Which NRF2 Products Have Peer Reviewed Studies

English: Graph of Nrf2 publications (pubmed search) by year (Photo credit: Wikipedia)

There are currently over 2300 articles (peer reviewed clinical reviews and studies) on Pubmed.gov on the topic of NRF2 Activation. There are a ton of companies claiming they have scientific studies showing that their products are NRF2 Activators. Go to Pubmed.gov and type in the name of their product. Pubmed is a website operated by the National Institute of Health (NIH). PubMed comprises over 21 million citations for biomedical literature from MEDLINE, life science journals, and online books. PubMed citations and abstracts include the fields of biomedicine and health, covering portions of the life sciences, behavioral sciences, chemical sciences, and bioengineering. PubMed also provides access to additional relevant web sites and links to the other NCBI molecular biology resources. Last 200 NRF-2 Studies published on Pubmed

Liu P, Yin Z, Chen M, Huang C, Wu Z, Huang J, Ou S and Zheng J. Cytotoxicity of adducts formed between quercetin and methylglyoxal in PC-12 cells. (2021) Food Chem. 352, 129424 Pubmed Food Chem

Liu Y, Chang M, Hu Z, Xu X, Wu W, Ning M, Hang T and Song M. Danggui Buxue Decoction enhances the anticancer activity of gemcitabine and alleviates gemcitabine-induced myelosuppression. (2021) J Ethnopharmacol. 273, 113965 Pubmed J Ethnopharmacol

Yasuda T, Ishimoto T and Baba H. Conflicting metabolic alterations in cancer stem cells and regulation by the stromal niche. (2021) Regen Ther. 17, 8-12 Pubmed Regen Ther PMC Article

Guo JW, Cheng YP, Liu CY, Thong HY, Lo Y, Wu CY and Jee SH. Magnolol may contribute to barrier function improvement on imiquimod-induced psoriasis-like dermatitis animal model via the downregulation of interleukin-23. (2021) Exp Ther Med. 21, 448 Pubmed Exp Ther Med PMC Article

Sampath C, Wilus D, Tabatabai M, Freeman ML and Gangula PR. Mechanistic role of antioxidants in rescuing delayed gastric emptying in high fat diet induced diabetic female mice. (2021) Biomed Pharmacother. 137, 111370 Pubmed Biomed Pharmacother PMC Article

Arab HH, Eid AH, Mahmoud AM and Senousy MA. Linagliptin mitigates experimental inflammatory bowel disease in rats by targeting inflammatory and redox signaling. (2021) Life Sci. 273, 119295 Pubmed Life Sci

Dong W, Liu G, Zhang K, Tan Y, Zou H, Yuan Y, Gu J, Song R, Zhu J and Liu Z. Cadmium exposure induces rat proximal tubular cells injury via p62-dependent Nrf2 nucleus translocation mediated activation of AMPK/AKT/mTOR pathway. (2021) Ecotoxicol Environ Saf. 214, 112058 Pubmed Ecotoxicol Environ Saf

Schmidlin CJ, Tian W, Dodson M, Chapman E and Zhang DD. FAM129B-dependent activation of NRF2 promotes an invasive phenotype in BRAF mutant melanoma cells. (2021) Mol Carcinog. 60, 331-341 Pubmed Mol Carcinog

El-Sayed RM, Abo El Gheit RE and Badawi GA. Vincamine protects against cisplatin induced nephrotoxicity via activation of Nrf2/HO-1 and hindering TLR4/ IFN-γ/CD44 cells inflammatory cascade. (2021) Life Sci. 272, 119224 Pubmed Life Sci

Liu J, Qin X, Ma W, Jia S, Zhang X, Yang X, Pan D and Jin F. Corilagin induces apoptosis and autophagy in NRF2‑addicted U251 glioma cell line. (2021) Mol Med Rep. 23, Pubmed Mol Med Rep PMC Article

Kohandel Z, Farkhondeh T, Aschner M and Samarghandian S. Nrf2 a molecular therapeutic target for Astaxanthin. (2021) Biomed Pharmacother. 137, 111374 Pubmed Biomed Pharmacother

Li H, Gao C, Liu C, Liu L, Zhuang J, Yang J, Zhou C, Feng F, Sun C and Wu J. A review of the biological activity and pharmacology of cryptotanshinone, an important active constituent in Danshen. (2021) Biomed Pharmacother. 137, 111332 Pubmed Biomed Pharmacother

Chen X, Li Z, Hong H, Wang N, Chen J, Lu S, Zhang H, Zhang X and Bei C. Xanthohumol suppresses inflammation in chondrocytes and ameliorates osteoarthritis in mice. (2021) Biomed Pharmacother. 137, 111238 Pubmed Biomed Pharmacother

Sun S, Zhang J, Li H, Du Y, Li S, Li A, Suo X, Wang Y and Sun Q. Anti-inflammatory activity of the water extract of Chloranthus serratus roots in LPS-stimulated RAW264.7 cells mediated by the Nrf2/HO-1, MAPK and NF-κB signaling pathways. (2021) J Ethnopharmacol. 271, 113880 Pubmed J Ethnopharmacol

Cao H, Zhang L, Qu Z, Tian S, Wang Z, Jiang Y, Hou Q, Jia L and Wang W. The protective effect of hydroxylated fullerene pretreatment on pilocarpine-induced status epilepticus. (2021) Brain Res. 147468 Pubmed Brain Res

Bi Z, Zhang Q, Fu Y, Seno A, Wadgaonkar P, Qiu Y, Almutairy B, Xu L, Zhang W, Thakur C and Chen F. Cooperation between NRF2-mediated transcription and MDIG-dependent epigenetic modifications in arsenic-induced carcinogenesis and cancer stem cells. (2021) Semin Cancer Biol. Pubmed Semin Cancer Biol

Ji SY, Cha HJ, Molagoda IMN, Kim MY, Kim SY, Hwangbo H, Lee H, Kim GY, Kim DH, Hyun JW, Kim HS, Kim S, Jin CY and Choi YH. Suppression of Lipopolysaccharide-Induced Inflammatory and Oxidative Response by 5-Aminolevulinic Acid in RAW 264.7 Macrophages and Zebrafish Larvae. (2021) Biomol Ther (Seoul). Pubmed Biomol Ther (Seoul)

Calabrese EJ, Priest ND and Kozumbo WJ. Thresholds for Carcinogens. (2021) Chem Biol Interact. 109464 Pubmed Chem Biol Interact

Zhao F, Hong X, Li D, Wei Z, Ci X and Zhang S. Diosmetin induces apoptosis in ovarian cancer cells by activating reactive oxygen species and inhibiting the Nrf2 pathway. (2021) Med Oncol. 38, 54 Pubmed Med Oncol

Ikawa T, Sato M, Oh-Hashi K, Furuta K and Hirata Y. Oxindole-curcumin hybrid compound enhances the transcription of γ-glutamylcysteine ligase. (2021) Eur J Pharmacol. 896, 173898 Pubmed Eur J Pharmacol

Hammad AM, Swiss GMS, Hall FS, Hikmat S, Sari Y, Al-Qirim TM and Amawi HA. Ceftriaxone reduces waterpipe tobacco smoke withdrawal-induced anxiety in rats via modulating the expression of TNF-α/NFĸB, Nrf2, and GLT-1. (2021) Neuroscience. Pubmed Neuroscience

Lei L, Guo Y, Lin J, Lin X, He S, Qin Z and Lin Q. Inhibition of endotoxin-induced acute lung injury in rats by bone marrow-derived mesenchymal stem cells: Role of Nrf2/HO-1 signal axis in inhibition of NLRP3 activation. (2021) Biochem Biophys Res Commun. 551, 7-13 Pubmed Biochem Biophys Res Commun

Yang S, Huang XL, Chen J, Mao LN, Liu X, Yuan WS, Wu XJ and Luo GW. Curcumin protects BEAS‑2B cells from PM‑induced oxidative stress and inflammation by activating NRF2/antioxidant response element pathways. (2021) Int J Mol Med. 47, 1 Pubmed Int J Mol Med PMC Article

Kumar N, Perez-Novo C, Shaw P, Logie E, Privat-Maldonado A, Dewilde S, Smits E, Berghe WV and Bogaerts A. Physical plasma-derived oxidants sensitize pancreatic cancer cells to ferroptotic cell death. (2021) Free Radic Biol Med. 166, 187-200 Pubmed Free Radic Biol Med

Harris CM, Zamperoni KE, Sernoskie SC, Chow NSM and Massey TE. Effects of in vivo treatment of mice with sulforaphane on repair of DNA pyridyloxylbutylation. (2021) Toxicology. 454, 152753 Pubmed Toxicology

Wang X, Li C, Huan Y, Cao H, Sun S, Lei L, Liu Q, Liu S, Ji W, Huang K, Shen Z and Zhou J. Diphenyl diselenide ameliorates diabetic nephropathy in streptozotocin-induced diabetic rats via suppressing oxidative stress and inflammation. (2021) Chem Biol Interact. 338, 109427 Pubmed Chem Biol Interact

Falfushynska H, Horyn O, Osypenko I, Rzymski P, Wejnerowski Ł, Dziuba MK and Sokolova IM. Multibiomarker-based assessment of toxicity of central European strains of filamentous cyanobacteria Aphanizomenon gracile and Raphidiopsis raciborskii to zebrafish Danio rerio. (2021) Water Res. 194, 116923 Pubmed Water Res

Teng RJ, Jing X, Martin DP, Hogg N, Haefke A, Konduri GG, Day BW, Naylor S and Pritchard KA. N-acetyl-lysyltyrosylcysteine amide, a novel systems pharmacology agent, reduces bronchopulmonary dysplasia in hyperoxic neonatal rat pups. (2021) Free Radic Biol Med. 166, 73-89 Pubmed Free Radic Biol Med PMC Article

Yu ZM, Wan XM, Xiao M, Zheng C and Zhou XL. Puerarin induces Nrf2 as a cytoprotective mechanism to prevent cadmium-induced autophagy inhibition and NLRP3 inflammasome activation in AML12 hepatic cells. (2021) J Inorg Biochem. 217, 111389 Pubmed J Inorg Biochem

Bellanti F and Vendemiale G. The Aging Liver: Redox Biology and Liver Regeneration. (2021) Antioxid Redox Signal. Pubmed Antioxid Redox Signal

Su X, Wang S, Zhang H, Yang G, Bai Y, Liu P, Meng L, Jiang X and Xin Y. Sulforaphane prevents angiotensin II-induced cardiomyopathy by activation of Nrf2 through epigenetic modification. (2021) J Cell Mol Med. Pubmed J Cell Mol Med

Zhang J, Jiang D, Lin S, Cheng Y, Pan J, Ding W, Chen Y and Fan J. Prolyl endopeptidase disruption reduces hepatic inflammation and oxidative stress in methionine-choline-deficient diet-induced steatohepatitis. (2021) Life Sci. 270, 119131 Pubmed Life Sci

Cheng X, Liu D, Song H, Tian X, Yan C and Han Y. Overexpression of Kininogen-1 aggravates oxidative stress and mitochondrial dysfunction in DOX-induced cardiotoxicity. (2021) Biochem Biophys Res Commun. 550, 142-150 Pubmed Biochem Biophys Res Commun

Xu C, Mao L, Tian H, Lin S, Zhao X, Lin J, Li D, Li X and Mei X. MICAL1 (molecule interacting with CasL 1) protects oligodendrocyte cells from oxidative injury through regulating apoptosis, autophagy in spinal cord injury. (2021) Neurosci Lett. 750, 135712 Pubmed Neurosci Lett

Ndlovu S, Nagiah S, Abdul NS, Ghazi T and Chuturgoon AA. Deoxynivalenol downregulates NRF2-induced cytoprotective response in human hepatocellular carcinoma (HepG2) cells. (2021) Toxicon. 193, 4-12 Pubmed Toxicon

Zhang F, Shao C, Chen Z, Li Y, Jing X and Huang Q. Low Dose of Trichostatin A Improves Radiation Resistance by Activating Akt/Nrf2-Dependent Antioxidation Pathway in Cancer Cells. (2021) Radiat Res. 195, 366-377 Pubmed Radiat Res

Rajput SA, Wang XQ and Yan HC. Morin hydrate: A comprehensive review on novel natural dietary bioactive compound with versatile biological and pharmacological potential. (2021) Biomed Pharmacother. 138, 111511 Pubmed Biomed Pharmacother

Schiavello M, Gazzano E, Bergandi L, Silvagno F, Libener R, Riganti C and Aldieri E. Identification of Redox-Sensitive Transcription Factors as Markers of Malignant Pleural Mesothelioma. (2021) Cancers (Basel). 13, Pubmed Cancers (Basel) PMC Article

Abdel-Wahab BA, Walbi IA, Albarqi HA, Ali FEM and Hassanein EHM. Roflumilast protects from cisplatin-induced testicular toxicity in male rats and enhances its cytotoxicity in prostate cancer cell line. Role of NF-κB-p65, cAMP/PKA and Nrf2/HO-1, NQO1 signaling. (2021) Food Chem Toxicol. 151, 112133 Pubmed Food Chem Toxicol

Schirrmacher V. Less Can Be More: The Hormesis Theory of Stress Adaptation in the Global Biosphere and Its Implications. (2021) Biomedicines. 9, Pubmed Biomedicines PMC Article

Amara I, Ontario ML, Scuto M, Lo Dico GM, Sciuto S, Greco V, Abid-Essefi S, Signorile A, Salinaro AT and Calabrese V. Protects SH-SY5YCells from DEHP-Induced Endoplasmic Reticulum Stress and Apoptosis. (2021) Antioxidants (Basel). 10, Pubmed Antioxidants (Basel)

Kalezic A, Udicki M, Srdic Galic B, Aleksic M, Korac A, Jankovic A and Korac B. Redox profile of breast tumor and associated adipose tissue in premenopausal women - Interplay between obesity and malignancy. (2021) Redox Biol. 41, 101939 Pubmed Redox Biol PMC Article

Ahmadian S, Sabzichi M, Rashidi M, Mohammadian J, Mahmoudi S, Maroufi NF, Ramezani F, Ghorbani M, Mohammadi M, Pirouzpanah M and Bijanpour H. Sensitization of A-549 lung cancer cells to Cisplatin by Quinacrine-loaded lipidic nanoparticles via suppressing Nrf2 mediated defense mechanism. (2021) Naunyn Schmiedebergs Arch Pharmacol. Pubmed Naunyn Schmiedebergs Arch Pharmacol

Luo P, Zheng M, Zhang R, Zhang H, Liu Y, Li W, Sun X, Yu Q, Tipoe GL and Xiao J. -Allylmercaptocysteine improves alcoholic liver disease partly through a direct modulation of insulin receptor signaling. (2021) Acta Pharm Sin B. 11, 668-679 Pubmed Acta Pharm Sin B PMC Article

Sun XH, Zhang H, Fan XP and Wang ZH. Astilbin Protects Against Carbon Tetrachloride-Induced Liver Fibrosis in Rats. (2021) Pharmacology. 1-9 Pubmed Pharmacology

Zheng K, Dong Y, Yang R, Liang Y, Wu H and He Z. Regulation of ferroptosis by bioactive phytochemicals: Implications for medical nutritional therapy. (2021) Pharmacol Res. 168, 105580 Pubmed Pharmacol Res

Su H, Yang F, Fu R, Li X, French R, Mose E, Pu X, Trinh B, Kumar A, Liu J, Antonucci L, Todoric J, Liu Y, Hu Y, Diaz-Meco MT, Moscat J, Metallo CM, Lowy AM, Sun B and Karin M. Cancer cells escape autophagy inhibition via NRF2-induced macropinocytosis. (2021) Cancer Cell. Pubmed Cancer Cell

Mohammed RA and Mansour SM. Sodium hydrogen sulfide upregulates cystathionine β-synthase and protects striatum against 3-nitropropionic acid-induced neurotoxicity in rats. (2021) J Pharm Pharmacol. 73, 310-321 Pubmed J Pharm Pharmacol

Sun D, Sun C, Qiu G, Yao L, Yu J, Al Sberi H, Fouda MS, Othman MS, Lokman MS, Kassab RB and Abdel Moneim AE. Allicin mitigates hepatic injury following cyclophosphamide administration via activation of Nrf2/ARE pathways and through inhibition of inflammatory and apoptotic machinery. (2021) Environ Sci Pollut Res Int. Pubmed Environ Sci Pollut Res Int

Xiao N, Zhao Y, He W, Yao Y, Wu N, Xu M, Du H and Tu Y. Egg yolk oils exert anti-inflammatory effect via regulating Nrf2/NF-κB pathway. (2021) J Ethnopharmacol. 274, 114070 Pubmed J Ethnopharmacol

El Khatib N, Morel S, Hugon G, Rapior S, Carnac G and Saint N. Identification of a Sesquiterpene Lactone from Leaves with Antioxidant Activity in Primary Human Muscle Cells. (2021) Molecules. 26, Pubmed Molecules PMC Article

Pei X, Jiang H, Liu X, Li L, Li C, Xiao X, Li D and Tang S. Targeting HMGB1 inhibits T-2 toxin-induced neurotoxicity via regulation of oxidative stress, neuroinflammation and neuronal apoptosis. (2021) Food Chem Toxicol. 151, 112134 Pubmed Food Chem Toxicol

Zhang B, Kirn LA and Burke R. The Vhl E3 ubiquitin ligase complex regulates melanisation via sima, cnc and the copper import protein Ctr1A. (2021) Biochim Biophys Acta Mol Cell Res. 1868, 119022 Pubmed Biochim Biophys Acta Mol Cell Res

Liu T, Lv YF, Zhao JL, You QD and Jiang ZY. Regulation of Nrf2 by phosphorylation: Consequences for biological function and therapeutic implications. (2021) Free Radic Biol Med. 168, 129-141 Pubmed Free Radic Biol Med

Bader S, Wilmers J, Pelzer M, Jendrossek V and Rudner J. Activation of anti-oxidant Keap1/Nrf2 pathway modulates efficacy of dihydroartemisinin-based monotherapy and combinatory therapy with ionizing radiation. (2021) Free Radic Biol Med. 168, 44-54 Pubmed Free Radic Biol Med

Brasil FB, Bertolini Gobbo RC, Souza de Almeida FJ, Luckachaki MD, Dall'Oglio EL and de Oliveira MR. The signaling pathway PI3K/Akt/Nrf2/HO-1 plays a role in the mitochondrial protection promoted by astaxanthin in the SH-SY5Y cells exposed to hydrogen peroxide. (2021) Neurochem Int. 105024 Pubmed Neurochem Int

Cho BO, Kim JH, Che DN, Kang HJ, Shin JY, Hao S, Park JH, Wang F, Lee YJ and Jang SI. Kushenol C Prevents Tert-Butyl Hydroperoxide and Acetaminophen-Induced Liver Injury. (2021) Molecules. 26, Pubmed Molecules PMC Article

Ross D and Siegel D. The diverse functionality of NQO1 and its roles in redox control. (2021) Redox Biol. 41, 101950 Pubmed Redox Biol

Tan Y, Cao H, Li Q and Sun J. The role of transcription factor Ap1 in the activation of the Nrf2/ARE pathway through TET1 in diabetic nephropathy. (2021) Cell Biol Int. Pubmed Cell Biol Int

Choi BH, Kim JM and Kwak MK. The multifaceted role of NRF2 in cancer progression and cancer stem cells maintenance. (2021) Arch Pharm Res. 44, 263-280 Pubmed Arch Pharm Res

Zhang J, Zhou B, Sun J, Chen H and Yang Z. Betulin ameliorates 7,12-dimethylbenz(a)anthracene-induced rat mammary cancer by modulating MAPK and AhR/Nrf-2 signaling pathway. (2021) J Biochem Mol Toxicol. e22779 Pubmed J Biochem Mol Toxicol

Obrador E, Salvador-Palmer R, Jihad-Jebbar A, López-Blanch R, Dellinger TH, Dellinger RW and Estrela JM. Pterostilbene in Cancer Therapy. (2021) Antioxidants (Basel). 10, Pubmed Antioxidants (Basel) PMC Article

Qian ZJ, Chen MF, Chen J, Zhang Y, Zhou C, Hong P and Yang P. Intracellular ethanol-mediated oxidation and apoptosis in HepG2/CYP2E1 cells impaired by two active peptides from seahorse ( bleeler) protein hydrolysates via the Nrf2/HO-1 and akt pathways. (2021) Food Sci Nutr. 9, 1584-1602 Pubmed Food Sci Nutr PMC Article

Park C, Park J, Kim WJ, Kim W, Cheong H and Kim SJ. Malonic Acid Isolated from Inhibits UVB-Induced Oxidative Stress and Inflammation in HaCaT Keratinocytes. (2021) Polymers (Basel). 13, Pubmed Polymers (Basel) PMC Article

Xu Y, Tu W, Sun D, Chen X, Ge Y, Yao S, Li B, Zhenbo Zhang and Liu Y. Nrf2 alleviates radiation-induced rectal injury by inhibiting of necroptosis. (2021) Biochem Biophys Res Commun. 554, 49-55 Pubmed Biochem Biophys Res Commun

Ibrahim Al-Obaide MA, Arutla V, Bacolod MD, Wang W, Zhang R and Srivenugopal KS. Genomic Space of in Human Glioma Revisited: Novel Motifs, Regulatory RNAs, NRF1, 2, and CTCF Involvement in Gene Expression. (2021) Int J Mol Sci. 22, Pubmed Int J Mol Sci PMC Article

Cen M, Ouyang W, Zhang W, Yang L, Lin X, Dai M, Hu H, Tang H, Liu H, Xia J and Xu F. MitoQ protects against hyperpermeability of endothelium barrier in acute lung injury via a Nrf2-dependent mechanism. (2021) Redox Biol. 41, 101936 Pubmed Redox Biol PMC Article

. Autophagy-Deficient Pancreatic Cancer Cells Depend on Macropinocytosis. (2021) Cancer Discov. Pubmed Cancer Discov

Kim J. Pre-Clinical Neuroprotective Evidences and Plausible Mechanisms of Sulforaphane in Alzheimer's Disease. (2021) Int J Mol Sci. 22, Pubmed Int J Mol Sci PMC Article

Mirzaei S, Mohammadi AT, Gholami MH, Hashemi F, Zarrabi A, Zabolian A, Hushmandi K, Makvandi P, Samec M, Liskova A, Kubatka P, Nabavi N, Aref AR, Ashrafizadeh M, Khan H and Najafi M. Nrf2 signaling pathway in cisplatin chemotherapy: Potential involvement in organ protection and chemoresistance. (2021) Pharmacol Res. 167, 105575 Pubmed Pharmacol Res

Piovan A, Filippini R, Corbioli G, Costa VD, Giunco EMV, Burbello G, Pagetta A, Giusti P and Zusso M. Carotenoid Extract Derived from Euglena gracilis Overcomes Lipopolysaccharide-Induced Neuroinflammation in Microglia: Role of NF-κB and Nrf2 Signaling Pathways. (2021) Mol Neurobiol. Pubmed Mol Neurobiol

Sun J, Zhou C, Zhao Y, Zhang X, Chen W, Zhou Q, Hu B, Gao D, Raatz L, Wang Z, Nelson PJ, Jiang Y, Ren N, Bruns CJ and Zhou H. Quiescin sulfhydryl oxidase 1 promotes sorafenib-induced ferroptosis in hepatocellular carcinoma by driving EGFR endosomal trafficking and inhibiting NRF2 activation. (2021) Redox Biol. 41, 101942 Pubmed Redox Biol

Walters TS, McIntosh DJ, Ingram SM, Tillery L, Motley ED, Arinze IJ and Misra S. SUMO-Modification of Human Nrf2 at K and K Regulates Its Nucleocytoplasmic Localization, Stability and Transcriptional Activity. (2021) Cell Physiol Biochem. 55, 141-159 Pubmed Cell Physiol Biochem

Klein MI, Cannataro VL, Townsend JP, Newman S, Stern DF and Zhao H. Identifying modules of cooperating cancer drivers. (2021) Mol Syst Biol. 17, e9810 Pubmed Mol Syst Biol PMC Article

Rahman S, Mathew S, Nair P, Ramadan WS and Vazhappilly CG. Health benefits of cyanidin-3-glucoside as a potent modulator of Nrf2-mediated oxidative stress. (2021) Inflammopharmacology. Pubmed Inflammopharmacology

Alshammari GM, Al-Qahtani WH, AlFaris NA, Alzahrani NS, Alkhateeb MA and Yahya MA. Quercetin prevents cadmium chloride-induced hepatic steatosis and fibrosis by downregulating the transcription of miR-21. (2021) Biofactors. Pubmed Biofactors

Yue CF, Li LS, Ai L, Deng JK and Guo YM. sMicroRNA-28-5p acts as a metastasis suppressor in gastric cancer by targeting Nrf2. (2021) Exp Cell Res. 402, 112553 Pubmed Exp Cell Res

Yuan T, Sun J, Tian J, Hu J, Yin H and Yin J. Involvement of ABC transporters in the detoxification of non-substrate nanoparticles in lung and cervical cancer cells. (2021) Toxicology. 455, 152762 Pubmed Toxicology

Liao W, Zhao S, Yang Z, Yang W, Huang L, Liu F, Liu M, Ge J, Wang Y and Jiang S. Illicium verum and Eucommia ulmoides leaf extracts promote nutrient availability and antioxidant capacity in piglets by upregulating duodenal and jejunal Nrf2/TNF-α. (2021) J Anim Physiol Anim Nutr (Berl). Pubmed J Anim Physiol Anim Nutr (Berl)

Kim EH, Kim SJ, Na HK, Han W, Kim NJ, Suh YG and Surh YJ. 15-Deoxy-Δ-prostaglandin J Upregulates VEGF Expression via NRF2 and Heme Oxygenase-1 in Human Breast Cancer Cells. (2021) Cells. 10, Pubmed Cells PMC Article

Kim SH, Yum HW, Kim SH, Kim W, Kim SJ, Kim C, Kim K, Suh YG and Surh YJ. Protective Effects of Taurine Chloramine on Experimentally Induced Colitis: NFκB, STAT3, and Nrf2 as Potential Targets. (2021) Antioxidants (Basel). 10, Pubmed Antioxidants (Basel) PMC Article

Meng C, Zhan J, Chen D, Shao G, Zhang H, Gu W and Luo J. The deubiquitinase USP11 regulates cell proliferation and ferroptotic cell death via stabilization of NRF2 USP11 deubiquitinates and stabilizes NRF2. (2021) Oncogene. 40, 1706-1720 Pubmed Oncogene

Barrera G, Cucci MA, Grattarola M, Dianzani C, Muzio G and Pizzimenti S. Control of Oxidative Stress in Cancer Chemoresistance: Spotlight on Nrf2 Role. (2021) Antioxidants (Basel). 10, Pubmed Antioxidants (Basel)

Abo El-Magd NF, El-Mesery M, El-Karef A and El-Shishtawy MM. Amelioration effect of black seed oil against high-fat diet-induced obesity in rats through Nrf2/HO-1 pathway. (2021) J Food Biochem. e13693 Pubmed J Food Biochem

Yang C, Zhang Y, Lin S, Liu Y and Li W. Suppressing the KIF20A/NUAK1/Nrf2/GPX4 signaling pathway induces ferroptosis and enhances the sensitivity of colorectal cancer to oxaliplatin. (2021) Aging (Albany NY). 13, Pubmed Aging (Albany NY)

Liang X and Wang R. The Nrf2 inhibitor brusatol has a protective role in a rat model of oxygen-induced retinopathy of prematurity. (2021) Vis Neurosci. 38, E002 Pubmed Vis Neurosci

Yang HL, Lin CP, Vudhya Gowrisankar Y, Huang PJ, Chang WL, Shrestha S and Hseu YC. The anti-melanogenic effects of ellagic acid through induction of autophagy in melanocytes and suppression of UVA-activated α-MSH pathways via Nrf2 activation in keratinocytes. (2021) Biochem Pharmacol. 185, 114454 Pubmed Biochem Pharmacol

Wallis KF, Morehead LC, Bird JT, Byrum SD and Miousse IR. Differences in cell death in methionine versus cysteine depletion. (2021) Environ Mol Mutagen. 62, 216-226 Pubmed Environ Mol Mutagen

Guerrero-Rubio MA, Hernández-García S, García-Carmona F and Gandía-Herrero F. Flavonoids' Effects on Longevity, Fat Accumulation, Stress Resistance and Gene Modulation Involve mTOR, SKN-1 and DAF-16. (2021) Antioxidants (Basel). 10, Pubmed Antioxidants (Basel) PMC Article

Reis R, Orak D, Yilmaz D, Cimen H and Sipahi H. Modulation of cigarette smoke extract-induced human bronchial epithelial damage by eucalyptol and curcumin. (2021) Hum Exp Toxicol. 960327121997986 Pubmed Hum Exp Toxicol

Telkoparan-Akillilar P, Panieri E, Cevik D, Suzen S and Saso L. Therapeutic Targeting of the NRF2 Signaling Pathway in Cancer. (2021) Molecules. 26, Pubmed Molecules PMC Article

Zhang Z, Peng L, Fu Y, Wang W, Wang P and Zhou F. Ginnalin A Binds to the Subpockets of Keap1 Kelch Domain To Activate the Nrf2-Regulated Antioxidant Defense System in SH-SY5Y Cells. (2021) ACS Chem Neurosci. 12, 872-882 Pubmed ACS Chem Neurosci

Kim CW, Oh ET and Park HJ. A strategy to prevent atherosclerosis via TNF receptor regulation. (2021) FASEB J. 35, e21391 Pubmed FASEB J

Tascioglu Aliyev A, Panieri E, Stepanić V, Gurer-Orhan H and Saso L. Involvement of NRF2 in Breast Cancer and Possible Therapeutical Role of Polyphenols and Melatonin. (2021) Molecules. 26, Pubmed Molecules

Yuvaraj S, Ramprasath T, Saravanan B, Vasudevan V, Sasikumar S and Selvam GS. Chrysin attenuates high-fat-diet-induced myocardial oxidative stress via upregulating eNOS and Nrf2 target genes in rats. (2021) Mol Cell Biochem. Pubmed Mol Cell Biochem

Meng M, Zhang R, Han R, Kong Y, Wang R and Hou L. The polysaccharides from the fruiting body prevent lipopolysaccharide/D-galactosamine-induced acute liver injury the miR-122-Nrf2/ARE pathways. (2021) Food Funct. 12, 1973-1982 Pubmed Food Funct

Weng Q, Sun H, Fang C, Xia F, Liao H, Lee J, Wang J, Xie A, Ren J, Guo X, Li F, Yang B and Ling D. Catalytic activity tunable ceria nanoparticles prevent chemotherapy-induced acute kidney injury without interference with chemotherapeutics. (2021) Nat Commun. 12, 1436 Pubmed Nat Commun PMC Article

Borlinghaus J, Foerster Née Reiter J, Kappler U, Antelmann H, Noll U, Gruhlke MCH and Slusarenko AJ. Allicin, the Odor of Freshly Crushed Garlic: A Review of Recent Progress in Understanding Allicin's Effects on Cells. (2021) Molecules. 26, Pubmed Molecules PMC Article

Zhao B, Li GP, Peng JJ, Ren LH, Lei LC, Ye HM, Wang ZY and Zhao S. Schizandrin B attenuates hypoxia/reoxygenation injury in H9c2 cells by activating the AMPK/Nrf2 signaling pathway. (2021) Exp Ther Med. 21, 220 Pubmed Exp Ther Med PMC Article

Endo S, Kawai M, Hoshi M, Segawa J, Fujita M, Matsukawa T, Fujimoto N, Matsunaga T and Ikari A. Targeting Nrf2-antioxidant signaling reverses acquired cabazitaxel resistance in prostate cancer cells. (2021) J Biochem. Pubmed J Biochem

Jia XB, Zhang Q, Xu L, Yao WJ and Wei L. Lotus leaf flavonoids induce apoptosis of human lung cancer A549 cells through the ROS/p38 MAPK pathway. (2021) Biol Res. 54, 7 Pubmed Biol Res PMC Article

El Shaffei I, Abdel-Latif GA, Farag DB, Schaalan M and Salama RM. Ameliorative effect of betanin on experimental cisplatin-induced liver injury; the novel impact of miRNA-34a on the SIRT1/PGC-1α signaling pathway. (2021) J Biochem Mol Toxicol. e22753 Pubmed J Biochem Mol Toxicol

Padilla J and Lee J. A Novel Therapeutic Target, BACH1, Regulates Cancer Metabolism. (2021) Cells. 10, Pubmed Cells PMC Article

Soliman AM, Mekkawy MH, Karam HM, Higgins M, Dinkova-Kostova AT and Ghorab MM. Novel iodinated quinazolinones bearing sulfonamide as new scaffold targeting radiation induced oxidative stress. (2021) Bioorg Med Chem Lett. 128002 Pubmed Bioorg Med Chem Lett

Papalexi E, Mimitou EP, Butler AW, Foster S, Bracken B, Mauck WM, Wessels HH, Hao Y, Yeung BZ, Smibert P and Satija R. Characterizing the molecular regulation of inhibitory immune checkpoints with multimodal single-cell screens. (2021) Nat Genet. 53, 322-331 Pubmed Nat Genet PMC Article

Rui Q, Cao S, Wang X, Duan X, Iao X, Dong W, Fang Q, Zhang X and Xue Q. LMTK2 regulates inflammation in lipopolysaccharide-stimulated BV2 cells. (2021) Exp Ther Med. 21, 219 Pubmed Exp Ther Med PMC Article

Verdina A, Di Segni M, Amoreo CA, Sperduti I, Buglioni S, Mottolese M, Di Rocco G and Soddu S. HIPK2 is a potential predictive marker of a favorable response for adjuvant chemotherapy in stage II colorectal cancer. (2021) Oncol Rep. 45, 899-910 Pubmed Oncol Rep

Addison R, Weatherhead SC, Pawitri A, Smith GR, Rider A, Grantham HJ, Cockell SJ and Reynolds NJ. Therapeutic wavelengths of ultraviolet B radiation activate apoptotic, circadian rhythm, redox signalling and key canonical pathways in psoriatic epidermis. (2021) Redox Biol. 41, 101924 Pubmed Redox Biol

Fu C, Zheng Y, Lin K, Wang H, Chen T, Li L, Huang J, Lin W, Zhu J, Li P, Fu X and Lin Z. Neuroprotective effect of apigenin against hypoxic-ischemic brain injury in neonatal rats activation of the PI3K/Akt/Nrf2 signaling pathway. (2021) Food Funct. 12, 2270-2281 Pubmed Food Funct

Xie C, Ma H, Shi Y, Li J, Wu H, Wang B, Shao Z, Huang C, Chen J, Sun L, Zhou Y, Tian N, Wu Y, Gao W, Wu A, Wang X and Zhang X. Cardamonin protects nucleus pulposus cells against IL-1β-induced inflammation and catabolism via Nrf2/NF-κB axis. (2021) Food Funct. 12, 2703-2714 Pubmed Food Funct

Chun KS, Kim DH and Surh YJ. Role of Reductive versus Oxidative Stress in Tumor Progression and Anticancer Drug Resistance. (2021) Cells. 10, Pubmed Cells

Li Z, Wang Y, Zhang Y, Wang X, Gao B, Li Y, Li R and Wang J. Protective Effects of Fisetin on Hepatic Ischemia-reperfusion Injury Through Alleviation of Apoptosis and Oxidative Stress. (2021) Arch Med Res. 52, 163-173 Pubmed Arch Med Res

Wang Z, Zheng N, Liang J, Wang Q, Zu X, Wang H, Yuan H, Zhang R, Guo S, Liu Y and Zhou J. Emodin resists to Cyprinid herpesvirus 3 replication via the pathways of Nrf2/Keap1-ARE and NF-κB in the ornamental koi carp (Cyprinus carpio haematopterus). (2021) Comp Biochem Physiol C Toxicol Pharmacol. 109023 Pubmed Comp Biochem Physiol C Toxicol Pharmacol

Mirzaei S, Zarrabi A, Hashemi F, Zabolian A, Saleki H, Azami N, Hamzehlou S, Farahani MV, Hushmandi K, Ashrafizadeh M, Khan H and Kumar AP. Nrf2 Signaling Pathway in Chemoprotection and Doxorubicin Resistance: Potential Application in Drug Discovery. (2021) Antioxidants (Basel). 10, Pubmed Antioxidants (Basel) PMC Article

Vairetti M, Di Pasqua LG, Cagna M, Richelmi P, Ferrigno A and Berardo C. Changes in Glutathione Content in Liver Diseases: An Update. (2021) Antioxidants (Basel). 10, Pubmed Antioxidants (Basel) PMC Article

Tan HH, Thomas NF, Inayat-Hussain SH and Chan KM. (E)-N-(2-(3, 5-Dimethoxystyryl) phenyl) furan-2-carboxamide (BK3C231) induces cytoprotection in CCD18-Co human colon fibroblast cells through Nrf2/ARE pathway activation. (2021) Sci Rep. 11, 4773 Pubmed Sci Rep PMC Article

Krajka-Kuźniak V, Paluszczak J, Kleszcz R and Baer-Dubowska W. (+)-Usnic acid modulates the Nrf2-ARE pathway in FaDu hypopharyngeal carcinoma cells. (2021) Mol Cell Biochem. Pubmed Mol Cell Biochem

Kang JI, Kim DH, Sung KW, Shim SM, Cha-Molstad H, Soung NK, Lee KH, Hwang J, Lee HG, Kwon YT and Kim BY. p62-Induced Cancer-Associated Fibroblast Activation via the Nrf2-ATF6 Pathway Promotes Lung Tumorigenesis. (2021) Cancers (Basel). 13, Pubmed Cancers (Basel) PMC Article

Chen Y, Shao X, Cao J, Zhu H, Yang B, He Q and Ying M. Phosphorylation regulates cullin-based ubiquitination in tumorigenesis. (2021) Acta Pharm Sin B. 11, 309-321 Pubmed Acta Pharm Sin B PMC Article

Shchulkin AV, Abalenikhina YV, Erokhina PD, Chernykh IV and Yakusheva EN. The Role of P-Glycoprotein in Decreasing Cell Membranes Permeability during Oxidative Stress. (2021) Biochemistry (Mosc). 86, 197-206 Pubmed Biochemistry (Mosc)

Ansari MA, Raish M, Bin Jardan YA, Ahmad A, Shahid M, Ahmad SF, Haq N, Khan MR and Bakheet SA. Sinapic acid ameliorates D-galactosamine/lipopolysaccharide-induced fulminant hepatitis in rats: Role of nuclear factor erythroid-related factor 2/heme oxygenase-1 pathways. (2021) World J Gastroenterol. 27, 592-608 Pubmed World J Gastroenterol PMC Article

Kim SH, Kim M, Kwon D, Pyo JS, Kim JH, Kwak JH and Jung YS. -Phenyl Cinnamamide Derivatives Protect Hepatocytes against Oxidative Stress by Inducing Cellular Glutathione Synthesis via Nuclear Factor (Erythroid-Derived 2)-Like 2 Activation. (2021) Molecules. 26, Pubmed Molecules PMC Article

Ha YJ, Choi YS, Oh YR, Kang EH, Khang G, Park YB and Lee YJ. Fucoxanthin Suppresses Osteoclastogenesis via Modulation of MAP Kinase and Nrf2 Signaling. (2021) Mar Drugs. 19, Pubmed Mar Drugs PMC Article

Szopa A, Bogatko K, Herbet M, Serefko A, Ostrowska M, Wośko S, Świąder K, Szewczyk B, Wlaź A, Skałecki P, Wróbel A, Mandziuk S, Pochodyła A, Kudela A, Dudka J, Radziwoń-Zaleska M, Wlaź P and Poleszak E. The Interaction of Selective A1 and A2A Adenosine Receptor Antagonists with Magnesium and Zinc Ions in Mice: Behavioural, Biochemical and Molecular Studies. (2021) Int J Mol Sci. 22, Pubmed Int J Mol Sci PMC Article

Li H, Jiang M, Zhao SY, Zhang SQ, Lu L, He X, Feng GX, Wu X and Fan SJ. Exosomes are involved in total body irradiation-induced intestinal injury in mice. (2021) Acta Pharmacol Sin. Pubmed Acta Pharmacol Sin

Ibrahim S, Chaigne J, Dakik H, Fourbon Y, Corset L, Lecomte T, Raoul W and Guéguinou M. SK4 oncochannels regulate calcium entry and promote cell migration in KRAS-mutated colorectal cancer. (2021) Cell Calcium. 96, 102384 Pubmed Cell Calcium

Garufi A, Giorno E, Gilardini Montani MS, Pistritto G, Crispini A, Cirone M and D'Orazi G. P62/SQSTM1/Keap1/NRF2 Axis Reduces Cancer Cells Death-Sensitivity in Response to Zn(II)-Curcumin Complex. (2021) Biomolecules. 11, Pubmed Biomolecules PMC Article

Zhang M, Zhang X, Chu X, Cheng L and Cai C. Long non-coding RNA MALAT1 plays a protective role in bronchopulmonary dysplasia via the inhibition of apoptosis and interaction with the Keap1/Nrf2 signal pathway. (2021) Transl Pediatr. 10, 265-275 Pubmed Transl Pediatr PMC Article

Hamada S, Matsumoto R, Tanaka Y, Taguchi K, Yamamoto M and Masamune A. Nrf2 Activation Sensitizes K-Ras Mutant Pancreatic Cancer Cells to Glutaminase Inhibition. (2021) Int J Mol Sci. 22, Pubmed Int J Mol Sci PMC Article

Wang H, Lu J, Mandel JA, Zhang W, Schwalbe M, Gorka J, Liu Y, Marburger B, Wang J, Ranganathan S and Prochownik EV. Patient-Derived Mutant Forms of NFE2L2/NRF2 Drive Aggressive Murine Hepatoblastomas. (2021) Cell Mol Gastroenterol Hepatol. Pubmed Cell Mol Gastroenterol Hepatol

Lee D, Zhang MS, Tsang FH, Bao MH, Xu IM, Kit-Ho Lai R, Chiu DK, Tse AP, Law CT, Chan CY, Yuen VW, Chui NN, Oi-Lin Ng I, Wong CM and Wong CC. Adaptive and Constitutive Activations of Malic Enzymes Confer Liver Cancer Multi-layered Protection against ROS. (2021) Hepatology. Pubmed Hepatology

Hedrich WD and Wang H. Friend or Foe: Xenobiotic Activation of Nrf2 in Disease Control and Cardioprotection. (2021) Pharm Res. 38, 213-241 Pubmed Pharm Res

Peng D, Zaika A, Que J and El-Rifai W. The antioxidant response in Barrett's tumorigenesis: A double-edged sword. (2021) Redox Biol. 41, 101894 Pubmed Redox Biol PMC Article

Milne JV, Zhang BZ, Fujihara KM, Dawar S, Phillips WA and Clemons NJ. Transketolase regulates sensitivity to APR-246 in p53-null cells independently of oxidative stress modulation. (2021) Sci Rep. 11, 4480 Pubmed Sci Rep PMC Article

Zhang H, Ge F, Shui X, Xiang Y, Wang X, Liao C and Wang J. NIX protein enhances antioxidant capacity of and reduces the apoptosis induced by HSP90 inhibitor luminespib/NVP-AUY922 in PC12 cells. (2021) Cell Stress Chaperones. Pubmed Cell Stress Chaperones

Das M and Devi KP. Dihydroactinidiolide regulates Nrf2/HO-1 expression and inhibits caspase-3/Bax pathway to protect SH-SY5Y human neuroblastoma cells from oxidative stress induced neuronal apoptosis. (2021) Neurotoxicology. 84, 53-63 Pubmed Neurotoxicology

Sekine H and Motohashi H. Roles of CNC Transcription Factors NRF1 and NRF2 in Cancer. (2021) Cancers (Basel). 13, Pubmed Cancers (Basel) PMC Article

Wang W, Li S and Song M. polysaccharide inhibits high glucose-induced oxidative stress, inflammatory response, and apoptosis in RPE cells. (2021) J Recept Signal Transduct Res. 1-8 Pubmed J Recept Signal Transduct Res

Bian S, Zhao Y, Li F, Lu S, Yang S, Liu M, Wang S, Zhao D, Zhang W and Wang J. Knockdown of p62/sequestosome enhances ginsenoside Rh2-induced apoptosis in cervical cancer HeLa cells with no effect on autophagy. (2021) Biosci Biotechnol Biochem. Pubmed Biosci Biotechnol Biochem

Xie K, Chen L and Yang J. RNA Sequencing Evidences the Prevention of Oxidative Stress is Effective in Injury-Induced Heterotopic Ossification Treatment. (2021) J Biomed Nanotechnol. 17, 196-204 Pubmed J Biomed Nanotechnol

Kaikini AA, Muke S, Peshattiwar V, Bagle S, Dighe V and Sathaye S. Ethyl ferulate, a lipophilic phenylpropanoid, prevents diabetes-associated renal injury in rats by amelioration of hyperglycemia-induced oxidative stress via activation of nuclear factor erythroid 2-related factor 2. (2021) J Food Biochem. e13607 Pubmed J Food Biochem

Ma S, McGuire MH, Mangala LS, Lee S, Stur E, Hu W, Bayraktar E, Villar-Prados A, Ivan C, Wu SY, Yokoi A, Dasari SK, Jennings NB, Liu J, Lopez-Berestein G, Ram P and Sood AK. Gain-of-function p53 protein transferred via small extracellular vesicles promotes conversion of fibroblasts to a cancer-associated phenotype. (2021) Cell Rep. 34, 108726 Pubmed Cell Rep PMC Article

Tao J, Krutsenko Y, Moghe A, Singh S, Poddar M, Bell A, Oertel M, Singhi AD, Geller D, Chen X, Lujambio A, Liu S and Monga SP. Nrf2 and β-catenin coactivation in hepatocellular cancer: Biological and therapeutic implications. (2021) Hepatology. Pubmed Hepatology

Rizvi A, Farhan M, Nabi F, Khan RH, Adil M and Ahmad A. Transcriptional control of the oxidative stress response and implications of using plant derived molecules for therapeutic interventions in cancer. (2021) Curr Med Chem. Pubmed Curr Med Chem

Sheng Y, Yang G, Casey K, Curry S, Oliver M, Han SM, Leeuwenburgh C and Xiao R. A novel role of the mitochondrial iron-sulfur cluster assembly protein ISCU-1/ISCU in longevity and stress response. (2021) Geroscience. Pubmed Geroscience

Sayed EA, Badr G, Hassan KA, Waly H, Ozdemir B, Mahmoud MH and Alamery S. Induction of liver fibrosis by CCl4 mediates pathological alterations in the spleen and lymph nodes: The potential therapeutic role of propolis. (2021) Saudi J Biol Sci. 28, 1272-1282 Pubmed Saudi J Biol Sci PMC Article

Mohamed ME, Abduldaium MS and Younis NS. Cardioprotective Effect of Linalool against Isoproterenol-Induced Myocardial Infarction. (2021) Life (Basel). 11, Pubmed Life (Basel) PMC Article

Terasaki M, Takahashi S, Nishimura R, Kubota A, Kojima H, Ohta T, Hamada J, Kuramitsu Y, Maeda H, Miyashita K, Takahashi M and Mutoh M. A Marine Carotenoid of Fucoxanthinol Accelerates the Growth of Human Pancreatic Cancer PANC-1 Cells. (2021) Nutr Cancer. 1-16 Pubmed Nutr Cancer

Ferraz-Bannitz R, Welendorf CR, Coelho PO, Salgado W, Nonino CB, Beraldo RA and Foss-Freitas MC. Bariatric surgery can acutely modulate ER-stress and inflammation on subcutaneous adipose tissue in non-diabetic patients with obesity. (2021) Diabetol Metab Syndr. 13, 19 Pubmed Diabetol Metab Syndr PMC Article

Mahn A and Castillo A. Potential of Sulforaphane as a Natural Immune System Enhancer: A Review. (2021) Molecules. 26, Pubmed Molecules PMC Article

Li D, Hong X, Zhao F, Ci X and Zhang S. Targeting Nrf2 may reverse the drug resistance in ovarian cancer. (2021) Cancer Cell Int. 21, 116 Pubmed Cancer Cell Int PMC Article

Qiu YH, Zhang TS, Wang XW, Wang MY, Zhao WX, Zhou HM, Zhang CH, Cai ML, Chen XF, Zhao WL and Shao RG. Mitochondria autophagy: a potential target for cancer therapy. (2021) J Drug Target. 1-16 Pubmed J Drug Target

Dar AA, Fehaid A, Alkhatani S, Alarifi S, Alqahtani WS, Albasher G, Almeer R, Alfarraj S and Moneim AA. The protective role of luteolin against the methotrexate-induced hepato-renal toxicity via its antioxidative, anti-inflammatory, and anti-apoptotic effects in rats. (2021) Hum Exp Toxicol. 960327121991905 Pubmed Hum Exp Toxicol

El-Akad RH, Abou Zeid AH, El-Rafie HM, Kandil ZA and Farag MA. Comparative metabolites profiling of Caryota mitis & Caryota urens via UPLC/MS and isolation of two novel in silico chemopreventive flavonoids. (2021) J Food Biochem. e13648 Pubmed J Food Biochem

Zhang H, Wang S, Liu Q, Zheng H, Liu X, Wang X, Shen T and Ren D. Dracomolphin A-E, new lignans from Dracocephalum moldavica. (2021) Fitoterapia. 150, 104841 Pubmed Fitoterapia

Kuscuoglu D, Bewersdorf L, Wenzel K, Gross A, Kobazi Ensari G, Luo Y, Kilic K, Hittatiya K, Golob-Schwarzl N, Leube RE, Preisinger C, George J, Metwally M, Eslam M, Lampertico P, Petta S, Mangia A, Berg T, Boonstra A, Brouwer WP, Abate ML, Loglio A, Sutton A, Nahon P, Schaefer B, Zoller H, Aigner E, Trautwein C, Haybaeck J and Strnad P. Dual proteotoxic stress accelerates liver injury via activation of p62-Nrf2. (2021) J Pathol. Pubmed J Pathol

Sanghvi VR, Mohan P, Singh K, Cao L, Berishaj M, Wolfe AL, Schatz JH, Lailler N, de Stanchina E, Viale A and Wendel HG. NRF2 Activation Confers Resistance to eIF4A Inhibitors in Cancer Therapy. (2021) Cancers (Basel). 13, Pubmed Cancers (Basel) PMC Article

Kozieł MJ, Kowalska K and Piastowska-Ciesielska AW. Nrf2: a main responsive element in cells to mycotoxin-induced toxicity. (2021) Arch Toxicol. Pubmed Arch Toxicol

Nakajima M, Matsuyama M, Kawaguchi M, Kiwamoto T, Matsuno Y, Morishima Y, Yoshida K, Sherpa M, Yazaki K, Osawa H, Muratani M, Ishii Y and Hizawa N. Nrf2 Regulates Granuloma Formation and Macrophage Activation during Mycobacterium avium Infection via Mediating Nramp1 and HO-1 Expressions. (2021) mBio. 12, Pubmed mBio PMC Article

Soliman MM, Aldhahrani A, Elshazly SA, Shukry M and Abouzed TK. Borate Ameliorates Sodium Nitrite-Induced Oxidative Stress Through Regulation of Oxidant/Antioxidant Status: Involvement of the Nrf2/HO-1 and NF-κB Pathways. (2021) Biol Trace Elem Res. Pubmed Biol Trace Elem Res

Elgohary S, Elkhodiry AA, Amin NS, Stein U and El Tayebi HM. Thymoquinone: A Tie-Breaker in SARS-CoV2-Infected Cancer Patients?. (2021) Cells. 10, Pubmed Cells PMC Article

Talebi M, Talebi M, Farkhondeh T, Mishra G, İlgün S and Samarghandian S. New insights into the role of the Nrf2 signaling pathway in green tea catechin applications. (2021) Phytother Res. Pubmed Phytother Res

Korac B, Kalezic A, Pekovic-Vaughan V, Korac A and Jankovic A. Redox changes in obesity, metabolic syndrome, and diabetes. (2021) Redox Biol. 101887 Pubmed Redox Biol

Kim MB, Kang H, Li Y, Park YK and Lee JY. Fucoxanthin inhibits lipopolysaccharide-induced inflammation and oxidative stress by activating nuclear factor E2-related factor 2 via the phosphatidylinositol 3-kinase/AKT pathway in macrophages. (2021) Eur J Nutr. Pubmed Eur J Nutr

Ali FEM, Hassanein EHM, El-Bahrawy AH, Omar ZMM, Rashwan EK, Abdel-Wahab BA and Abd-Elhamid TH. Nephroprotective effect of umbelliferone against cisplatin-induced kidney damage is mediated by regulation of NRF2, cytoglobin, SIRT1/FOXO-3, and NF- kB-p65 signaling pathways. (2021) J Biochem Mol Toxicol. e22738 Pubmed J Biochem Mol Toxicol

Tian ZY and Yang Y. [Effect of Nrf2 in tumor progression and its inhibitors in cancer therapy]. (2021) Zhongguo Zhong Yao Za Zhi. 46, 24-32 Pubmed Zhongguo Zhong Yao Za Zhi

Fu K, Chen M, Zheng H, Li C, Yang F and Niu Q. Pelargonidin ameliorates MCAO-induced cerebral ischemia/reperfusion injury in rats by the action on the Nrf2/HO-1 pathway. (2021) Transl Neurosci. 12, 20-31 Pubmed Transl Neurosci PMC Article

Hundsberger H, Stierschneider A, Sarne V, Ripper D, Schimon J, Weitzenböck HP, Schild D, Jacobi N, Eger A, Atzler J, Klein CT and Wiesner C. Concentration-Dependent Pro- and Antitumor Activities of Quercetin in Human Melanoma Spheroids: Comparative Analysis of 2D and 3D Cell Culture Models. (2021) Molecules. 26, Pubmed Molecules PMC Article

Park JM, Han YM, Park YJ and Hahm KB. Dietary intake of walnut prevented -associated gastric cancer through rejuvenation of chronic atrophic gastritis. (2021) J Clin Biochem Nutr. 68, 37-50 Pubmed J Clin Biochem Nutr PMC Article

Gong J and Xu H. Current Perspectives on the Role of Nrf2 in 5-Fluorouracil Resistance in Colorectal Cancer. (2021) Anticancer Agents Med Chem. Pubmed Anticancer Agents Med Chem

Zhang Y, Solinas A, Cairo S, Evert M, Chen X and Calvisi DF. Molecular Mechanisms of Hepatoblastoma. (2021) Semin Liver Dis. 41, 28-41 Pubmed Semin Liver Dis

Abd-Ella EM, El-Kott AF, El-Kenawy AE, Khalifa HS, Bin-Meferij MM and Alramlawy AM. Dehydroepiandrosterone protects against acetaminophen-induced liver damage in rats by upregulation of Bcl-2 and activation of sirt signalling. (2020) J Physiol Pharmacol. 71, Pubmed J Physiol Pharmacol

Li B, Yang L, Peng X, Fan Q, Wei S, Yang S, Li X, Jin H, Wu B, Huang M, Tang S, Liu J and Li H. Emerging mechanisms and applications of ferroptosis in the treatment of resistant cancers. (2020) Biomed Pharmacother. 130, 110710 Pubmed Biomed Pharmacother

Han M, Yu H, Yang K, Liu P, Yan H, Yang Z and Yang H. A Network Pharmacology-Based Approach to Investigating the Mechanisms of Fushen Granule Effects on Intestinal Barrier Injury in Chronic Renal Failure. (2021) Evid Based Complement Alternat Med. 2021, 2097569 Pubmed Evid Based Complement Alternat Med PMC Article

Zheng B, Yang Y, Li J, Li J, Zuo S, Chu X, Xu S, Ma D and Chu L. Magnesium Isoglycyrrhizinate Alleviates Arsenic Trioxide-Induced Cardiotoxicity: Contribution of Nrf2 and TLR4/NF-κB Signaling Pathway. (2021) Drug Des Devel Ther. 15, 543-556 Pubmed Drug Des Devel Ther PMC Article

Taha-Mehlitz S, Bianco G, Coto-Llerena M, Kancherla V, Bantug GR, Gallon J, Ercan C, Panebianco F, Eppenberger-Castori S, von Strauss M, Staubli S, Bolli M, Peterli R, Matter MS, Terracciano LM, von Flüe M, Ng CKY, Soysal SD, Kollmar O and Piscuoglio S. Adenylosuccinate lyase is oncogenic in colorectal cancer by causing mitochondrial dysfunction and independent activation of NRF2 and mTOR-MYC-axis. (2021) Theranostics. 11, 4011-4029 Pubmed Theranostics PMC Article

Calgarotto AK, Longhini AL, Pericole de Souza FV, Duarte ASS, Ferro KP, Santos I, Maso V, Olalla Saad ST and Torello CO. Immunomodulatory Effect of Green Tea Treatment in Combination with Low-dose Chemotherapy in Elderly Acute Myeloid Leukemia Patients with Myelodysplasia-related Changes. Integr Cancer Ther. 20, 15347354211002647 Pubmed Integr Cancer Ther PMC Article

Batinic-Haberle I, Tovmasyan A, Huang Z, Duan W, Du L, Siamakpour-Reihani S, Cao Z, Sheng H, Spasojevic I and Alvarez Secord A. HO-Driven Anticancer Activity of Mn Porphyrins and the Underlying Molecular Pathways. (2021) Oxid Med Cell Longev. 2021, 6653790 Pubmed Oxid Med Cell Longev PMC Article

Tsai TH, Lieu AS, Wang YW, Yang SF, Hsu YC and Lin CL. Therapeutic Potential of RTA 404 in Human Brain Malignant Glioma Cell Lines via Cell Cycle Arrest via p21/AKT Signaling. (2021) Biomed Res Int. 2021, 5552226 Pubmed Biomed Res Int PMC Article

Alexander JF, Seua AV, Arroyo LD, Ray PR, Wangzhou A, Heiβ-Lückemann L, Schedlowski M, Price TJ, Kavelaars A and Heijnen CJ. Nasal administration of mitochondria reverses chemotherapy-induced cognitive deficits. (2021) Theranostics. 11, 3109-3130 Pubmed Theranostics PMC Article

Han C, Wang Z, Chen S, Li L, Xu Y, Kang W, Wei C, Ma H, Wang M and Jin X. Berbamine Suppresses the Progression of Bladder Cancer by Modulating the ROS/NF-B Axis. (2021) Oxid Med Cell Longev. 2021, 8851763 Pubmed Oxid Med Cell Longev PMC Article

Chen K, Wu S, Ye S, Huang H, Zhou Y, Zhou H, Wu S, Mao Y, Shangguan F, Lan L and Chen B. Dimethyl Fumarate Induces Metabolic Crisie to Suppress Pancreatic Carcinoma. (2021) Front Pharmacol. 12, 617714 Pubmed Front Pharmacol PMC Article

Gao X, Xu D, Zhang X and Zhao H. Protective Effect of Lemon Peel Polyphenols on Oxidative Stress-Induced Damage to Human Keratinocyte HaCaT Cells Through Activation of the Nrf2/HO-1 Signaling Pathway. (2020) Front Nutr. 7, 606776 Pubmed Front Nutr PMC Article

Ladak Z, Garcia E, Yoon J, Landry T, Armstrong EA, Yager JY and Persad S. Sulforaphane (SFA) protects neuronal cells from oxygen & glucose deprivation (OGD). (2021) PLoS One. 16, e0248777 Pubmed PLoS One PMC Article

Yang CC and Yang CM. Chinese Herbs and Repurposing Old Drugs as Therapeutic Agents in the Regulation of Oxidative Stress and Inflammation in Pulmonary Diseases. (2021) J Inflamm Res. 14, 657-687 Pubmed J Inflamm Res PMC Article

Bhattacharya S, Mereness JA, Baran AM, Misra RS, Peterson DR, Ryan RM, Reynolds AM, Pryhuber GS and Mariani TJ. Lymphocyte-Specific Biomarkers Associated With Preterm Birth and Bronchopulmonary Dysplasia. (2020) Front Immunol. 11, 563473 Pubmed Front Immunol PMC Article

Fu Y and Jia J. Isoliquiritigenin Confers Neuroprotection and Alleviates Amyloid-β42-Induced Neuroinflammation in Microglia by Regulating the Nrf2/NF-κB Signaling. (2021) Front Neurosci. 15, 638772 Pubmed Front Neurosci PMC Article

Zou L, Cheng G, Xu C, Liu H, Wang Y, Li N, Fan X, Zhu C and Xia W. Copper Nanoparticles Induce Oxidative Stress via the Heme Oxygenase 1 Signaling Pathway in vitro Studies. (2021) Int J Nanomedicine. 16, 1565-1573 Pubmed Int J Nanomedicine PMC Article

Zhang Y, Chen J, Che Z, Shu C, Chen D, Ding K, Li A and Zhou J. JP3 enhances the toxicity of cisplatin on drug-resistant gastric cancer cells while reducing the damage to normal cells. (2021) J Cancer. 12, 1894-1906 Pubmed J Cancer PMC Article

Moon SJ, Jhun J, Ryu J, Kwon JY, Kim SY, Jung K, Cho ML and Min JK. The anti-arthritis effect of sulforaphane, an activator of Nrf2, is associated with inhibition of both B cell differentiation and the production of inflammatory cytokines. (2021) PLoS One. 16, e0245986 Pubmed PLoS One PMC Article

Eid BG and Abdel-Naim AB. Piceatannol Attenuates Testosterone-Induced Benign Prostatic Hyperplasia in Rats by Modulation of Nrf2/HO-1/NFκB Axis. (2020) Front Pharmacol. 11, 614897 Pubmed Front Pharmacol PMC Article

Sheng X, Yang Y, Liu J, Yu J, Guo Q, Guan W and Liu F. Ophiopogonin A Alleviates Hemorrhagic Shock-Induced Renal Injury via Induction of Nrf2 Expression. (2020) Front Physiol. 11, 619740 Pubmed Front Physiol PMC Article

Tang C, Hong J, Hu C, Huang C, Gao J, Huang J, Wang D, Geng Q and Dong Y. Palmatine Protects against Cerebral Ischemia/Reperfusion Injury by Activation of the AMPK/Nrf2 Pathway. (2021) Oxid Med Cell Longev. 2021, 6660193 Pubmed Oxid Med Cell Longev PMC Article

Hafez AM, Harb OA, Alattar AZ, Hefzi N, Ahmed RZ, Shaker SE, Ibrahim A and El-Taher AK. Clinico-pathological and prognostic implications of Srx, Nrf2, and PROX1 expression in gastric cancer and adjacent non-neoplastic mucosa - an immunohistochemical study. (2020) Contemp Oncol (Pozn). 24, 229-240 Pubmed Contemp Oncol (Pozn) PMC Article

Yuan H, Yang Q, Yang B, Xu H, Nasif O, Muruganantham S and Chen J. Phyllanthin Averts Oxidative Stress and Neuroinflammation in Cerebral Ischemic-Reperfusion Injury through Modulation of the NF-κB and AMPK/Nrf2 Pathways. (2021) J Environ Pathol Toxicol Oncol. 40, 85-97 Pubmed J Environ Pathol Toxicol Oncol

Raish M, Shahid M, Bin Jardan YA, Ansari MA, Alkharfy KM, Ahad A, Abdelrahman IA, Ahmad A and Al-Jenoobi FI. Gastroprotective Effect of Sinapic Acid on Ethanol-Induced Gastric Ulcers in Rats: Involvement of Nrf2/HO-1 and NF-κB Signaling and Antiapoptotic Role. (2021) Front Pharmacol. 12, 622815 Pubmed Front Pharmacol PMC Article

Nemmar A, Al-Salam S, Beegam S, Zaaba NE, Yasin J, Hamadi N and Ali BH. Cardiac Inflammation, Oxidative Stress, Nrf2 Expression, and Coagulation Events in Mice with Experimental Chronic Kidney Disease. (2021) Oxid Med Cell Longev. 2021, 8845607 Pubmed Oxid Med Cell Longev PMC Article

Jiang Y, Zhou W, Zhang X, Wang Y, Yang D and Li S. Protective Effect of Blood Cora Polysaccharides on H9c2 Rat Heart Cells Injury Induced by Oxidative Stress by Activating Nrf2/HO-1 Signal Pathway. (2021) Front Nutr. 8, 632161 Pubmed Front Nutr PMC Article

Chen D, Gao ZQ, Wang YY, Wan BB, Liu G, Chen JL, Wu YX, Zhou Q, Jiang SY, Yu RQ and Pang QF. Sodium Propionate Enhances Nrf2-Mediated Protective Defense Against Oxidative Stress and Inflammation in Lipopolysaccharide-Induced Neonatal Mice. (2021) J Inflamm Res. 14, 803-816 Pubmed J Inflamm Res PMC Article

Zhang Y, Han Z, Jiang A, Wu D, Li S, Liu Z, Wei Z, Yang Z and Guo C. Protective Effects of on Lipopolysaccharide-Induced Acute Lung Injury in Mice by Inhibiting NF-κB and Activating Nrf2/HO-1 Signaling Pathways. (2020) Front Pharmacol. 11, 591836 Pubmed Front Pharmacol PMC Article