Clinical Trials & Research

English: Graph of Nrf2 publications (pubmed se...

English: Graph of Nrf2 publications (pubmed search) by year (Photo credit: Wikipedia)

There are currently over 2300 articles (peer reviewed clinical reviews and studies) on on the topic of NRF2 Activation.

There are a ton of companies claiming they have scientific studies showing that their products are NRF2 Activators. Go to and type in the name of their product.

Pubmed is a website operated by the National Institute of Health (NIH).  PubMed comprises over 21 million citations for biomedical literature from MEDLINE, life science journals, and online books. PubMed citations and abstracts include the fields of biomedicine and health, covering portions of the life sciences, behavioral sciences, chemical sciences, and bioengineering. PubMed also provides access to additional relevant web sites and links to the other NCBI molecular biology resources.

Last 200 NRF-2 Studies published on Pubmed

Akın-Balı DF, Aktas SH, Unal MA and Kankılıc T. Identification of novel Nrf2/Keap1 pathway mutations in pediatric acute lymphoblastic leukemia. (2020) Pediatr Hematol Oncol. 37, 58-75 Pubmed Pediatr Hematol Oncol
Niki T, Endo J, Takahashi-Niki K, Yasuda T, Okamoto A, Saito Y, Ariga H and Iguchi-Ariga SMM. DJ-1-binding compound B enhances Nrf2 activity through the PI3-kinase-Akt pathway by DJ-1-dependent inactivation of PTEN. (2020) Brain Res.. 1729, 146641 Pubmed Brain Res.
Liu C, Zhao Y, Wang J, Yang Y, Zhang Y, Qu X, Peng S, Yao Z, Zhao S, He B, Mi Q, Zhu Y, Liu X, Zou J, Zhang X and Du Q. FoxO3 reverses 5-fluorouracil resistance in human colorectal cancer cells by inhibiting the Nrf2/TR1 signaling pathway. (2020) Cancer Lett.. 470, 29-42 Pubmed Cancer Lett.
Badamjav R, Sonom D, Wu Y, Zhang Y, Kou J, Yu B and Li F. The protective effects of Thalictrum minus L. on lipopolysaccharide-induced acute lung injury. (2020) J Ethnopharmacol. 248, 112355 Pubmed J Ethnopharmacol
Kushwaha PP, Gupta S, Singh AK, Prajapati KS, Shuaib M and Kumar S. MicroRNA Targeting Nicotinamide Adenine Dinucleotide Phosphate Oxidases in Cancer. (2020) Antioxid. Redox Signal.. 32, 267-284 Pubmed Antioxid. Redox Signal.
Hosseini H, Teimouri M, Shabani M, Koushki M, Babaei Khorzoughi R, Namvarjah F, Izadi P and Meshkani R. Resveratrol alleviates non-alcoholic fatty liver disease through epigenetic modification of the Nrf2 signaling pathway. (2020) Int. J. Biochem. Cell Biol.. 119, 105667 Pubmed Int. J. Biochem. Cell Biol.
Qi W, Boliang W, Xiaoxi T, Guoqiang F, Jianbo X and Gang W. Cardamonin protects against doxorubicin-induced cardiotoxicity in mice by restraining oxidative stress and inflammation associated with Nrf2 signaling. (2020) Biomed. Pharmacother.. 122, 109547 Pubmed Biomed. Pharmacother.
Zhang Z, Li H, Liang Z, Li C, Yang Z, Li Y, Cao L, She Y, Wang W, Liu C and Chen L. Vaporized perfluorocarbon inhalation attenuates primary blast lung injury in canines by inhibiting mitogen-activated protein kinase/nuclear factor-κB activation and inducing nuclear factor, erythroid 2 like 2 pathway. (2020) Toxicol. Lett.. 319, 49-57 Pubmed Toxicol. Lett.
Kalvala AK, Yerra VG and Kumar A. LONP1 induction by SRT1720 attenuates mitochondrial dysfunction against high glucose induced neurotoxicity in PC12 cells. (2020) Toxicol In Vitro. 62, 104695 Pubmed Toxicol In Vitro
Dwivedi DK and Jena GB. Diethylnitrosamine and thioacetamide-induced hepatic damage and early carcinogenesis in rats: Role of Nrf2 activator dimethyl fumarate and NLRP3 inhibitor glibenclamide. (2020) Biochem. Biophys. Res. Commun.. 522, 381-387 Pubmed Biochem. Biophys. Res. Commun.
Wang ML, Zhong QY, Lin BQ, Liu YH, Huang YF, Chen Y, Yuan J, Su ZR and Zhan JY. Andrographolide sodium bisulfate attenuates UV‑induced photo‑damage by activating the keap1/Nrf2 pathway and downregulating the NF‑κB pathway in HaCaT keratinocytes. (2020) Int. J. Mol. Med.. 45, 343-352 Pubmed Int. J. Mol. Med.
Zhou H, Wang Y, You Q and Jiang Z. Recent progress in the development of small molecule Nrf2 activators: a patent review (2017-present). (2020) Expert Opin Ther Pat. Pubmed Expert Opin Ther Pat
Zhao Y, Zhu Q, Bu X, Zhou Y, Bai D, Guo Q, Gao Y and Lu N. Triggering apoptosis by oroxylin A through caspase-8 activation and p62/SQSTM1 proteolysis. (2020) Redox Biol. 29, 101392 Pubmed Redox Biol PMC Article
Yao J, Long H, Zhao J, Zhong G and Li J. Nifedipine inhibits oxidative stress and ameliorates osteoarthritis by activating the nuclear factor erythroid-2-related factor 2 pathway. (2020) Life Sci.. 117292 Pubmed Life Sci.
Lin CC, Lin WN, Cho RL, Yang CC, Yeh YC, Hsiao LD, Tseng HC and Yang CM. Induction of HO-1 by Mevastatin Mediated via a Nox/ROS-Dependent c-Src/PDGFRα/PI3K/Akt/Nrf2/ARE Cascade Suppresses TNF-α-Induced Lung Inflammation. (2020) J Clin Med. 9, Pubmed J Clin Med
Wang L, Li C, Sreeharsha N, Mishra A, Shrotriya V and Sharma A. Neuroprotective effect of Wogonin on Rat's brain exposed to gamma irradiation. (2020) J. Photochem. Photobiol. B, Biol.. 204, 111775 Pubmed J. Photochem. Photobiol. B, Biol.
Riis S, Murray JB and O'Connor R. IGF-1 Signalling Regulates Mitochondria Dynamics and Turnover through a Conserved GSK-3β-Nrf2-BNIP3 Pathway. (2020) Cells. 9, Pubmed Cells
Hseu YC, Chen XZ, Vudhya Gowrisankar Y, Yen HR, Chuang JY and Yang HL. The Skin-Whitening Effects of Ectoine via the Suppression of α-MSH-Stimulated Melanogenesis and the Activation of Antioxidant Nrf2 Pathways in UVA-Irradiated Keratinocytes. (2020) Antioxidants (Basel). 9, Pubmed Antioxidants (Basel)
Wen L, Yang S, Li P, Chen R, Wang Q, Kaspo B, Fan H and Hu J. iASPP-Mediated ROS Inhibition Drives 5-Fu Resistance Dependent on Nrf2 Antioxidative Signaling Pathway in Gastric Adenocarcinoma. (2020) Dig. Dis. Sci.. Pubmed Dig. Dis. Sci.
Khurana N, Chandra PK, Kim H, Abdel-Mageed AB, Mondal D and Sikka SC. Bardoxolone-Methyl (CDDO-Me) Suppresses Androgen Receptor and Its Splice-Variant AR-V7 and Enhances Efficacy of Enzalutamide in Prostate Cancer Cells. (2020) Antioxidants (Basel). 9, Pubmed Antioxidants (Basel)
Zhao J, Niu X, Yu J, Xiao X, Li W, Zang L, Hu Z, Siu-Po Ip P and Li W. Poria cocos polysaccharides attenuated ox-LDL-induced inflammation and oxidative stress via ERK activated Nrf2/HO-1 signaling pathway and inhibited foam cell formation in VSMCs. (2020) Int. Immunopharmacol.. 80, 106173 Pubmed Int. Immunopharmacol.
Molagoda IMN, Lee KT, Choi YH and Kim GY. Anthocyanins from L. Inhibit Oxidative Stress-Mediated Apoptosis by Activating the Nrf2/HO-1 Signaling Pathway. (2020) Antioxidants (Basel). 9, Pubmed Antioxidants (Basel)
Tian L, Sun S, Cui L, Wang S, Peng Z, Tan Q, Hou W and Cai M. Repetitive Transcranial Magnetic Stimulation Elicits Antidepressant- and Anxiolytic-like Effect via Nuclear Factor-E2-related Factor 2-mediated Anti-inflammation Mechanism in Rats. (2020) Neuroscience. Pubmed Neuroscience
Lee DH, Park JS, Lee YS, Han J, Lee DK, Kwon SW, Han DH, Lee YH and Bae SH. SQSTM1/p62 activates NFE2L2/NRF2 via ULK1-mediated autophagic KEAP1 degradation and protects mouse liver from lipotoxicity. (2020) Autophagy. 1-25 Pubmed Autophagy
Escoll M, Lastra D, Pajares M, Robledinos-Antón N, Rojo AI, Fernández-Ginés R, Mendiola M, Martínez-Marín V, Esteban I, López-Larrubia P, Gargini R and Cuadrado A. Transcription factor NRF2 uses the Hippo pathway effector TAZ to induce tumorigenesis in glioblastomas. (2020) Redox Biol. 30, 101425 Pubmed Redox Biol
Lin H, Qiao Y, Yang H, Nan Q, Qu W, Feng F, Liu W, Chen Y and Sun H. Small molecular Nrf2 inhibitors as chemosensitizers for cancer therapy. (2020) Future Med Chem. Pubmed Future Med Chem
Sánchez-Martín P, Sou YS, Kageyama S, Koike M, Waguri S and Komatsu M. NBR1-mediated p62-liquid droplets enhance the Keap1-Nrf2 system. (2020) EMBO Rep.. e48902 Pubmed EMBO Rep.
Liu Y, Tao S, Liao L, Li Y, Li H, Li Z, Lin L, Wan X, Yang X and Chen L. TRIM25 promotes the cell survival and growth of hepatocellular carcinoma through targeting Keap1-Nrf2 pathway. (2020) Nat Commun. 11, 348 Pubmed Nat Commun
Mukhopadhyay S, Goswami D, Adiseshaiah PP, Burgan W, Yi M, Guerin TM, Kozlov SV, Nissley DV and McCormick F. Undermining glutaminolysis bolsters chemotherapy while NRF2 promotes chemoresistance in KRAS-driven pancreatic cancers. (2020) Cancer Res.. Pubmed Cancer Res.
Pomatto LCD, Dill T, Carboneau B, Levan S, Kato J, Mercken EM, Pearson KJ, Bernier M and de Cabo R. Deletion of Nrf2 shortens lifespan in C57BL6/J male mice but does not alter the health and survival benefits of caloric restriction. (2020) Free Radic. Biol. Med.. Pubmed Free Radic. Biol. Med.
Gong JH, Zheng YB, Zhang MR, Wang YX, Yang SQ, Wang RH, Miao QF, Liu XJ and Zhen YS. Dexamethasone enhances the antitumor efficacy of Gemcitabine by glucocorticoid receptor signaling. (2020) Cancer Biol. Ther.. 1-12 Pubmed Cancer Biol. Ther.
Zeng Z, Wang ZY, Li YK, Ye DM, Zeng J, Hu JL, Chen PF, Xiao J, Zou J and Li ZH. Nuclear factor erythroid 2 (NF-E2)-related factor 2 (Nrf2) in non-small cell lung cancer. (2020) Life Sci.. 117325 Pubmed Life Sci.
Szwed M, Torgersen ML, Kumari RV, Yadava SK, Pust S, Iversen TG, Skotland T, Giri J and Sandvig K. Biological response and cytotoxicity induced by lipid nanocapsules. (2020) J Nanobiotechnology. 18, 5 Pubmed J Nanobiotechnology PMC Article
Robinson RM, Reyes L, Duncan RM, Bian H, Strobel ED, Hyman SL, Reitz AB and Dolloff NG. Tuning isoform selectivity and bortezomib sensitivity with a new class of alkenyl indene PDI inhibitor. (2020) Eur J Med Chem. 186, 111906 Pubmed Eur J Med Chem
Zhou Y, Zhou Y, Wang K, Li T, Yang M, Wang R, Chen Y, Cao M and Hu R. Flumethasone enhances the efficacy of chemotherapeutic drugs in lung cancer by inhibiting Nrf2 signaling pathway. (2020) Cancer Lett.. Pubmed Cancer Lett.
Wang J, Gao Y, Lin F, Han K and Wang X. Omentin-1 attenuates lipopolysaccharide (LPS)-induced U937 macrophages activation by inhibiting the TLR4/MyD88/NF-κB signaling. (2020) Arch. Biochem. Biophys.. 679, 108187 Pubmed Arch. Biochem. Biophys.
Sun Y, Zhou S, Guo H, Zhang J, Ma T, Zheng Y, Zhang Z and Cai L. Protective effects of sulforaphane on type 2 diabetes-induced cardiomyopathy via AMPK-mediated activation of lipid metabolic pathways and NRF2 function. (2020) Metab. Clin. Exp.. 102, 154002 Pubmed Metab. Clin. Exp.
Cho JH, Lee YM, Bae SH and Chou JY. Activation of tumor-promoting pathways implicated in hepatocellular adenoma/carcinoma, a long-term complication of glycogen storage disease type Ia. (2020) Biochem. Biophys. Res. Commun.. 522, 1-7 Pubmed Biochem. Biophys. Res. Commun. PMC Article
Chen X, Cao X, Xiao W, Li B and Xue Q. PRDX5 as a novel binding partner in Nrf2-mediated NSCLC progression under oxidative stress. (2020) Aging (Albany NY). 12, 122-137 Pubmed Aging (Albany NY)
Ashrafizadeh M, Ahmadi Z, Samarghandian S, Mohammadinejad R, Yaribeygi H, Sathyapalan T and Sahebkar A. MicroRNA-mediated regulation of Nrf2 signaling pathway: Implications in disease therapy and protection against oxidative stress. (2020) Life Sci.. 117329 Pubmed Life Sci.
Zhou Y, Wang K, Zhou Y, Li T, Yang M, Wang R, Chen Y, Cao M and Hu R. HEATR1 deficiency promotes pancreatic cancer proliferation and gemcitabine resistance by up-regulating Nrf2 signaling. (2020) Redox Biol. 29, 101390 Pubmed Redox Biol PMC Article
Namyen J, Permpoonputtana K, Nopparat C, Tocharus J, Tocharus C and Govitrapong P. Protective Effects of Melatonin on Methamphetamine-Induced Blood-Brain Barrier Dysfunction in Rat Model. (2020) Neurotox Res. Pubmed Neurotox Res
Mizumura K, Maruoka S, Shimizu T and Gon Y. Role of Nrf2 in the pathogenesis of respiratory diseases. (2020) Respir Investig. 58, 28-35 Pubmed Respir Investig
Li Y, Yan H, Xu X, Liu H, Wu C and Zhao L. Erastin/sorafenib induces cisplatin-resistant non-small cell lung cancer cell ferroptosis through inhibition of the Nrf2/xCT pathway. (2020) Oncol Lett. 19, 323-333 Pubmed Oncol Lett PMC Article
Kobayashi A and Waku T. New addiction to the NRF2-related factor NRF3 in cancer cells: Ubiquitin-independent proteolysis through the 20S proteasome. (2020) Cancer Sci.. 111, 6-14 Pubmed Cancer Sci. PMC Article
Ferino A, Rapozzi V and Xodo LE. The ROS-KRAS-Nrf2 axis in the control of the redox homeostasis and the intersection with survival-apoptosis pathways: Implications for photodynamic therapy. (2020) J. Photochem. Photobiol. B, Biol.. 202, 111672 Pubmed J. Photochem. Photobiol. B, Biol.
Zhang X, Chu X, Gong X, Zhou H and Cai C. The expression of miR-125b in Nrf2-silenced A549 cells exposed to hyperoxia and its relationship with apoptosis. (2020) J. Cell. Mol. Med.. 24, 965-972 Pubmed J. Cell. Mol. Med. PMC Article
Kim DH, Jang JH, Kwon OS, Cha HJ, Youn HJ, Chun KS and Surh YJ. Nuclear Factor Erythroid-Derived 2-Like 2-Induced Reductive Stress Favors Self-Renewal of Breast Cancer Stem-Like Cells the FoxO3a-Bmi-1 Axis. (2020) Antioxid. Redox Signal.. Pubmed Antioxid. Redox Signal.
Bernardo PS, Guimarães GHC, De Faria FCC, Longo GMDC, Lopes GPF, Netto CD, Costa PRR and Maia RC. LQB‑118 compound inhibits migration and induces cell death in glioblastoma cells. (2020) Oncol. Rep.. 43, 346-357 Pubmed Oncol. Rep.
Lee JE, Zhong X, Lee JY, Surh YJ and Na HK. 15-Keto prostaglandin E induces heme oxygenase-1 expression through activation of Nrf2 in human colon epithelial CCD 841 CoN cells. (2020) Arch. Biochem. Biophys.. 679, 108162 Pubmed Arch. Biochem. Biophys.
Sukseree S, Schwarze UY, Gruber R, Gruber F, Quiles Del Rey M, Mancias JD, Bartlett JD, Tschachler E and Eckhart L. ATG7 is essential for secretion of iron from ameloblasts and normal growth of murine incisors during aging. (2020) Autophagy. 1-7 Pubmed Autophagy
Jabbarzadeh Kaboli P, Afzalipour Khoshkbejari M, Mohammadi M, Abiri A, Mokhtarian R, Vazifemand R, Amanollahi S, Yazdi Sani S, Li M, Zhao Y, Wu X, Shen J, Cho CH and Xiao Z. Targets and mechanisms of sulforaphane derivatives obtained from cruciferous plants with special focus on breast cancer - contradictory effects and future perspectives. (2020) Biomed. Pharmacother.. 121, 109635 Pubmed Biomed. Pharmacother.
Wang Z, Zhang J, Li M, Kong L and Yu J. The expression of p-p62 and nuclear Nrf2 in esophageal squamous cell carcinoma and association with radioresistance. (2020) Thorac Cancer. 11, 130-139 Pubmed Thorac Cancer PMC Article
Bailly C. Potential use of edaravone to reduce specific side effects of chemo-, radio- and immuno-therapy of cancers. (2019) Int. Immunopharmacol.. 77, 105967 Pubmed Int. Immunopharmacol.
Saigusa D, Motoike IN, Saito S, Zorzi M, Aoki Y, Kitamura H, Suzuki M, Katsuoka F, Ishii H, Kinoshita K, Motohashi H and Yamamoto M. Impacts of NRF2 activation in non-small-cell lung cancer cell lines on extracellular metabolites. (2019) Cancer Sci.. Pubmed Cancer Sci.
Guo W and Zhou BP. Oncometabolite modification of Keap1 links GSTZ1 deficiency with cancer. (2019) Genes Dis. 6, 333-334 Pubmed Genes Dis PMC Article
Kim GY, Suh J, Jang JH, Kim DH, Park OJ, Park SK and Surh YJ. Genistein Inhibits Proliferation of Mutated Breast Cancer Cells: The GPR30-Akt Axis as a Potential Target. (2019) J Cancer Prev. 24, 197-207 Pubmed J Cancer Prev PMC Article
Tang KK, Liu XY, Wang ZY, Qu KC and Fan RF. Trehalose alleviates cadmium-induced brain damage by ameliorating oxidative stress, autophagy inhibition, and apoptosis. (2019) Metallomics. 11, 2043-2051 Pubmed Metallomics
Jackson E, Heidl M, Imfeld D, Meeus L, Schuetz R and Campiche R. Discovery of a Highly Selective MC1R Agonists Pentapeptide to Be Used as a Skin Pigmentation Enhancer and with Potential Anti-Aging Properties. (2019) Int J Mol Sci. 20, Pubmed Int J Mol Sci PMC Article
Ming J, Ye J, Zhang Y, Xu Q, Yang X, Shao X, Qiang J and Xu P. Optimal dietary curcumin improved growth performance, and modulated innate immunity, antioxidant capacity and related genes expression of NF-κB and Nrf2 signaling pathways in grass carp (Ctenopharyngodon idella) after infection with Aeromonas hydrophila. (2019) Fish Shellfish Immunol.. 97, 540-553 Pubmed Fish Shellfish Immunol.
Lv Y, Jiang H, Li S, Han B, Liu Y, Yang D, Li J, Yang Q, Wu P and Zhang Z. Sulforaphane prevents chromium-induced lung injury in rats via activation of the Akt/GSK-3β/Fyn pathway. (2019) Environ. Pollut.. 259, 113812 Pubmed Environ. Pollut.
Namani A, Liu K, Wang S, Zhou X, Liao Y, Wang H, Wang XJ and Tang X. Genome-wide global identification of NRF2 binding sites in A549 non-small cell lung cancer cells by ChIP-Seq reveals NRF2 regulation of genes involved in focal adhesion pathways. (2019) Aging (Albany NY). 11, 12600-12623 Pubmed Aging (Albany NY) PMC Article
Chi Y, Di Q, Han G, Li M and Sun B. Mir-29b mediates the regulation of Nrf2 on airway epithelial remodeling and Th1/Th2 differentiation in COPD rats. (2019) Saudi J Biol Sci. 26, 1915-1921 Pubmed Saudi J Biol Sci PMC Article
Wang H, Liu C, Zhao Y, Zhang W, Xu K, Li D, Zhou Y, Li H, Xiao G, Lu B and Gao G. Inhibition of LONP1 protects against erastin-induced ferroptosis in Pancreatic ductal adenocarcinoma PANC1 cells. (2019) Biochem. Biophys. Res. Commun.. Pubmed Biochem. Biophys. Res. Commun.
Liu N, Lin X and Huang C. Activation of the reverse transsulfuration pathway through NRF2/CBS confers erastin-induced ferroptosis resistance. (2019) Br. J. Cancer. Pubmed Br. J. Cancer
Yan E, Zhang J, Han H, Wu J, Gan Z, Wei C, Zhang L, Wang C and Wang T. Curcumin Alleviates IUGR Jejunum Damage by Increasing Antioxidant Capacity through Nrf2/Keap1 Pathway in Growing Pigs. (2019) Animals (Basel). 10, Pubmed Animals (Basel)
Huang XT, Liu W, Zhou Y, Hao CX, Zhou Y, Zhang CY, Sun CC, Luo ZQ and Tang SY. Dihydroartemisinin attenuates lipopolysaccharide‑induced acute lung injury in mice by suppressing NF‑κB signaling in an Nrf2‑dependent manner. (2019) Int. J. Mol. Med.. 44, 2213-2222 Pubmed Int. J. Mol. Med. PMC Article
Qu Z, Chen Y, Luo ZH, Shen XL and Hu YJ. 7-methoxyflavanone alleviates neuroinflammation in lipopolysaccharide-stimulated microglial cells by inhibiting TLR4/MyD88/MAPK signalling and activating the Nrf2/NQO-1 pathway. (2019) J. Pharm. Pharmacol.. Pubmed J. Pharm. Pharmacol.
Mahalakshmi B, Huang HL, Lee SD and Velmurugan BK. Functional role of ferroptosis on cancers, activation and deactivation by various therapeutic candidates-an update. (2019) Chem. Biol. Interact.. 108930 Pubmed Chem. Biol. Interact.
Wang X, Wang T, Pan T, Huang M, Ren W, Xu G, Amin HK, Kassab RB and Abdel Moneim AE. Senna alexandrina extract supplementation reverses hepatic oxidative, inflammatory, and apoptotic effects of cadmium chloride administration in rats. (2019) Environ Sci Pollut Res Int. Pubmed Environ Sci Pollut Res Int
Čipak Gašparović A, Milković L, Dandachi N, Stanzer S, Pezdirc I, Vrančić J, Šitić S, Suppan C and Balic M. Chronic Oxidative Stress Promotes Molecular Changes Associated with Epithelial Mesenchymal Transition, NRF2, and Breast Cancer Stem Cell Phenotype. (2019) Antioxidants (Basel). 8, Pubmed Antioxidants (Basel) PMC Article
Medina MV, Sapochnik D, Garcia Sola ME and Coso OA. Regulation of the Expression of Heme Oxygenase-1. Signal Transduction, Gene Promoter Activation and Beyond. (2019) Antioxid. Redox Signal.. Pubmed Antioxid. Redox Signal.
Xia YH, Lu Z, Wang SM and Hu LX. Nrf2 activation mediates tumor-specific hepatic stellate cells-induced DIgR2 expression in dendritic cells. (2019) Aging (Albany NY). 11, Pubmed Aging (Albany NY)
Rius-Pérez S, Pérez S, Martí-Andrés P, Monsalve M and Sastre J. NF-κB SIGNALING COMPLEXES IN ACUTE INFLAMMATION. (2019) Antioxid. Redox Signal.. Pubmed Antioxid. Redox Signal.
El-Naggar AM, Somasekharan SP, Wang Y, Cheng H, Negri GL, Pan M, Wang XQ, Delaidelli A, Rafn B, Cran J, Zhang F, Zhang H, Colborne S, Gleave M, Mandinova A, Kedersha N, Hughes CS, Surdez D, Delattre O, Wang Y, Huntsman DG, Morin GB and Sorensen PH. Class I HDAC inhibitors enhance YB-1 acetylation and oxidative stress to block sarcoma metastasis. (2019) EMBO Rep.. 20, e48375 Pubmed EMBO Rep. PMC Article
Lim JKM and Leprivier G. The impact of oncogenic RAS on redox balance and implications for cancer development. (2019) Cell Death Dis. 10, 955 Pubmed Cell Death Dis PMC Article
El-Shitany NA and Eid BG. Icariin modulates carrageenan-induced acute inflammation through HO-1/Nrf2 and NF-kB signaling pathways. (2019) Biomed. Pharmacother.. 120, 109567 Pubmed Biomed. Pharmacother.
Jiménez-Vidal L, Espitia-Pérez P, Torres-Ávila J, Ricardo-Caldera D, Salcedo-Arteaga S, Galeano-Páez C, Pastor-Sierra K and Espitia-Pérez L. Nuclear factor erythroid 2 - related factor 2 and its relationship with cellular response in nickel exposure: a systems biology analysis. (2019) BMC Pharmacol Toxicol. 20, 78 Pubmed BMC Pharmacol Toxicol PMC Article
Dunnick JK, Shockley KR, Morgan DL, Travlos GS, Gerrish K, Ton TT, Wilson R, Brar SS, Brix AE, Waidyanatha S, Mutlu E and Pandiri AKR. Hepatic Transcriptomic Patterns in the Neonatal Rat After Pentabromodiphenyl Ether Exposure. (2019) Toxicol Pathol. 192623319888433 Pubmed Toxicol Pathol
Fatehi Hassanabad A, Chehade R, Breadner D and Raphael J. Esophageal carcinoma: Towards targeted therapies. (2019) Cell Oncol (Dordr). Pubmed Cell Oncol (Dordr)
Ștefanache T, Forna N, Bădescu M, Jitaru D, Dragos ML, Rezuș C, Diaconescu BM, Bădulescu O, Rezuș E, Ciocoiu M and Bădescu C. Modulation of the activity of certain genes involved in tumor cell metabolism in the presence of the cytotoxic peptides defensin and cathelicidin LL37. (2019) Exp Ther Med. 18, 5033-5040 Pubmed Exp Ther Med PMC Article
Zhao Y, Liu X, Fu X, Mo Z, Jiang Y and Yan Y. Protective effects of epigallocatechin gallate against ischemia reperfusion injury in rat skeletal muscle via activating Nrf2/HO-1 signaling pathway. (2019) Life Sci.. 239, 117014 Pubmed Life Sci.
Park SY, Fernando IPS, Han EJ, Kim MJ, Jung K, Kang DS, Ahn CB and Ahn G. In Vivo Hepatoprotective Effects of a Peptide Fraction from Krill Protein Hydrolysates against Alcohol-Induced Oxidative Damage. (2019) Mar Drugs. 17, Pubmed Mar Drugs PMC Article
Wu C, Zhang H, Zhang J, Zhang H, Zeng Y, Fang S, Li P, Zhang Y, Lin X, Wang L, Xue Y and Guan M. Increased oxidative stress, inflammation and fibrosis in perirenal adipose tissue of patients with cortisol-producing adenoma. (2019) Adipocyte. 8, 347-356 Pubmed Adipocyte PMC Article
Zhang E, Yin S, Zhao S, Zhao C, Yan M, Fan L and Hu H. Protective effects of glycycoumarin on liver diseases. (2019) Phytother Res. Pubmed Phytother Res
Han H, Wang H, Du Y and Gao L. Grape Seed Procyanidins Attenuates Cisplatin-induced Human Embryonic Renal Cell Cytotoxicity by Modulating Heme Oxygenase-1 in Vitro. (2019) Cell Biochem. Biophys.. 77, 367-377 Pubmed Cell Biochem. Biophys.
Peng N, Jin L, He A, Deng C and Wang X. Effect of sulphoraphane on newborn mouse cardiomyocytes undergoing ischaemia/reperfusion injury. (2019) Pharm Biol. 57, 753-759 Pubmed Pharm Biol PMC Article
Griñán-Ferré C, Marsal-García L, Bellver-Sanchis A, Kondengaden SM, Turga RC, Vázquez S and Pallàs M. Pharmacological inhibition of G9a/GLP restores cognition and reduces oxidative stress, neuroinflammation and β-Amyloid plaques in an early-onset Alzheimer's disease mouse model. (2019) Aging (Albany NY). 11, 11591-11608 Pubmed Aging (Albany NY) PMC Article
Wang H, Liu K, Chi Z, Zhou X, Ren G, Zhou R, Li Y, Tang X and Wang XJ. Interplay of MKP-1 and Nrf2 drives tumor growth and drug resistance in non-small cell lung cancer. (2019) Aging (Albany NY). 11, 11329-11346 Pubmed Aging (Albany NY) PMC Article
D'Souza LC, Mishra S, Chakraborty A, Shekher A, Sharma A and Gupta SC. Oxidative stress and cancer development: Are non-coding RNAs the missing links?. (2019) Antioxid. Redox Signal.. Pubmed Antioxid. Redox Signal.
Zhang XY, Jia YP, Zhao Q, Wang WY, Zhang Z, Li W and Sun LC. Ameliorative effect of acetylshikonin on cigarette smoke-induced lung inflammation in mice. (2019) J Asian Nat Prod Res. 1-17 Pubmed J Asian Nat Prod Res
Zhong Y, Hu X and Miao L. Isoflurane preconditioning protects hepatocytes from oxygen glucose deprivation injury by regulating FoxO6. (2019) J. Biosci.. 44, Pubmed J. Biosci.
Yu Q, Xia Z, Liong EC and Tipoe GL. Chronic aerobic exercise improves insulin sensitivity and modulates Nrf2 and NF‑κB/IκBα pathways in the skeletal muscle of rats fed with a high fat diet. (2019) Mol Med Rep. 20, 4963-4972 Pubmed Mol Med Rep PMC Article
Casaril AM, Domingues M, Bampi SR, Lourenço DA, Smaniotto TÂ, Segatto N, Vieira B, Seixas FK, Collares T, Lenardão EJ and Savegnago L. The antioxidant and immunomodulatory compound 3-[(4-chlorophenyl)selanyl]-1-methyl-1H-indole attenuates depression-like behavior and cognitive impairment developed in a mouse model of breast tumor. (2019) Brain Behav. Immun.. Pubmed Brain Behav. Immun.
Song Z, Zhang Y, Zhang H, Rajendran RS, Wang R, Hsiao CD, Li J, Xia Q and Liu K. Isoliquiritigenin triggers developmental toxicity and oxidative stress-mediated apoptosis in zebrafish embryos/larvae via Nrf2-HO1/JNK-ERK/mitochondrion pathway. (2019) Chemosphere. 246, 125727 Pubmed Chemosphere
Peng L, Hu C, Zhang C, Lu Y, Man S and Ma L. Anti-cancer activity of Conyza blinii saponin against cervical carcinoma through MAPK/TGF-β/Nrf2 signaling pathways. (2019) J Ethnopharmacol. 251, 112503 Pubmed J Ethnopharmacol
Sun S, Du Y, Yin C, Suo X, Wang R, Xia R and Zhang X. Water-separated part of Chloranthus serratus alleviates lipopolysaccharide- induced RAW264.7 cell injury mainly by regulating the MAPK and Nrf2/HO-1 inflammatory pathways. (2019) BMC Complement Altern Med. 19, 343 Pubmed BMC Complement Altern Med PMC Article
Ali J, Khan AU, Shah FA, Ali H, Islam SU, Kim YS and Khan S. Mucoprotective effects of Saikosaponin-A in 5-fluorouracil-induced intestinal mucositis in mice model. (2019) Life Sci.. 239, 116888 Pubmed Life Sci.
Hu L, Li H, Lee ED, Grandis JR, Bauman JE and Johnson DE. Gene targets of sulforaphane in head and neck squamous cell carcinoma. (2019) Mol Med Rep. 20, 5335-5344 Pubmed Mol Med Rep PMC Article
Zheng A, Chevalier N, Calderoni M, Dubuis G, Dormond O, Ziros PG, Sykiotis GP and Widmann C. CRISPR/Cas9 genome-wide screening identifies KEAP1 as a sorafenib, lenvatinib, and regorafenib sensitivity gene in hepatocellular carcinoma. (2019) Oncotarget. 10, 7058-7070 Pubmed Oncotarget PMC Article
Zhang Z, Jiang D, Wang C, Garzotto M, Kopp R, Wilmot B, Thuillier P, Dang A, Palma A, Farris PE and Shannon J. Polymorphisms in oxidative stress pathway genes and prostate cancer risk. (2019) Cancer Causes Control. 30, 1365-1375 Pubmed Cancer Causes Control
Kahroba H, Shirmohamadi M, Hejazi MS and Samadi N. The Role of Nrf2 signaling in cancer stem cells: From stemness and self-renewal to tumorigenesis and chemoresistance. (2019) Life Sci.. 239, 116986 Pubmed Life Sci.
Luo J, Long Y, Ren G, Zhang Y, Chen J, Huang R and Yang L. Punicalagin Reversed the Hepatic Injury of Tetrachloromethane by Antioxidation and Enhancement of Autophagy. (2019) J Med Food. 22, 1271-1279 Pubmed J Med Food PMC Article
Nam LB and Keum YS. Binding partners of NRF2: Functions and regulatory mechanisms. (2019) Arch. Biochem. Biophys.. 678, 108184 Pubmed Arch. Biochem. Biophys.
Nagappan A, Kim JH, Jung DY and Jung MH. Cryptotanshinone from the Bunge Attenuates Ethanol-Induced Liver Injury by Activation of AMPK/SIRT1 and Nrf2 Signaling Pathways. (2019) Int J Mol Sci. 21, Pubmed Int J Mol Sci
Banella C, Catalano G, Travaglini S, Divona M, Masciarelli S, Guerrera G, Fazi F, Lo Coco F, Voso MT and Noguera N. PML/RARa Interferes with NRF2 Transcriptional Activity Increasing the Sensitivity to Ascorbate of Acute Promyelocytic Leukemia Cells. (2019) Cancers (Basel). 12, Pubmed Cancers (Basel)
Towers CG and Thorburn A. Circumventing autophagy inhibition. (2019) Cell Cycle. 18, 3421-3431 Pubmed Cell Cycle PMC Article
Szade A, Szade K, Nowak WN, Bukowska-Strakova K, Muchova L, Gońka M, Żukowska M, Cieśla M, Kachamakova-Trojanowska N, Rams-Baron M, Ratuszna A, Dulak J and Józkowicz A. Cobalt protoporphyrin IX increases endogenous G-CSF and mobilizes HSC and granulocytes to the blood. (2019) EMBO Mol Med. 11, e09571 Pubmed EMBO Mol Med PMC Article
Murray JR, de la Vega L, Hayes JD, Duan L and Penning TM. Induction of the Antioxidant Response by the Transcription Factor NRF2 Increases Bioactivation of the Mutagenic Air Pollutant 3-Nitrobenzanthrone in Human Lung Cells. (2019) Chem. Res. Toxicol.. 32, 2538-2551 Pubmed Chem. Res. Toxicol. PMC Article
Huang S, Wang H, Chen W, Zhan M, Xu S, Huang X, Lin R, Shen H and Wang J. Tamoxifen inhibits cell proliferation by impaired glucose metabolism in gallbladder cancer. (2019) J. Cell. Mol. Med.. Pubmed J. Cell. Mol. Med.
Vaghefinezhad N, Farsani SF and Gharaghani S. In Silico Drug-Designing Studies on Sulforaphane Analogues: Pharmacophore Mapping, Molecular Docking and QSAR Modeling. (2019) Curr Drug Discov Technol. Pubmed Curr Drug Discov Technol
Gagliardi M, Cotella D, Santoro C, Corà D, Barlev NA, Piacentini M and Corazzari M. Aldo-keto reductases protect metastatic melanoma from ER stress-independent ferroptosis. (2019) Cell Death Dis. 10, 902 Pubmed Cell Death Dis PMC Article
Yao P, Chen Y, Li Y, Zhang Y, Qi H and Xu W. [Hippocampal neuronal ferroptosis involved in cognitive dysfunction in rats with sepsis-related encephalopathy through the Nrf2/GPX4 signaling pathway]. (2019) Zhonghua Wei Zhong Bing Ji Jiu Yi Xue. 31, 1389-1394 Pubmed Zhonghua Wei Zhong Bing Ji Jiu Yi Xue
Takahashi M, Fujii G, Hamoya T, Kurokawa Y, Matsuzawa Y, Miki K, Komiya M, Narita T and Mutoh M. Activation of NF-E2 p45-related factor-2 transcription and inhibition of intestinal tumor development by AHCC, a standardized extract of cultured mycelia. (2019) J Clin Biochem Nutr. 65, 203-208 Pubmed J Clin Biochem Nutr PMC Article
LeBoeuf SE, Wu WL, Karakousi TR, Karadal B, Jackson SR, Davidson SM, Wong KK, Koralov SB, Sayin VI and Papagiannakopoulos T. Activation of Oxidative Stress Response in Cancer Generates a Druggable Dependency on Exogenous Non-essential Amino Acids. (2019) Cell Metab.. Pubmed Cell Metab.
Yamaguchi Y, Kamai T, Higashi S, Murakami S, Arai K, Shirataki H and Yoshida KI. Nrf2 gene mutation and single nucleotide polymorphism rs6721961 of the Nrf2 promoter region in renal cell cancer. (2019) BMC Cancer. 19, 1137 Pubmed BMC Cancer PMC Article
Guo M, Lu H, Qin J, Qu S, Wang W, Guo Y, Liao W, Song M, Chen J and Wang Y. Biochanin A Provides Neuroprotection Against Cerebral Ischemia/Reperfusion Injury by Nrf2-Mediated Inhibition of Oxidative Stress and Inflammation Signaling Pathway in Rats. (2019) Med. Sci. Monit.. 25, 8975-8983 Pubmed Med. Sci. Monit. PMC Article
Pellegatta S, Di Ianni N, Pessina S, Paterra R, Anghileri E, Eoli M and Finocchiaro G. ABCC3 Expressed by CD56 CD16 NK Cells Predicts Response in Glioblastoma Patients Treated with Combined Chemotherapy and Dendritic Cell Immunotherapy. (2019) Int J Mol Sci. 20, Pubmed Int J Mol Sci PMC Article
Bai M, Pan CL, Jiang GX, Zhang YM and Zhang Z. Effects of butylphthalide on oxidative stress and inflammatory response in rats with myocardial infarction through Akt/Nrf2 signaling pathway. (2019) Eur Rev Med Pharmacol Sci. 23, 9642-9650 Pubmed Eur Rev Med Pharmacol Sci
Lan J, Zheng J, Feng J and Peng W. Nrf2 mediates the antinociceptive activity of dexmedetomidine in an acute inflammatory visceral pain rat model by activating the NF-κB sensor. (2019) Cell Biochem. Funct.. Pubmed Cell Biochem. Funct.
Silva MM, Rocha CRR, Kinker GS, Pelegrini AL and Menck CFM. The balance between NRF2/GSH antioxidant mediated pathway and DNA repair modulates cisplatin resistance in lung cancer cells. (2019) Sci Rep. 9, 17639 Pubmed Sci Rep PMC Article
Dai N, Huang SQ, Tang CL, Tan CF, Dai P, Zeng TT, Zhu ZW and Yang ZX. [Electroacupuncture improves locomotor function by regulating expression of inflammation and oxidative stress-related proteins in mice with spinal cord injury]. (2019) Zhen Ci Yan Jiu. 44, 781-6 Pubmed Zhen Ci Yan Jiu
Chang LC, Fan CW, Tseng WK and Hua CC. Associations between the Nrf2/Keap1 pathway and mitochondrial functions in colorectal cancer are affected by metastasis. (2019) Cancer Biomark. Pubmed Cancer Biomark
Zhang X, Wang Y, Li X, Yang A, Li Z and Wang D. The anti-carcinogenesis properties of erianin in the modulation of oxidative stress-mediated apoptosis and immune response in liver cancer. (2019) Aging (Albany NY). 11, 10284-10300 Pubmed Aging (Albany NY) PMC Article
Jang BS, Han W and Kim IA. Tumor mutation burden, immune checkpoint crosstalk and radiosensitivity in single-cell RNA sequencing data of breast cancer. (2019) Radiother Oncol. Pubmed Radiother Oncol
Song C, Heping H, Shen Y, Jin S, Li D, Zhang A, Ren X, Wang K, Zhang L, Wang J and Shi D. AMPK/p38/Nrf2 activation as a protective feedback to restrain oxidative stress and inflammation in microglia stimulated with sodium fluoride. (2019) Chemosphere. 244, 125495 Pubmed Chemosphere
Chu Q, Jia R, Chen W, Liu Y, Li Y, Ye X, Jiang Y and Zheng X. Purified Tetrastigma hemsleyanum vines polysaccharide attenuates EC-induced toxicity in Caco-2 cells and Caenorhabditis elegans via DAF-16/FOXO pathway. (2019) Int. J. Biol. Macromol.. Pubmed Int. J. Biol. Macromol.
Almeida M, Soares M, Ramalhinho AC, Moutinho JF, Breitenfeld L and Pereira L. The prognostic value of NRF2 in breast cancer patients: a systematic review with meta-analysis. (2019) Breast Cancer Res. Treat.. Pubmed Breast Cancer Res. Treat.
Ren J, Su D, Li L, Cai H, Zhang M, Zhai J, Li M, Wu X and Hu K. Anti-inflammatory effects of Aureusidin in LPS-stimulated RAW264.7 macrophages via suppressing NF-κB and activating ROS- and MAPKs-dependent Nrf2/HO-1 signaling pathways. (2019) Toxicol. Appl. Pharmacol.. 387, 114846 Pubmed Toxicol. Appl. Pharmacol.
Feng SL, Tian Y, Huo S, Qu B, Liu RM, Xu P, Li YZ and Xie Y. Nobiletin potentiates paclitaxel anticancer efficacy in A549/T xenograft model: Pharmacokinetic and pharmacological study. (2019) Phytomedicine. 67, 153141 Pubmed Phytomedicine
Borella R, Forti L, Gibellini L, De Gaetano A, De Biasi S, Nasi M, Cossarizza A and Pinti M. Synthesis and Anticancer Activity of CDDO and CDDO-Me, Two Derivatives of Natural Triterpenoids. (2019) Molecules. 24, Pubmed Molecules PMC Article
Khiatah B, Qi M, Du W, T-Chen K, van Megen KM, Perez RG, Isenberg JS, Kandeel F, Roep BO, Ku HT and Al-Abdullah IH. Intra-pancreatic tissue-derived mesenchymal stromal cells: a promising therapeutic potential with anti-inflammatory and pro-angiogenic profiles. (2019) Stem Cell Res Ther. 10, 322 Pubmed Stem Cell Res Ther PMC Article
Londhe AM, Gadhe CG, Lim SM and Pae AN. Investigation of Molecular Details of Keap1-Nrf2 Inhibitors Using Molecular Dynamics and Umbrella Sampling Techniques. (2019) Molecules. 24, Pubmed Molecules PMC Article
Zhang XQ, Yao C, Bian WH, Chen X, Xue JX, Zhu ZY, Ying Y, Xu YL and Wang C. Effects of Astragaloside IV on treatment of breast cancer cells execute possibly through regulation of Nrf2 via PI3K/AKT/mTOR signaling pathway. (2019) Food Sci Nutr. 7, 3403-3413 Pubmed Food Sci Nutr PMC Article
Ashrafizadeh M, Ahmadi Z, Farkhondeh T and Samarghandian S. Back to Nucleus: Combating with Cadmium Toxicity Using Nrf2 Signaling Pathway as a Promising Therapeutic Target. (2019) Biol Trace Elem Res. Pubmed Biol Trace Elem Res
Zhu T, Fang F, Sun D, Yang S, Zhang X, Yu X and Yang L. Piceatannol Inhibits P. acnes-Induced Keratinocyte Proliferation and Migration by Downregulating Oxidative Stress and the Inflammatory Response. (2019) Inflammation. Pubmed Inflammation
Wang T, Liu Q and Duan L. MBNL1 regulates resistance of HeLa cells to cisplatin via Nrf2. (2019) Biochem. Biophys. Res. Commun.. Pubmed Biochem. Biophys. Res. Commun.
Yang C, Gong J, Xu W, Liu Z and Cui D. Next-generation sequencing identified somatic alterations that may underlie the etiology of Chinese papillary thyroid carcinoma. (2019) Eur. J. Cancer Prev.. Pubmed Eur. J. Cancer Prev.
Wang T, Dai F, Li GH, Chen XM, Li YR, Wang SQ, Ren DM, Wang XN, Lou HX, Zhou B and Shen T. Trans-4,4'-dihydroxystilbene ameliorates cigarette smoke-induced progression of chronic obstructive pulmonary disease via inhibiting oxidative stress and inflammatory response. (2019) Free Radic. Biol. Med.. Pubmed Free Radic. Biol. Med.
Mussard E, Cesaro A, Lespessailles E, Legrain B, Berteina-Raboin S and Toumi H. Andrographolide, a Natural Antioxidant: An Update. (2019) Antioxidants (Basel). 8, Pubmed Antioxidants (Basel) PMC Article
Uddin MS, Mamun AA, Jakaria M, Thangapandiyan S, Ahmad J, Rahman MA, Mathew B, Abdel-Daim MM and Aleya L. Emerging promise of sulforaphane-mediated Nrf2 signaling cascade against neurological disorders. (2019) Sci. Total Environ.. 135624 Pubmed Sci. Total Environ.
Ruhee RT, Ma S and Suzuki K. Sulforaphane Protects Cells against Lipopolysaccharide-Stimulated Inflammation in Murine Macrophages. (2019) Antioxidants (Basel). 8, Pubmed Antioxidants (Basel) PMC Article
Qu H, Gao X, Wang ZY and Yi JJ. Comparative study on hepatoprotection of pine nut (Pinus koraiensis Sieb. et Zucc.) polysaccharide against different types of chemical-induced liver injury models in vivo. (2019) Int. J. Biol. Macromol.. Pubmed Int. J. Biol. Macromol.
Panigrahi DP, Bhol CS, R N, Nagini S, Patil S, Maiti TK and Bhutia SK. Abrus agglutinin inhibits oral carcinogenesis through inactivation of NRF2 signaling pathway. (2019) Int. J. Biol. Macromol.. Pubmed Int. J. Biol. Macromol.
Lian W, Liu X and Chen W. TNFα Induces Multidrug Resistance-Associated Protein 4 Expression through p38-E2F1-Nrf2 Signaling in Obstructive Cholestasis. (2019) Yonsei Med. J.. 60, 1045-1053 Pubmed Yonsei Med. J. PMC Article
Zimta AA, Cenariu D, Irimie A, Magdo L, Nabavi SM, Atanasov AG and Berindan-Neagoe I. The Role of Nrf2 Activity in Cancer Development and Progression. (2019) Cancers (Basel). 11, Pubmed Cancers (Basel) PMC Article
Lee SM, Kim NH, Lee S, Kim YN, Heo JD, Jeong EJ and Rho JR. Deacetylphylloketal, a New Phylloketal Derivative from a Marine Sponge, Genus , with Potent Anti-Inflammatory Activity in In Vitro Co-Culture Model of Intestine. (2019) Mar Drugs. 17, Pubmed Mar Drugs PMC Article
Badshah H, Ikram M, Ali W, Ahmad S, Hahm JR and Kim MO. Caffeine May Abrogate LPS-Induced Oxidative Stress and Neuroinflammation by Regulating Nrf2/TLR4 in Adult Mouse Brains. (2019) Biomolecules. 9, Pubmed Biomolecules PMC Article
Schultrich K, Henderson CJ, Braeuning A and Buhrke T. Correlation between 3-MCPD-induced organ toxicity and oxidative stress response in male mice. (2019) Food Chem. Toxicol.. 110957 Pubmed Food Chem. Toxicol.
Liu X, Bai J, Jiang C, Song Z, Zhao Y, Nauwynck H and Jiang P. Therapeutic effect of Xanthohumol against highly pathogenic porcine reproductive and respiratory syndrome viruses. (2019) Vet. Microbiol.. 238, 108431 Pubmed Vet. Microbiol.
Ooi A. Advances in hereditary leiomyomatosis and renal cell carcinoma (HLRCC) research. (2019) Semin. Cancer Biol.. Pubmed Semin. Cancer Biol.
Kiesslich T, Mayr C and Neureiter D. NRF2: The key to tumor- and patient-dependent chemosensitivity in biliary tract cancer?. (2019) EBioMedicine. 49, 9-10 Pubmed EBioMedicine PMC Article
Geng X, Yang B, Li R, Teng T, Ladu MJ, Sun GY, Greenlief CM and Lee JC. Effects of Docosahexaenoic Acid and Its Peroxidation Product on Amyloid-β Peptide-Stimulated Microglia. (2019) Mol. Neurobiol.. Pubmed Mol. Neurobiol.
Li R, Jia Z and Zhu H. Regulation of Nrf2 Signaling. (2019) React Oxyg Species (Apex). 8, 312-322 Pubmed React Oxyg Species (Apex) PMC Article
Nadal E, Palmero R and Muñoz-Pinedo C. Mutations in the Antioxidant KEAP1/NRF2 Pathway Define an Aggressive Subset of NSCLC Resistant to Conventional Treatments. (2019) J Thorac Oncol. 14, 1881-1883 Pubmed J Thorac Oncol
Wang J, Lu Q, Cai J, Wang Y, Lai X, Qiu Y, Huang Y, Ke Q, Zhang Y, Guan Y, Wu H, Wang Y, Liu X, Shi Y, Zhang K, Wang M and Peng Xiang A. Nestin regulates cellular redox homeostasis in lung cancer through the Keap1-Nrf2 feedback loop. (2019) Nat Commun. 10, 5043 Pubmed Nat Commun PMC Article
Ho CJ and Gorski SM. Molecular Mechanisms Underlying Autophagy-Mediated Treatment Resistance in Cancer. (2019) Cancers (Basel). 11, Pubmed Cancers (Basel) PMC Article
Lu Y, Hu P, Zhou H, Yang Z, Sun YU, Hoffman RM and Chen J. Double-negative T Cells Inhibit Proliferation and Invasion of Human Pancreatic Cancer Cells in Co-culture. (2019) Anticancer Res.. 39, 5911-5918 Pubmed Anticancer Res.
Montesano A, Senesi P, Vacante F, Mollica G, Benedini S, Mariotti M, Luzi L and Terruzzi I. L-Carnitine counteracts in vitro fructose-induced hepatic steatosis through targeting oxidative stress markers. (2019) J. Endocrinol. Invest.. Pubmed J. Endocrinol. Invest.
Yu H, Wu CL, Wang X, Ban Q, Quan C, Liu M, Dong H, Li J, Kim GY, Choi YH, Wang Z and Jin CY. SP600125 enhances C-2-induced cell death by the switch from autophagy to apoptosis in bladder cancer cells. (2019) J. Exp. Clin. Cancer Res.. 38, 448 Pubmed J. Exp. Clin. Cancer Res. PMC Article
Luk ST, Ng KY, Zhou L, Tong M, Wong TL, Yu H, Lo CM, Man K, Guan XY, Lee TK and Ma S. Deficiency in embryonic stem cell marker REX1 activates MKK6-dependent p38 MAPK signaling to drive hepatocarcinogenesis. (2019) Hepatology. Pubmed Hepatology
Yi J, Huang WZ, Wen YQ and Yi YC. Effect of miR-101 on proliferation and oxidative stress-induced apoptosis of breast cancer cells via Nrf2 signaling pathway. (2019) Eur Rev Med Pharmacol Sci. 23, 8931-8939 Pubmed Eur Rev Med Pharmacol Sci
Kawaguchi T, Nakano D, Koga H and Torimura T. Effects of a DPP4 Inhibitor on Progression of NASH-related HCC and the p62/ Keap1/Nrf2-Pentose Phosphate Pathway in a Mouse Model. (2019) Liver Cancer. 8, 359-372 Pubmed Liver Cancer PMC Article
Cheng Q, Shen Y, Cheng Z, Shao Q, Wang C, Sun H and Zhang Q. Achyranthes bidentata polypeptide k suppresses neuroinflammation in BV2 microglia through Nrf2-dependent mechanism. (2019) Ann Transl Med. 7, 575 Pubmed Ann Transl Med PMC Article
Cheleschi S, Gallo I, Barbarino M, Giannotti S, Mondanelli N, Giordano A, Tenti S and Fioravanti A. MicroRNA Mediate Visfatin and Resistin Induction of Oxidative Stress in Human Osteoarthritic Synovial Fibroblasts Via NF-κB Pathway. (2019) Int J Mol Sci. 20, Pubmed Int J Mol Sci PMC Article
Vabeiryureilai M, Lalrinzuali K and Jagetia GC. Chemopreventive effect of hesperidin, a citrus bioflavonoid in two stage skin carcinogenesis in Swiss albino mice. (2019) Heliyon. 5, e02521 Pubmed Heliyon PMC Article
Li J, Wang Q, Yang Y, Lei C, Yang F, Liang L, Chen C, Xia J, Wang K and Tang N. GSTZ1 deficiency promotes hepatocellular carcinoma proliferation via activation of the KEAP1/NRF2 pathway. (2019) J. Exp. Clin. Cancer Res.. 38, 438 Pubmed J. Exp. Clin. Cancer Res. PMC Article
Stenvinkel P, Painer J, Johnson RJ and Natterson-Horowitz B. Biomimetics - Nature's roadmap to insights and solutions for burden of lifestyle diseases. (2019) J. Intern. Med.. Pubmed J. Intern. Med.
Jiang S, Yang Z, Huang L, Yang W, Song D, Liu F, Ge J, Wang Y and Jiang S. Effect of Illicium verum or Eucommia ulmoides leaf extracts on the anti-stress ability, and mRNA and protein expression of Nrf2 and TNF-α in Duroc × Landrace × Yorkshire and Chinese native Licha-black nursery piglets. (2019) J Anim Physiol Anim Nutr (Berl). Pubmed J Anim Physiol Anim Nutr (Berl)
Dash S, Aydin Y and Moroz K. Chaperone-Mediated Autophagy in the Liver: Good or Bad?. (2019) Cells. 8, Pubmed Cells PMC Article
Lipponen A, Natunen T, Hujo M, Ciszek R, Hämäläinen E, Tohka J, Hiltunen M, Paananen J, Poulsen D, Kansanen E, Ekolle Ndode-Ekane X, Levonen AL and Pitkänen A. In Vitro and In Vivo Pipeline for Validation of Disease-Modifying Effects of Systems Biology-Derived Network Treatments for Traumatic Brain Injury-Lessons Learned. (2019) Int J Mol Sci. 20, Pubmed Int J Mol Sci PMC Article
Shi Y, Fan S, Wu M, Zuo Z, Li X, Jiang L, Shen Q, Xu P, Zeng L, Zhou Y, Huang Y, Yang Z, Zhou J, Gao J, Zhou H, Xu S, Ji H, Shi P, Wu DD, Yang C and Chen Y. YTHDF1 links hypoxia adaptation and non-small cell lung cancer progression. (2019) Nat Commun. 10, 4892 Pubmed Nat Commun PMC Article
Zhang L, Wu P, Zhang L, SreeHarsha N, Mishra A and Su X. Ameliorative effect of rosiglitazone, a peroxisome proliferator gamma agonist on adriamycin-induced cardio toxicity via suppressing oxidative stress and apoptosis. (2019) IUBMB Life. Pubmed IUBMB Life
Sheng L, Cao X, Zhen Q, Yang X and Yang Z. [Legionella pneumophila activates Nrf2-Keap1 pathway to inhibit autophagy of mouse RAW264.7 macrophages]. (2019) Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi. 35, 878-885 Pubmed Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi
Chen Y, Zheng Z, Li C, Pan Y, Tang X and Wang XJ. Synthetic Imine Resveratrol Analog 2-Methoxyl-3,6-Dihydroxyl-IRA Ameliorates Colitis by Activating Protective Nrf2 Pathway and Inhibiting NLRP3 Expression. (2019) Oxid Med Cell Longev. 2019, 7180284 Pubmed Oxid Med Cell Longev PMC Article
Lee SE, Park SH, Yoo JA, Kwon K, Kim JW, Oh SW, Park SJ, Kim J, Yu E, Han BS, Cho JY and Lee J. Antagonizing Effects of DC. Extract against Benzo[a]pyrene-Induced Damage to Human Keratinocytes. (2019) Oxid Med Cell Longev. 2019, 2386163 Pubmed Oxid Med Cell Longev PMC Article
Namani A, Zheng Z, Wang XJ and Tang X. Systematic Identification of Multi Omics-based Biomarkers in Mutated TCGA Lung Adenocarcinoma. (2019) J Cancer. 10, 6813-6821 Pubmed J Cancer PMC Article
Dong J, Li W, Cheng LM and Wang GG. Lycopene attenuates LPS-induced liver injury by inactivation of NF-κB/COX-2 signaling. (2019) Int J Clin Exp Pathol. 12, 817-825 Pubmed Int J Clin Exp Pathol PMC Article
Chen M, Samuel VP, Wu Y, Dang M, Lin Y, Sriramaneni R, Sah SK, Chinnaboina GK and Zhang G. Nrf2/HO-1 Mediated Protective Activity of Genistein Against Doxorubicin-Induced Cardiac Toxicity. (2019) J. Environ. Pathol. Toxicol. Oncol.. 38, 143-152 Pubmed J. Environ. Pathol. Toxicol. Oncol.
Tian Y, Song W, Li D, Cai L and Zhao Y. Resveratrol As A Natural Regulator Of Autophagy For Prevention And Treatment Of Cancer. (2019) Onco Targets Ther. 12, 8601-8609 Pubmed Onco Targets Ther PMC Article
Wu X, Sun R, Wang H, Yang B, Wang F, Xu H, Chen S, Zhao R, Pi J and Xu Y. Enhanced p62-NRF2 Feedback Loop due to Impaired Autophagic Flux Contributes to Arsenic-Induced Malignant Transformation of Human Keratinocytes. (2019) Oxid Med Cell Longev. 2019, 1038932 Pubmed Oxid Med Cell Longev PMC Article
Xu L, Zhao Y, Pan F, Zhu M, Yao L, Liu Y, Feng J, Xiong J, Chen X, Ren F, Tan Y and Wang H. Inhibition of the Nrf2-TrxR Axis Sensitizes the Drug-Resistant Chronic Myelogenous Leukemia Cell Line K562/G01 to Imatinib Treatments. (2019) Biomed Res Int. 2019, 6502793 Pubmed Biomed Res Int PMC Article
Liao HH, Zhang N, Meng YY, Feng H, Yang JJ, Li WJ, Chen S, Wu HM, Deng W and Tang QZ. Myricetin Alleviates Pathological Cardiac Hypertrophy via TRAF6/TAK1/MAPK and Nrf2 Signaling Pathway. (2019) Oxid Med Cell Longev. 2019, 6304058 Pubmed Oxid Med Cell Longev PMC Article
Lin ZH, Chan YF, Pan MH, Tung YC and Su ZY. Aged Citrus Peel (Chenpi) Prevents Acetaminophen-Induced Hepatotoxicity by Epigenetically Regulating Nrf2 Pathway. (2019) Am. J. Chin. Med.. 47, 1833-1851 Pubmed Am. J. Chin. Med.
Hu L, Zhang Y, Miao W and Cheng T. Reactive Oxygen Species and Nrf2: Functional and Transcriptional Regulators of Hematopoiesis. (2019) Oxid Med Cell Longev. 2019, 5153268 Pubmed Oxid Med Cell Longev PMC Article
Zhou Q, Wang X, Shao X, Wang H, Liu X, Ke X, Xiong C, Wei L and Zou H. -Butylhydroquinone Treatment Alleviates Contrast-Induced Nephropathy in Rats by Activating the Nrf2/Sirt3/SOD2 Signaling Pathway. (2019) Oxid Med Cell Longev. 2019, 4657651 Pubmed Oxid Med Cell Longev PMC Article
Francisco Fernandez M, Charfi C, Piloto-Ferrer J, Lidia González M, Lamy S and Annabi B. Targeting Ovarian Cancer Cell Cytotoxic Drug Resistance Phenotype with L. Extract. (2019) Evid Based Complement Alternat Med. 2019, 6073019 Pubmed Evid Based Complement Alternat Med PMC Article
Simonetti V, Quagliariello V, Franzini M, Iaffaioli RV, Maurea N and Valdenassi L. Ozone Exerts Cytoprotective and Anti-Inflammatory Effects in Cardiomyocytes and Skin Fibroblasts after Incubation with Doxorubicin. (2019) Evid Based Complement Alternat Med. 2019, 2169103 Pubmed Evid Based Complement Alternat Med PMC Article
Wang J, Zhang J, Chen L, Cai J, Li Z, Zhang Z, Zheng Q, Wang Y, Zhou S, Liu Q and Cai L. Combination of Broccoli Sprout Extract and Zinc Provides Better Protection against Intermittent Hypoxia-Induced Cardiomyopathy Than Monotherapy in Mice. (2019) Oxid Med Cell Longev. 2019, 2985901 Pubmed Oxid Med Cell Longev PMC Article
Woo Y, Lee HJ, Jung YM and Jung YJ. mTOR-Mediated Antioxidant Activation in Solid Tumor Radioresistance. (2019) J Oncol. 2019, 5956867 Pubmed J Oncol PMC Article
Liu Y, Zhang J, Liu H, Guan G, Zhang T, Wang L, Qi X, Zheng H, Chen CC, Liu J, Cao D, Lu F and Chen X. Compensatory upregulation of aldo-keto reductase 1B10 to protect hepatocytes against oxidative stress during hepatocarcinogenesis. (2019) Am J Cancer Res. 9, 2730-2748 Pubmed Am J Cancer Res PMC Article
Estrela JM, Salvador R, Marchio P, Valles SL, López-Blanch R, Rivera P, Benlloch M, Alcácer J, Pérez CL, Pellicer JA and Obrador E. Glucocorticoid receptor antagonism overcomes resistance to BRAF inhibition in BRAF-mutated metastatic melanoma. (2019) Am J Cancer Res. 9, 2580-2598 Pubmed Am J Cancer Res PMC Article
Liu X, Wang Y, Wu D, Li S, Wang C, Han Z, Wang J, Wang K, Yang Z and Wei Z. Magnolol Prevents Acute Alcoholic Liver Damage by Activating PI3K/Nrf2/PPARγ and Inhibiting NLRP3 Signaling Pathway. (2019) Front Pharmacol. 10, 1459 Pubmed Front Pharmacol PMC Article
Weng CF, Wu CF, Kao SH, Chen JC and Lin HH. Down-Regulation of miR-34a-5p Potentiates Protective Effect of Adipose-Derived Mesenchymal Stem Cells Against Ischemic Myocardial Infarction by Stimulating the Expression of C1q/Tumor Necrosis Factor-Related Protein-9. (2019) Front Physiol. 10, 1445 Pubmed Front Physiol PMC Article
Varmazyar R, Noori-Zadeh A, Abbaszadeh HA, Hamidabadi HG, Rajaei F, Darabi S, Rezaie MJ, Abdollahifar MA, Zafari F and Bakhtiyari S. Neural stem cells neuroprotection by simvastatin via autophagy induction and apoptosis inhibition. (2019) Bratisl Lek Listy. 120, 744-751 Pubmed Bratisl Lek Listy
Shen CJ, Lin PL, Lin HC, Cheng YW, Huang HS and Lee H. RV-59 suppresses cytoplasmic Nrf2-mediated 5-fluorouracil resistance and tumor growth in colorectal cancer. (2019) Am J Cancer Res. 9, 2789-2796 Pubmed Am J Cancer Res PMC Article
Wang P, Song J and Ye D. CRL3s: The BTB-CUL3-RING E3 Ubiquitin Ligases. (2020) Adv. Exp. Med. Biol.. 1217, 211-223 Pubmed Adv. Exp. Med. Biol.
Quinn TJ, Ding X, Li X, Wilson GD, Buelow K, Sivananthan A, Thermozier S, Henderson A, Epperly MW, Franicola D, Wipf P, Greenberger JS, Stevens CW and Kabolizadeh P. Amelioration of Mucositis in Proton Therapy of Fanconi Anemia Fanca Mice by JP4-039. In Vivo. 33, 1757-1766 Pubmed In Vivo PMC Article
Hseu YC, Chang CT, Gowrisankar YV, Chen XZ, Lin HC, Yen HR and Yang HL. Zerumbone Exhibits Antiphotoaging and Dermatoprotective Properties in Ultraviolet A-Irradiated Human Skin Fibroblast Cells via the Activation of Nrf2/ARE Defensive Pathway. (2019) Oxid Med Cell Longev. 2019, 4098674 Pubmed Oxid Med Cell Longev PMC Article
Hämäläinen M, Teppo HR, Skarp S, Haapasaari KM, Porvari K, Vuopala K, Kietzmann T and Karihtala P. NRF1 and NRF2 mRNA and Protein Expression Decrease Early during Melanoma Carcinogenesis: An Insight into Survival and MicroRNAs. (2019) Oxid Med Cell Longev. 2019, 2647068 Pubmed Oxid Med Cell Longev PMC Article