Clinical Trials & Research

English: Graph of Nrf2 publications (pubmed se...

English: Graph of Nrf2 publications (pubmed search) by year (Photo credit: Wikipedia)

There are currently over 2300 articles (peer reviewed clinical reviews and studies) on on the topic of NRF2 Activation.

There are a ton of companies claiming they have scientific studies showing that their products are NRF2 Activators. Go to and type in the name of their product.

Pubmed is a website operated by the National Institute of Health (NIH).  PubMed comprises over 21 million citations for biomedical literature from MEDLINE, life science journals, and online books. PubMed citations and abstracts include the fields of biomedicine and health, covering portions of the life sciences, behavioral sciences, chemical sciences, and bioengineering. PubMed also provides access to additional relevant web sites and links to the other NCBI molecular biology resources.

Last 200 NRF-2 Studies published on Pubmed

Park CW, Ahn JH, Lee TK, Park YE, Kim B, Lee JC, Kim DW, Shin MC, Park Y, Cho JH, Ryoo S, Kim YM, Won MH and Park JH. Post-treatment with oxcarbazepine confers potent neuroprotection against transient global cerebral ischemic injury by activating Nrf2 defense pathway. (2020) Biomed. Pharmacother.. 124, 109850 Pubmed Biomed. Pharmacother.
Zhou Y, Zhou Y, Wang K, Li T, Yang M, Wang R, Chen Y, Cao M and Hu R. Flumethasone enhances the efficacy of chemotherapeutic drugs in lung cancer by inhibiting Nrf2 signaling pathway. (2020) Cancer Lett.. 474, 94-105 Pubmed Cancer Lett.
Song C, Heping H, Shen Y, Jin S, Li D, Zhang A, Ren X, Wang K, Zhang L, Wang J and Shi D. AMPK/p38/Nrf2 activation as a protective feedback to restrain oxidative stress and inflammation in microglia stimulated with sodium fluoride. (2020) Chemosphere. 244, 125495 Pubmed Chemosphere
Ashrafizadeh M, Ahmadi Z, Samarghandian S, Mohammadinejad R, Yaribeygi H, Sathyapalan T and Sahebkar A. MicroRNA-mediated regulation of Nrf2 signaling pathway: Implications in disease therapy and protection against oxidative stress. (2020) Life Sci.. 244, 117329 Pubmed Life Sci.
Shin JW, Chun KS, Kim DH, Kim SJ, Kim SH, Cho NC, Na HK and Surh YJ. Curcumin induces stabilization of Nrf2 protein through Keap1 cysteine modification. (2020) Biochem. Pharmacol.. 173, 113820 Pubmed Biochem. Pharmacol.
Abed DA, Lee S and Hu L. Discovery of disubstituted xylylene derivatives as small molecule direct inhibitors of Keap1-Nrf2 protein-protein interaction. (2020) Bioorg. Med. Chem.. 28, 115343 Pubmed Bioorg. Med. Chem.
Nabeshima T, Hamada S, Taguchi K, Tanaka Y, Matsumoto R, Yamamoto M and Masamune A. deletion accelerates mutant /-driven cholangiocarcinoma. (2020) Am. J. Physiol. Gastrointest. Liver Physiol.. 318, G419-G427 Pubmed Am. J. Physiol. Gastrointest. Liver Physiol.
Zhao J, Niu X, Yu J, Xiao X, Li W, Zang L, Hu Z, Siu-Po Ip P and Li W. Poria cocos polysaccharides attenuated ox-LDL-induced inflammation and oxidative stress via ERK activated Nrf2/HO-1 signaling pathway and inhibited foam cell formation in VSMCs. (2020) Int. Immunopharmacol.. 80, 106173 Pubmed Int. Immunopharmacol.
Chen Y, Bian W and Xu B. Pretreatment with dexmedetomidine alleviates lung injury in a rat model of intestinal ischemia reperfusion. (2020) Mol Med Rep. 21, 1233-1241 Pubmed Mol Med Rep PMC Article
Uddin MS, Mamun AA, Jakaria M, Thangapandiyan S, Ahmad J, Rahman MA, Mathew B, Abdel-Daim MM and Aleya L. Emerging promise of sulforaphane-mediated Nrf2 signaling cascade against neurological disorders. (2020) Sci. Total Environ.. 707, 135624 Pubmed Sci. Total Environ.
Tian L, Sun SS, Cui LB, Wang SQ, Peng ZW, Tan QR, Hou WG and Cai M. Repetitive Transcranial Magnetic Stimulation Elicits Antidepressant- and Anxiolytic-like Effect via Nuclear Factor-E2-related Factor 2-mediated Anti-inflammation Mechanism in Rats. (2020) Neuroscience. 429, 119-133 Pubmed Neuroscience
Zhou H, Wang Y, You Q and Jiang Z. Recent progress in the development of small molecule Nrf2 activators: a patent review (2017-present). (2020) Expert Opin Ther Pat. 30, 209-225 Pubmed Expert Opin Ther Pat
Wang L, Li C, Sreeharsha N, Mishra A, Shrotriya V and Sharma A. Neuroprotective effect of Wogonin on Rat's brain exposed to gamma irradiation. (2020) J. Photochem. Photobiol. B, Biol.. 204, 111775 Pubmed J. Photochem. Photobiol. B, Biol.
Qu Z, Chen Y, Luo ZH, Shen XL and Hu YJ. 7-methoxyflavanone alleviates neuroinflammation in lipopolysaccharide-stimulated microglial cells by inhibiting TLR4/MyD88/MAPK signalling and activating the Nrf2/NQO-1 pathway. (2020) J. Pharm. Pharmacol.. 72, 385-395 Pubmed J. Pharm. Pharmacol.
Ramesh PS, Devegowda D, Singh A and Thimmulappa RK. NRF2, p53, and p16: Predictive biomarkers to stratify human papillomavirus associated head and neck cancer patients for de-escalation of cancer therapy. (2020) Crit. Rev. Oncol. Hematol.. 148, 102885 Pubmed Crit. Rev. Oncol. Hematol.
Sharma SH, Suresh Kumar J, Madhavan S and Nagarajan S. Morin supplementation modulates PERK branch of UPR and mitigates 1,2-dimethylhydrazine-induced angiogenesis and oxidative stress in the colon of experimental rats. (2020) Toxicol. Mech. Methods. 1-10 Pubmed Toxicol. Mech. Methods
He L, Long J, Zhou X, Liu Y, Li T and Wu X. Serine is required for the maintenance of redox balance and proliferation in the intestine under oxidative stress. (2020) FASEB J.. Pubmed FASEB J.
Chu X, Zhang X, Gong X, Zhou H and Cai C. Effects of hyperoxia exposure on the expression of Nrf2 and heme oxygenase-1 in lung tissues of premature rats. (2020) Mol. Cell. Probes. 101529 Pubmed Mol. Cell. Probes
Niki T, Endo J, Takahashi-Niki K, Yasuda T, Okamoto A, Saito Y, Ariga H and Iguchi-Ariga SMM. DJ-1-binding compound B enhances Nrf2 activity through the PI3-kinase-Akt pathway by DJ-1-dependent inactivation of PTEN. (2020) Brain Res.. 1729, 146641 Pubmed Brain Res.
Chan Kwon Y, Sik Kim H and Lee BM. Detoxifying effects of optimal hyperoxia (40% oxygenation) exposure on benzo[a]pyrene-induced toxicity in human keratinocytes. (2020) J. Toxicol. Environ. Health Part A. 1-13 Pubmed J. Toxicol. Environ. Health Part A
Yang G, Yin H, Lin F, Gao S, Zhan K, Tong H, Tang X, Pan Q and Gou X. Long noncoding RNA TUG1 regulates prostate cancer cell proliferation, invasion and migration via the Nrf2 signaling axis. (2020) Pathol. Res. Pract.. 152851 Pubmed Pathol. Res. Pract.
Deng S, Essandoh K, Wang X, Li Y, Huang W, Chen J, Peng J, Jiang DS, Mu X, Wang C, Peng T, Guan JL, Wang Y, Jegga A, Huang K and Fan GC. Tsg101 positively regulates P62-Keap1-Nrf2 pathway to protect hearts against oxidative damage. (2020) Redox Biol. 101453 Pubmed Redox Biol
Dudas J, Ladanyi A, Ingruber J, Steinbichler TB and Riechelmann H. Epithelial to Mesenchymal Transition: A Mechanism that Fuels Cancer Radio/Chemoresistance. (2020) Cells. 9, Pubmed Cells
Gu L, Li S, Bai J, Zhang Q and Han Z. α-Lipoic acid protects against microcystin-LR induced hepatotoxicity through regeneration of glutathione via activation of Nrf2. (2020) Environ. Toxicol.. Pubmed Environ. Toxicol.
Morris AR, Stanton DL, Roman D and Liu AC. Systems Level Understanding of Circadian Integration with Cell Physiology. (2020) J. Mol. Biol.. Pubmed J. Mol. Biol.
Wing Leung H, Ting Lau EY, Ning Leung CO, Leng Lei MM, Kit Mok EH, Ma VWS, Shing Cho WC, Lin Ng IO, Ping Yun J, Hang Cai S, Jian Yu H, Ma S and Wah Lee TK. NRF2/SHH signaling cascade promotes tumor-initiating cell lineage and drug resistance in hepatocellular carcinoma. (2020) Cancer Lett.. 476, 48-56 Pubmed Cancer Lett.
Hsieh HL, Liu SH, Chen YL, Huang CY and Wu SJ. Astragaloside IV suppresses inflammatory response via suppression of NF-κB, and MAPK signalling in human bronchial epithelial cells. (2020) Arch. Physiol. Biochem.. 1-10 Pubmed Arch. Physiol. Biochem.
Kurt B, Ozleyen A, Antika G, Yilmaz YB and Tumer TB. Multitarget Profiling of a Strigolactone Analogue for Early Events of Alzheimer's Disease: In Vitro Therapeutic Activities against Neuroinflammation. (2020) ACS Chem Neurosci. 11, 501-507 Pubmed ACS Chem Neurosci
Hennig P, Fenini G, Di Filippo M and Beer HD. Electrophiles Against (Skin) Diseases: More Than Nrf2. (2020) Biomolecules. 10, Pubmed Biomolecules
Saigusa D, Motoike IN, Saito S, Zorzi M, Aoki Y, Kitamura H, Suzuki M, Katsuoka F, Ishii H, Kinoshita K, Motohashi H and Yamamoto M. Impacts of NRF2 activation in non-small-cell lung cancer cell lines on extracellular metabolites. (2020) Cancer Sci.. 111, 667-678 Pubmed Cancer Sci. PMC Article
Liu P, Dodson M, Fang D, Chapman E and Zhang DD. NRF2 negatively regulates primary ciliogenesis and hedgehog signaling. (2020) PLoS Biol.. 18, e3000620 Pubmed PLoS Biol.
Bellezza I, Riuzzi F, Chiappalupi S, Arcuri C, Giambanco I, Sorci G and Donato R. Reductive stress in striated muscle cells. (2020) Cell. Mol. Life Sci.. Pubmed Cell. Mol. Life Sci.
Wang W, Zhao H and Chen B. DJ-1 protects retinal pericytes against high glucose-induced oxidative stress through the Nrf2 signaling pathway. (2020) Sci Rep. 10, 2477 Pubmed Sci Rep PMC Article
Chen Y, Sun Y, Zhao W, Ma Y, Yan Z and Nie X. Elevated SRC3 expression predicts pemetrexed resistance in lung adenocarcinoma. (2020) Biomed. Pharmacother.. 125, 109958 Pubmed Biomed. Pharmacother.
Wang ML, Zhong QY, Lin BQ, Liu YH, Huang YF, Chen Y, Yuan J, Su ZR and Zhan JY. Andrographolide sodium bisulfate attenuates UV‑induced photo‑damage by activating the keap1/Nrf2 pathway and downregulating the NF‑κB pathway in HaCaT keratinocytes. (2020) Int. J. Mol. Med.. 45, 343-352 Pubmed Int. J. Mol. Med. PMC Article
Wu R, Zhang H, Zhao M, Li J, Hu Y, Fu J, Pi J, Wang H and Xu Y. Nrf2 in keratinocytes protects against skin fibrosis via regulating epidermal lesion and inflammatory response. (2020) Biochem. Pharmacol.. 174, 113846 Pubmed Biochem. Pharmacol.
Su R, Su W and Jiao Q. Corrigendum to: NGF protects neuroblastoma cells against β-amyloid induced apoptosis via the Nrf2/HO-1 pathway. (2020) FEBS Open Bio. 10, 288 Pubmed FEBS Open Bio PMC Article
Zhou W, Fang C, Zhang L, Wang Q, Li D and Zhu D. Thioredoxin domain-containing protein 9 (TXNDC9) contributes to oxaliplatin resistance through regulation of autophagy-apoptosis in colorectal adenocarcinoma. (2020) Biochem. Biophys. Res. Commun.. Pubmed Biochem. Biophys. Res. Commun.
LeBoeuf SE, Wu WL, Karakousi TR, Karadal B, Jackson SR, Davidson SM, Wong KK, Koralov SB, Sayin VI and Papagiannakopoulos T. Activation of Oxidative Stress Response in Cancer Generates a Druggable Dependency on Exogenous Non-essential Amino Acids. (2020) Cell Metab.. 31, 339-350.e4 Pubmed Cell Metab. PMC Article
Campello L, Kutsyr O, Noailles A, Michalska P, Fernández-Sánchez L, Martínez-Gil N, Ortuño-Lizarán I, Sánchez-Sáez X, de Juan E, Lax P, León R, García AG, Cuenca N and Maneu V. New Nrf2-Inducer Compound ITH12674 Slows the Progression of Retinitis Pigmentosa in the Mouse Model rd10. (2020) Cell. Physiol. Biochem.. 54, 142-159 Pubmed Cell. Physiol. Biochem.
Guo K, Ge J, Zhang C, Lv MW, Zhang Q, Talukder M and Li JL. `Cadmium induced cardiac inflammation in chicken (Gallus gallus) via modulating cytochrome P450 systems and Nrf2 mediated antioxidant defense. (2020) Chemosphere. 249, 125858 Pubmed Chemosphere
Kang HS, Kwon HY, Kim IK, Ban WH, Kim SW, Kang HH, Yeo CD and Lee SH. Intermittent hypoxia exacerbates tumor progression in a mouse model of lung cancer. (2020) Sci Rep. 10, 1854 Pubmed Sci Rep PMC Article
Wang T, Liu Q and Duan L. MBNL1 regulates resistance of HeLa cells to cisplatin via Nrf2. (2020) Biochem. Biophys. Res. Commun.. 522, 763-769 Pubmed Biochem. Biophys. Res. Commun.
Wang H, Liu C, Zhao Y, Zhang W, Xu K, Li D, Zhou Y, Li H, Xiao G, Lu B and Gao G. Inhibition of LONP1 protects against erastin-induced ferroptosis in Pancreatic ductal adenocarcinoma PANC1 cells. (2020) Biochem. Biophys. Res. Commun.. 522, 1063-1068 Pubmed Biochem. Biophys. Res. Commun.
Sánchez JMH, Lumbreras E, Díez-Campelo M, González T, López DA, Abáigar M, Del Rey M, Martín AÁ, de Paz R, Erquiaga S, Arrizabalaga B, Hernández-Rivas JM and Vicente AER. Genome-wide transcriptomics leads to the identification of deregulated genes after deferasirox therapy in low-risk MDS patients. (2020) Pharmacogenomics J.. Pubmed Pharmacogenomics J.
Lin H and Wang X. The effects of gasotransmitters on bronchopulmonary dysplasia. (2020) Eur. J. Pharmacol.. 873, 172983 Pubmed Eur. J. Pharmacol.
Krajka-Kuźniak V, Cykowiak M, Szaefer H, Kleszcz R and Baer-Dubowska W. Combination of xanthohumol and phenethyl isothiocyanate inhibits NF-κB and activates Nrf2 in pancreatic cancer cells. (2020) Toxicol In Vitro. 104799 Pubmed Toxicol In Vitro
Dunnick JK, Shockley KR, Morgan DL, Travlos GS, Gerrish K, Ton TT, Wilson R, Brar SS, Brix AE, Waidyanatha S, Mutlu E and Pandiri AKR. Hepatic Transcriptomic Patterns in the Neonatal Rat After Pentabromodiphenyl Ether Exposure. (2020) Toxicol Pathol. 48, 338-349 Pubmed Toxicol Pathol
Abdelzaher WY, AboBakr Ali AHS and El-Tahawy NFG. Mast cell stabilizer modulates Sirt1/Nrf2/TNF pathway and inhibits oxidative stress, inflammation, and apoptosis in rat model of cyclophosphamide hepatotoxicity. (2020) Immunopharmacol Immunotoxicol. 1-9 Pubmed Immunopharmacol Immunotoxicol
Li Y, Huang J, He S, Lu Z, Zhang J, Li X, Yang Z, Hoffman RM and Wu Q. APELA/ELA32 Reduces Iodixanol-induced Apoptosis, Inflammatory Response and Mitochondrial and DNA Damage in Renal Tubular Epithelial Cells. (2020) Anticancer Res.. 40, 635-643 Pubmed Anticancer Res.
Mo M, Li S, Dong Z, Li C, Sun Y, Li A and Zhao Z. S-allylmercaptocysteine ameliorates lipopolysaccharide-induced acute lung injury in mice by inhibiting inflammation and oxidative stress via nuclear factor kappa B and Keap1/Nrf2 pathways. (2020) Int. Immunopharmacol.. 81, 106273 Pubmed Int. Immunopharmacol.
Liu YT, Chen HW, Lii CK, Jhuang JH, Huang CS, Li ML and Yao HT. A Diterpenoid, 14-Deoxy-11, 12-Didehydroandrographolide, in p Reduces Steatohepatitis and Liver Injury in Mice Fed a High-Fat and High-Cholesterol Diet. (2020) Nutrients. 12, Pubmed Nutrients
Li Y, Liu L, Sun P, Zhang Y, Wu T, Sun H, Cheng KW and Chen F. Fucoxanthinol from the Diatom Ameliorates Neuroinflammatory Responses in Lipopolysaccharide-Stimulated BV-2 Microglia. (2020) Mar Drugs. 18, Pubmed Mar Drugs
Xu L, Shen L, Yu X, Li P, Wang Q and Li C. Effects of irisin on osteoblast apoptosis and osteoporosis in postmenopausal osteoporosis rats through upregulating Nrf2 and inhibiting NLRP3 inflammasome. (2020) Exp Ther Med. 19, 1084-1090 Pubmed Exp Ther Med PMC Article
Feng S, Zhou H, Wu D, Zheng D, Qu B, Liu R, Zhang C, Li Z, Xie Y and Luo HB. Nobiletin and its derivatives overcome multidrug resistance (MDR) in cancer: total synthesis and discovery of potent MDR reversal agents. (2020) Acta Pharm Sin B. 10, 327-343 Pubmed Acta Pharm Sin B PMC Article
Daverey A and Agrawal SK. Curcumin Protects against White Matter Injury through NF-κB and Nrf2 Cross Talk. (2020) J. Neurotrauma. Pubmed J. Neurotrauma
Xing C, Wang Y, Dai X, Yang F, Luo J, Liu P, Zhang C, Cao H and Hu G. The protective effects of resveratrol on antioxidant function and the mRNA expression of inflammatory cytokines in the ovaries of hens with fatty liver hemorrhagic syndrome. (2020) Poult. Sci.. 99, 1019-1027 Pubmed Poult. Sci.
Liu C, Zhao Y, Wang J, Yang Y, Zhang Y, Qu X, Peng S, Yao Z, Zhao S, He B, Mi Q, Zhu Y, Liu X, Zou J, Zhang X and Du Q. FoxO3 reverses 5-fluorouracil resistance in human colorectal cancer cells by inhibiting the Nrf2/TR1 signaling pathway. (2020) Cancer Lett.. 470, 29-42 Pubmed Cancer Lett.
Yasuda D, Ohe T, Takahashi K, Imamura R, Kojima H, Okabe T, Ichimura Y, Komatsu M, Yamamoto M, Nagano T and Mashino T. Inhibitors of the protein-protein interaction between phosphorylated p62 and Keap1 attenuate chemoresistance in a human hepatocellular carcinoma cell line. (2020) Free Radic. Res.. 1-291 Pubmed Free Radic. Res.
Casaril AM, Domingues M, Bampi SR, Lourenço DA, Smaniotto TÂ, Segatto N, Vieira B, Seixas FK, Collares T, Lenardão EJ and Savegnago L. The antioxidant and immunomodulatory compound 3-[(4-chlorophenyl)selanyl]-1-methyl-1H-indole attenuates depression-like behavior and cognitive impairment developed in a mouse model of breast tumor. (2020) Brain Behav. Immun.. 84, 229-241 Pubmed Brain Behav. Immun.
Bandekar M, Maurya DK, Sharma D, Checker R, Gota V, Mishra N and Sandur SK. Xenogeneic transplantation of Human WJ-MSCs Rescues Mice from Acute Radiation Syndrome via Nrf2 Dependent Regeneration of Damaged Tissues. (2020) Am. J. Transplant.. Pubmed Am. J. Transplant.
Sarfraz I, Rasul A, Hussain G, Shah MA, Zahoor AF, Asrar M, Selamoglu Z, Ji XY, Adem Ş and Sarker SD. 6-Phosphogluconate dehydrogenase fuels multiple aspects of cancer cells: From cancer initiation to metastasis and chemoresistance. (2020) Biofactors. Pubmed Biofactors
Torrente L, Prieto-Farigua N, Falzone A, Elkins CM, Boothman DA, Haura EB and DeNicola GM. Inhibition of TXNRD or SOD1 overcomes NRF2-mediated resistance to β-lapachone. (2020) Redox Biol. 30, 101440 Pubmed Redox Biol PMC Article
Jin F, Chen X, Yan H, Xu Z, Yang B, Luo P and He Q. Bisdemethoxycurcumin attenuates cisplatin-induced renal injury through anti-apoptosis, anti-oxidant and anti-inflammatory. (2020) Eur. J. Pharmacol.. 173026 Pubmed Eur. J. Pharmacol.
Feng SL, Tian Y, Huo S, Qu B, Liu RM, Xu P, Li YZ and Xie Y. Nobiletin potentiates paclitaxel anticancer efficacy in A549/T xenograft model: Pharmacokinetic and pharmacological study. (2020) Phytomedicine. 67, 153141 Pubmed Phytomedicine
Escoll M, Lastra D, Pajares M, Robledinos-Antón N, Rojo AI, Fernández-Ginés R, Mendiola M, Martínez-Marín V, Esteban I, López-Larrubia P, Gargini R and Cuadrado A. Transcription factor NRF2 uses the Hippo pathway effector TAZ to induce tumorigenesis in glioblastomas. (2020) Redox Biol. 30, 101425 Pubmed Redox Biol PMC Article
Nguyen THP, Mahalakshmi B and Velmurugan BK. Functional role of ferroptosis on cancers, activation and deactivation by various therapeutic candidates-an update. (2020) Chem. Biol. Interact.. 317, 108930 Pubmed Chem. Biol. Interact.
Qi W, Boliang W, Xiaoxi T, Guoqiang F, Jianbo X and Gang W. Cardamonin protects against doxorubicin-induced cardiotoxicity in mice by restraining oxidative stress and inflammation associated with Nrf2 signaling. (2020) Biomed. Pharmacother.. 122, 109547 Pubmed Biomed. Pharmacother.
Song ZL, Bai F, Zhang B and Fang J. Synthesis of Dithiolethiones and Identification of Potential Neuroprotective Agents via Activation of Nrf2-Driven Antioxidant Enzymes. (2020) J. Agric. Food Chem.. 68, 2214-2231 Pubmed J. Agric. Food Chem.
Ming J, Ye J, Zhang Y, Xu Q, Yang X, Shao X, Qiang J and Xu P. Optimal dietary curcumin improved growth performance, and modulated innate immunity, antioxidant capacity and related genes expression of NF-κB and Nrf2 signaling pathways in grass carp (Ctenopharyngodon idella) after infection with Aeromonas hydrophila. (2020) Fish Shellfish Immunol.. 97, 540-553 Pubmed Fish Shellfish Immunol.
Neto da Silva K, Garbin Cappellaro L, Ueda CN, Rodrigues L, Pertile Remor A, Martins RP, Latini A and Glaser V. Glyphosate-based herbicide impairs energy metabolism and increases autophagy in C6 astroglioma cell line. (2020) J. Toxicol. Environ. Health Part A. 1-15 Pubmed J. Toxicol. Environ. Health Part A
Hosseini H, Teimouri M, Shabani M, Koushki M, Babaei Khorzoughi R, Namvarjah F, Izadi P and Meshkani R. Resveratrol alleviates non-alcoholic fatty liver disease through epigenetic modification of the Nrf2 signaling pathway. (2020) Int. J. Biochem. Cell Biol.. 119, 105667 Pubmed Int. J. Biochem. Cell Biol.
Murray D and Mirzayans R. Nonlinearities in the cellular response to ionizing radiation and the role of p53 therein. (2020) Int. J. Radiat. Biol.. 1-11 Pubmed Int. J. Radiat. Biol.
Lin H, Qiao Y, Yang H, Nan Q, Qu W, Feng F, Liu W, Chen Y and Sun H. Small molecular Nrf2 inhibitors as chemosensitizers for cancer therapy. (2020) Future Med Chem. 12, 243-267 Pubmed Future Med Chem
Sanchez-Lopez E, Ghia EM, Antonucci L, Sharma N, Rassenti LZ, Xu J, Sun B, Kipps TJ and Karin M. NF-κB-p62-NRF2 survival signaling is associated with high ROR1 expression in chronic lymphocytic leukemia. (2020) Cell Death Differ.. Pubmed Cell Death Differ.
Wang T, Li C, Han B, Wang Z, Meng X, Zhang L, He J and Fu F. Neuroprotective effects of Danshensu on rotenone-induced Parkinson's disease models in vitro and in vivo. (2020) BMC Complement Med Ther. 20, 20 Pubmed BMC Complement Med Ther
Hseu YC, Chen XZ, Vudhya Gowrisankar Y, Yen HR, Chuang JY and Yang HL. The Skin-Whitening Effects of Ectoine via the Suppression of α-MSH-Stimulated Melanogenesis and the Activation of Antioxidant Nrf2 Pathways in UVA-Irradiated Keratinocytes. (2020) Antioxidants (Basel). 9, Pubmed Antioxidants (Basel)
Khurana N, Chandra PK, Kim H, Abdel-Mageed AB, Mondal D and Sikka SC. Bardoxolone-Methyl (CDDO-Me) Suppresses Androgen Receptor and Its Splice-Variant AR-V7 and Enhances Efficacy of Enzalutamide in Prostate Cancer Cells. (2020) Antioxidants (Basel). 9, Pubmed Antioxidants (Basel)
Molagoda IMN, Lee KT, Choi YH and Kim GY. Anthocyanins from L. Inhibit Oxidative Stress-Mediated Apoptosis by Activating the Nrf2/HO-1 Signaling Pathway. (2020) Antioxidants (Basel). 9, Pubmed Antioxidants (Basel)
Pomatto LCD, Dill T, Carboneau B, Levan S, Kato J, Mercken EM, Pearson KJ, Bernier M and de Cabo R. Deletion of Nrf2 shortens lifespan in C57BL6/J male mice but does not alter the health and survival benefits of caloric restriction. (2020) Free Radic. Biol. Med.. Pubmed Free Radic. Biol. Med.
Zhu J, Singh M, Selivanova G and Peuget S. Pifithrin-α alters p53 post-translational modifications pattern and differentially inhibits p53 target genes. (2020) Sci Rep. 10, 1049 Pubmed Sci Rep PMC Article
Smolková K, Mikó E, Kovács T, Leguina-Ruzzi A, Adrienn S and Bai P. NRF2 in regulating cancer metabolism. (2020) Antioxid. Redox Signal.. Pubmed Antioxid. Redox Signal.
Liu Y, Pang Y, Caisova V, Ding J, Yu D, Zhou Y, Huynh TT, Ghayee H, Pacak K and Yang C. Targeting NRF2-Governed Glutathione Synthesis for -Mutated Pheochromocytoma and Paraganglioma. (2020) Cancers (Basel). 12, Pubmed Cancers (Basel)
Battino M, Giampieri F, Cianciosi D, Ansary J, Chen X, Zhang D, Gil E and Forbes-Hernández T. The roles of strawberry and honey phytochemicals on human health: A possible clue on the molecular mechanisms involved in the prevention of oxidative stress and inflammation. (2020) Phytomedicine. 153170 Pubmed Phytomedicine
Li D, Tian H, Li X, Mao L, Zhao X, Lin J, Lin S, Xu C, Liu Y, Guo Y and Mei X. Zinc promotes functional recovery after spinal cord injury by activating Nrf2/HO-1 defense pathway and inhibiting inflammation of NLRP3 in nerve cells. (2020) Life Sci.. 245, 117351 Pubmed Life Sci.
Wang X, Saud SM, Wang F, He S, Zhang X, Hua B and Li W. Protective effect of ShaoYao decoction on colitis-associated colorectal cancer by inducing Nrf2 signaling pathway. (2020) J Ethnopharmacol. 252, 112600 Pubmed J Ethnopharmacol
Tong Y, Wang K, Sheng S and Cui J. Polydatin ameliorates chemotherapy-induced cognitive impairment (chemobrain) by inhibiting oxidative stress, inflammatory response, and apoptosis in rats. (2020) Biosci. Biotechnol. Biochem.. 1-10 Pubmed Biosci. Biotechnol. Biochem.
Fresta CG, Fidilio A, Lazzarino G, Musso N, Grasso M, Merlo S, Amorini AM, Bucolo C, Tavazzi B, Lazzarino G, Lunte SM, Caraci F and Caruso G. Modulation of Pro-Oxidant and Pro-Inflammatory Activities of M1 Macrophages by the Natural Dipeptide Carnosine. (2020) Int J Mol Sci. 21, Pubmed Int J Mol Sci
Gao X, Mi Y, Guo N, Luan J, Xu H, Hu Z, Wang N, Zhang D, Gou X and Xu L. The mechanism of propofol in cancer development: An updated review. (2020) Asia Pac J Clin Oncol. Pubmed Asia Pac J Clin Oncol
Lin CC, Lin WN, Cho RL, Yang CC, Yeh YC, Hsiao LD, Tseng HC and Yang CM. Induction of HO-1 by Mevastatin Mediated via a Nox/ROS-Dependent c-Src/PDGFRα/PI3K/Akt/Nrf2/ARE Cascade Suppresses TNF-α-Induced Lung Inflammation. (2020) J Clin Med. 9, Pubmed J Clin Med
Zhang HB, Tu XK, Song SW, Liang RS and Shi SS. Baicalin Reduces Early Brain Injury after Subarachnoid Hemorrhage in Rats. (2020) Chin J Integr Med. Pubmed Chin J Integr Med
Alam MB, Chowdhury NS, Sohrab MH, Rana MS, Hasan CM and Lee SH. Cerevisterol Alleviates Inflammation via Suppression of MAPK/NF-κB/AP-1 and Activation of the Nrf2/HO-1 Signaling Cascade. (2020) Biomolecules. 10, Pubmed Biomolecules
Shimokawa M, Yoshizumi T, Itoh S, Iseda N, Sakata K, Yugawa K, Toshima T, Harada N, Ikegami T and Mori M. Modulation of Nqo1 Activity Intercepts Anoikis Resistance and Reduces Metastatic Potential of Hepatocellular Carcinoma. (2020) Cancer Sci.. Pubmed Cancer Sci.
Qi W, Lu C, Huang H, Zhang W, Song S and Liu B. (+)-Usnic Acid Induces ROS-dependent Apoptosis via Inhibition of Mitochondria Respiratory Chain Complexes and Nrf2 Expression in Lung Squamous Cell Carcinoma. (2020) Int J Mol Sci. 21, Pubmed Int J Mol Sci
Li T, Jiang D and Wu K. p62 promotes bladder cancer cell growth by activating KEAP1/NRF2-dependent antioxidative response. (2020) Cancer Sci.. Pubmed Cancer Sci.
Wen L, Yang S, Li P, Chen R, Wang Q, Kaspo B, Fan H and Hu J. iASPP-Mediated ROS Inhibition Drives 5-Fu Resistance Dependent on Nrf2 Antioxidative Signaling Pathway in Gastric Adenocarcinoma. (2020) Dig. Dis. Sci.. Pubmed Dig. Dis. Sci.
Kurokawa Y, Fujii G, Tomono S, Miyamoto S, Hamoya T, Takahashi M, Narita T, Komiya M, Kobayashi M, Higami Y and Mutoh M. The Radical Scavenger NZ-419 Suppresses Intestinal Polyp Development in -Mutant Mice. (2020) J Clin Med. 9, Pubmed J Clin Med
Riis S, Murray JB and O'Connor R. IGF-1 Signalling Regulates Mitochondria Dynamics and Turnover through a Conserved GSK-3β-Nrf2-BNIP3 Pathway. (2020) Cells. 9, Pubmed Cells
Podkalicka P, Mucha O, Kruczek S, Biela A, Andrysiak K, Stępniewski J, Mikulski M, Gałęzowski M, Sitarz K, Brzózka K, Józkowicz A, Dulak J and Łoboda A. Synthetically Lethal Interactions of Heme Oxygenase-1 and Fumarate Hydratase Genes. (2020) Biomolecules. 10, Pubmed Biomolecules
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