Which NRF2 Products Have Peer Reviewed Studies

English: Graph of Nrf2 publications (pubmed search) by year (Photo credit: Wikipedia)

There are currently over 2300 articles (peer reviewed clinical reviews and studies) on Pubmed.gov on the topic of NRF2 Activation. There are a ton of companies claiming they have scientific studies showing that their products are NRF2 Activators. Go to Pubmed.gov and type in the name of their product. Pubmed is a website operated by the National Institute of Health (NIH). PubMed comprises over 21 million citations for biomedical literature from MEDLINE, life science journals, and online books. PubMed citations and abstracts include the fields of biomedicine and health, covering portions of the life sciences, behavioral sciences, chemical sciences, and bioengineering. PubMed also provides access to additional relevant web sites and links to the other NCBI molecular biology resources. Last 200 NRF-2 Studies published on Pubmed

Thai SF, Jones CP, Robinette BL, Ren H, Vallant B, Fisher A and Kitchin KT. Effects of Copper Nanoparticles on mRNA and Small RNA Expression in Human Hepatocellular Carcinoma (HepG2) Cells. (2021) J Nanosci Nanotechnol. 21, 5083-5098 Pubmed J Nanosci Nanotechnol

Liu P, Yin Z, Chen M, Huang C, Wu Z, Huang J, Ou S and Zheng J. Cytotoxicity of adducts formed between quercetin and methylglyoxal in PC-12 cells. (2021) Food Chem. 352, 129424 Pubmed Food Chem

Xiang D, Yang J, Xu Y, Lan L, Li G, Zhang C and Liu D. Estrogen cholestasis induces gut and liver injury in rats involving in activating PI3K/Akt and MAPK signaling pathways. (2021) Life Sci. 276, 119367 Pubmed Life Sci

Brasil FB, Bertolini Gobbo RC, Souza de Almeida FJ, Luckachaki MD, Dall'Oglio EL and de Oliveira MR. The signaling pathway PI3K/Akt/Nrf2/HO-1 plays a role in the mitochondrial protection promoted by astaxanthin in the SH-SY5Y cells exposed to hydrogen peroxide. (2021) Neurochem Int. 146, 105024 Pubmed Neurochem Int

Zhang B, Kirn LA and Burke R. The Vhl E3 ubiquitin ligase complex regulates melanisation via sima, cnc and the copper import protein Ctr1A. (2021) Biochim Biophys Acta Mol Cell Res. 1868, 119022 Pubmed Biochim Biophys Acta Mol Cell Res

Yoshida GJ and Saya H. Molecular pathology underlying the robustness of cancer stem cells. (2021) Regen Ther. 17, 38-50 Pubmed Regen Ther PMC Article

Ali FEM, Sayed AM, El-Bahrawy AH, Omar ZMM and Hassanein EHM. Targeting KEAP1/Nrf2, AKT, and PPAR-γ signals as a potential protective mechanism of diosmin against gentamicin-induced nephrotoxicity. (2021) Life Sci. 275, 119349 Pubmed Life Sci

Shan HJ, Zhu LQ, Yao C, Zhang ZQ, Liu YY, Jiang Q, Zhou XZ, Wang XD and Cao C. MAFG-driven osteosarcoma cell progression is inhibited by a novel miRNA miR-4660. (2021) Mol Ther Nucleic Acids. 24, 385-402 Pubmed Mol Ther Nucleic Acids PMC Article

Liu M, Zheng B, Liu P, Zhang J, Chu X, Dong C, Shi J, Liang Y, Chu L, Liu Y and Han X. Exploration of the hepatoprotective effect and mechanism of magnesium isoglycyrrhizinate in mice with arsenic trioxide‑induced acute liver injury. (2021) Mol Med Rep. 23, Pubmed Mol Med Rep PMC Article

Rajput SA, Wang XQ and Yan HC. Morin hydrate: A comprehensive review on novel natural dietary bioactive compound with versatile biological and pharmacological potential. (2021) Biomed Pharmacother. 138, 111511 Pubmed Biomed Pharmacother

Xiao N, Zhao Y, He W, Yao Y, Wu N, Xu M, Du H and Tu Y. Egg yolk oils exert anti-inflammatory effect via regulating Nrf2/NF-κB pathway. (2021) J Ethnopharmacol. 274, 114070 Pubmed J Ethnopharmacol

Oh S, Tsujimoto T, Kim B, Uchida F, Suzuki H, Iizumi S, Isobe T, Sakae T, Tanaka K and Shoda J. Weight-loss-independent benefits of exercise on liver steatosis and stiffness in Japanese men with NAFLD. (2021) JHEP Rep. 3, 100253 Pubmed JHEP Rep PMC Article

. Autophagy-Deficient Pancreatic Cancer Cells Depend on Macropinocytosis. (2021) Cancer Discov. 11, OF28 Pubmed Cancer Discov

Ge MH, Tian H, Mao L, Li DY, Lin JQ, Hu HS, Huang SC, Zhang CJ and Mei XF. Zinc attenuates ferroptosis and promotes functional recovery in contusion spinal cord injury by activating Nrf2/GPX4 defense pathway. (2021) CNS Neurosci Ther. Pubmed CNS Neurosci Ther

Arab HH, Eid AH, Mahmoud AM and Senousy MA. Linagliptin mitigates experimental inflammatory bowel disease in rats by targeting inflammatory and redox signaling. (2021) Life Sci. 273, 119295 Pubmed Life Sci

Li X, Zhou L, Zhang Y, He X, Lu H, Zhang L, Tian Y, Liu X, Zheng H, Shao J and Long M. mGPDH Deficiency leads to melanoma metastasis via induced NRF2. (2021) J Cell Mol Med. Pubmed J Cell Mol Med

Jiang C, Li R, Xiu C, Ma X, Hu H, Wei L, Tang Y, Tao M and Zhao J. Upregulating CXCR7 accelerates endothelial progenitor cell-mediated endothelial repair by activating Akt/Keap-1/Nrf2 signaling in diabetes mellitus. (2021) Stem Cell Res Ther. 12, 264 Pubmed Stem Cell Res Ther

Jin L and Tong L. PAQR3 inhibits proliferation and aggravates ferroptosis in acute lymphoblastic leukemia through modulation Nrf2 stability. (2021) Immun Inflamm Dis. Pubmed Immun Inflamm Dis

Liu T, Lv YF, Zhao JL, You QD and Jiang ZY. Regulation of Nrf2 by phosphorylation: Consequences for biological function and therapeutic implications. (2021) Free Radic Biol Med. 168, 129-141 Pubmed Free Radic Biol Med

Liu J, Qin X, Ma W, Jia S, Zhang X, Yang X, Pan D and Jin F. Corilagin induces apoptosis and autophagy in NRF2‑addicted U251 glioma cell line. (2021) Mol Med Rep. 23, Pubmed Mol Med Rep PMC Article

Kalezic A, Udicki M, Srdic Galic B, Aleksic M, Korac A, Jankovic A and Korac B. Redox profile of breast tumor and associated adipose tissue in premenopausal women - Interplay between obesity and malignancy. (2021) Redox Biol. 41, 101939 Pubmed Redox Biol PMC Article

Yue CF, Li LS, Ai L, Deng JK and Guo YM. sMicroRNA-28-5p acts as a metastasis suppressor in gastric cancer by targeting Nrf2. (2021) Exp Cell Res. 402, 112553 Pubmed Exp Cell Res

Schmidlin CJ, Tian W, Dodson M, Chapman E and Zhang DD. FAM129B-dependent activation of NRF2 promotes an invasive phenotype in BRAF mutant melanoma cells. (2021) Mol Carcinog. 60, 331-341 Pubmed Mol Carcinog

Su X, Wang S, Zhang H, Yang G, Bai Y, Liu P, Meng L, Jiang X and Xin Y. Sulforaphane prevents angiotensin II-induced cardiomyopathy by activation of Nrf2 through epigenetic modification. (2021) J Cell Mol Med. 25, 4408-4419 Pubmed J Cell Mol Med

Addison R, Weatherhead SC, Pawitri A, Smith GR, Rider A, Grantham HJ, Cockell SJ and Reynolds NJ. Therapeutic wavelengths of ultraviolet B radiation activate apoptotic, circadian rhythm, redox signalling and key canonical pathways in psoriatic epidermis. (2021) Redox Biol. 41, 101924 Pubmed Redox Biol PMC Article

Yuan T, Sun J, Tian J, Hu J, Yin H and Yin J. Involvement of ABC transporters in the detoxification of non-substrate nanoparticles in lung and cervical cancer cells. (2021) Toxicology. 455, 152762 Pubmed Toxicology

Calabrese EJ, Priest ND and Kozumbo WJ. Thresholds for carcinogens. (2021) Chem Biol Interact. 341, 109464 Pubmed Chem Biol Interact

Pei X, Jiang H, Liu X, Li L, Li C, Xiao X, Li D and Tang S. Targeting HMGB1 inhibits T-2 toxin-induced neurotoxicity via regulation of oxidative stress, neuroinflammation and neuronal apoptosis. (2021) Food Chem Toxicol. 151, 112134 Pubmed Food Chem Toxicol

Sun J, Zhou C, Zhao Y, Zhang X, Chen W, Zhou Q, Hu B, Gao D, Raatz L, Wang Z, Nelson PJ, Jiang Y, Ren N, Bruns CJ and Zhou H. Quiescin sulfhydryl oxidase 1 promotes sorafenib-induced ferroptosis in hepatocellular carcinoma by driving EGFR endosomal trafficking and inhibiting NRF2 activation. (2021) Redox Biol. 41, 101942 Pubmed Redox Biol PMC Article

Abdel-Wahab BA, Walbi IA, Albarqi HA, Ali FEM and Hassanein EHM. Roflumilast protects from cisplatin-induced testicular toxicity in male rats and enhances its cytotoxicity in prostate cancer cell line. Role of NF-κB-p65, cAMP/PKA and Nrf2/HO-1, NQO1 signaling. (2021) Food Chem Toxicol. 151, 112133 Pubmed Food Chem Toxicol

Sampath C, Wilus D, Tabatabai M, Freeman ML and Gangula PR. Mechanistic role of antioxidants in rescuing delayed gastric emptying in high fat diet induced diabetic female mice. (2021) Biomed Pharmacother. 137, 111370 Pubmed Biomed Pharmacother PMC Article

Mirzaei S, Mohammadi AT, Gholami MH, Hashemi F, Zarrabi A, Zabolian A, Hushmandi K, Makvandi P, Samec M, Liskova A, Kubatka P, Nabavi N, Aref AR, Ashrafizadeh M, Khan H and Najafi M. Nrf2 signaling pathway in cisplatin chemotherapy: Potential involvement in organ protection and chemoresistance. (2021) Pharmacol Res. 167, 105575 Pubmed Pharmacol Res

Ross D and Siegel D. The diverse functionality of NQO1 and its roles in redox control. (2021) Redox Biol. 41, 101950 Pubmed Redox Biol PMC Article

Cen M, Ouyang W, Zhang W, Yang L, Lin X, Dai M, Hu H, Tang H, Liu H, Xia J and Xu F. MitoQ protects against hyperpermeability of endothelium barrier in acute lung injury via a Nrf2-dependent mechanism. (2021) Redox Biol. 41, 101936 Pubmed Redox Biol PMC Article

Guo JW, Cheng YP, Liu CY, Thong HY, Lo Y, Wu CY and Jee SH. Magnolol may contribute to barrier function improvement on imiquimod-induced psoriasis-like dermatitis animal model via the downregulation of interleukin-23. (2021) Exp Ther Med. 21, 448 Pubmed Exp Ther Med PMC Article

Dong W, Liu G, Zhang K, Tan Y, Zou H, Yuan Y, Gu J, Song R, Zhu J and Liu Z. Cadmium exposure induces rat proximal tubular cells injury via p62-dependent Nrf2 nucleus translocation mediated activation of AMPK/AKT/mTOR pathway. (2021) Ecotoxicol Environ Saf. 214, 112058 Pubmed Ecotoxicol Environ Saf

Xu Y, Tu W, Sun D, Chen X, Ge Y, Yao S, Li B, Zhenbo Zhang and Liu Y. Nrf2 alleviates radiation-induced rectal injury by inhibiting of necroptosis. (2021) Biochem Biophys Res Commun. 554, 49-55 Pubmed Biochem Biophys Res Commun

Bader S, Wilmers J, Pelzer M, Jendrossek V and Rudner J. Activation of anti-oxidant Keap1/Nrf2 pathway modulates efficacy of dihydroartemisinin-based monotherapy and combinatory therapy with ionizing radiation. (2021) Free Radic Biol Med. 168, 44-54 Pubmed Free Radic Biol Med

Kohandel Z, Farkhondeh T, Aschner M and Samarghandian S. Nrf2 a molecular therapeutic target for Astaxanthin. (2021) Biomed Pharmacother. 137, 111374 Pubmed Biomed Pharmacother

Consonni FM, Bleve A, Totaro MG, Storto M, Kunderfranco P, Termanini A, Pasqualini F, Alì C, Pandolfo C, Sgambelluri F, Grazia G, Santinami M, Maurichi A, Milione M, Erreni M, Doni A, Fabbri M, Gribaldo L, Rulli E, Soares MP, Torri V, Mortarini R, Anichini A and Sica A. Heme catabolism by tumor-associated macrophages controls metastasis formation. (2021) Nat Immunol. 22, 595-606 Pubmed Nat Immunol

Liu P, Li J, Liu M, Zhang M, Xue Y, Zhang Y, Han X, Jing X and Chu L. Hesperetin modulates the Sirt1/Nrf2 signaling pathway in counteracting myocardial ischemia through suppression of oxidative stress, inflammation, and apoptosis. (2021) Biomed Pharmacother. 139, 111552 Pubmed Biomed Pharmacother

Ayoup MS, Abu-Serie MM, Abdel-Hamid H and Teleb M. Beyond direct Nrf2 activation; reinvestigating 1,2,4-oxadiazole scaffold as a master key unlocking the antioxidant cellular machinery for cancer therapy. (2021) Eur J Med Chem. 220, 113475 Pubmed Eur J Med Chem

Wang Q, Bin C, Xue Q, Gao Q, Huang A, Wang K and Tang N. GSTZ1 sensitizes hepatocellular carcinoma cells to sorafenib-induced ferroptosis via inhibition of NRF2/GPX4 axis. (2021) Cell Death Dis. 12, 426 Pubmed Cell Death Dis

Lei L, Guo Y, Lin J, Lin X, He S, Qin Z and Lin Q. Inhibition of endotoxin-induced acute lung injury in rats by bone marrow-derived mesenchymal stem cells: Role of Nrf2/HO-1 signal axis in inhibition of NLRP3 activation. (2021) Biochem Biophys Res Commun. 551, 7-13 Pubmed Biochem Biophys Res Commun

Sezgin-Bayindir Z, Losada-Barreiro S, Bravo-Díaz C, Sova M, Kristl J and Saso L. Nanotechnology-Based Drug Delivery to Improve the Therapeutic Benefits of NRF2 Modulators in Cancer Therapy. (2021) Antioxidants (Basel). 10, Pubmed Antioxidants (Basel)

Consoli V, Sorrenti V, Grosso S and Vanella L. Heme Oxygenase-1 Signaling and Redox Homeostasis in Physiopathological Conditions. (2021) Biomolecules. 11, Pubmed Biomolecules PMC Article

Qin S, He X, Lin H, Schulte BA, Zhao M, Tew KD and Wang GY. Nrf2 inhibition sensitizes breast cancer stem cells to ionizing radiation via suppressing DNA repair. (2021) Free Radic Biol Med. 169, 238-247 Pubmed Free Radic Biol Med

Kulkarni A, McDermott JR, Kathad U, Modali R, Richard JP, Sharma P and Bhatia K. The acylfulvene alkylating agent, LP-184, retains nanomolar potency in non-small cell lung cancer carrying otherwise therapy-refractory mutations. (2021) Oncotarget. 12, 791-806 Pubmed Oncotarget PMC Article

Yue CF, Li LS, Ai L, Deng JK and Guo YM. Corrigendum to "sMicroRNA-28-5p acts as a metastasis suppressor in gastric cancer by targeting Nrf2". (2021) Exp Cell Res. 112616 Pubmed Exp Cell Res

Majumder D, Debnath R, Nath P, Libin Kumar KV, Debnath M, Tribedi P and Maiti D. Bromelain and Olea europaea (L.) leaf extract mediated alleviation of benzo(a)pyrene induced lung cancer through Nrf2 and NFκB pathway. (2021) Environ Sci Pollut Res Int. Pubmed Environ Sci Pollut Res Int

Mao M, Yang L, Hu J, Liu B, Liu C, Zhang X, Liu Y, Wang P and Li H. OCT3/4 enhances tumor immune response by upregulating the TET1-dependent NRF2/MDM2 axis in bladder cancer. (2021) Genomics. Pubmed Genomics

Zhang Z and Costa M. p62 functions as a signal hub in metal carcinogenesis. (2021) Semin Cancer Biol. Pubmed Semin Cancer Biol

Tang Z, Ju Y, Dai X, Ni N, Liu Y, Zhang D, Gao H, Sun H, Zhang J and Gu P. HO-1-mediated ferroptosis as a target for protection against retinal pigment epithelium degeneration. (2021) Redox Biol. 43, 101971 Pubmed Redox Biol

Bi Z, Zhang Q, Fu Y, Seno A, Wadgaonkar P, Qiu Y, Almutairy B, Xu L, Zhang W, Thakur C and Chen F. Cooperation between NRF2-mediated transcription and MDIG-dependent epigenetic modifications in arsenic-induced carcinogenesis and cancer stem cells. (2021) Semin Cancer Biol. Pubmed Semin Cancer Biol

Sriramajayam K, Peng D, Lu H, Zhou S, Bhat N, McDonald OG, Que J, Zaika A and El-Rifai W. Activation of NRF2 by APE1/REF1 is redox-dependent in Barrett's related esophageal adenocarcinoma cells. (2021) Redox Biol. 43, 101970 Pubmed Redox Biol

Harris CM, Zamperoni KE, Sernoskie SC, Chow NSM and Massey TE. Effects of in vivo treatment of mice with sulforaphane on repair of DNA pyridyloxylbutylation. (2021) Toxicology. 454, 152753 Pubmed Toxicology

Jin M, Yang Y, Dai Y, Cai R, Wu L, Jiao Y, Zhang Z, Yang H, Zhou Y, Tang L, Li L and Li Y. 27-Hydroxycholesterol is a specific factor in the neoplastic microenvironment of HCC that causes MDR via GRP75 regulation of the redox balance and metabolic reprogramming. (2021) Cell Biol Toxicol. Pubmed Cell Biol Toxicol

Chang M, Wilson CJ, Karunatilleke NC, Moselhy MH, Karttunen M and Choy WY. Exploring the Conformational Landscape of the Neh4 and Neh5 Domains of Nrf2 Using Two Different Force Fields and Circular Dichroism. (2021) J Chem Theory Comput. Pubmed J Chem Theory Comput

Hill KS, McDowell A, McCorkle JR, Schuler E, Ellingson SR, Plattner R and Kolesar JM. KEAP1 Is Required for Artesunate Anticancer Activity in Non-Small-Cell Lung Cancer. (2021) Cancers (Basel). 13, Pubmed Cancers (Basel) PMC Article

Poznanski SM, Singh K, Ritchie TM, Aguiar JA, Fan IY, Portillo AL, Rojas EA, Vahedi F, El-Sayes A, Xing S, Butcher M, Lu Y, Doxey AC, Schertzer JD, Hirte HW and Ashkar AA. Metabolic flexibility determines human NK cell functional fate in the tumor microenvironment. (2021) Cell Metab. Pubmed Cell Metab

Stefan J, Kim TK, Schedel F, Janjetovic Z, Crossman DK, Steinbrink K, Slominski RM, Zmijewski J, Tulic MK, Reiter RJ, Kleszczyński K and Slominski AT. Differential and Overlapping Effects of Melatonin and Its Metabolites on Keratinocyte Function: Bioinformatics and Metabolic Analyses. (2021) Antioxidants (Basel). 10, Pubmed Antioxidants (Basel) PMC Article

Miller HE and Bishop AJR. Correlation AnalyzeR: functional predictions from gene co-expression correlations. (2021) BMC Bioinformatics. 22, 206 Pubmed BMC Bioinformatics PMC Article

Kang Q, Tong Y, Gowd V, Wang M, Chen F and Cheng KW. Oral administration of EGCG solution equivalent to daily achievable dosages of regular tea drinkers effectively suppresses miR483-3p induced metastasis of hepatocellular carcinoma cells in mice. (2021) Food Funct. 12, 3381-3392 Pubmed Food Funct

Feng L, Chen M, Li Y, Li M, Hu S, Zhou B, Zhu L, Yu L, Zhou Q, Tan L, An H, Wang X and Jin H. Sirt1 deacetylates and stabilizes p62 to promote hepato-carcinogenesis. (2021) Cell Death Dis. 12, 405 Pubmed Cell Death Dis PMC Article

Su H, Yang F, Sun B and Karin M. Macropinocytosis: the big drinker behind cancer cell self-consumption. (2021) Autophagy. 1-2 Pubmed Autophagy

Wu Y, Chen H, Zou Y, Yi R, Mu J and Zhao X. Lactobacillus plantarum HFY09 alleviates alcohol-induced gastric ulcers in mice via an anti-oxidative mechanism. (2021) J Food Biochem. e13726 Pubmed J Food Biochem

Ahmed SA and Mohammed WI. Carvedilol induces the antiapoptotic proteins Nrf and Bcl and inhibits cellular apoptosis in aluminum-induced testicular toxicity in male Wistar rats. (2021) Biomed Pharmacother. 139, 111594 Pubmed Biomed Pharmacother

Buha A, Baralić K, Djukic-Cosic D, Bulat Z, Tinkov A, Panieri E and Saso L. The Role of Toxic Metals and Metalloids in Nrf2 Signaling. (2021) Antioxidants (Basel). 10, Pubmed Antioxidants (Basel)

Kabel AM, Arab HH and Abd Elmaaboud MA. Attenuation of diethyl nitrosamine-induced hepatocellular carcinoma by taxifolin and/or alogliptin: The interplay between toll-like receptor 4, transforming growth factor beta-1, and apoptosis. (2021) Hum Exp Toxicol. 9603271211008496 Pubmed Hum Exp Toxicol

Mirzaei S, Hushmandi K, Zabolian A, Saleki H, Torabi SMR, Ranjbar A, SeyedSaleh S, Sharifzadeh SO, Khan H, Ashrafizadeh M, Zarrabi A and Ahn KS. Elucidating Role of Reactive Oxygen Species (ROS) in Cisplatin Chemotherapy: A Focus on Molecular Pathways and Possible Therapeutic Strategies. (2021) Molecules. 26, Pubmed Molecules PMC Article

Cheng X, Liu D, Song H, Tian X, Yan C and Han Y. Overexpression of Kininogen-1 aggravates oxidative stress and mitochondrial dysfunction in DOX-induced cardiotoxicity. (2021) Biochem Biophys Res Commun. 550, 142-150 Pubmed Biochem Biophys Res Commun

Ekuban FA, Zong C, Takikawa M, Morikawa K, Sakurai T, Ichihara S, Itoh K, Yamamoto M, Ohsako S and Ichihara G. Genetic ablation of Nrf2 exacerbates neurotoxic effects of acrylamide in mice. (2021) Toxicology. 456, 152785 Pubmed Toxicology

Song MY, Lee DY, Chun KS and Kim EH. The Role of NRF2/KEAP1 Signaling Pathway in Cancer Metabolism. (2021) Int J Mol Sci. 22, Pubmed Int J Mol Sci

Gupta P and Mohanty D. SMMPPI: a machine learning-based approach for prediction of modulators of protein-protein interactions and its application for identification of novel inhibitors for RBD:hACE2 interactions in SARS-CoV-2. (2021) Brief Bioinform. Pubmed Brief Bioinform PMC Article

Ji SY, Cha HJ, Molagoda IMN, Kim MY, Kim SY, Hwangbo H, Lee H, Kim GY, Kim DH, Hyun JW, Kim HS, Kim S, Jin CY and Choi YH. Suppression of Lipopolysaccharide-Induced Inflammatory and Oxidative Response by 5-Aminolevulinic Acid in RAW 264.7 Macrophages and Zebrafish Larvae. (2021) Biomol Ther (Seoul). Pubmed Biomol Ther (Seoul)

Hammad AM, Swiss GMS, Hall FS, Hikmat S, Sari Y, Al-Qirim TM and Amawi HA. Ceftriaxone Reduces Waterpipe Tobacco Smoke Withdrawal-induced Anxiety in rats via Modulating the Expression of TNF-α/NFĸB, Nrf2, and GLT-1. (2021) Neuroscience. 463, 128-142 Pubmed Neuroscience

Kulkarni N, Gadde R, Gugnani KS, Vu N, Yoo C, Zaveri R and Betharia S. Neuroprotective effects of disubstituted dithiolethione ACDT against manganese-induced toxicity in SH-SY5Y cells. (2021) Neurochem Int. 147, 105052 Pubmed Neurochem Int

Cao H, Zhang L, Qu Z, Tian S, Wang Z, Jiang Y, Hou Q, Jia L and Wang W. The protective effect of hydroxylated fullerene pretreatment on pilocarpine-induced status epilepticus. (2021) Brain Res. 1764, 147468 Pubmed Brain Res

Zeng H, Zhao X and Tang C. Downregulation of SELENBP1 enhances oral squamous cell carcinoma chemoresistance through KEAP1-NRF2 signaling. (2021) Cancer Chemother Pharmacol. Pubmed Cancer Chemother Pharmacol

Leon LM, Gautier M, Allan R, Ilié M, Nottet N, Pons N, Paquet A, Lebrigand K, Truchi M, Fassy J, Magnone V, Kinnebrew G, Radovich M, Cheok MH, Barbry P, Vassaux G, Marquette CH, Ponzio G, Ivan M, Pottier N, Hofman P, Mari B and Rezzonico R. Correction: The nuclear hypoxia-regulated NLUCAT1 long non-coding RNA contributes to an aggressive phenotype in lung adenocarcinoma through regulation of oxidative stress. (2021) Oncogene. 40, 2621 Pubmed Oncogene

Badea MA, Balas M and Dinischiotu A. Biological properties and development of hypoxia in a breast cancer 3D model generated by hanging drop technique. (2021) Cell Biochem Biophys. Pubmed Cell Biochem Biophys

Chen YS, Chang HS, Hsiao HH, Chen YF, Kuo YP, Yen FL and Yen CH. Identification of Root Extract as a Liver Cancer Cell-Normal Keratinocyte Dual-Selective NRF2 Regulator. (2021) Antioxidants (Basel). 10, Pubmed Antioxidants (Basel) PMC Article

Du J, Carroll RS, Steers GJ, Wagner BA, O'Leary BR, Jensen CS, Buettner GR and Cullen JJ. Catalase Modulates the Radio-Sensitization of Pancreatic Cancer Cells by Pharmacological Ascorbate. (2021) Antioxidants (Basel). 10, Pubmed Antioxidants (Basel) PMC Article

Estaras M, Gonzalez-Portillo MR, Martinez R, Garcia A, Estevez M, Fernandez-Bermejo M, Mateos JM, Vara D, Blanco-Fernández G, Lopez-Guerra D, Roncero V, Salido GM and Gonzalez A. Melatonin Modulates the Antioxidant Defenses and the Expression of Proinflammatory Mediators in Pancreatic Stellate Cells Subjected to Hypoxia. (2021) Antioxidants (Basel). 10, Pubmed Antioxidants (Basel) PMC Article

Sulaimon LA, Adisa RA, Samuel TA, Joel IY, Ayankojo AG, Abdulkareem FB and Olaniyi TO. Molecular mechanism of mitoquinol mesylate in mitigating the progression of hepatocellular carcinoma-in silico and in vivo studies. (2021) J Cell Biochem. Pubmed J Cell Biochem

Zhao F, Hong X, Li D, Wei Z, Ci X and Zhang S. Diosmetin induces apoptosis in ovarian cancer cells by activating reactive oxygen species and inhibiting the Nrf2 pathway. (2021) Med Oncol. 38, 54 Pubmed Med Oncol

Kreß JKC, Jessen C, Marquardt A, Hufnagel A and Meierjohann S. NRF2 Enables EGFR Signaling in Melanoma Cells. (2021) Int J Mol Sci. 22, Pubmed Int J Mol Sci PMC Article

Abo El-Magd NF, El-Mesery M, El-Karef A and El-Shishtawy MM. Amelioration effect of black seed oil against high-fat diet-induced obesity in rats through Nrf2/HO-1 pathway. (2021) J Food Biochem. 45, e13693 Pubmed J Food Biochem

Jovanović M, Tenji D, Nikolić B, Srdić-Rajić T, Svirčev E and Mitić-Ćulafić D. In Vitro Study of Two Edible Polygonoideae Plants: Phenolic Profile, Cytotoxicity, and Modulation of Keap1-Nrf2 Gene Expression. (2021) Foods. 10, Pubmed Foods PMC Article

AboYoussef AM, Khalaf MM, Malak MN and Hamzawy MA. Repurposing of sildenafil as antitumour; induction of cyclic guanosine monophosphate/protein kinase G pathway, caspase-dependent apoptosis and pivotal reduction of Nuclear factor kappa light chain enhancer of activated B cells in lung cancer. (2021) J Pharm Pharmacol. Pubmed J Pharm Pharmacol

Yang S, Huang XL, Chen J, Mao LN, Liu X, Yuan WS, Wu XJ and Luo GW. Curcumin protects BEAS‑2B cells from PM‑induced oxidative stress and inflammation by activating NRF2/antioxidant response element pathways. (2021) Int J Mol Med. 47, Pubmed Int J Mol Med PMC Article

Prochownik EV. Reconciling the Biological and Transcriptional Variability of Hepatoblastoma with Its Mutational Uniformity. (2021) Cancers (Basel). 13, Pubmed Cancers (Basel)

Xu C, Mao L, Tian H, Lin S, Zhao X, Lin J, Li D, Li X and Mei X. MICAL1 (molecule interacting with CasL 1) protects oligodendrocyte cells from oxidative injury through regulating apoptosis, autophagy in spinal cord injury. (2021) Neurosci Lett. 750, 135712 Pubmed Neurosci Lett

Calabrese EJ, Kozumbo WJ, Kapoor R, Dhawan G, Jimenez PCL and Giordano J. NRF2 activation putatively mediates clinical benefits of low-dose radiotherapy in COVID-19 pneumonia and acute respiratory distress syndrome (ards): novel mechanistic considerations. (2021) Radiother Oncol. Pubmed Radiother Oncol PMC Article

Bellanti F and Vendemiale G. The Aging Liver: Redox Biology and Liver Regeneration. (2021) Antioxid Redox Signal. Pubmed Antioxid Redox Signal

Bian S, Zhao Y, Li F, Lu S, Yang S, Liu M, Wang S, Zhao D, Zhang W and Wang J. Knockdown of p62/sequestosome enhances ginsenoside Rh2-induced apoptosis in cervical cancer HeLa cells with no effect on autophagy. (2021) Biosci Biotechnol Biochem. 85, 1097-1103 Pubmed Biosci Biotechnol Biochem

Bateman NW, Tarney CM, Abulez T, Soltis AR, Zhou M, Conrads K, Litzi T, Oliver J, Hood B, Driggers P, Viollet C, Dalgard C, Wilkerson M, Catherino W, Hamilton CA, Darcy KM, Casablanca Y, Al-Hendy A, Segars J, Conrads TP and Larry Maxwell G. Proteogenomic landscape of uterine leiomyomas from hereditary leiomyomatosis and renal cell cancer patients. (2021) Sci Rep. 11, 9371 Pubmed Sci Rep PMC Article

Guerrero-Rubio MA, Hernández-García S, García-Carmona F and Gandía-Herrero F. Flavonoids' Effects on Longevity, Fat Accumulation, Stress Resistance and Gene Modulation Involve mTOR, SKN-1 and DAF-16. (2021) Antioxidants (Basel). 10, Pubmed Antioxidants (Basel) PMC Article

Alzahrani AM, Rajendran P, Veeraraghavan VP and Hanieh H. Cardiac Protective Effect of Kirenol against Doxorubicin-Induced Cardiac Hypertrophy in H9c2 Cells through Nrf2 Signaling via PI3K/AKT Pathways. (2021) Int J Mol Sci. 22, Pubmed Int J Mol Sci PMC Article

Schirrmacher V. Less Can Be More: The Hormesis Theory of Stress Adaptation in the Global Biosphere and Its Implications. (2021) Biomedicines. 9, Pubmed Biomedicines PMC Article

Yang C, Zhang Y, Lin S, Liu Y and Li W. Suppressing the KIF20A/NUAK1/Nrf2/GPX4 signaling pathway induces ferroptosis and enhances the sensitivity of colorectal cancer to oxaliplatin. (2021) Aging (Albany NY). 13, Pubmed Aging (Albany NY)

Sun XH, Zhang H, Fan XP and Wang ZH. Astilbin Protects Against Carbon Tetrachloride-Induced Liver Fibrosis in Rats. (2021) Pharmacology. 1-9 Pubmed Pharmacology

Ibrahim Al-Obaide MA, Arutla V, Bacolod MD, Wang W, Zhang R and Srivenugopal KS. Genomic Space of in Human Glioma Revisited: Novel Motifs, Regulatory RNAs, NRF1, 2, and CTCF Involvement in Gene Expression. (2021) Int J Mol Sci. 22, Pubmed Int J Mol Sci PMC Article

El Khatib N, Morel S, Hugon G, Rapior S, Carnac G and Saint N. Identification of a Sesquiterpene Lactone from Leaves with Antioxidant Activity in Primary Human Muscle Cells. (2021) Molecules. 26, Pubmed Molecules PMC Article

Chun KS, Kim DH and Surh YJ. Role of Reductive versus Oxidative Stress in Tumor Progression and Anticancer Drug Resistance. (2021) Cells. 10, Pubmed Cells PMC Article

Borlinghaus J, Foerster Née Reiter J, Kappler U, Antelmann H, Noll U, Gruhlke MCH and Slusarenko AJ. Allicin, the Odor of Freshly Crushed Garlic: A Review of Recent Progress in Understanding Allicin's Effects on Cells. (2021) Molecules. 26, Pubmed Molecules PMC Article

Kim SH, Yum HW, Kim SH, Kim W, Kim SJ, Kim C, Kim K, Suh YG and Surh YJ. Protective Effects of Taurine Chloramine on Experimentally Induced Colitis: NFκB, STAT3, and Nrf2 as Potential Targets. (2021) Antioxidants (Basel). 10, Pubmed Antioxidants (Basel) PMC Article

Cho BO, Kim JH, Che DN, Kang HJ, Shin JY, Hao S, Park JH, Wang F, Lee YJ and Jang SI. Kushenol C Prevents Tert-Butyl Hydroperoxide and Acetaminophen-Induced Liver Injury. (2021) Molecules. 26, Pubmed Molecules PMC Article

Amara I, Ontario ML, Scuto M, Lo Dico GM, Sciuto S, Greco V, Abid-Essefi S, Signorile A, Salinaro AT and Calabrese V. Protects SH-SY5YCells from DEHP-Induced Endoplasmic Reticulum Stress and Apoptosis. (2021) Antioxidants (Basel). 10, Pubmed Antioxidants (Basel) PMC Article

Obrador E, Salvador-Palmer R, Jihad-Jebbar A, López-Blanch R, Dellinger TH, Dellinger RW and Estrela JM. Pterostilbene in Cancer Therapy. (2021) Antioxidants (Basel). 10, Pubmed Antioxidants (Basel) PMC Article

Soliman AM, Mekkawy MH, Karam HM, Higgins M, Dinkova-Kostova AT and Ghorab MM. Novel iodinated quinazolinones bearing sulfonamide as new scaffold targeting radiation induced oxidative stress. (2021) Bioorg Med Chem Lett. 42, 128002 Pubmed Bioorg Med Chem Lett

Park C, Park J, Kim WJ, Kim W, Cheong H and Kim SJ. Malonic Acid Isolated from Inhibits UVB-Induced Oxidative Stress and Inflammation in HaCaT Keratinocytes. (2021) Polymers (Basel). 13, Pubmed Polymers (Basel) PMC Article

Zheng K, Dong Y, Yang R, Liang Y, Wu H and He Z. Regulation of ferroptosis by bioactive phytochemicals: Implications for medical nutritional therapy. (2021) Pharmacol Res. 168, 105580 Pubmed Pharmacol Res

Song CH, Kim N, Nam RH, Choi SI, Kang C, Jang JY, Nho H, Shin E and Lee HN. Nuclear Factor Erythroid 2-related Factor 2 Knockout Suppresses the Development of Aggressive Colorectal Cancer Formation Induced by Azoxymethane/Dextran Sulfate Sodium-Treatment in Female Mice. (2021) J Cancer Prev. 26, 41-53 Pubmed J Cancer Prev PMC Article

Luo P, Zheng M, Zhang R, Zhang H, Liu Y, Li W, Sun X, Yu Q, Tipoe GL and Xiao J. -Allylmercaptocysteine improves alcoholic liver disease partly through a direct modulation of insulin receptor signaling. (2021) Acta Pharm Sin B. 11, 668-679 Pubmed Acta Pharm Sin B PMC Article

Barrera G, Cucci MA, Grattarola M, Dianzani C, Muzio G and Pizzimenti S. Control of Oxidative Stress in Cancer Chemoresistance: Spotlight on Nrf2 Role. (2021) Antioxidants (Basel). 10, Pubmed Antioxidants (Basel) PMC Article

Li KW, Liang YY, Wang Q, Li Y, Zhou SJ, Wei HC, Zhou CZ and Wan XH. Brucea javanica: A review on anticancer of its pharmacological properties and clinical researches. (2021) Phytomedicine. 153560 Pubmed Phytomedicine

Kim J. Pre-Clinical Neuroprotective Evidences and Plausible Mechanisms of Sulforaphane in Alzheimer's Disease. (2021) Int J Mol Sci. 22, Pubmed Int J Mol Sci PMC Article

Schiavello M, Gazzano E, Bergandi L, Silvagno F, Libener R, Riganti C and Aldieri E. Identification of Redox-Sensitive Transcription Factors as Markers of Malignant Pleural Mesothelioma. (2021) Cancers (Basel). 13, Pubmed Cancers (Basel) PMC Article

Tascioglu Aliyev A, Panieri E, Stepanić V, Gurer-Orhan H and Saso L. Involvement of NRF2 in Breast Cancer and Possible Therapeutical Role of Polyphenols and Melatonin. (2021) Molecules. 26, Pubmed Molecules PMC Article

Park JY, Saeidi S, Kim EH, Kim DH, Na HK, Keum JS and Surh YJ. Heregulin-β1 Activates NF-E2-related Factor 2 and Induces Manganese Superoxide Dismutase Expression in Human Breast Cancer Cells via Protein Kinase B and Extracellular Signal-regulated Protein Kinase Signaling Pathways. (2021) J Cancer Prev. 26, 54-63 Pubmed J Cancer Prev PMC Article

Padilla J and Lee J. A Novel Therapeutic Target, BACH1, Regulates Cancer Metabolism. (2021) Cells. 10, Pubmed Cells PMC Article

Mohammed RA and Mansour SM. Sodium hydrogen sulfide upregulates cystathionine β-synthase and protects striatum against 3-nitropropionic acid-induced neurotoxicity in rats. (2021) J Pharm Pharmacol. 73, 310-321 Pubmed J Pharm Pharmacol

Telkoparan-Akillilar P, Panieri E, Cevik D, Suzen S and Saso L. Therapeutic Targeting of the NRF2 Signaling Pathway in Cancer. (2021) Molecules. 26, Pubmed Molecules PMC Article

Kim EH, Kim SJ, Na HK, Han W, Kim NJ, Suh YG and Surh YJ. 15-Deoxy-Δ-prostaglandin J Upregulates VEGF Expression via NRF2 and Heme Oxygenase-1 in Human Breast Cancer Cells. (2021) Cells. 10, Pubmed Cells PMC Article

Liao W, Zhao S, Yang Z, Yang W, Huang L, Liu F, Liu M, Ge J, Wang Y and Jiang S. Illicium verum and Eucommia ulmoides leaf extracts promote nutrient availability and antioxidant capacity in piglets by upregulating duodenal and jejunal Nrf2/TNF-α. (2021) J Anim Physiol Anim Nutr (Berl). Pubmed J Anim Physiol Anim Nutr (Berl)

Klein MI, Cannataro VL, Townsend JP, Newman S, Stern DF and Zhao H. Identifying modules of cooperating cancer drivers. (2021) Mol Syst Biol. 17, e9810 Pubmed Mol Syst Biol PMC Article

Tan Y, Cao H, Li Q and Sun J. The role of transcription factor Ap1 in the activation of the Nrf2/ARE pathway through TET1 in diabetic nephropathy. (2021) Cell Biol Int. Pubmed Cell Biol Int

Piovan A, Filippini R, Corbioli G, Costa VD, Giunco EMV, Burbello G, Pagetta A, Giusti P and Zusso M. Carotenoid Extract Derived from Euglena gracilis Overcomes Lipopolysaccharide-Induced Neuroinflammation in Microglia: Role of NF-κB and Nrf2 Signaling Pathways. (2021) Mol Neurobiol. Pubmed Mol Neurobiol

Jia XB, Zhang Q, Xu L, Yao WJ and Wei L. Lotus leaf flavonoids induce apoptosis of human lung cancer A549 cells through the ROS/p38 MAPK pathway. (2021) Biol Res. 54, 7 Pubmed Biol Res PMC Article

Sun D, Sun C, Qiu G, Yao L, Yu J, Al Sberi H, Fouda MS, Othman MS, Lokman MS, Kassab RB and Abdel Moneim AE. Allicin mitigates hepatic injury following cyclophosphamide administration via activation of Nrf2/ARE pathways and through inhibition of inflammatory and apoptotic machinery. (2021) Environ Sci Pollut Res Int. Pubmed Environ Sci Pollut Res Int

El Shaffei I, Abdel-Latif GA, Farag DB, Schaalan M and Salama RM. Ameliorative effect of betanin on experimental cisplatin-induced liver injury; the novel impact of miRNA-34a on the SIRT1/PGC-1α signaling pathway. (2021) J Biochem Mol Toxicol. e22753 Pubmed J Biochem Mol Toxicol

Verdina A, Di Segni M, Amoreo CA, Sperduti I, Buglioni S, Mottolese M, Di Rocco G and Soddu S. HIPK2 is a potential predictive marker of a favorable response for adjuvant chemotherapy in stage II colorectal cancer. (2021) Oncol Rep. 45, 899-910 Pubmed Oncol Rep

Zhang J, Zhou B, Sun J, Chen H and Yang Z. Betulin ameliorates 7,12-dimethylbenz(a)anthracene-induced rat mammary cancer by modulating MAPK and AhR/Nrf-2 signaling pathway. (2021) J Biochem Mol Toxicol. e22779 Pubmed J Biochem Mol Toxicol

Liang X and Wang R. The Nrf2 inhibitor brusatol has a protective role in a rat model of oxygen-induced retinopathy of prematurity. (2021) Vis Neurosci. 38, E002 Pubmed Vis Neurosci

Rahman S, Mathew S, Nair P, Ramadan WS and Vazhappilly CG. Health benefits of cyanidin-3-glucoside as a potent modulator of Nrf2-mediated oxidative stress. (2021) Inflammopharmacology. Pubmed Inflammopharmacology

Qian ZJ, Chen MF, Chen J, Zhang Y, Zhou C, Hong P and Yang P. Intracellular ethanol-mediated oxidation and apoptosis in HepG2/CYP2E1 cells impaired by two active peptides from seahorse ( bleeler) protein hydrolysates via the Nrf2/HO-1 and akt pathways. (2021) Food Sci Nutr. 9, 1584-1602 Pubmed Food Sci Nutr PMC Article

Ahmadian S, Sabzichi M, Rashidi M, Mohammadian J, Mahmoudi S, Maroufi NF, Ramezani F, Ghorbani M, Mohammadi M, Pirouzpanah M and Bijanpour H. Sensitization of A-549 lung cancer cells to Cisplatin by Quinacrine-loaded lipidic nanoparticles via suppressing Nrf2 mediated defense mechanism. (2021) Naunyn Schmiedebergs Arch Pharmacol. Pubmed Naunyn Schmiedebergs Arch Pharmacol

Endo S, Kawai M, Hoshi M, Segawa J, Fujita M, Matsukawa T, Fujimoto N, Matsunaga T and Ikari A. Targeting Nrf2-antioxidant signaling reverses acquired cabazitaxel resistance in prostate cancer cells. (2021) J Biochem. Pubmed J Biochem

Alshammari GM, Al-Qahtani WH, AlFaris NA, Alzahrani NS, Alkhateeb MA and Yahya MA. Quercetin prevents cadmium chloride-induced hepatic steatosis and fibrosis by downregulating the transcription of miR-21. (2021) Biofactors. Pubmed Biofactors

Choi BH, Kim JM and Kwak MK. The multifaceted role of NRF2 in cancer progression and cancer stem cells maintenance. (2021) Arch Pharm Res. 44, 263-280 Pubmed Arch Pharm Res

Walters TS, McIntosh DJ, Ingram SM, Tillery L, Motley ED, Arinze IJ and Misra S. SUMO-Modification of Human Nrf2 at K and K Regulates Its Nucleocytoplasmic Localization, Stability and Transcriptional Activity. (2021) Cell Physiol Biochem. 55, 141-159 Pubmed Cell Physiol Biochem

Yuvaraj S, Ramprasath T, Saravanan B, Vasudevan V, Sasikumar S and Selvam GS. Chrysin attenuates high-fat-diet-induced myocardial oxidative stress via upregulating eNOS and Nrf2 target genes in rats. (2021) Mol Cell Biochem. Pubmed Mol Cell Biochem

Reis R, Orak D, Yilmaz D, Cimen H and Sipahi H. Modulation of cigarette smoke extract-induced human bronchial epithelial damage by eucalyptol and curcumin. (2021) Hum Exp Toxicol. 960327121997986 Pubmed Hum Exp Toxicol

Papalexi E, Mimitou EP, Butler AW, Foster S, Bracken B, Mauck WM, Wessels HH, Hao Y, Yeung BZ, Smibert P and Satija R. Characterizing the molecular regulation of inhibitory immune checkpoints with multimodal single-cell screens. (2021) Nat Genet. 53, 322-331 Pubmed Nat Genet PMC Article

Xie C, Ma H, Shi Y, Li J, Wu H, Wang B, Shao Z, Huang C, Chen J, Sun L, Zhou Y, Tian N, Wu Y, Gao W, Wu A, Wang X and Zhang X. Cardamonin protects nucleus pulposus cells against IL-1β-induced inflammation and catabolism via Nrf2/NF-κB axis. (2021) Food Funct. 12, 2703-2714 Pubmed Food Funct

Su H, Yang F, Fu R, Li X, French R, Mose E, Pu X, Trinh B, Kumar A, Liu J, Antonucci L, Todoric J, Liu Y, Hu Y, Diaz-Meco MT, Moscat J, Metallo CM, Lowy AM, Sun B and Karin M. Cancer cells escape autophagy inhibition via NRF2-induced macropinocytosis. (2021) Cancer Cell. Pubmed Cancer Cell

Weng Q, Sun H, Fang C, Xia F, Liao H, Lee J, Wang J, Xie A, Ren J, Guo X, Li F, Yang B and Ling D. Catalytic activity tunable ceria nanoparticles prevent chemotherapy-induced acute kidney injury without interference with chemotherapeutics. (2021) Nat Commun. 12, 1436 Pubmed Nat Commun PMC Article

Xie K, Chen L and Yang J. RNA Sequencing Evidences the Prevention of Oxidative Stress is Effective in Injury-Induced Heterotopic Ossification Treatment. (2021) J Biomed Nanotechnol. 17, 196-204 Pubmed J Biomed Nanotechnol

Shchulkin AV, Abalenikhina YV, Erokhina PD, Chernykh IV and Yakusheva EN. The Role of P-Glycoprotein in Decreasing Cell Membranes Permeability during Oxidative Stress. (2021) Biochemistry (Mosc). 86, 197-206 Pubmed Biochemistry (Mosc)

Li Z, Wang Y, Zhang Y, Wang X, Gao B, Li Y, Li R and Wang J. Protective Effects of Fisetin on Hepatic Ischemia-reperfusion Injury Through Alleviation of Apoptosis and Oxidative Stress. (2021) Arch Med Res. 52, 163-173 Pubmed Arch Med Res

Ha YJ, Choi YS, Oh YR, Kang EH, Khang G, Park YB and Lee YJ. Fucoxanthin Suppresses Osteoclastogenesis via Modulation of MAP Kinase and Nrf2 Signaling. (2021) Mar Drugs. 19, Pubmed Mar Drugs PMC Article

Ibrahim S, Chaigne J, Dakik H, Fourbon Y, Corset L, Lecomte T, Raoul W and Guéguinou M. SK4 oncochannels regulate calcium entry and promote cell migration in KRAS-mutated colorectal cancer. (2021) Cell Calcium. 96, 102384 Pubmed Cell Calcium

Szopa A, Bogatko K, Herbet M, Serefko A, Ostrowska M, Wośko S, Świąder K, Szewczyk B, Wlaź A, Skałecki P, Wróbel A, Mandziuk S, Pochodyła A, Kudela A, Dudka J, Radziwoń-Zaleska M, Wlaź P and Poleszak E. The Interaction of Selective A1 and A2A Adenosine Receptor Antagonists with Magnesium and Zinc Ions in Mice: Behavioural, Biochemical and Molecular Studies. (2021) Int J Mol Sci. 22, Pubmed Int J Mol Sci PMC Article

Kim SH, Kim M, Kwon D, Pyo JS, Kim JH, Kwak JH and Jung YS. -Phenyl Cinnamamide Derivatives Protect Hepatocytes against Oxidative Stress by Inducing Cellular Glutathione Synthesis via Nuclear Factor (Erythroid-Derived 2)-Like 2 Activation. (2021) Molecules. 26, Pubmed Molecules PMC Article

Hamada S, Matsumoto R, Tanaka Y, Taguchi K, Yamamoto M and Masamune A. Nrf2 Activation Sensitizes K-Ras Mutant Pancreatic Cancer Cells to Glutaminase Inhibition. (2021) Int J Mol Sci. 22, Pubmed Int J Mol Sci PMC Article

Joshi L, Plastira I, Bernhart E, Reicher H, Koyani CN, Madl T, Madreiter-Sokolowski C, Koshenov Z, Graier WF, Hallström S and Sattler W. Lysophosphatidic Acid Induces Aerobic Glycolysis, Lipogenesis, and Increased Amino Acid Uptake in BV-2 Microglia. (2021) Int J Mol Sci. 22, Pubmed Int J Mol Sci PMC Article

Hossain KFB, Akter M, Rahman MM, Sikder MT, Rahaman MS, Yamasaki S, Kimura G, Tomihara T, Kurasaki M and Saito T. Amelioration of Metal-Induced Cellular Stress by α-Lipoic Acid and Dihydrolipoic Acid through Antioxidative Effects in PC12 Cells and Caco-2 Cells. (2021) Int J Environ Res Public Health. 18, Pubmed Int J Environ Res Public Health PMC Article

Kang JI, Kim DH, Sung KW, Shim SM, Cha-Molstad H, Soung NK, Lee KH, Hwang J, Lee HG, Kwon YT and Kim BY. p62-Induced Cancer-Associated Fibroblast Activation via the Nrf2-ATF6 Pathway Promotes Lung Tumorigenesis. (2021) Cancers (Basel). 13, Pubmed Cancers (Basel) PMC Article

Vairetti M, Di Pasqua LG, Cagna M, Richelmi P, Ferrigno A and Berardo C. Changes in Glutathione Content in Liver Diseases: An Update. (2021) Antioxidants (Basel). 10, Pubmed Antioxidants (Basel) PMC Article

Garufi A, Giorno E, Gilardini Montani MS, Pistritto G, Crispini A, Cirone M and D'Orazi G. P62/SQSTM1/Keap1/NRF2 Axis Reduces Cancer Cells Death-Sensitivity in Response to Zn(II)-Curcumin Complex. (2021) Biomolecules. 11, Pubmed Biomolecules PMC Article

Mirzaei S, Zarrabi A, Hashemi F, Zabolian A, Saleki H, Azami N, Hamzehlou S, Farahani MV, Hushmandi K, Ashrafizadeh M, Khan H and Kumar AP. Nrf2 Signaling Pathway in Chemoprotection and Doxorubicin Resistance: Potential Application in Drug Discovery. (2021) Antioxidants (Basel). 10, Pubmed Antioxidants (Basel) PMC Article

Zhang M, Zhang X, Chu X, Cheng L and Cai C. Long non-coding RNA MALAT1 plays a protective role in bronchopulmonary dysplasia via the inhibition of apoptosis and interaction with the Keap1/Nrf2 signal pathway. (2021) Transl Pediatr. 10, 265-275 Pubmed Transl Pediatr PMC Article

Wang Z, Zheng N, Liang J, Wang Q, Zu X, Wang H, Yuan H, Zhang R, Guo S, Liu Y and Zhou J. Emodin resists to Cyprinid herpesvirus 3 replication via the pathways of Nrf2/Keap1-ARE and NF-κB in the ornamental koi carp (Cyprinus carpio haematopterus). (2021) Comp Biochem Physiol C Toxicol Pharmacol. 246, 109023 Pubmed Comp Biochem Physiol C Toxicol Pharmacol

Zhang Y, Solinas A, Cairo S, Evert M, Chen X and Calvisi DF. Molecular Mechanisms of Hepatoblastoma. (2021) Semin Liver Dis. 41, 28-41 Pubmed Semin Liver Dis

Altamimi JZ, Alfaris NA, Alshammari GM, Alagal RI, Aljabryn DH, Aldera H, Alkhateeb MA and Yahya MA. Ellagic acid protects against diabetic cardiomyopathy in rats by stimulating cardiac silent information regulator 1 signaling. (2020) J Physiol Pharmacol. 71, Pubmed J Physiol Pharmacol

Abd-Ella EM, El-Kott AF, El-Kenawy AE, Khalifa HS, Bin-Meferij MM and Alramlawy AM. Dehydroepiandrosterone protects against acetaminophen-induced liver damage in rats by upregulation of Bcl-2 and activation of sirt signalling. (2020) J Physiol Pharmacol. 71, Pubmed J Physiol Pharmacol

Mei X, Feng H and Shao B. Alleviation of sepsis-associated encephalopathy by ginsenoside via inhibition of oxidative stress and cell apoptosis: An experimental study. (2020) Pak J Pharm Sci. 33, 2567-2577 Pubmed Pak J Pharm Sci

Yang CC and Yang CM. Chinese Herbs and Repurposing Old Drugs as Therapeutic Agents in the Regulation of Oxidative Stress and Inflammation in Pulmonary Diseases. (2021) J Inflamm Res. 14, 657-687 Pubmed J Inflamm Res PMC Article

Han M, Yu H, Yang K, Liu P, Yan H, Yang Z and Yang H. A Network Pharmacology-Based Approach to Investigating the Mechanisms of Fushen Granule Effects on Intestinal Barrier Injury in Chronic Renal Failure. (2021) Evid Based Complement Alternat Med. 2021, 2097569 Pubmed Evid Based Complement Alternat Med PMC Article

Mihailovic S, Coric V, Radic T, Radojevic AS, Matic M, Dragicevic D, Djokic M, Vasic V, Dzamic Z, Simic T, Hadzi-Djokic J and Pljesa Ercegovac M. The Association of Polymorphisms in and Genes Involved in Redox Homeostasis in the Development and Progression of Clear Cell Renal Cell Carcinoma. (2021) Oxid Med Cell Longev. 2021, 6617969 Pubmed Oxid Med Cell Longev PMC Article

Zhan X, Li J and Zhou T. Targeting Nrf2-Mediated Oxidative Stress Response Signaling Pathways as New Therapeutic Strategy for Pituitary Adenomas. (2021) Front Pharmacol. 12, 565748 Pubmed Front Pharmacol PMC Article

Cao L, Xu C, Yi P, Li H, Lin Y, Cai G, Wang S, Ou D, Li M and Chen J. Asparaginyl endopeptidase (AEP) regulates myocardial apoptosis in response to radiation exposure via alterations in NRF2 activation. (2021) Am J Cancer Res. 11, 1206-1225 Pubmed Am J Cancer Res PMC Article

Jiang Y, Zhou W, Zhang X, Wang Y, Yang D and Li S. Protective Effect of Blood Cora Polysaccharides on H9c2 Rat Heart Cells Injury Induced by Oxidative Stress by Activating Nrf2/HO-1 Signal Pathway. (2021) Front Nutr. 8, 632161 Pubmed Front Nutr PMC Article

Yang B, Hu M, Fu Y, Sun D, Zheng W, Liao H, Zhang Z and Chen X. LASS2 mediates Nrf2-driven progestin resistance in endometrial cancer. (2021) Am J Transl Res. 13, 1280-1289 Pubmed Am J Transl Res PMC Article

He D, Fu S, Zhou A, Su Y, Gao X, Zhang Y, Huang B, Du J and Liu D. Camptothecin Regulates Microglia Polarization and Exerts Neuroprotective Effects Activating AKT/Nrf2/HO-1 and Inhibiting NF-κB Pathways and . (2021) Front Immunol. 12, 619761 Pubmed Front Immunol PMC Article

Gao F, Wu X, Mao X, Niu F, Zhang B, Dong J and Liu B. Astaxanthin provides neuroprotection in an experimental model of traumatic brain injury via the Nrf2/HO-1 pathway. (2021) Am J Transl Res. 13, 1483-1493 Pubmed Am J Transl Res PMC Article

Calgarotto AK, Longhini AL, Pericole de Souza FV, Duarte ASS, Ferro KP, Santos I, Maso V, Olalla Saad ST and Torello CO. Immunomodulatory Effect of Green Tea Treatment in Combination with Low-dose Chemotherapy in Elderly Acute Myeloid Leukemia Patients with Myelodysplasia-related Changes. Integr Cancer Ther. 20, 15347354211002647 Pubmed Integr Cancer Ther PMC Article

Lin Z, Bao Y, Hong B, Wang Y, Zhang X and Wu Y. Salvianolic acid B attenuated cisplatin-induced cardiac injury and oxidative stress via modulating Nrf2 signal pathway. (2021) J Toxicol Sci. 46, 199-207 Pubmed J Toxicol Sci

Chen K, Wu S, Ye S, Huang H, Zhou Y, Zhou H, Wu S, Mao Y, Shangguan F, Lan L and Chen B. Dimethyl Fumarate Induces Metabolic Crisie to Suppress Pancreatic Carcinoma. (2021) Front Pharmacol. 12, 617714 Pubmed Front Pharmacol PMC Article

Huang Y, Yang Y, Xu Y, Ma Q, Guo F, Zhao Y, Tao Y, Li M and Guo J. Nrf2/HO-1 Axis Regulates the Angiogenesis of Gastric Cancer via Targeting VEGF. (2021) Cancer Manag Res. 13, 3155-3169 Pubmed Cancer Manag Res PMC Article

Zhao Y, Xiao W, Peng W, Huang Q, Wu K, Evans CE, Liu X and Jin H. Oridonin-Loaded Nanoparticles Inhibit Breast Cancer Progression Through Regulation of ROS-Related Nrf2 Signaling Pathway. (2021) Front Bioeng Biotechnol. 9, 600579 Pubmed Front Bioeng Biotechnol PMC Article

Tang YC, Hsiao JR, Jiang SS, Chang JY, Chu PY, Liu KJ, Fang HL, Lin LM, Chen HH, Huang YW, Chen YT, Tsai FY, Lin SF, Chuang YJ and Kuo CC. c-MYC-directed NRF2 drives malignant progression of head and neck cancer via glucose-6-phosphate dehydrogenase and transketolase activation. (2021) Theranostics. 11, 5232-5247 Pubmed Theranostics PMC Article

Raish M, Shahid M, Bin Jardan YA, Ansari MA, Alkharfy KM, Ahad A, Abdelrahman IA, Ahmad A and Al-Jenoobi FI. Gastroprotective Effect of Sinapic Acid on Ethanol-Induced Gastric Ulcers in Rats: Involvement of Nrf2/HO-1 and NF-κB Signaling and Antiapoptotic Role. (2021) Front Pharmacol. 12, 622815 Pubmed Front Pharmacol PMC Article

Liu JJ, Zhao GX, He LL, Wang Z, Zibrila AI, Niu BC, Gong HY, Xu JN, Soong L, Li CF and Lu Y. polysaccharides inhibit ischemia/reperfusion-induced myocardial injury via the Nrf2 antioxidant pathway. (2021) Toxicol Rep. 8, 657-667 Pubmed Toxicol Rep PMC Article

Shi Z, Zhang L, Zheng J, Sun H and Shao C. Ferroptosis: Biochemistry and Biology in Cancers. (2021) Front Oncol. 11, 579286 Pubmed Front Oncol PMC Article

Wang M, Wu X, Yu L, Hu ZY, Li X, Meng X, Lv CT, Kim GY, Choi YH, Wang Z, Xu HW and Jin CY. LCT-3d Induces Oxidative Stress-Mediated Apoptosis by Upregulating Death Receptor 5 in Gastric Cancer Cells. (2021) Front Oncol. 11, 658608 Pubmed Front Oncol PMC Article

Taha-Mehlitz S, Bianco G, Coto-Llerena M, Kancherla V, Bantug GR, Gallon J, Ercan C, Panebianco F, Eppenberger-Castori S, von Strauss M, Staubli S, Bolli M, Peterli R, Matter MS, Terracciano LM, von Flüe M, Ng CKY, Soysal SD, Kollmar O and Piscuoglio S. Adenylosuccinate lyase is oncogenic in colorectal cancer by causing mitochondrial dysfunction and independent activation of NRF2 and mTOR-MYC-axis. (2021) Theranostics. 11, 4011-4029 Pubmed Theranostics PMC Article

Zou L, Cheng G, Xu C, Liu H, Wang Y, Li N, Fan X, Zhu C and Xia W. Copper Nanoparticles Induce Oxidative Stress via the Heme Oxygenase 1 Signaling Pathway in vitro Studies. (2021) Int J Nanomedicine. 16, 1565-1573 Pubmed Int J Nanomedicine PMC Article

Zhang Y, Chen J, Che Z, Shu C, Chen D, Ding K, Li A and Zhou J. JP3 enhances the toxicity of cisplatin on drug-resistant gastric cancer cells while reducing the damage to normal cells. (2021) J Cancer. 12, 1894-1906 Pubmed J Cancer PMC Article

Batinic-Haberle I, Tovmasyan A, Huang Z, Duan W, Du L, Siamakpour-Reihani S, Cao Z, Sheng H, Spasojevic I and Alvarez Secord A. HO-Driven Anticancer Activity of Mn Porphyrins and the Underlying Molecular Pathways. (2021) Oxid Med Cell Longev. 2021, 6653790 Pubmed Oxid Med Cell Longev PMC Article

Chen D, Gao ZQ, Wang YY, Wan BB, Liu G, Chen JL, Wu YX, Zhou Q, Jiang SY, Yu RQ and Pang QF. Sodium Propionate Enhances Nrf2-Mediated Protective Defense Against Oxidative Stress and Inflammation in Lipopolysaccharide-Induced Neonatal Mice. (2021) J Inflamm Res. 14, 803-816 Pubmed J Inflamm Res PMC Article

Tsai TH, Lieu AS, Wang YW, Yang SF, Hsu YC and Lin CL. Therapeutic Potential of RTA 404 in Human Brain Malignant Glioma Cell Lines via Cell Cycle Arrest via p21/AKT Signaling. (2021) Biomed Res Int. 2021, 5552226 Pubmed Biomed Res Int PMC Article

Naeem K, Tariq Al Kury L, Nasar F, Alattar A, Alshaman R, Shah FA, Khan AU and Li S. Natural Dietary Supplement, Carvacrol, Alleviates LPS-Induced Oxidative Stress, Neurodegeneration, and Depressive-Like Behaviors via the Nrf2/HO-1 Pathway. (2021) J Inflamm Res. 14, 1313-1329 Pubmed J Inflamm Res PMC Article

Kim D, Cheon J, Yoon H and Jun HS. Cudrania tricuspidata Root Extract Prevents Methylglyoxal-Induced Inflammation and Oxidative Stress via Regulation of the PKC-NOX4 Pathway in Human Kidney Cells. (2021) Oxid Med Cell Longev. 2021, 5511881 Pubmed Oxid Med Cell Longev PMC Article

Ladak Z, Garcia E, Yoon J, Landry T, Armstrong EA, Yager JY and Persad S. Sulforaphane (SFA) protects neuronal cells from oxygen & glucose deprivation (OGD). (2021) PLoS One. 16, e0248777 Pubmed PLoS One PMC Article

Fathi R, Akbari A, Nasiri K and Chardahcherik M. Ginger ( roscoe) extract could upregulate the renal expression of and and prevents ethanol-induced toxicity in rat kidney. Avicenna J Phytomed. 11, 134-145 Pubmed Avicenna J Phytomed PMC Article

Hushpulian DM, Ammal Kaidery N, Ahuja M, Poloznikov AA, Sharma SM, Gazaryan IG and Thomas B. Challenges and Limitations of Targeting the Keap1-Nrf2 Pathway for Neurotherapeutics: Bach1 De-Repression to the Rescue. (2021) Front Aging Neurosci. 13, 673205 Pubmed Front Aging Neurosci PMC Article

Tang C, Hong J, Hu C, Huang C, Gao J, Huang J, Wang D, Geng Q and Dong Y. Palmatine Protects against Cerebral Ischemia/Reperfusion Injury by Activation of the AMPK/Nrf2 Pathway. (2021) Oxid Med Cell Longev. 2021, 6660193 Pubmed Oxid Med Cell Longev PMC Article

Wu Y, Hu J, Long X, Pan Y, Mu J, Park KY and Zhao X. ZS62 Alleviates Alcohol-Induced Gastric Injury in Mice via an Anti-Oxidative Mechanism. (2021) Drug Des Devel Ther. 15, 1667-1676 Pubmed Drug Des Devel Ther PMC Article