAT3-Mediated GATA6 Pathway Contributes to -Butylhydroquinone- (tBHQ-) Protected TNF-Activated Vascular Cell Adhesion Molecule 1 (VCAM-1) in Vascular Endothelium. (2020) Oxid Med Cell Longev. 2020, 6584059 Pubmed Oxid Med Cell Longev PMC Article
Inhibition of Nrf2/HO-1 signaling pathway by Dextran Sulfate suppresses angiogenesis of Gastric Cancer. (2021) J Cancer. 12, 1042-1060 Pubmed J Cancer PMC Article
Prognostic and clinicopathological significance of NRF2 expression in non-small cell lung cancer: A meta-analysis. (2020) PLoS One. 15, e0241241 Pubmed PLoS One PMC Article
Alpha-Arbutin Promotes Wound Healing by Lowering ROS and Upregulating Insulin/IGF-1 Pathway in Human Dermal Fibroblast. (2020) Front Physiol. 11, 586843 Pubmed Front Physiol PMC Article
The genetic paradigms of dietary restriction fail to extend life span in cep-1(gk138) mutant of C. elegans p53 due to possible background mutations. (2020) PLoS One. 15, e0241478 Pubmed PLoS One PMC Article
Polymorphism Impacts Proinflammatory Cytokine Levels, Survival, and Transplant-Related Mortality After Hematopoietic Stem Cell Transplantation in Adult Patients Receiving Busulfan-Based Conditioning Regimens. (2020) Front Pharmacol. 11, 563321 Pubmed Front Pharmacol PMC Article
Orosomucoid 1 Attenuates Doxorubicin-Induced Oxidative Stress and Apoptosis in Cardiomyocytes via Nrf2 Signaling. (2020) Biomed Res Int. 2020, 5923572 Pubmed Biomed Res Int PMC Article
Inhibitory Effect of Delphinidin on Oxidative Stress Induced by HO in HepG2 Cells. (2020) Oxid Med Cell Longev. 2020, 4694760 Pubmed Oxid Med Cell Longev PMC Article
Long Non-Coding RNA PVT1 Regulates the Resistance of the Breast Cancer Cell Line MDA-MB-231 to Doxorubicin via Nrf2. Technol Cancer Res Treat. 19, 1533033820980763 Pubmed Technol Cancer Res Treat PMC Article