Which NRF2 Products Have Peer Reviewed Studies

English: Graph of Nrf2 publications (pubmed search) by year (Photo credit: Wikipedia)

There are currently over 2300 articles (peer reviewed clinical reviews and studies) on Pubmed.gov on the topic of NRF2 Activation. There are a ton of companies claiming they have scientific studies showing that their products are NRF2 Activators. Go to Pubmed.gov and type in the name of their product. Pubmed is a website operated by the National Institute of Health (NIH). PubMed comprises over 21 million citations for biomedical literature from MEDLINE, life science journals, and online books. PubMed citations and abstracts include the fields of biomedicine and health, covering portions of the life sciences, behavioral sciences, chemical sciences, and bioengineering. PubMed also provides access to additional relevant web sites and links to the other NCBI molecular biology resources. Last 200 NRF-2 Studies published on Pubmed

Kim SJ, Saeidi S, Cho NC, Kim SH, Lee HB, Han W, Noh DY and Surh YJ. Interaction of Nrf2 with dimeric STAT3 induces IL-23 expression: Implications for breast cancer progression. (2021) Cancer Lett. 500, 147-160 Pubmed Cancer Lett

Yao X, Sun K, Yu S, Luo J, Guo J, Lin J, Wang G, Guo Z, Ye Y and Guo F. Chondrocyte ferroptosis contribute to the progression of osteoarthritis. (2021) J Orthop Translat. 27, 33-43 Pubmed J Orthop Translat PMC Article

Jiang M, Jin J, Ye X, Wang J, Shen H, Zhen J and Zhou Y. Construction of Lycetin Nanocarriers and Its Effect on the Proliferation and Apoptosis of Hepatocellular Carcinoma Cells by Regulating Nuclear Factor E2 Related Factor/Antioxidant Response Element Pathway. (2021) J Nanosci Nanotechnol. 21, 1054-1060 Pubmed J Nanosci Nanotechnol

Wang X, Saud SM, Zhang X, Li W and Hua B. Corrigendum to: "Protective effect of Shaoyao decoction against colorectal cancer via the Keap1-Nrf2-ARE signaling pathway", [J. Ethnopharmacol. 241 (2019) 111981]. (2021) J Ethnopharmacol. 266, 113532 Pubmed J Ethnopharmacol

Al Mamun A, Wu Y, Monalisa I, Jia C, Zhou K, Munir F and Xiao J. Role of pyroptosis in spinal cord injury and its therapeutic implications. (2021) J Adv Res. 28, 97-109 Pubmed J Adv Res PMC Article

Fouzder C, Mukhuty A, Mukherjee S, Malick C and Kundu R. Trigonelline inhibits Nrf2 via EGFR signalling pathway and augments efficacy of Cisplatin and Etoposide in NSCLC cells. (2021) Toxicol In Vitro. 70, 105038 Pubmed Toxicol In Vitro

Li J, Yang C and Wang Y. miR‑126 overexpression attenuates oxygen‑glucose deprivation/reperfusion injury by inhibiting oxidative stress and inflammatory response via the activation of SIRT1/Nrf2 signaling pathway in human umbilical vein endothelial cells. (2021) Mol Med Rep. 23, Pubmed Mol Med Rep PMC Article

Ashrafizadeh M, Zarrabi A, Orouei S, Kiavash Hushmandi , Hakimi A, Amirhossein Zabolian , Daneshi S, Samarghandian S, Baradaran B and Najafi M. MicroRNA-mediated autophagy regulation in cancer therapy: The role in chemoresistance/chemosensitivity. (2021) Eur J Pharmacol. 892, 173660 Pubmed Eur J Pharmacol

Li Z, Bi H, Jiang H, Song J, Meng Q, Zhang Y and Fei X. Neuroprotective effect of emodin against Alzheimer's disease via Nrf2 signaling in U251 cells and APP/PS1 mice. (2021) Mol Med Rep. 23, Pubmed Mol Med Rep PMC Article

Orozco-Morales M, Hernández-Pedro NY, Barrios-Bernal P, Arrieta O, Ruiz-Godoy LM, Aschner M, Santamaría A and Colín-González AL. S-allylcysteine induces cytotoxic effects in two human lung cancer cell lines via induction of oxidative damage, downregulation of Nrf2 and NF-κB, and apoptosis. (2021) Anticancer Drugs. 32, 117-126 Pubmed Anticancer Drugs

Kong Q, Deng H, Li C, Wang X, Shimoda Y, Tao S, Kato K, Zhang J, Yamanaka K and An Y. Sustained high expression of NRF2 and its target genes induces dysregulation of cellular proliferation and apoptosis is associated with arsenite-induced malignant transformation of human bronchial epithelial cells. (2021) Sci Total Environ. 756, 143840 Pubmed Sci Total Environ

de Souza ICC, Gobbo RCB, de Almeida FJS, Luckachaki MD and de Oliveira MR. Carnosic acid depends on glutathione to promote mitochondrial protection in methylglyoxal-exposed SH-SY5Y cells. (2021) Metab Brain Dis. Pubmed Metab Brain Dis

Khan A, Khan A, Khalid S, Shal B, Kang E, Lee H, Laumet G, Seo EK and Khan S. 7β-(3-Ethyl--crotonoyloxy)-1α-(2-methylbutyryloxy)-3,14-dehydro- Notonipetranone Attenuates Neuropathic Pain by Suppressing Oxidative Stress, Inflammatory and Pro-Apoptotic Protein Expressions. (2021) Molecules. 26, Pubmed Molecules PMC Article

Zhuang S, Liu B, Guo S, Xue Y, Wu L, Liu S, Zhang C and Ni X. Germacrone alleviates neurological deficits following traumatic brain injury by modulating neuroinflammation and oxidative stress. (2021) BMC Complement Med Ther. 21, 6 Pubmed BMC Complement Med Ther PMC Article

Panigrahi DP, Bhol CS, Nivetha R, Nagini S, Patil S, Maiti TK and Bhutia SK. Corrigendum to "Abrus agglutinin inhibits oral carcinogenesis through inactivation of NRF2 signaling pathway" [Int J Biol Macromol. 2020; 155:1123-1132.]. (2021) Int J Biol Macromol. Pubmed Int J Biol Macromol

Wang X, Hu LP, Qin WT, Yang Q, Chen DY, Li Q, Zhou KX, Huang PQ, Xu CJ, Li J, Yao LL, Wang YH, Tian GA, Yang JY, Yang MW, Liu DJ, Sun YW, Jiang SH, Zhang XL and Zhang ZG. Identification of a subset of immunosuppressive P2RX1-negative neutrophils in pancreatic cancer liver metastasis. (2021) Nat Commun. 12, 174 Pubmed Nat Commun

Zhang MH, Li J, Zhu XY, Zhang YQ, Ye ST, Leng YR, Yang T, Zhang H and Kong LY. Physalin B ameliorates nonalcoholic steatohepatitis by stimulating autophagy and NRF2 activation mediated improvement in oxidative stress. (2021) Free Radic Biol Med. 164, 1-12 Pubmed Free Radic Biol Med

Wan Z, Li H, Wu X, Zhao H, Wang R, Li M, Liu J, Liu Q, Wang R and Li X. Hepatoprotective effect of gentiopicroside in combination with leflunomide and/or methotrexate in arthritic rats. (2021) Life Sci. 265, 118689 Pubmed Life Sci

Tan CT, Chang HC, Zhou Q, Yu C, Fu NY, Sabapathy K and Yu VC. MOAP-1-mediated dissociation of p62/SQSTM1 bodies releases Keap1 and suppresses Nrf2 signaling. (2021) EMBO Rep. e50854 Pubmed EMBO Rep PMC Article

Cui G, Wei F, Wei M, Xie L, Lin Z and Feng X. Modulatory effect of Tagetes erecta flowers essential oils via Nrf2/HO-1/NF-κB/p65 axis mediated suppression of N-methyl-N'nitro-N-nitroguanidine (MNNG) induced gastric cancer in rats. (2021) Mol Cell Biochem. Pubmed Mol Cell Biochem

Liu P, Ma D, Wang P, Pan C, Fang Q and Wang J. Nrf2 overexpression increases risk of high tumor mutation burden in acute myeloid leukemia by inhibiting MSH2. (2021) Cell Death Dis. 12, 20 Pubmed Cell Death Dis PMC Article

Lou JS, Zhao LP, Huang ZH, Chen XY, Xu JT, Tai WC, Tsim KWK, Chen YT and Xie T. Ginkgetin derived from Ginkgo biloba leaves enhances the therapeutic effect of cisplatin via ferroptosis-mediated disruption of the Nrf2/HO-1 axis in EGFR wild-type non-small-cell lung cancer. (2021) Phytomedicine. 80, 153370 Pubmed Phytomedicine

Saeedi-Boroujeni A, Mahmoudian-Sani MR, Bahadoram M and Alghasi A. COVID-19: A Case for Inhibiting NLRP3 Inflammasome, Suppression of Inflammation with Curcumin?. (2021) Basic Clin Pharmacol Toxicol. 128, 37-45 Pubmed Basic Clin Pharmacol Toxicol

Kamble D, Mahajan M, Dhat R and Sitasawad S. Keap1-Nrf2 Pathway Regulates ALDH and Contributes to Radioresistance in Breast Cancer Stem Cells. (2021) Cells. 10, Pubmed Cells

Morimyama H, Daino K, Ishikawa A, Imaoka T, Nishimura M, Nishimura Y, Takabatake M, Morioka T, Inoue K, Fukushi M, Shimada Y and Kakinuma S. Exome of Radiation-induced Rat Mammary Carcinoma Shows Copy-number Losses and Mutations in Human-relevant Cancer Genes. (2021) Anticancer Res. 41, 55-70 Pubmed Anticancer Res

Tang Z, Lai CC, Luo J, Ding YT, Chen Q and Guan ZZ. Mangiferin prevents the impairment of mitochondrial dynamics and an increase in oxidative stress caused by excessive fluoride in SH-SY5Y cells. (2021) J Biochem Mol Toxicol. e22705 Pubmed J Biochem Mol Toxicol

Xu Q, Fan Y, Loor JJ, Liang Y, Lv H, Sun X, Jia H and Xu C. Aloin protects mice from diet-induced non-alcoholic steatohepatitis activation of Nrf2/HO-1 signaling. (2021) Food Funct. Pubmed Food Funct

Brasil FB, Gobbo RCB, de Almeida FJS, Luckachaki MD, Dos Santos Petry F and de Oliveira MR. The Isothiocyanate Sulforaphane Depends on the Nrf2/γ-GCL/GSH Axis to Prevent Mitochondrial Dysfunction in Cells Exposed to Methylglyoxal. (2021) Neurochem Res. Pubmed Neurochem Res

Mota M, Metge BJ, Hinshaw DC, Alsheikh HA, Chen D, Samant RS and Shevde LA. Merlin deficiency alters the redox management program in breast cancer. (2021) Mol Oncol. Pubmed Mol Oncol

Li N, Wang J, Zang X, Wang Z, Zhang T, Zhao B, Miao J and Lin Z. HS probe CPC inhibits autophagy and promotes apoptosis by inhibiting glutathionylation of Keap1 at Cys434. (2021) Apoptosis. Pubmed Apoptosis

Yang L, Yuan Z, Zhang Y, Cui Z, Li Y, Hou J, Liu X, Liu Z, Shi R, Tian Q, Wang J and Wang L. MiniPDX-guided postoperative anticancer treatment can effectively prolong the survival of patients with hepatocellular carcinoma. (2021) Cancer Chemother Pharmacol. 87, 125-134 Pubmed Cancer Chemother Pharmacol

Li S, Wang X, Xiao Y, Wang Y, Wan Y, Li X, Li Q, Tang X, Cai D, Ran B and Wu C. Curcumin ameliorates mercuric chloride-induced liver injury via modulating cytochrome P450 signaling and Nrf2/HO-1 pathway. (2021) Ecotoxicol Environ Saf. 208, 111426 Pubmed Ecotoxicol Environ Saf

Musso N, Caruso G, Bongiorno D, Grasso M, Bivona DA, Campanile F, Caraci F and Stefani S. Different Modulatory Effects of Four Methicillin-Resistant Clones on MG-63 Osteoblast-Like Cells. (2021) Biomolecules. 11, Pubmed Biomolecules

Zhang T, Shi L, Li Y, Mu W, Zhang H, Li Y, Wang X, Zhao W, Qi Y and Liu L. Polysaccharides extracted from Rheum tanguticum ameliorate radiation-induced enteritis via activation of Nrf2/HO-1. (2021) J Radiat Res. 62, 46-57 Pubmed J Radiat Res PMC Article

Ko E, Kim D, Min DW, Kwon SH and Lee JY. Nrf2 regulates cell motility through RhoA-ROCK1 signalling in non-small-cell lung cancer cells. (2021) Sci Rep. 11, 1247 Pubmed Sci Rep

Panieri E and Saso L. INHIBITION OF THE NRF2/KEAP1 AXIS: A PROMISING THERAPEUTIC STRATEGY TO ALTER REDOX BALANCE OF CANCER CELLS. (2021) Antioxid Redox Signal. Pubmed Antioxid Redox Signal

Küper A, Baumann J, Göpelt K, Baumann M, Sänger C, Metzen E, Kranz P and Brockmeier U. Overcoming hypoxia-induced resistance of pancreatic and lung tumor cells by disrupting the PERK-NRF2-HIF-axis. (2021) Cell Death Dis. 12, 82 Pubmed Cell Death Dis

Chen KY, Huang YH, Teo WH, Chang CW, Chen YS, Yeh YC, Lee CJ and Lo JF. Loss of Tid1/DNAJA3 Co-Chaperone Promotes Progression and Recurrence of Hepatocellular Carcinoma after Surgical Resection: A Novel Model to Stratify Risk of Recurrence. (2021) Cancers (Basel). 13, Pubmed Cancers (Basel) PMC Article

Martinez R, Huang W, Samadani R, Mackowiak B, Centola G, Chen L, Conlon IL, Hom K, Kane MA, Fletcher S and Shapiro P. Mechanistic Analysis of an Extracellular Signal-Regulated Kinase 2-Interacting Compound that Inhibits Mutant BRAF-Expressing Melanoma Cells by Inducing Oxidative Stress. (2021) J Pharmacol Exp Ther. 376, 84-97 Pubmed J Pharmacol Exp Ther

Pathria G and Ronai ZA. Harnessing the Co-vulnerabilities of Amino Acid-Restricted Cancers. (2021) Cell Metab. 33, 9-20 Pubmed Cell Metab

Kang YP, Mockabee-Macias A, Jiang C, Falzone A, Prieto-Farigua N, Stone E, Harris IS and DeNicola GM. Non-canonical Glutamate-Cysteine Ligase Activity Protects against Ferroptosis. (2021) Cell Metab. 33, 174-189.e7 Pubmed Cell Metab

Fouzder C, Mukhuty A and Kundu R. Kaempferol inhibits Nrf2 signalling pathway via downregulation of Nrf2 mRNA and induces apoptosis in NSCLC cells. (2021) Arch Biochem Biophys. 697, 108700 Pubmed Arch Biochem Biophys

Ali A, Shah SA, Zaman N, Uddin MN, Khan W, Ali A, Riaz M and Kamil A. Vitamin D exerts neuroprotection via SIRT1/nrf-2/ NF-kB signaling pathways against D-galactose-induced memory impairment in adult mice. (2021) Neurochem Int. 142, 104893 Pubmed Neurochem Int

Sun HJ, Wu ZY, Nie XW, Wang XY and Bian JS. Implications of hydrogen sulfide in liver pathophysiology: Mechanistic insights and therapeutic potential. (2021) J Adv Res. 27, 127-135 Pubmed J Adv Res PMC Article

Nemmar A, Al-Salam S, Nuaman SA, Kazim M, Mohamed F, Beegam S, Yuvaraju P, Yasin J and Ali BH. Exacerbation of Coagulation and Cardiac Injury in Rats with Cisplatin-Induced Nephrotoxicity Following Intratracheal Instillation of Cerium Oxide Nanoparticles. (2021) Cell Physiol Biochem. 55, 1-16 Pubmed Cell Physiol Biochem

Abdelzaher WY, Ahmed SM, Welson NN, Marraiki N, Batiha GE and Kamel MY. Vinpocetine ameliorates L-arginine induced acute pancreatitis via Sirt1/Nrf2/TNF pathway and inhibition of oxidative stress, inflammation, and apoptosis. (2021) Biomed Pharmacother. 133, 110976 Pubmed Biomed Pharmacother

Maldonado R, Talana CA, Song C, Dixon A, Uehara K and Weichhaus M. β-hydroxybutyrate does not alter the effects of glucose deprivation on breast cancer cells. (2021) Oncol Lett. 21, 65 Pubmed Oncol Lett PMC Article

Riess JW, Frankel P, Shackelford D, Dunphy M, Badawi RD, Nardo L, Cherry SR, Lanza I, Reid J, Gonsalves WI, Kunos C, Gandara DR, Lara PN, Newman E and Paik PK. Phase 1 Trial of MLN0128 (Sapanisertib) and CB-839 HCl (Telaglenastat) in Patients With Advanced NSCLC (NCI 10327): Rationale and Study Design. (2021) Clin Lung Cancer. 22, 67-70 Pubmed Clin Lung Cancer

Hahm ER, Kim SH, Singh KB and Singh SV. RNA-seq reveals novel cancer-selective and disease subtype-independent mechanistic targets of withaferin A in human breast cancer cells. (2021) Mol Carcinog. 60, 3-14 Pubmed Mol Carcinog PMC Article

Paithankar JG, Saini S, Dwivedi S, Sharma A and Chowdhuri DK. Heavy metal associated health hazards: An interplay of oxidative stress and signal transduction. (2021) Chemosphere. 262, 128350 Pubmed Chemosphere

Lim JY, Lee JH, Yun DH, Lee YM and Kim DK. Inhibitory effects of nodakenin on inflammation and cell death in lipopolysaccharide-induced liver injury mice. (2021) Phytomedicine. 81, 153411 Pubmed Phytomedicine

Liao H, Ye J, Gao L and Liu Y. The main bioactive compounds of Scutellaria baicalensis Georgi. for alleviation of inflammatory cytokines: A comprehensive review. (2021) Biomed Pharmacother. 133, 110917 Pubmed Biomed Pharmacother

Bailly C. Atractylenolides, essential components of Atractylodes-based traditional herbal medicines: Antioxidant, anti-inflammatory and anticancer properties. (2021) Eur J Pharmacol. 891, 173735 Pubmed Eur J Pharmacol

Zhu DC, Wang YH, Lin JH, Miao ZM, Xu JJ and Wu YS. Maltol inhibits the progression of osteoarthritis the nuclear factor-erythroid 2-related factor-2/heme oxygenase-1 signal pathway and . (2021) Food Funct. Pubmed Food Funct

Liu J, Cui JY, Lu YF, Corton JC and Klaassen CD. Sex-, Age-, and Race/Ethnicity-Dependent Variations in Drug-Processing and NRF2-Regulated Genes in Human Livers. (2021) Drug Metab Dispos. 49, 111-119 Pubmed Drug Metab Dispos

Waz S, Heeba GH, Hassanin SO and Abdel-Latif RG. Nephroprotective effect of exogenous hydrogen sulfide donor against cyclophosphamide-induced toxicity is mediated by Nrf2/HO-1/NF-κB signaling pathway. (2021) Life Sci. 264, 118630 Pubmed Life Sci

Alvariño R, Alonso E, Tabudravu JN, Pérez-Fuentes N, Alfonso A and Botana LM. Tavarua Deoxyriboside A and Jasplakinolide as Potential Neuroprotective Agents: Effects on Cellular Models of Oxidative Stress and Neuroinflammation. (2021) ACS Chem Neurosci. 12, 150-162 Pubmed ACS Chem Neurosci

Zhang J, Wang J, Fang H, Yu H, Zhao Y, Shen J, Zhou C and Jin Y. Pterostilbene inhibits deoxynivalenol-induced oxidative stress and inflammatory response in bovine mammary epithelial cells. (2021) Toxicon. 189, 10-18 Pubmed Toxicon

Wang Y, You Y, Tian Y, Sun H, Li X, Wang X, Wang Y and Liu J. PP04 Ameliorates High-Fat Diet-Induced Hyperlipidemia by Regulating Lipid Metabolism in C57BL/6N Mice. (2020) J Agric Food Chem. 68, 15154-15163 Pubmed J Agric Food Chem

Yang G, Xiang Y, Zhou W, Zhong X, Zhang Y, Lin D and Huang X. 1-Bromopropane-induced apoptosis in OVCAR-3 cells via oxidative stress and inactivation of Nrf2. (2020) Toxicol Ind Health. 748233720979427 Pubmed Toxicol Ind Health

Cheng X, Aabdin ZU, Wang Y, Ma N, Dai H, Shi X and Shen X. Glutamine pretreatment protects bovine mammary epithelial cells from inflammation and oxidative stress induced by γ-d-glutamyl-meso-diaminopimelic acid (iE-DAP). (2020) J Dairy Sci. Pubmed J Dairy Sci

Sun Y, Ren J and Wang F. [6]-Gingerol impedes 7,12-dimethylbenz(a)anthracene-induced inflammation and cell proliferation-associated hamster buccal pouch carcinogenesis through modulating Nrf2 signaling events. (2020) J Biochem Mol Toxicol. e22689 Pubmed J Biochem Mol Toxicol

Gunne S, Heinicke U, Parnham MJ, Laux V, Zacharowski K and von Knethen A. Nrf2-A Molecular Target for Sepsis Patients in Critical Care. (2020) Biomolecules. 10, Pubmed Biomolecules PMC Article

Eassawy MMT, Salem AA and Ismail AFM. Biochemical study on the protective effect of curcumin on acetaminophen and gamma-irradiation induced hepatic toxicity in rats. (2020) Environ Toxicol. Pubmed Environ Toxicol

Calabrese V, Scuto M, Salinaro AT, Dionisio G, Modafferi S, Ontario ML, Greco V, Sciuto S, Schmitt CP, Calabrese EJ and Peters V. Hydrogen Sulfide and Carnosine: Modulation of Oxidative Stress and Inflammation in Kidney and Brain Axis. (2020) Antioxidants (Basel). 9, Pubmed Antioxidants (Basel) PMC Article

Li J, Xiong C, Xu P, Luo Q and Zhang R. Puerarin induces apoptosis in prostate cancer cells via inactivation of the Keap1/Nrf2/ARE signaling pathway. (2020) Bioengineered. Pubmed Bioengineered

Zhang Y, Wei Z, Yang M, Liu D, Pan M, Wu C, Zhang W and Mai K. Dietary taurine modulates hepatic oxidative status, ER stress and inflammation in juvenile turbot (Scophthalmus maximus L.) fed high carbohydrate diets. (2020) Fish Shellfish Immunol. 109, 1-11 Pubmed Fish Shellfish Immunol

Jayawardena TU, Sanjeewa KKA, Lee HG, Nagahawatta DP, Yang HW, Kang MC and Jeon YJ. Particulate Matter-Induced Inflammation/Oxidative Stress in Macrophages: Fucosterol from as a Potent Protector, Activated via NF-κB/MAPK Pathways and Nrf2/HO-1 Involvement. (2020) Mar Drugs. 18, Pubmed Mar Drugs PMC Article

Wu WL and Papagiannakopoulos T. The Center Cannot Hold: NRF2 Battles Ferroptosis in the 3rd Dimension. (2020) Mol Cell. 80, 760-761 Pubmed Mol Cell

Ishida K, Kaji K, Sato S, Ogawa H, Takagi H, Takaya H, Kawaratani H, Moriya K, Namisaki T, Akahane T and Yoshiji H. Sulforaphane ameliorates ethanol plus carbon tetrachloride-induced liver fibrosis in mice through the Nrf2-mediated antioxidant response and acetaldehyde metabolization with inhibition of the LPS/TLR4 signaling pathway. (2020) J Nutr Biochem. 89, 108573 Pubmed J Nutr Biochem

Sahu R, Kar RK, Sunita P, Bose P, Kumari P, Bharti S, Srivastava S and Pattanayak SP. LC-MS characterized methanolic extract of zanthoxylum armatum possess anti-breast cancer activity through Nrf2-Keap1 pathway: An in-silico, in-vitro and in-vivo evaluation. (2020) J Ethnopharmacol. 269, 113758 Pubmed J Ethnopharmacol

Taguchi K and Yamamoto M. The KEAP1-NRF2 System as a Molecular Target of Cancer Treatment. (2020) Cancers (Basel). 13, Pubmed Cancers (Basel) PMC Article

Hashemzaei M and Rezaee R. A review on pain-relieving activity of berberine. (2020) Phytother Res. Pubmed Phytother Res

Song X, Tan L, Wang M, Ren C, Guo C, Yang B, Ren Y, Cao Z, Li Y and Pei J. Myricetin: A review of the most recent research. (2020) Biomed Pharmacother. 134, 111017 Pubmed Biomed Pharmacother

Xiao S, Liu N, Yang X, Ji G and Li M. Polygalacin D suppresses esophageal squamous cell carcinoma growth and metastasis through regulating miR-142-5p/Nrf2 axis. (2020) Free Radic Biol Med. 164, 58-75 Pubmed Free Radic Biol Med

Cardozo LFMF, Alvarenga LA, Ribeiro M, Dai L, Shiels PG, Stenvinkel P, Lindholm B and Mafra D. Cruciferous vegetables: rationale for exploring potential salutary effects of sulforaphane-rich foods in patients with chronic kidney disease. (2020) Nutr Rev. Pubmed Nutr Rev

Dun Su , Wang X, Ma Y, Hao J, Jinshen Wang , Yongqu Lu , Yulin Liu , Xingfang Wang and Zhang L. Nrf2-induced miR-23a-27a-24-2 cluster modulates damage repair of intestinal mucosa by targeting the Bach1/HO-1 axis in inflammatory bowel diseases. (2020) Free Radic Biol Med. 163, 1-9 Pubmed Free Radic Biol Med

Pasani S, Sahoo S and Jolly MK. Hybrid E/M Phenotype(s) and Stemness: A Mechanistic Connection Embedded in Network Topology. (2020) J Clin Med. 10, Pubmed J Clin Med PMC Article

Narożna M, Krajka-Kuźniak V, Bednarczyk-Cwynar B, Kleszcz R, Kujawski J and Baer-Dubowska W. The Effect of Novel Oleanolic Acid Oximes Conjugated with Indomethacin on the Nrf2-ARE And NF-κB Signaling Pathways in Normal Hepatocytes and Human Hepatocellular Cancer Cells. (2020) Pharmaceuticals (Basel). 14, Pubmed Pharmaceuticals (Basel)

Rahban M, Habibi-Rezaei M, Mazaheri M, Saso L and Moosavi-Movahedi AA. Anti-Viral Potential and Modulation of Nrf2 by Curcumin: Pharmacological Implications. (2020) Antioxidants (Basel). 9, Pubmed Antioxidants (Basel) PMC Article

Zhang Q, Cheng X, Zhang H, Zhang T, Wang Z, Zhang W and Yu W. Dissecting molecular mechanisms underlying HO-induced apoptosis of mouse bone marrow mesenchymal stem cell: role of Mst1 inhibition. (2020) Stem Cell Res Ther. 11, 526 Pubmed Stem Cell Res Ther PMC Article

Fabrizio FP, Sparaneo A and Muscarella LA. NRF2 Regulation by Noncoding RNAs in Cancers: The Present Knowledge and the Way Forward. (2020) Cancers (Basel). 12, Pubmed Cancers (Basel) PMC Article

Liu M, Jia S, Dong T, Zhao F, Xu T, Yang Q, Gong J and Fang M. Metabolomic and Transcriptomic Analysis of MCF-7 Cells Exposed to 23 Chemicals at Human-Relevant Levels: Estimation of Individual Chemical Contribution to Effects. (2020) Environ Health Perspect. 128, 127008 Pubmed Environ Health Perspect PMC Article

Ribeiro Reily Rocha C, Reily Rocha A, Molina Silva M, Rodrigues Gomes L, Teatin Latancia M, Andrade Tomaz M, de Souza I, Karolynne Seregni Monteiro L and Frederico Martins Menck C. Revealing Temozolomide Resistance Mechanisms via Genome-Wide CRISPR Libraries. (2020) Cells. 9, Pubmed Cells PMC Article

Jin X, Gong L, Peng Y, Li L and Liu G. Enhancer-bound Nrf2 licenses HIF-1α transcription under hypoxia to promote cisplatin resistance in hepatocellular carcinoma cells. (2020) Aging (Albany NY). 12, Pubmed Aging (Albany NY)

Zhang Y, Sun J, Dong Y, Shen X and Zhang Z. Vicenin-2 inhibits the Helicobacterium pylori infection associated gastric carcinogenic events through modulation of PI3K/AKT and Nrf2 signaling in GES-1 cells. (2020) J Biochem Mol Toxicol. e22680 Pubmed J Biochem Mol Toxicol

Kim EN, Kim TY, Park EK, Kim JY and Jeong GS. Fruit Has Anti-Inflammatory Effect and Induces Osteogenic Differentiation by Regulating Nrf2/HO-1 Signaling Pathway in In Vitro and In Vivo Models of Periodontitis. (2020) Antioxidants (Basel). 9, Pubmed Antioxidants (Basel) PMC Article

Almeer RS, Alkahtani S, Alarifi S, Moneim AEA, Abdi S and Albasher G. Ziziphus spina-christi leaf extract mitigates mercuric chloride-induced cortical damage in rats. (2020) Comb Chem High Throughput Screen. Pubmed Comb Chem High Throughput Screen

Robertson H, Dinkova-Kostova AT and Hayes JD. NRF2 and the Ambiguous Consequences of Its Activation during Initiation and the Subsequent Stages of Tumourigenesis. (2020) Cancers (Basel). 12, Pubmed Cancers (Basel) PMC Article

He H, Ma Y, Huang H, Huang C, Chen Z, Chen D, Gu Y, Wang X and Chen J. A comprehensive understanding about the pharmacological effect of diallyl disulfide other than its anti-carcinogenic activities. (2020) Eur J Pharmacol. 893, 173803 Pubmed Eur J Pharmacol

Cao X, Chen XM, Xiao WZ, Li B, Zhang B, Wu Q and Xue Q. ROS‑mediated hypomethylation of PRDX5 promotes STAT3 binding and activates the Nrf2 signaling pathway in NSCLC. (2020) Int J Mol Med. Pubmed Int J Mol Med

Sitthideatphaiboon P, Galan-Cobo A, Negrao MV, Qu X, Poteete A, Zhang F, Liu DD, Lewis WE, Kemp HN, Lewis J, Rinsurongkawong W, Giri U, Lee JJ, Zhang J, Roth JA, Swisher SG and Heymach JV. LKB1 mutations in NSCLC are associated with KEAP1/NRF2-dependent radiotherapy resistance targetable by glutaminase inhibition. (2020) Clin Cancer Res. Pubmed Clin Cancer Res

Albazal A, Delshad AA and Roghani M. Melatonin reverses cognitive deficits in streptozotocin-induced type 1 diabetes in the rat through attenuation of oxidative stress and inflammation. (2020) J Chem Neuroanat. 112, 101902 Pubmed J Chem Neuroanat

Wang Y, Chen X, Huang Z, Chen D, Yu B, Yu J, Chen H, He J, Luo Y and Zheng P. Dietary Ferulic Acid Supplementation Improves Antioxidant Capacity and Lipid Metabolism in Weaned Piglets. (2020) Nutrients. 12, Pubmed Nutrients PMC Article

Chen G, Chang W, Li X, Han L, Zhou D, Feng Y, Li B, Zhu F and Li N. n-BuOH extract of Bletilla striata exerts chemopreventive effects on lung against SiO nanoparticles through activation of Nrf2 pathway. (2020) Phytomedicine. 82, 153445 Pubmed Phytomedicine

Scarpa JR, DiNatale RG, Mano R, Silagy AW, Kuo F, Irie T, McCormick PJ, Fischer GW, Hakimi AA and Mincer JS. Identifying Clear Cell Renal Cell Carcinoma Coexpression Networks Associated with Opioid Signaling and Survival. (2020) Cancer Res. Pubmed Cancer Res

Oshi M, Angarita FA, Tokumaru Y, Yan L, Matsuyama R, Endo I and Takabe K. High Expression of NRF2 Is Associated with Increased Tumor-Infiltrating Lymphocytes and Cancer Immunity in ER-Positive/HER2-Negative Breast Cancer. (2020) Cancers (Basel). 12, Pubmed Cancers (Basel) PMC Article

Burgos RA, Alarcón P, Quiroga J, Manosalva C and Hancke J. Andrographolide, an Anti-Inflammatory Multitarget Drug: All Roads Lead to Cellular Metabolism. (2020) Molecules. 26, Pubmed Molecules PMC Article

Jessen C, Kreß JKC, Baluapuri A, Hufnagel A, Schmitz W, Kneitz S, Roth S, Marquardt A, Appenzeller S, Ade CP, Glutsch V, Wobser M, Friedmann-Angeli JP, Mosteo L, Goding CR, Schilling B, Geissinger E, Wolf E and Meierjohann S. Correction: The transcription factor NRF2 enhances melanoma malignancy by blocking differentiation and inducing COX2 expression. (2020) Oncogene. Pubmed Oncogene

Takahashi N, Cho P, Selfors LM, Kuiken HJ, Kaul R, Fujiwara T, Harris IS, Zhang T, Gygi SP and Brugge JS. 3D Culture Models with CRISPR Screens Reveal Hyperactive NRF2 as a Prerequisite for Spheroid Formation via Regulation of Proliferation and Ferroptosis. (2020) Mol Cell. 80, 828-844.e6 Pubmed Mol Cell PMC Article

Ryu D, Lee JH and Kwak MK. NRF2 level is negatively correlated with TGF-β1-induced lung cancer motility and migration via NOX4-ROS signaling. (2020) Arch Pharm Res. 43, 1297-1310 Pubmed Arch Pharm Res

Regmi S, Raut PK, Pathak S, Shrestha P, Park PH and Jeong JH. Enhanced viability and function of mesenchymal stromal cell spheroids is mediated autophagy induction. (2020) Autophagy. 1-20 Pubmed Autophagy

Larrick JW, Larrick JW and Mendelsohn AR. SUMO Wrestles with Mitophagy to Extend Lifespan. (2020) Rejuvenation Res. 23, 527-532 Pubmed Rejuvenation Res

Zamani E, Parviz M, Roghani M, Hosseini M, Mohseni-Moghaddam P and Nikbakhtzadeh M. Netrin-1 protects the SH-SY5Y cells against amyloid beta neurotoxicity through NF-κB/Nrf2 dependent mechanism. (2020) Mol Biol Rep. 47, 9271-9277 Pubmed Mol Biol Rep

Scheifele C, Zhu Q, Ignatov A, Kalinski T and Nass N. Glyoxalase 1 expression analysis by immunohistochemistry in breast cancer. (2020) Pathol Res Pract. 216, 153257 Pubmed Pathol Res Pract

Zhang S, Niu Y, Yang Z, Zhang Y, Guo Q, Yang Y, Zhou X, Ding Y and Liu C. Biochanin A alleviates gingival inflammation and alveolar bone loss in rats with experimental periodontitis. (2020) Exp Ther Med. 20, 251 Pubmed Exp Ther Med PMC Article

Singh B, Patwardhan RS, Jayakumar S, Sharma D and Sandur SK. Oxidative stress associated metabolic adaptations regulate radioresistance in human lung cancer cells. (2020) J Photochem Photobiol B. 213, 112080 Pubmed J Photochem Photobiol B

Jiang T, Zhou J, Liu W, Tao W, He J, Jin W, Guo H, Yang N and Li Y. The anti-inflammatory potential of protein-bound anthocyanin compounds from purple sweet potato in LPS-induced RAW264.7 macrophages. (2020) Food Res Int. 137, 109647 Pubmed Food Res Int

Manga P and Choudhury N. The Unfolded Protein and Integrated Stress Response in Melanoma and Vitiligo. (2020) Pigment Cell Melanoma Res. Pubmed Pigment Cell Melanoma Res

Zhong S, Xue J, Cao JJ, Sun B, Sun QF, Bian LG, Hu LY and Pan SJ. The therapeutic value of XL388 in human glioma cells. (2020) Aging (Albany NY). 12, 22550-22563 Pubmed Aging (Albany NY) PMC Article

Horiuchi M, Taguchi K, Hirose W, Tsuchida K, Suzuki M, Taniyama Y, Kamei T and Yamamoto M. Cellular Nrf2 Levels Determine Cell Fate during Chemical Carcinogenesis in Esophageal Epithelium. (2020) Mol Cell Biol. Pubmed Mol Cell Biol

Gupta N, Verma K, Nalla S, Kulshreshtha A, Lall R and Prasad S. Free Radicals as a Double-Edged Sword: The Cancer Preventive and Therapeutic Roles of Curcumin. (2020) Molecules. 25, Pubmed Molecules PMC Article

Tamatam CM, Reddy NM, Potteti HR, Ankireddy A, Noone PM, Yamamoto M, Kensler TW and Reddy SP. Preconditioning the immature lung with enhanced Nrf2 activity protects against oxidant-induced hypoalveolarization in mice. (2020) Sci Rep. 10, 19034 Pubmed Sci Rep PMC Article

Zhou S, Guo J, Zhao L, Liao Y, Zhou Q, Cui Y, Hu W, Chen J, Ren X, Wei Q, Jiang S, Zheng Y, Li L, Wilcox CS, Persson PB, Patzak A, Tian J and Yin Lai E. ADAMTS13 inhibits oxidative stress and ameliorates progressive chronic kidney disease following ischaemia/reperfusion injury. (2020) Acta Physiol (Oxf). e13586 Pubmed Acta Physiol (Oxf)

Jamali N, Zal F, Mostafavi-Pour Z, Samare-Najaf M, Poordast T and Dehghanian A. Ameliorative Effects of Quercetin and Metformin and Their Combination Against Experimental Endometriosis in Rats. (2020) Reprod Sci. Pubmed Reprod Sci

Qureshi MA, Khan S, Tauheed MS, Syed SA, Ujjan ID, Lail A and Sharafat S. Pan-Cancer Multiomics Analysis of TC2N Gene Suggests its Important Role(s) in Tumourigenesis of Many Cancers. (2020) Asian Pac J Cancer Prev. 21, 3199-3209 Pubmed Asian Pac J Cancer Prev

Wu YX, Zeng S, Wan BB, Wang YY, Sun HX, Liu G, Gao ZQ, Chen D, Chen YQ, Lu MD and Pang QF. Sophoricoside attenuates lipopolysaccharide-induced acute lung injury by activating the AMPK/Nrf2 signaling axis. (2020) Int Immunopharmacol. 107187 Pubmed Int Immunopharmacol

Azouz AA, Abdel-Nassir Abdel-Razek E and Abo-Youssef AM. Amlodipine alleviates cisplatin-induced nephrotoxicity in rats through gamma-glutamyl transpeptidase (GGT) enzyme inhibition, associated with regulation of Nrf2/HO-1, MAPK/NF-κB, and Bax/Bcl-2 signaling. (2020) Saudi Pharm J. 28, 1317-1325 Pubmed Saudi Pharm J PMC Article

Baird L and Yamamoto M. NRF2-dependent bioactivation of mitomycin C as a novel strategy to target KEAP1-NRF2 pathway activation in human cancer. (2020) Mol Cell Biol. Pubmed Mol Cell Biol

Jaganjac M, Milkovic L, Sunjic SB and Zarkovic N. The NRF2, Thioredoxin, and Glutathione System in Tumorigenesis and Anticancer Therapies. (2020) Antioxidants (Basel). 9, Pubmed Antioxidants (Basel) PMC Article

Li Z, Teng M, Wang Y, Feng Y, Xiao Z, Hu H, Wang Q, Lu Y, Li C, Zeng K and Yang B. Dihydroartemisinin administration improves the effectiveness of 5-aminolevulinic acid-mediated photodynamic therapy for the treatment of high-risk human papillomavirus infection. (2020) Photodiagnosis Photodyn Ther. 102078 Pubmed Photodiagnosis Photodyn Ther

Hu Z, Wang X, Li D, Cao L, Cui H and Xu G. UFBP1, a key component in ufmylation, enhances drug sensitivity by promoting proteasomal degradation of oxidative stress-response transcription factor Nrf2. (2020) Oncogene. Pubmed Oncogene

De Cicco P, Maisto M, Tenore GC and Ianaro A. Olive Leaf Extract, from L., Reduces Palmitate-Induced Inflammation via Regulation of Murine Macrophages Polarization. (2020) Nutrients. 12, Pubmed Nutrients PMC Article

de Oliveira MR, de Souza ICC and Brasil FB. Mitochondrial Protection and Anti-inflammatory Effects Induced by Emodin in the Human Neuroblastoma SH-SY5Y Cells Exposed to Hydrogen Peroxide: Involvement of the AMPK/Nrf2 Signaling Pathway. (2020) Neurochem Res. Pubmed Neurochem Res

Saha S, Buttari B, Panieri E, Profumo E and Saso L. An Overview of Nrf2 Signaling Pathway and Its Role in Inflammation. (2020) Molecules. 25, Pubmed Molecules PMC Article

Okazaki K, Anzawa H, Liu Z, Ota N, Kitamura H, Onodera Y, Alam MM, Matsumaru D, Suzuki T, Katsuoka F, Tadaka S, Motoike I, Watanabe M, Hayasaka K, Sakurada A, Okada Y, Yamamoto M, Suzuki T, Kinoshita K, Sekine H and Motohashi H. Enhancer remodeling promotes tumor-initiating activity in NRF2-activated non-small cell lung cancers. (2020) Nat Commun. 11, 5911 Pubmed Nat Commun PMC Article

Kim MW, Kang JH, Jung HJ, Park SY, Phan THL, Namgung H, Seo SY, Yoon YS and Oh SH. Allyl Isothiocyanate Protects Acetaminophen-Induced Liver Injury via NRF2 Activation by Decreasing Spontaneous Degradation in Hepatocyte. (2020) Nutrients. 12, Pubmed Nutrients PMC Article

Thanas C, Ziros PG, Chartoumpekis DV, Renaud CO and Sykiotis GP. The Keap1/Nrf2 Signaling Pathway in the Thyroid-2020 Update. (2020) Antioxidants (Basel). 9, Pubmed Antioxidants (Basel) PMC Article

Liang J, Liu L, Kang X, Hu F and Mao L. Mechanism underlying the effect of SO2-induced oxidation on human skin keratinocytes. (2020) Medicine (Baltimore). 99, e23152 Pubmed Medicine (Baltimore) PMC Article

Inesta-Vaquera F, Navasumrit P, Henderson CJ, Frangova TG, Honda T, Dinkova-Kostova AT, Ruchirawat M and Wolf CR. Application of the in vivo oxidative stress reporter Hmox1 as mechanistic biomarker of arsenic toxicity. (2020) Environ Pollut. 116053 Pubmed Environ Pollut

Clerici S and Boletta A. Role of the KEAP1-NRF2 Axis in Renal Cell Carcinoma. (2020) Cancers (Basel). 12, Pubmed Cancers (Basel) PMC Article

Logie E and Vanden Berghe W. Tackling Chronic Inflammation with Withanolide Phytochemicals-A Withaferin a Perspective. (2020) Antioxidants (Basel). 9, Pubmed Antioxidants (Basel) PMC Article

Wang W, Zhang S, Yang F, Xie J, Chen J and Li Z. Diosmetin alleviates acute kidney injury by promoting the TUG1/Nrf2/HO-1 pathway in sepsis rats. (2020) Int Immunopharmacol. 88, 106965 Pubmed Int Immunopharmacol

Yang Y, Zheng J, Wang M, Zhang J, Tian T, Wang Z, Yuan S, Liu L, Zhu P, Gu F, Fu S, Shan Y, Pan Z and Zhou W. NQO1 promotes an aggressive phenotype in hepatocellular carcinoma via amplifying ERK-NRF2 signaling. (2020) Cancer Sci. Pubmed Cancer Sci

Meng XW, He CX, Chen X, Yang XS and Liu C. The extract of Gnaphalium affine D. Don protects against HO-induced apoptosis by targeting PI3K/AKT/GSK-3β signaling pathway in cardiomyocytes. (2020) J Ethnopharmacol. 113579 Pubmed J Ethnopharmacol

Merk R, Heßelbach K, Osipova A, Popadić D, Schmidt-Heck W, Kim GJ, Günther S, Piñeres AG, Merfort I and Humar M. Particulate Matter (PM) from Biomass Combustion Induces an Anti-Oxidative Response and Cancer Drug Resistance in Human Bronchial Epithelial BEAS-2B Cells. (2020) Int J Environ Res Public Health. 17, Pubmed Int J Environ Res Public Health PMC Article

Gureev AP, Sadovnikova IS, Starkov NN, Starkov AA and Popov VN. p62-Nrf2-p62 Mitophagy Regulatory Loop as a Target for Preventive Therapy of Neurodegenerative Diseases. (2020) Brain Sci. 10, Pubmed Brain Sci PMC Article

Ma Y, Pan C, Tang X, Zhang M, Shi H, Wang T and Zhang Y. MicroRNA-200a represses myocardial infarction-related cell death and inflammation by targeting the Keap1/Nrf2 and β-catenin pathways. (2020) Hellenic J Cardiol. Pubmed Hellenic J Cardiol

Yardım A, Kandemir FM, Çomaklı S, Özdemir S, Caglayan C, Kucukler S and Çelik H. Protective Effects of Curcumin Against Paclitaxel-Induced Spinal Cord and Sciatic Nerve Injuries in Rats. (2020) Neurochem Res. Pubmed Neurochem Res

Guo S, Li Y, Wei B, Liu W, Li R, Cheng W, Zhang X, He X, Li X and Duan C. Tim-3 deteriorates neuroinflammatory and neurocyte apoptosis after subarachnoid hemorrhage through the Nrf2/HMGB1 signaling pathway in rats. (2020) Aging (Albany NY). 12, 21161-21185 Pubmed Aging (Albany NY) PMC Article

Kaji H, Matsui-Yuasa I, Matsumoto K, Omura A, Kiyomoto K and Kojima-Yuasa A. Sesaminol prevents Parkinson's disease by activating the Nrf2-ARE signaling pathway. (2020) Heliyon. 6, e05342 Pubmed Heliyon PMC Article

Calabrese EJ and Kozumbo WJ. The phytoprotective agent sulforaphane prevents inflammatory degenerative diseases and age-related pathologies via Nrf2-mediated hormesis. (2020) Pharmacol Res. 105283 Pubmed Pharmacol Res

Friedmann Angeli JP and Meierjohann S. NRF2 dependent stress defence in tumor antioxidant control and immune evasion. (2020) Pigment Cell Melanoma Res. Pubmed Pigment Cell Melanoma Res

S Narasimhan KK, Devarajan A, Karan G, Sundaram S, Wang Q, van Groen T, Monte FD and Rajasekaran NS. Reductive stress promotes protein aggregation and impairs neurogenesis. (2020) Redox Biol. 37, 101739 Pubmed Redox Biol PMC Article

Mohs A, Otto T, Schneider KM, Peltzer M, Boekschoten M, Holland CH, Hudert CA, Kalveram L, Wiegand S, Saez-Rodriguez J, Longerich T, Hengstler JG and Trautwein C. Hepatocyte-specific NRF2 activation controls fibrogenesis and carcinogenesis in steatohepatitis. (2020) J Hepatol. Pubmed J Hepatol

Piotrowska M, Swierczynski M, Fichna J and Piechota-Polanczyk A. The Nrf2 in the pathophysiology of the intestine: Molecular mechanisms and therapeutic implications for inflammatory bowel diseases. (2020) Pharmacol Res. 105243 Pubmed Pharmacol Res

Deville SS, Luft S, Kaufmann M and Cordes N. Keap1 inhibition sensitizes head and neck squamous cell carcinoma cells to ionizing radiation via impaired non-homologous end joining and induced autophagy. (2020) Cell Death Dis. 11, 887 Pubmed Cell Death Dis PMC Article

Di Sotto A, Mancinelli R, Gullì M, Eufemi M, Mammola CL, Mazzanti G and Di Giacomo S. Chemopreventive Potential of Caryophyllane Sesquiterpenes: An Overview of Preliminary Evidence. (2020) Cancers (Basel). 12, Pubmed Cancers (Basel) PMC Article

Mita-Mendoza NK, Magallon-Tejada A, Parmar P, Furtado R, Aldrich M, Saidi A, Taylor T, Smith J, Seydel K and Daily JP. Dimethyl fumarate reduces TNF and Plasmodium falciparum induced brain endothelium activation in vitro. (2020) Malar J. 19, 376 Pubmed Malar J PMC Article

DeBlasi JM and DeNicola GM. Dissecting the Crosstalk between NRF2 Signaling and Metabolic Processes in Cancer. (2020) Cancers (Basel). 12, Pubmed Cancers (Basel) PMC Article

Abouzed TK, Beltagy ER, Kahilo KA and Ibrahim WM. Molecular changes associated with the anticancer effect of sulforaphane against Ehrlich solid tumour in mice. (2020) J Biochem Mol Toxicol. e22655 Pubmed J Biochem Mol Toxicol

Li YJ, Shimizu T, Shinkai Y, Ihara T, Sugamata M, Kato K, Kobayashi M, Hirata Y, Inagaki H, Uzuki M, Akimoto T, Umezawa M, Takeda K, Azuma A, Yamamoto M and Kawada T. Nrf2 Lowers the Risk of Lung Injury via Modulating the Airway Innate Immune Response Induced by Diesel Exhaust in Mice. (2020) Biomedicines. 8, Pubmed Biomedicines PMC Article

Heft Neal ME, Bhangale AD, Birkeland AC, McHugh JB, Shuman AG, Rosko AJ, Swiecicki PL, Spector ME and Brenner JC. Prognostic Significance of Oxidation Pathway Mutations in Recurrent Laryngeal Squamous Cell Carcinoma. (2020) Cancers (Basel). 12, Pubmed Cancers (Basel) PMC Article

Liu Z and Sun X. A Critical Review of the Abilities, Determinants, and Possible Molecular Mechanisms of Seaweed Polysaccharides Antioxidants. (2020) Int J Mol Sci. 21, Pubmed Int J Mol Sci PMC Article

Liu YH, Jiang M, Li RQ, Basnet R, Huang JZ, Song SY and Shu QY. Identification, Characterization, and Mutational Analysis of a Probable KEAP1 Ortholog in Rice ( L.). (2020) Plants (Basel). 9, Pubmed Plants (Basel) PMC Article

Li W, Sun K, Hu F, Chen L, Zhang X, Wang F and Yan B. Protective effects of natural compounds against oxidative stress in ischemic diseases and cancers via activating the Nrf2 signaling pathway: A mini review. (2020) J Biochem Mol Toxicol. e22658 Pubmed J Biochem Mol Toxicol

Guo F, Wang X and Liu X. Protective effects of irigenin against 1-methyl-4-phenylpyridinium-induced neurotoxicity through regulating the Keap1/Nrf2 pathway. (2020) Phytother Res. Pubmed Phytother Res

Mohamed ME, Abduldaium YS and Younis NS. Ameliorative Effect of Linalool in Cisplatin-Induced Nephrotoxicity: The Role of HMGB1/TLR4/NF-κB and Nrf2/HO1 Pathways. (2020) Biomolecules. 10, Pubmed Biomolecules PMC Article

Celesia A, Morana O, Fiore T, Pellerito C, D'Anneo A, Lauricella M, Carlisi D, De Blasio A, Calvaruso G, Giuliano M and Emanuele S. ROS-Dependent ER Stress and Autophagy Mediate the Anti-Tumor Effects of Tributyltin (IV) Ferulate in Colon Cancer Cells. (2020) Int J Mol Sci. 21, Pubmed Int J Mol Sci PMC Article

Sampath C, Okoro EU, Gipson MJ, Chukkapalli SS, Farmer-Dixon CM and Gangula PR. Porphyromonas gingivalis infection alters Nrf2-Phase II enzymes and nitric oxide in primary human aortic endothelial cells. (2020) J Periodontol. Pubmed J Periodontol

Lu J, Wilfred P, Korbie D and Trau M. Regulation of Canonical Oncogenic Signaling Pathways in Cancer via DNA Methylation. (2020) Cancers (Basel). 12, Pubmed Cancers (Basel) PMC Article

Huang YJ, Wang KL, Chen HY, Chiang YF and Hsia SM. Protective Effects of Epigallocatechin Gallate (EGCG) on Endometrial, Breast, and Ovarian Cancers. (2020) Biomolecules. 10, Pubmed Biomolecules PMC Article

Xiao Z, Liu W, Mu YP, Zhang H, Wang XN, Zhao CQ, Chen JM and Liu P. Pharmacological Effects of Salvianolic Acid B Against Oxidative Damage. (2020) Front Pharmacol. 11, 572373 Pubmed Front Pharmacol PMC Article

Zhao J, Lin X, Meng D, Zeng L, Zhuang R, Huang S, Lv W and Hu J. Nrf2 Mediates Metabolic Reprogramming in Non-Small Cell Lung Cancer. (2020) Front Oncol. 10, 578315 Pubmed Front Oncol PMC Article

Yuan Y, Fan S, Shu L, Huang W, Xie L, Bi C, Yu H, Wang Y and Li Y. Exploration the Mechanism of Doxorubicin-Induced Heart Failure in Rats by Integration of Proteomics and Metabolomics Data. (2020) Front Pharmacol. 11, 600561 Pubmed Front Pharmacol PMC Article

Wang J, Zhang X, Yang F, Yang Y, Wang T, Liu W, Zhou H and Zhao W. RASSF1A Enhances Chemosensitivity of NSCLC Cells Through Activating Autophagy by Regulating MAP1S to Inactivate Keap1-Nrf2 Pathway. (2021) Drug Des Devel Ther. 15, 21-35 Pubmed Drug Des Devel Ther PMC Article

Xu J, Guo H, Xing Z, Zhang W, He J, Cheng J and Cai R. Mild Oxidative Stress Reduces NRF2 SUMOylation to Promote // Mutant Lung Adenocarcinoma Cell Migration and Invasion. (2020) Oxid Med Cell Longev. 2020, 6240125 Pubmed Oxid Med Cell Longev PMC Article

Xu JC, Chen TY, Liao LT, Chen T, Li QL, Xu JX, Hu JW, Zhou PH and Zhang YQ. NETO2 promotes esophageal cancer progression by inducing proliferation and metastasis via PI3K/AKT and ERK pathway. (2021) Int J Biol Sci. 17, 259-270 Pubmed Int J Biol Sci PMC Article

Ashrafizadeh M, Zarrabi A, Hushmandi K, Zarrin V, Moghadam ER, Hashemi F, Makvandi P, Samarghandian S, Khan H, Hashemi F, Najafi M and Mirzaei H. Toward Regulatory Effects of Curcumin on Transforming Growth Factor-Beta Across Different Diseases: A Review. (2020) Front Pharmacol. 11, 585413 Pubmed Front Pharmacol PMC Article

Deng X, Lin N, Fu J, Xu L, Luo H, Jin Y, Liu Y, Sun L and Su J. The Nrf2/PGC1 Pathway Regulates Antioxidant and Proteasomal Activity to Alter Cisplatin Sensitivity in Ovarian Cancer. (2020) Oxid Med Cell Longev. 2020, 4830418 Pubmed Oxid Med Cell Longev PMC Article

Luo YH, Cheng HJ, Tsai FY, Tsou TC, Lin SY and Lin P. Primary Amine Modified Gold Nanodots Regulate Macrophage Function and Antioxidant Response: Potential Therapeutics Targeting of Nrf2. (2020) Int J Nanomedicine. 15, 8411-8426 Pubmed Int J Nanomedicine PMC Article

Fan X, Wei W, Huang J, Peng L and Ci X. Daphnetin Attenuated Cisplatin-Induced Acute Nephrotoxicity With Enhancing Antitumor Activity of Cisplatin by Upregulating SIRT1/SIRT6-Nrf2 Pathway. (2020) Front Pharmacol. 11, 579178 Pubmed Front Pharmacol PMC Article

Yin H, Xie J, Jiang P, Jiang X, Duan D, Qi J, Luo Z, Ma C and Hong H. Chiauranib selectively inhibits colorectal cancer with wild-type by modulation of ROS through activating the p53 signaling pathway. (2020) Am J Cancer Res. 10, 3666-3685 Pubmed Am J Cancer Res PMC Article

Mhillaj E, Papi M, Paciello F, Silvestrini A, Rolesi R, Palmieri V, Perini G, Fetoni AR, Trabace L and Mancuso C. Celecoxib Exerts Neuroprotective Effects in β-Amyloid-Treated SH-SY5Y Cells Through the Regulation of Heme Oxygenase-1: Novel Insights for an Old Drug. (2020) Front Cell Dev Biol. 8, 561179 Pubmed Front Cell Dev Biol PMC Article

Shi J, Li R, Yang S, Phang Y, Zheng C and Zhang H. The Protective Effects and Potential Mechanisms of : Focus on Anti-Inflammatory, Antioxidant, and Antiapoptotic Activities. (2020) Evid Based Complement Alternat Med. 2020, 8205983 Pubmed Evid Based Complement Alternat Med PMC Article

Luo P, Wu S, Ji K, Yuan X, Li H, Chen J, Tian Y, Qiu Y and Zhong X. LncRNA MIR4435-2HG mediates cisplatin resistance in HCT116 cells by regulating Nrf2 and HO-1. (2020) PLoS One. 15, e0223035 Pubmed PLoS One PMC Article

Ye W, Ma J, Wang F, Wu T, He M, Li J, Pei R, Zhang L, Wang Y and Zhou J. LncRNA 1 Regulates miR-144-3p to Facilitate Epithelial-Mesenchymal Transition of Lens Epithelial Cells via the ROS/NRF2/Notch1/Snail Pathway. (2020) Oxid Med Cell Longev. 2020, 8184314 Pubmed Oxid Med Cell Longev PMC Article

Zhang Y, Ma Y, Zhao C, Zhang H, Pu Y and Yin L. Synergistic Carcinogenesis of HPV18 and MNNG in Het-1A Cells through p62-KEAP1-NRF2 and PI3K/AKT/mTOR Pathway. (2020) Oxid Med Cell Longev. 2020, 6352876 Pubmed Oxid Med Cell Longev PMC Article

Yu Y, Wu DM, Li J, Deng SH, Liu T, Zhang T, He M, Zhao YY and Xu Y. Bixin Attenuates Experimental Autoimmune Encephalomyelitis by Suppressing TXNIP/NLRP3 Inflammasome Activity and Activating NRF2 Signaling. (2020) Front Immunol. 11, 593368 Pubmed Front Immunol PMC Article

Huang JF, Zheng XQ, Lin JL, Zhang K, Tian HJ, Zhou WX, Wang H, Gao Z, Jin HM and Wu AM. Sinapic Acid Inhibits IL-1β-Induced Apoptosis and Catabolism in Nucleus Pulposus Cells and Ameliorates Intervertebral Disk Degeneration. (2020) J Inflamm Res. 13, 883-895 Pubmed J Inflamm Res PMC Article

Li P, Bukhari SNA, Khan T, Chitti R, Bevoor DB, Hiremath AR, SreeHarsha N, Singh Y and Gubbiyappa KS. Apigenin-Loaded Solid Lipid Nanoparticle Attenuates Diabetic Nephropathy Induced by Streptozotocin Nicotinamide Through Nrf2/HO-1/NF-kB Signalling Pathway. (2020) Int J Nanomedicine. 15, 9115-9124 Pubmed Int J Nanomedicine PMC Article

Hu J, Li Y, Li H, Shi F, Xie L, Zhao L, Tang M, Luo X, Jia W, Fan J, Zhou J, Gao Q, Qiu S, Wu W, Zhang X, Liao W, Bode AM and Cao Y. Targeting Epstein-Barr virus oncoprotein LMP1-mediated high oxidative stress suppresses EBV lytic reactivation and sensitizes tumors to radiation therapy. (2020) Theranostics. 10, 11921-11937 Pubmed Theranostics PMC Article

Konkova M, Abramova M, Kalianov A, Ershova E, Dolgikh O, Umriukhin P, Izhevskaya V, Kutsev S, Veiko N and Kostyuk S. Mesenchymal Stem Cells Early Response to Low-Dose Ionizing Radiation. (2020) Front Cell Dev Biol. 8, 584497 Pubmed Front Cell Dev Biol PMC Article

Omotuyi OI, Nash O, Enejoh OA, Oribamise EI and Adelakun NS. flavonoids attenuate experimental nephropathy: Involvement of pro-inflammatory genes downregulation. (2020) Toxicol Rep. 7, 1421-1427 Pubmed Toxicol Rep PMC Article

Zhang X, Zhang R, Chen H, Wang L, Ren C, Pataer A, Wu S, Meng QH, Ha MJ, Morris J, Xi Y, Wang J, Zhang J, Gibbons DL, Heymach JV, Meric-Bernstam F, Minna J, Swisher SG, Roth JA and Fang B. KRT-232 and navitoclax enhance trametinib's anti-Cancer activity in non-small cell lung cancer patient-derived xenografts with KRAS mutations. (2020) Am J Cancer Res. 10, 4464-4475 Pubmed Am J Cancer Res PMC Article

Li C, Si J, Tan F, Park KY and Zhao X. KSFY06 Prevents Inflammatory Response and Oxidative Stress in Acute Liver Injury Induced by D-Gal/LPS in Mice. (2021) Drug Des Devel Ther. 15, 37-50 Pubmed Drug Des Devel Ther PMC Article

Larsson M, Rudqvist N, Spetz J, Shubbar E, Parris TZ, Langen B, Helou K and Forssell-Aronsson E. Long-term transcriptomic and proteomic effects in Sprague Dawley rat thyroid and plasma after internal low dose 131I exposure. (2020) PLoS One. 15, e0244098 Pubmed PLoS One PMC Article

Zhai T, Xu W, Liu Y, Qian K, Xiong Y and Chen Y. Honokiol Alleviates Methionine-Choline Deficient Diet-Induced Hepatic Steatosis and Oxidative Stress in C57BL/6 Mice by Regulating CFLAR-JNK Pathway. (2020) Oxid Med Cell Longev. 2020, 2313641 Pubmed Oxid Med Cell Longev PMC Article

Ju Q, Li X, Zhang H, Yan S, Li Y and Zhao Y. NFE2L2 Is a Potential Prognostic Biomarker and Is Correlated with Immune Infiltration in Brain Lower Grade Glioma: A Pan-Cancer Analysis. (2020) Oxid Med Cell Longev. 2020, 3580719 Pubmed Oxid Med Cell Longev PMC Article

Shan Y, Yang G, Huang H, Zhou Y, Hu X, Lu Q, Guo P, Hou J, Cao L, Tian F and Pan Q. Ubiquitin-Like Modifier Activating Enzyme 1 as a Novel Diagnostic and Prognostic Indicator That Correlates With Ferroptosis and the Malignant Phenotypes of Liver Cancer Cells. (2020) Front Oncol. 10, 592413 Pubmed Front Oncol PMC Article

Zhou L, Ning H, Wei H, Xu T, Zhao X, Fu A, Qian Q, Yang Z, Dou X and Li S. A Novel STAT3-Mediated GATA6 Pathway Contributes to -Butylhydroquinone- (tBHQ-) Protected TNF-Activated Vascular Cell Adhesion Molecule 1 (VCAM-1) in Vascular Endothelium. (2020) Oxid Med Cell Longev. 2020, 6584059 Pubmed Oxid Med Cell Longev PMC Article

Cvetković S, Nastasijević B, Mitić-Ćulafić D, Đukanović S, Tenji D, Knežević-Vukčević J and Nikolić B. New insight into the antigenotoxic activity of Gentiana lutea extracts - Protective effect against food borne mutagens. Mutat Res. 858-860, 503251 Pubmed Mutat Res

Xu Y, Yang Y, Huang Y, Ma Q, Shang J, Guo J, Cao X, Wang X and Li M. Inhibition of Nrf2/HO-1 signaling pathway by Dextran Sulfate suppresses angiogenesis of Gastric Cancer. (2021) J Cancer. 12, 1042-1060 Pubmed J Cancer PMC Article

Wang Q, Xu L, Wang G, Chen L, Li C, Jiang X, Gao H, Yang B and Tian W. Prognostic and clinicopathological significance of NRF2 expression in non-small cell lung cancer: A meta-analysis. (2020) PLoS One. 15, e0241241 Pubmed PLoS One PMC Article

Polouliakh N, Ludwig V, Meguro A, Kawagoe T, Heeb O and Mizuki N. Alpha-Arbutin Promotes Wound Healing by Lowering ROS and Upregulating Insulin/IGF-1 Pathway in Human Dermal Fibroblast. (2020) Front Physiol. 11, 586843 Pubmed Front Physiol PMC Article

Goyala A, Baruah A and Mukhopadhyay A. The genetic paradigms of dietary restriction fail to extend life span in cep-1(gk138) mutant of C. elegans p53 due to possible background mutations. (2020) PLoS One. 15, e0241478 Pubmed PLoS One PMC Article

Huang J, Hao C, Li Z, Wang L, Jiang J, Tang W, Wang L, Zhang W, Hu J and Yang W. Polymorphism Impacts Proinflammatory Cytokine Levels, Survival, and Transplant-Related Mortality After Hematopoietic Stem Cell Transplantation in Adult Patients Receiving Busulfan-Based Conditioning Regimens. (2020) Front Pharmacol. 11, 563321 Pubmed Front Pharmacol PMC Article

Cheng X, Liu D, Xing R, Song H, Tian X, Yan C and Han Y. Orosomucoid 1 Attenuates Doxorubicin-Induced Oxidative Stress and Apoptosis in Cardiomyocytes via Nrf2 Signaling. (2020) Biomed Res Int. 2020, 5923572 Pubmed Biomed Res Int PMC Article

Xu J, Zhang Y, Ren G, Yang R, Chen J, Xiang X, Qin H and Chen J. Inhibitory Effect of Delphinidin on Oxidative Stress Induced by HO in HepG2 Cells. (2020) Oxid Med Cell Longev. 2020, 4694760 Pubmed Oxid Med Cell Longev PMC Article

Luo Y, Zhang W, Xu L, Chen Y, Xu Y and Yuan L. Long Non-Coding RNA PVT1 Regulates the Resistance of the Breast Cancer Cell Line MDA-MB-231 to Doxorubicin via Nrf2. Technol Cancer Res Treat. 19, 1533033820980763 Pubmed Technol Cancer Res Treat PMC Article