English: Graph of Nrf2 publications (pubmed se...

English: Graph of Nrf2 publications (pubmed search) by year (Photo credit: Wikipedia)

There are currently over 2300 articles (peer reviewed clinical reviews and studies) on Pubmed.gov on the topic of NRF2 Activation. There are a ton of companies claiming they have scientific studies showing that their products are NRF2 Activators. Go to Pubmed.gov and type in the name of their product. Pubmed is a website operated by the National Institute of Health (NIH).  PubMed comprises over 21 million citations for biomedical literature from MEDLINE, life science journals, and online books. PubMed citations and abstracts include the fields of biomedicine and health, covering portions of the life sciences, behavioral sciences, chemical sciences, and bioengineering. PubMed also provides access to additional relevant web sites and links to the other NCBI molecular biology resources. Last 200 NRF-2 Studies published on Pubmed
Cheng L, Wang H, Li S, Liu Z and Wang C. New insights into the mechanism of Keap1-Nrf2 interaction based on cancer-associated mutations. (2021) Life Sci. 282, 119791 Pubmed Life Sci
Zhao G, Qi L, Wang Y, Li X, Li Q, Tang X, Wang X and Wu C. Antagonizing effects of curcumin against mercury-induced autophagic death and trace elements disorder by regulating PI3K/AKT and Nrf2 pathway in the spleen. (2021) Ecotoxicol Environ Saf. 222, 112529 Pubmed Ecotoxicol Environ Saf
Yang X, Wang X, Gao D, Zhang Y, Chen X, Xia Q, Jin M, Sun C, He Q, Wang R and Liu K. Developmental toxicity caused by sanguinarine in zebrafish embryos via regulating oxidative stress, apoptosis and wnt pathways. (2021) Toxicol Lett. 350, 71-80 Pubmed Toxicol Lett
Liang H, Wu L, Hamunjo Chama MK, Ge X, Ren M, Chen X, Pan L and Xia D. Culture salinity modulates Nrf2 antioxidant signaling pathway and immune response of juvenile Genetically Improved Farmed Tilapia (GIFT) (Oreochromis niloticus) under different dietary protein levels. (2021) Fish Shellfish Immunol. 117, 220-227 Pubmed Fish Shellfish Immunol
Paiboonrungruang C, Simpson E, Xiong Z, Huang C, Li J, Li Y and Chen X. Development of targeted therapy of NRF2 esophageal squamous cell carcinoma. (2021) Cell Signal. 86, 110105 Pubmed Cell Signal PMC Article
Brasil FB, de Almeida FJS, Luckachaki MD, Dall'Oglio EL and de Oliveira MR. Suppression of Mitochondria-Related Bioenergetics Collapse and Redox Impairment by Tanshinone I, a Diterpenoid Found in Salvia miltiorrhiza Bunge (Danshen), in the Human Dopaminergic SH-SY5Y Cell Line Exposed to Chlorpyrifos. (2021) Neurotox Res. 39, 1495-1510 Pubmed Neurotox Res
Li Y, Zeng J, Tian YH, Hou Y, Da H, Fang J and Gao K. Isolation, identification, and activity evaluation of diterpenoid alkaloids from Aconitum sinomontanum. (2021) Phytochemistry. 190, 112880 Pubmed Phytochemistry
Chen L, Zhang WL, Xie DQ and Jia W. Sulforaphane alleviates hepatic ischemia-reperfusion injury through promoting the activation of Nrf-2/HO-1 signaling. (2021) Transpl Immunol. 68, 101439 Pubmed Transpl Immunol
Wang Z, Wang L, Jiang R, Li C, Chen X, Xiao H, Hou J, Hu L, Huang C and Wang Y. Ginsenoside Rg1 prevents bone marrow mesenchymal stem cell senescence via NRF2 and PI3K/Akt signaling. (2021) Free Radic Biol Med. 174, 182-194 Pubmed Free Radic Biol Med
Ma Y, Li S, Ye S, Tang S, Hu D, Wei L and Xiao F. Hexavalent chromium inhibits the formation of neutrophil extracellular traps and promotes the apoptosis of neutrophils via AMPK signaling pathway. (2021) Ecotoxicol Environ Saf. 223, 112614 Pubmed Ecotoxicol Environ Saf
Li L, Zhang Q, Zhang X, Xu X, Wang X, Huang X, Wang T, Jiang Z, Xiao L, Zhang L and Sun L. Protective effects of Nrf2 against sepsis-induced hepatic injury. (2021) Life Sci. 282, 119807 Pubmed Life Sci
Wen L, Yang QH, Ma XL, Li T, Xiao S and Sun CF. Inhibition of TNFAIP1 ameliorates the oxidative stress and inflammatory injury in myocardial ischemia/reperfusion injury through modulation of Akt/GSK-3β/Nrf2 pathway. (2021) Int Immunopharmacol. 99, 107993 Pubmed Int Immunopharmacol
Fu J, Xu M, Xu L, Ni H, Zhao B, Ni C, Huang M, Zhu J, Luo G and Yao M. Sulforaphane alleviates hyperalgesia and enhances analgesic potency of morphine in rats with cancer-induced bone pain. (2021) Eur J Pharmacol. 909, 174412 Pubmed Eur J Pharmacol
Skowron MA, Oing C, Bremmer F, Ströbel P, Murray MJ, Coleman N, Amatruda JF, Honecker F, Bokemeyer C, Albers P and Nettersheim D. The developmental origin of cancers defines basic principles of cisplatin resistance. (2021) Cancer Lett. 519, 199-210 Pubmed Cancer Lett
Zhao J, Xiao X, Li Y, Gao X, Zhang X, Liu Z, Yi Y, Fu X, Wang H, Guan Y, Xia X, Zhang W and Huang J. The prevalence of HLA-I LOH in Chinese pan-cancer patients and genomic features of patients harboring HLA-I LOH. (2021) Hum Mutat. 42, 1254-1264 Pubmed Hum Mutat
Kalyankumarraju M, Puppala ER, Ahmed S, Jagadeesh Kumar G, Tene K, N P S, Sahu BD, Barua CC and Naidu VGM. Zanthoxylum alatum Roxb. seed extract ameliorates stress aggravated DSS-induced ulcerative colitis in mice: Plausible role on NF-κB signaling axis. (2021) J Ethnopharmacol. 279, 114385 Pubmed J Ethnopharmacol
Grattarola M, Cucci MA, Roetto A, Dianzani C, Barrera G and Pizzimenti S. Post-translational down-regulation of Nrf2 and YAP proteins, by targeting deubiquitinases, reduces growth and chemoresistance in pancreatic cancer cells. (2021) Free Radic Biol Med. 174, 202-210 Pubmed Free Radic Biol Med
Aydin Y, Chedid M, Chava S, Danielle Williams D, Liu S, Hagedorn CH, Sumitran-Holgersson S, Reiss K, Moroz K, Lu H, Balart LA and Dash S. Retraction Note: Activation of PERK-Nrf2 oncogenic signaling promotes Mdm2-mediated Rb degradation in persistently infected HCV culture. (2021) Sci Rep. 11, 17779 Pubmed Sci Rep
Liu H, Zhu S, Han W, Cai Y and Liu C. DMEP induces mitochondrial damage regulated by inhibiting Nrf2 and SIRT1/PGC-1α signaling pathways in HepG2 cells. (2021) Ecotoxicol Environ Saf. 221, 112449 Pubmed Ecotoxicol Environ Saf
Lalrinzuali K, Vabeiryureilai M and Jagetia GC. Sonapatha (Oroxylum indicum) mediates cytotoxicity in cultured HeLa cells by inducing apoptosis and suppressing NF-κB, COX-2, RASSF7 and NRF2. (2021) Bioorg Chem. 114, 105126 Pubmed Bioorg Chem
Baranwal A, Aggarwal P, Rai A and Kumar N. Pharmacological actions and underlying mechanisms of Catechin: A review. (2021) Mini Rev Med Chem. Pubmed Mini Rev Med Chem
Wang Y, Chang W, Li X, Jiang Z, Zhou D, Feng Y, Li B, Chen G and Li N. Apigenin exerts chemopreventive effects on lung injury induced by SiO nanoparticles through the activation of Nrf2. (2021) J Nat Med. Pubmed J Nat Med
Cao L, Zhao J, Ma L, Chen J, Xu J, Rahman SU, Feng S, Li Y, Wu J and Wang X. Lycopene attenuates zearalenone-induced oxidative damage of piglet sertoli cells through the nuclear factor erythroid-2 related factor 2 signaling pathway. (2021) Ecotoxicol Environ Saf. 225, 112737 Pubmed Ecotoxicol Environ Saf
Deng N, Jiang H, Wu P, Yang Q, Li S, Li J, Wang X, Han B, Han B, Lv Z and Zhang Z. Inhibition of the Nrf2/p38MAPK pathway involved in deltamethrin-induced apoptosis and fibrosis in quail kidney. (2021) Food Chem Toxicol. 155, 112382 Pubmed Food Chem Toxicol
Alshammari GM, Al-Qahtani WH, AlFaris NA, Albekairi NA, Alqahtani S, Eid R, Yagoub AEA, Al-Harbi LN and Yahya MA. Quercetin alleviates cadmium chloride-induced renal damage in rats by suppressing endoplasmic reticulum stress through SIRT1-dependent deacetylation of Xbp-1s and eIF2α. (2021) Biomed Pharmacother. 141, 111862 Pubmed Biomed Pharmacother
Pahlke G, Ahlberg K, Oertel A, Janson-Schaffer T, Grabher S, Mock HP, Matros A and Marko D. Antioxidant Effects of Elderberry Anthocyanins in Human Colon Carcinoma Cells: A Study on Structure-Activity Relationships. (2021) Mol Nutr Food Res. 65, e2100229 Pubmed Mol Nutr Food Res
Torrente L and DeNicola GM. Targeting NRF2 and Its Downstream Processes: Opportunities and Challenges. (2021) Annu Rev Pharmacol Toxicol. Pubmed Annu Rev Pharmacol Toxicol
Zhang Y, Wang O, Ma N, Yi J, Mi H and Cai S. The preventive effect and underlying mechanism of Mill. fruits on dextran sulphate sodium-induced ulcerative colitis in mice. (2021) Food Funct. Pubmed Food Funct
Liang Z, Zhao W, Li X, Wang L, Meng L and Yu R. Cisplatin synergizes with PRLX93936 to induce ferroptosis in non-small cell lung cancer cells. (2021) Biochem Biophys Res Commun. 569, 79-85 Pubmed Biochem Biophys Res Commun
Zgorzynska E, Dziedzic B and Walczewska A. An Overview of the Nrf2/ARE Pathway and Its Role in Neurodegenerative Diseases. (2021) Int J Mol Sci. 22, Pubmed Int J Mol Sci
Da Silveira AR, Rosa ÉVF, Sari MHM, Sampaio TB, Dos Santos JT, Jardim NS, Müller SG, Oliveira MS, Nogueira CW and Furian AF. Therapeutic potential of beta-caryophyllene against aflatoxin B1-Induced liver toxicity: Biochemical and molecular insights in rats. (2021) Chem Biol Interact. 109635 Pubmed Chem Biol Interact
Younis NS, Elsewedy HS, Soliman WE, Shehata TM and Mohamed ME. Geraniol isolated from lemon grass to mitigate doxorubicin-induced cardiotoxicity through Nrf2 and NF-κB signaling. (2021) Chem Biol Interact. 347, 109599 Pubmed Chem Biol Interact
Chen SJ, Hseu YC, Gowrisankar YV, Chung YT, Zhang YZ, Way TD and Yang HL. The anti-melanogenic effects of 3-O-ethyl ascorbic acid via Nrf2-mediated α-MSH inhibition in UVA-irradiated keratinocytes and autophagy induction in melanocytes. (2021) Free Radic Biol Med. 173, 151-169 Pubmed Free Radic Biol Med
Mineo S, Takahashi N, Yamada-Hara M, Tsuzuno T, Aoki-Nonaka Y and Tabeta K. Rice bran-derived protein fractions enhance sulforaphane-induced anti-oxidative activity in gingival epithelial cells. (2021) Arch Oral Biol. 129, 105215 Pubmed Arch Oral Biol
Joshi A, Upadhyay KK, Vohra A, Shirsath K and Devkar R. Melatonin induces Nrf2-HO-1 reprogramming and corrections in hepatic core clock oscillations in Non-alcoholic fatty liver disease. (2021) FASEB J. 35, e21803 Pubmed FASEB J
Fu J, Ni C, Ni HD, Xu LS, He QL, Pan H, Huang DD, Sun YB, Luo G, Liu MJ and Yao M. Spinal Nrf2 translocation may inhibit neuronal NF-κB activation and alleviate allodynia in a rat model of bone cancer pain. (2021) J Neurochem. 158, 1110-1130 Pubmed J Neurochem
Niu LT, Wang YQ, Wong CCL, Gao SX, Mo XD and Huang XJ. Targeting IFN-γ-inducible lysosomal thiol reductase overcomes chemoresistance in AML through regulating the ROS-mediated mitochondrial damage. (2021) Transl Oncol. 14, 101159 Pubmed Transl Oncol PMC Article
Dempke WCM and Reck M. KEAP1/NRF2 (NFE2L2) mutations in NSCLC - Fuel for a superresistant phenotype?. (2021) Lung Cancer. 159, 10-17 Pubmed Lung Cancer
Agha KA, Ibrahim TS, Elsherbiny NM, El-Sherbiny M, Abdel-Aal EH, Abdel-Samii ZK and Abo-Dya NE. Design, synthesis and pharmacological screening of novel renoprotective methionine-based peptidomimetics: Amelioration of cisplatin-induced nephrotoxicity. (2021) Bioorg Chem. 114, 105100 Pubmed Bioorg Chem
Marderstein AR, Kulm S, Peng C, Tamimi R, Clark AG and Elemento O. A polygenic-score-based approach for identification of gene-drug interactions stratifying breast cancer risk. (2021) Am J Hum Genet. 108, 1752-1764 Pubmed Am J Hum Genet
Yu J, Yang Y, Li S and Meng P. Salinomycin triggers prostate cancer cell apoptosis by inducing oxidative and endoplasmic reticulum stress via suppressing Nrf2 signaling. (2021) Exp Ther Med. 22, 946 Pubmed Exp Ther Med PMC Article
Sanches LJ, Marinello PC, Brito WADS, Lopes NMD, Luiz RC, Cecchini R and Cecchini AL. Metformin pretreatment reduces effect to dacarbazine and suppresses melanoma cell resistance. (2021) Cell Biol Int. Pubmed Cell Biol Int
Tentscher PR, Escher BI, Schlichting R, König M, Bramaz N, Schirmer K and von Gunten U. Toxic effects of substituted p-benzoquinones and hydroquinones in in vitro bioassays are altered by reactions with the cell assay medium. (2021) Water Res. 202, 117415 Pubmed Water Res
Song Q, Peng S, Sun Z, Heng X and Zhu X. Temozolomide Drives Ferroptosis via a DMT1-Dependent Pathway in Glioblastoma Cells. (2021) Yonsei Med J. 62, 843-849 Pubmed Yonsei Med J PMC Article
Sun W, Shen Y, Xiao H and Li H. Resveratrol attenuates rotenone-induced inflammation and oxidative stress via STAT1 and Nrf2/Keap1/SLC7A11 pathway in a microglia cell line. (2021) Pathol Res Pract. 225, 153576 Pubmed Pathol Res Pract
Lee SC, Jee SC, Kim M, Kim S, Shin MK, Kim Y and Sung JS. Curcumin Suppresses the Lipid Accumulation and Oxidative Stress Induced by Benzo[a]pyrene Toxicity in HepG2 Cells. (2021) Antioxidants (Basel). 10, Pubmed Antioxidants (Basel) PMC Article
He C, Buongiorno LP, Wang W, Tang JCY, Miceli N, Taviano MF, Shan Y and Bao Y. The Inhibitory Effect of Sulforaphane on Bladder Cancer Cell Depends on GSH Depletion-Induced by Nrf2 Translocation. (2021) Molecules. 26, Pubmed Molecules PMC Article
Niederkorn M, Ishikawa C, M Hueneman K, Bartram J, Stepanchick E, R Bennett J, E Culver-Cochran A, Bolanos LC, Uible E, Choi K, Wunderlich M, Perentesis JP, M Chlon T, Filippi MD and Starczynowski DT. The deubiquitinase USP15 modulates cellular redox and is a therapeutic target in acute myeloid leukemia. (2021) Leukemia. Pubmed Leukemia
Lee W, Sim H, Choi YJ, Seo JY, Yun MY, Song GY and Bae JS. The Decursin Analog, CYJ-27, Suppresses Inflammation Via the Downregulation of NF-B and STAT-1. (2021) J Med Food. 24, 852-859 Pubmed J Med Food
Li F, Aljahdali IAM, Zhang R, Nastiuk KL, Krolewski JJ and Ling X. Kidney cancer biomarkers and targets for therapeutics: survivin (BIRC5), XIAP, MCL-1, HIF1α, HIF2α, NRF2, MDM2, MDM4, p53, KRAS and AKT in renal cell carcinoma. (2021) J Exp Clin Cancer Res. 40, 254 Pubmed J Exp Clin Cancer Res PMC Article
Qiu P, Hou W, Wang H, Lei KKW, Wang S, Chen W, Pardeshi LA, Prothro K, Shukla Y, Su SSM, Schrump DS, Chen Q, Deng CX, Xu X and Wang R. Sirt1 deficiency upregulates glutathione metabolism to prevent hepatocellular carcinoma initiation in mice. (2021) Oncogene. Pubmed Oncogene
Sayed AM, Hassanein EHM, Ali FEM, Omar ZMM, Rashwan EK, Mohammedsaleh ZM and Abd El-Ghafar OAM. Regulation of Keap-1/Nrf2/AKT and iNOS/NF-κB/TLR4 signals by apocynin abrogated methotrexate-induced testicular toxicity: Mechanistic insights and computational pharmacological analysis. (2021) Life Sci. 284, 119911 Pubmed Life Sci
Zhen X, Jindong L, Yang Z, Yashi R, Wei G, Wei J, Wei Z and Sudong L. Activation of Nrf2 Pathway by Dimethyl Fumarate Attenuates Renal Ischemia-Reperfusion Injury. (2021) Transplant Proc. Pubmed Transplant Proc
Zakria M, Ahmad N, Al Kury LT, Alattar A, Uddin Z, Siraj S, Ullah S, Alshaman R, Khan MI and Shah FA. Melatonin rescues the mice brain against cisplatin-induced neurodegeneration, an insight into antioxidant and anti-inflammatory effects. (2021) Neurotoxicology. 87, 1-10 Pubmed Neurotoxicology
Xie C, Zhou X, Liang C, Li X, Ge M, Chen Y, Yin J, Zhu J and Zhong C. Apatinib triggers autophagic and apoptotic cell death via VEGFR2/STAT3/PD-L1 and ROS/Nrf2/p62 signaling in lung cancer. (2021) J Exp Clin Cancer Res. 40, 266 Pubmed J Exp Clin Cancer Res PMC Article
Pallio G, D'Ascola A, Cardia L, Mannino F, Bitto A, Minutoli L, Picciolo G, Squadrito V, Irrera N, Squadrito F and Altavilla D. MAO-A Inhibition by Metaxalone Reverts IL-1β-Induced Inflammatory Phenotype in Microglial Cells. (2021) Int J Mol Sci. 22, Pubmed Int J Mol Sci PMC Article
Baer-Dubowska W, Narożna M and Krajka-Kuźniak V. Anti-Cancer Potential of Synthetic Oleanolic Acid Derivatives and Their Conjugates with NSAIDs. (2021) Molecules. 26, Pubmed Molecules PMC Article
Zhao Y, Lu J, Mao A, Zhang R and Guan S. Autophagy Inhibition Plays a Protective Role in Ferroptosis Induced by Alcohol via the p62-Keap1-Nrf2 Pathway. (2021) J Agric Food Chem. 69, 9671-9683 Pubmed J Agric Food Chem
Liu WC, Zhu YR, Zhao ZH, Jiang P and Yin FQ. Effects of Dietary Supplementation of Algae-Derived Polysaccharides on Morphology, Tight Junctions, Antioxidant Capacity and Immune Response of Duodenum in Broilers under Heat Stress. (2021) Animals (Basel). 11, Pubmed Animals (Basel) PMC Article
Cong P, Wang T, Tong C, Liu Y, Shi L, Mao S, Shi X, Jin H, Liu Y and Hou M. Resveratrol ameliorates thoracic blast exposure-induced inflammation, endoplasmic reticulum stress and apoptosis in the brain through the Nrf2/Keap1 and NF-κB signaling pathway. (2021) Injury. Pubmed Injury
Feng L, Zhao K, Sun L, Yin X, Zhang J, Liu C and Li B. SLC7A11 regulated by NRF2 modulates esophageal squamous cell carcinoma radiosensitivity by inhibiting ferroptosis. (2021) J Transl Med. 19, 367 Pubmed J Transl Med PMC Article
Hassanein EHM, Ahmed MA, Sayed AM, Rashwan EK, Abd El-Ghafar OAM and Mahmoud AM. Edaravone mitigates hemorrhagic cystitis by modulating Nrf2, TLR-4/NF-κB, and JAK1/STAT3 signaling in cyclophosphamide-intoxicated rats. (2021) J Biochem Mol Toxicol. e22889 Pubmed J Biochem Mol Toxicol
Yahyazadeh R, Baradaran Rahimi V, Yahyazadeh A, Mohajeri SA and Askari VR. Promising effects of gingerol against toxins: A review article. (2021) Biofactors. Pubmed Biofactors
He L, Guo C, Peng C and Li Y. Advances of natural activators for Nrf2 signaling pathway on cholestatic liver injury protection: A review. (2021) Eur J Pharmacol. 174447 Pubmed Eur J Pharmacol
Calderwood SK, Borges TJ, Eguchi T, Lang BJ, Murshid A, Okusha Y and Prince TL. Extracellular Hsp90 and protection of neuronal cells through Nrf2. (2021) Biochem Soc Trans. Pubmed Biochem Soc Trans
Lyu L, Chen Z and McCarty N. TRIM44 links the UPS to SQSTM1/p62-dependent aggrephagy and removing misfolded proteins. (2021) Autophagy. 1-16 Pubmed Autophagy
Zhang XX, Jin JW, Liu CH, Zhou M, He YX, Wang F and Liu FZ. [Effect of Nrf2/HO-1 signaling pathway in intestinal protection by Sishen Pills against ulcerative colitis in mice]. (2021) Zhongguo Zhong Yao Za Zhi. 46, 4187-4192 Pubmed Zhongguo Zhong Yao Za Zhi
Lv Z, Shen J, Gao X, Ruan Y, Ling J, Sun R, Dai J, Fan H, Cheng X and Cao P. Herbal formula Huangqi Guizhi Wuwu decoction attenuates paclitaxel-related neurotoxicity via inhibition of inflammation and oxidative stress. (2021) Chin Med. 16, 76 Pubmed Chin Med PMC Article
Zhang H, Wang Z, Hu K and Liu H. Downregulation of long noncoding RNA SNHG7 protects against inflammation and apoptosis in Parkinson's disease model by targeting the miR-425-5p/TRAF5/NF-κB axis. (2021) J Biochem Mol Toxicol. e22867 Pubmed J Biochem Mol Toxicol
. Bayer's Vividion Buy Targets Undruggable Proteins. (2021) Cancer Discov. Pubmed Cancer Discov
Lee S, Ha J, Park J, Kang E, Jeon SH, Han SB, Ningsih S, Paik JH and Cho S. Antioxidant and Anti-Inflammatory Effects of (Blume) Leaf Methanol Extracts through the Regulation of Nrf2 and TAK1. (2021) Antioxidants (Basel). 10, Pubmed Antioxidants (Basel) PMC Article
Chen B, Zhu D, Xie C, Shi Y, Ni L, Zhang H, Li S, Lu J, Xiao J, Xia W, Huang C and Wang X. 18β-Glycyrrhetinic acid inhibits IL-1β-induced inflammatory response in mouse chondrocytes and prevents osteoarthritic progression by activating Nrf2. (2021) Food Funct. Pubmed Food Funct
Shen P, Han L, Chen G, Cheng Z and Liu Q. Emodin Attenuates Acetaminophen-Induced Hepatotoxicity via the cGAS-STING Pathway. (2021) Inflammation. Pubmed Inflammation
Otsuka S, Setoyama K, Takada S, Nakanishi K, Terashi T, Norimatsu K, Tani A, Sakakima H, Maruyama I, Tancharoen S, Tanaka E and Kikuchi K. Preconditioning Exercise in Rats Attenuates Early Brain Injury Resulting from Subarachnoid Hemorrhage by Reducing Oxidative Stress, Inflammation, and Neuronal Apoptosis. (2021) Mol Neurobiol. Pubmed Mol Neurobiol
Ren X, Li Y, Zhou Y, Hu W, Yang C, Jing Q, Zhou C, Wang X, Hu J, Wang L, Yang J, Wang H, Xu H, Li H, Tong X, Wang Y and Du J. Overcoming the compensatory elevation of NRF2 renders hepatocellular carcinoma cells more vulnerable to disulfiram/copper-induced ferroptosis. (2021) Redox Biol. 46, 102122 Pubmed Redox Biol PMC Article
Vyas A, Harbison RA, Faden DL, Kubik M, Palmer D, Zhang Q, Osmanbeyoglu HU, Méndez E and Duvvuri U. Recurrent human papillomavirus-related head and neck cancer undergoes metabolic re-programming and is driven by oxidative phosphorylation. (2021) Clin Cancer Res. Pubmed Clin Cancer Res
Kim SL, Choi HS, Ko YC, Yun BS and Lee DS. 5-Hydroxymaltol Derived from Beetroot Juice through Fermentation Suppresses Inflammatory Effect and Oxidant Stress via Regulating NF-kB, MAPKs Pathway and NRF2/HO-1 Expression. (2021) Antioxidants (Basel). 10, Pubmed Antioxidants (Basel) PMC Article
Yu J, Li W, Xiao X, Huang Q, Yu J, Yang Y, Han T, Zhang D and Niu X. (-)-Epicatechin gallate blocks the development of atherosclerosis by regulating oxidative stress and . (2021) Food Funct. Pubmed Food Funct
Tanaka Y, Hamada S, Matsumoto R, Taguchi K, Yamamoto M and Masamune A. Nrf2 expression in pancreatic stellate cells promotes progression of cancer. (2021) Am J Physiol Gastrointest Liver Physiol. Pubmed Am J Physiol Gastrointest Liver Physiol
Xu Z, Li X, Li X, Gao Y and Mi X. Dioscin attenuates lipopolysaccharide-induced inflammatory myocardial injury through oxidative stress-related pathway. (2021) Ann Palliat Med. 10, 8827-8836 Pubmed Ann Palliat Med
Shati AA and El-Kott AF. Resolvin D1 protects against cadmium chloride-induced memory loss and hippocampal damage in rats: A comparison with docosahexaenoic acid. (2021) Hum Exp Toxicol. 9603271211038739 Pubmed Hum Exp Toxicol
Chen L, Jin XH, Luo J, Duan JL, Cai MY, Chen JW, Feng ZH, Guo AM, Wang FW and Xie D. ITLN1 inhibits tumor neovascularization and myeloid derived suppressor cells accumulation in colorectal carcinoma. (2021) Oncogene. Pubmed Oncogene
Awny MM, Al-Mokaddem AK and Ali BM. Mangiferin mitigates di-(2-ethylhexyl) phthalate-induced testicular injury in rats by modulating oxidative stress-mediated signals, inflammatory cascades, apoptotic pathways, and steroidogenesis. (2021) Arch Biochem Biophys. 711, 108982 Pubmed Arch Biochem Biophys
Zhang S, Zhao J and Ma W. Circ-Sirt1 inhibits proliferation, induces apoptosis, and ameliorates inflammation in human rheumatoid arthritis fibroblast-like synoviocytes. (2021) Autoimmunity. 1-12 Pubmed Autoimmunity
Papierska K, Krajka-Kuźniak V, Paluszczak J, Kleszcz R, Skalski M, Studzińska-Sroka E and Baer-Dubowska W. Lichen-Derived Depsides and Depsidones Modulate the Nrf2, NF-κB and STAT3 Signaling Pathways in Colorectal Cancer Cells. (2021) Molecules. 26, Pubmed Molecules PMC Article
Brasil FB, de Almeida FJS, Luckachaki MD, Dall'Oglio EL and de Oliveira MR. Pinocembrin pretreatment counteracts the chlorpyrifos-induced HO-1 downregulation, mitochondrial dysfunction, and inflammation in the SH-SY5Y cells. (2021) Metab Brain Dis. Pubmed Metab Brain Dis
Scuto M, Trovato Salinaro A, Caligiuri I, Ontario ML, Greco V, Sciuto N, Crea R, Calabrese EJ, Rizzolio F, Canzonieri V and Calabrese V. Redox modulation of vitagenes via plant polyphenols and vitamin D: Novel insights for chemoprevention and therapeutic interventions based on organoid technology. (2021) Mech Ageing Dev. 199, 111551 Pubmed Mech Ageing Dev
Hou Y, Li J, Wu JC, Wu QX and Fang J. Activation of Cellular Antioxidant Defense System by Naturally Occurring Dibenzopyrone Derivatives Confers Neuroprotection against Oxidative Insults. (2021) ACS Chem Neurosci. 12, 2798-2809 Pubmed ACS Chem Neurosci
Chew LY, Zhang H, He J and Yu F. The Nrf2-Keap1 pathway is activated by steroid hormone signaling to govern neuronal remodeling. (2021) Cell Rep. 36, 109466 Pubmed Cell Rep
Mishra R, Nawas AF and Mendelson CR. Role of NRF2 in immune modulator expression in developing lung. (2021) FASEB J. 35, e21758 Pubmed FASEB J
Iahtisham-Ul-Haq , Khan S, Awan KA and Iqbal MJ. Sulforaphane as a potential remedy against cancer: Comprehensive mechanistic review. (2021) J Food Biochem. e13886 Pubmed J Food Biochem
Liu WC, Ou BH, Liang ZL, Zhang R and Zhao ZH. Algae-derived polysaccharides supplementation ameliorates heat stress-induced impairment of bursa of Fabricius via modulating NF-κB signaling pathway in broilers. (2021) Poult Sci. 100, 101139 Pubmed Poult Sci PMC Article
Ryšavá A, Vostálová J and Rajnochová Svobodová A. Effect of ultraviolet radiation on the Nrf2 signaling pathway in skin cells. (2021) Int J Radiat Biol. 1-21 Pubmed Int J Radiat Biol
Chun KS, Raut PK, Kim DH and Surh YJ. Role of chemopreventive phytochemicals in NRF2-mediated redox homeostasis in humans. (2021) Free Radic Biol Med. 172, 699-715 Pubmed Free Radic Biol Med
Krajka-Kuźniak V and Baer-Dubowska W. Modulation of Nrf2 and NF-κB Signaling Pathways by Naturally Occurring Compounds in Relation to Cancer Prevention and Therapy. Are Combinations Better Than Single Compounds?. (2021) Int J Mol Sci. 22, Pubmed Int J Mol Sci PMC Article
Emanuele S, Celesia A, D'Anneo A, Lauricella M, Carlisi D, De Blasio A and Giuliano M. The Good and Bad of Nrf2: An Update in Cancer and New Perspectives in COVID-19. (2021) Int J Mol Sci. 22, Pubmed Int J Mol Sci PMC Article
Tang G, Xu Y, Zhang C, Wang N, Li H and Feng Y. Green Tea and Epigallocatechin Gallate (EGCG) for the Management of Nonalcoholic Fatty Liver Diseases (NAFLD): Insights into the Role of Oxidative Stress and Antioxidant Mechanism. (2021) Antioxidants (Basel). 10, Pubmed Antioxidants (Basel) PMC Article
Chen SJ, Lin TB, Peng HY, Lin CH, Lee AS, Liu HJ, Li CC and Tseng KW. Protective Effects of Fucoxanthin Dampen Pathogen-Associated Molecular Pattern (PAMP) Lipopolysaccharide-Induced Inflammatory Action and Elevated Intraocular Pressure by Activating Nrf2 Signaling and Generating Reactive Oxygen Species. (2021) Antioxidants (Basel). 10, Pubmed Antioxidants (Basel) PMC Article
Guzmán Mendoza NA, Homma K, Osada H, Toda E, Ban N, Nagai N, Negishi K, Tsubota K and Ozawa Y. Neuroprotective Effect of 4-Phenylbutyric Acid against Photo-Stress in the Retina. (2021) Antioxidants (Basel). 10, Pubmed Antioxidants (Basel) PMC Article
Narożna M, Krajka-Kuźniak V, Bednarczyk-Cwynar B, Kucińska M, Kleszcz R, Kujawski J, Piotrowska-Kempisty H, Plewiński A, Murias M and Baer-Dubowska W. Conjugation of Diclofenac with Novel Oleanolic Acid Derivatives Modulate Nrf2 and NF-κB Activity in Hepatic Cancer Cells and Normal Hepatocytes Leading to Enhancement of Its Therapeutic and Chemopreventive Potential. (2021) Pharmaceuticals (Basel). 14, Pubmed Pharmaceuticals (Basel) PMC Article
Khan A, Park TJ, Ikram M, Ahmad S, Ahmad R, Jo MG and Kim MO. Antioxidative and Anti-inflammatory Effects of Kojic Acid in Aβ-Induced Mouse Model of Alzheimer's Disease. (2021) Mol Neurobiol. Pubmed Mol Neurobiol
Chen X, Mu P, Zhu L, Mao X, Chen S, Zhong H and Deng Y. T-2 Toxin Induces Oxidative Stress at Low Doses via Atf3ΔZip2a/2b-Mediated Ubiquitination and Degradation of Nrf2. (2021) Int J Mol Sci. 22, Pubmed Int J Mol Sci PMC Article
Rabbani N, Xue M, Weickert MO and Thornalley PJ. Reversal of Insulin Resistance in Overweight and Obese Subjects by -Resveratrol and Hesperetin Combination-Link to Dysglycemia, Blood Pressure, Dyslipidemia, and Low-Grade Inflammation. (2021) Nutrients. 13, Pubmed Nutrients PMC Article
Recinella L, Chiavaroli A, Orlando G, Ferrante C, Veschi S, Cama A, Marconi GD, Diomede F, Gesmundo I, Granata R, Cai R, Sha W, Schally AV, Brunetti L and Leone S. Effects of growth hormone-releasing hormone receptor antagonist MIA-602 in mice with emotional disorders: a potential treatment for PTSD. (2021) Mol Psychiatry. Pubmed Mol Psychiatry
Dai B, Augustine JJ, Kang Y, Roife D, Li X, Deng J, Tan L, Rusling LA, Weinstein JN, Lorenzi PL, Kim MP and Fleming JB. Compound NSC84167 selectively targets NRF2-activated pancreatic cancer by inhibiting asparagine synthesis pathway. (2021) Cell Death Dis. 12, 693 Pubmed Cell Death Dis PMC Article
Sánchez-Ortega M, Carrera AC and Garrido A. Role of NRF2 in Lung Cancer. (2021) Cells. 10, Pubmed Cells PMC Article
Cai Y, Wang B, Xu W, Liu K, Gao Y, Guo C, Chen J, Kamal MA and Yuan C. Endometrial Cancer: genetic, metabolic characteristics, therapeutic strategies and nanomedicine. (2021) Curr Med Chem. Pubmed Curr Med Chem
Gao L, Liu Y, Du X, Ma S, Ge M, Tang H, Han C, Zhao X, Liu Y, Shao Y, Wu Z, Zhang L, Meng F and Xiao-Feng Qin F. The intrinsic role and mechanism of tumor expressed-CD38 on lung adenocarcinoma progression. (2021) Cell Death Dis. 12, 680 Pubmed Cell Death Dis PMC Article
Wang S, Yi X, Wu Z, Guo S, Dai W, Wang H, Shi Q, Zeng K, Guo W and Li C. CAMKK2 Defines Ferroptosis Sensitivity of Melanoma Cells by Regulating AMPK‒NRF2 Pathway. (2021) J Invest Dermatol. Pubmed J Invest Dermatol
Sanders OD, Rajagopal L and Rajagopal JA. Does oxidatively damaged DNA drive amyloid-β generation in Alzheimer's disease? A hypothesis. (2021) J Neurogenet. 1-7 Pubmed J Neurogenet
B Gowda SG, Tsukui T, Fuda H, Minami Y, Gowda D, Chiba H and Hui SP. Docosahexaenoic Acid Esters of Hydroxy Fatty Acid Is a Novel Activator of NRF2. (2021) Int J Mol Sci. 22, Pubmed Int J Mol Sci PMC Article
Calabrese EJ and Agathokleous E. Hormesis: Transforming disciplines that rely on the dose response. (2021) IUBMB Life. Pubmed IUBMB Life
Jin Z, Lu Y, Wu X, Pan T, Yu Z, Hou J, Wu A, Li J, Yang Z, Li C, Yan M, Yan C, Zhu Z, Liu B, Qiu W and Su L. The cross-talk between tumor cells and activated fibroblasts mediated by lactate/BDNF/TrkB signaling promotes acquired resistance to anlotinib in human gastric cancer. (2021) Redox Biol. 46, 102076 Pubmed Redox Biol PMC Article
Hou K, Shen J, Yan J, Zhai C, Zhang J, Pan JA, Zhang Y, Jiang Y, Wang Y, Lin RZ, Cong H, Gao S and Zong WX. Loss of TRIM21 alleviates cardiotoxicity by suppressing ferroptosis induced by the chemotherapeutic agent doxorubicin. (2021) EBioMedicine. 69, 103456 Pubmed EBioMedicine PMC Article
Mokhtari RB, Qorri B, Baluch N, Sparaneo A, Fabrizio FP, Muscarella LA, Tyker A, Kumar S, Cheng HM, Szewczuk MR, Das B and Yeger H. Next-generation multimodality of nutrigenomic cancer therapy: sulforaphane in combination with acetazolamide actively target bronchial carcinoid cancer in disabling the PI3K/Akt/mTOR survival pathway and inducing apoptosis. (2021) Oncotarget. 12, 1470-1489 Pubmed Oncotarget PMC Article
Reyes-Melo KY, Galván-Rodrigo AA, Martínez-Olivo IE, Núñez-Mojica G, Ávalos-Alanís FG, García A and Del Rayo Camacho-Corona M. Larrea tridentata and its biological activities. (2021) Curr Top Med Chem. Pubmed Curr Top Med Chem
Wang CM, Li YJ, Li JJ, Zang YL, Cui XH, Song M, Yang Q, Chen Y, Li Q, Cai WY, Weng XG, Wang YJ and Zhu XX. [Shenlian extract attenuates TNF-α-induced ECV304 injury by regulating Nrf2/Keap1 signaling pathway]. (2021) Zhongguo Zhong Yao Za Zhi. 46, 3402-3409 Pubmed Zhongguo Zhong Yao Za Zhi
Bashir DW, Rashad MM, Ahmed YH, Drweesh EA, Elzahany EAM, Abou-El-Sherbini KS and El-Leithy EMM. The ameliorative effect of nanoselenium on histopathological and biochemical alterations induced by melamine toxicity on the brain of adult male albino rats. (2021) Neurotoxicology. 86, 37-51 Pubmed Neurotoxicology
Matsumoto R, Hamada S, Tanaka Y, Taguchi K, Yamamoto M and Masamune A. Nrf2 Depletion Sensitizes Pancreatic Cancer Cells to Gemcitabine via Aldehyde Dehydrogenase 3a1 Repression. (2021) J Pharmacol Exp Ther. Pubmed J Pharmacol Exp Ther
Xiong J, Kuang X, Lu T, Yu K, Liu X, Zhang Z, Wang W, Zhao L, Fang Q, Wu D and Wang J. Correction: C3a and C5a facilitates the metastasis of myeloma cells by activating Nrf2. (2021) Cancer Gene Ther. Pubmed Cancer Gene Ther
Mardi A, Biglar A, Nejatbakhsh R and Abdanipour A. Valproic Acid Ameliorates Locomotor Function in the Rat Model of Contusion via Alteration of Mst1, Bcl-2, and Nrf2 Gene Expression. (2021) Iran Biomed J. 25, 303-7 Pubmed Iran Biomed J PMC Article
Huang Q, Ouyang DS and Liu Q. Isoeucommin A attenuates kidney injury in diabetic nephropathy through the Nrf2/HO-1 pathway. (2021) FEBS Open Bio. Pubmed FEBS Open Bio PMC Article
Pathak MP, Patowary P, Das A, Goyary D, Karmakar S, Bhutia YD, Roy PK, Das S and Chattopadhyay P. Crosstalk between AdipoR1/AdipoR2 and Nrf2/HO-1 signal pathways activated by β-caryophyllene suppressed the compound 48/80 induced pseudo-allergic reactions. (2021) Clin Exp Pharmacol Physiol. Pubmed Clin Exp Pharmacol Physiol
Botto L, Bulbarelli A, Lonati E, Cazzaniga E, Tassotti M, Mena P, Del Rio D and Palestini P. Study of the Antioxidant Effects of Coffee Phenolic Metabolites on C6 Glioma Cells Exposed to Diesel Exhaust Particles. (2021) Antioxidants (Basel). 10, Pubmed Antioxidants (Basel) PMC Article
Yang C, Zhang Y, Lin S, Liu Y and Li W. Correction for: Suppressing the KIF20A/NUAK1/Nrf2/GPX4 signaling pathway induces ferroptosis and enhances the sensitivity of colorectal cancer to oxaliplatin. (2021) Aging (Albany NY). 13, 19077 Pubmed Aging (Albany NY) PMC Article
Karunatilleke NC, Fast CS, Ngo V, Brickenden A, Duennwald ML, Konermann L and Choy WY. Nrf2, the Major Regulator of the Cellular Oxidative Stress Response, is Partially Disordered. (2021) Int J Mol Sci. 22, Pubmed Int J Mol Sci PMC Article
Penning TM, Jonnalagadda S, Trippier PC and Rižner TL. Aldo-Keto Reductases and Cancer Drug Resistance. (2021) Pharmacol Rev. 73, 1150-1171 Pubmed Pharmacol Rev PMC Article
Amin N, Du X, Chen S, Ren Q, Hussien AB, Botchway BOA, Hu Z and Fang M. Therapeutic impact of thymoquninone to alleviate ischemic brain injury via Nrf2/HO-1 pathway. (2021) Expert Opin Ther Targets. 25, 597-612 Pubmed Expert Opin Ther Targets
Mukherjee S, Ghosh S, Choudhury S, Gupta P, Adhikary A and Chattopadhyay S. Pomegranate Polyphenols Attenuate Inflammation and Hepatic Damage in Tumor-Bearing Mice: Crucial Role of NF-κB and the Nrf2/GSH Axis. (2021) J Nutr Biochem. 97, 108812 Pubmed J Nutr Biochem
van der Merwe M, van Niekerk G, Fourie C, du Plessis M and Engelbrecht AM. The impact of mitochondria on cancer treatment resistance. (2021) Cell Oncol (Dordr). Pubmed Cell Oncol (Dordr)
Simov V, Altman MD, Bianchi E, DelRizzo S, DiNunzio EN, Feng G, Goldenblatt P, Ingenito R, Johnson SA, Mansueto MS, Mayhood T, Mortison JD, Serebrov V, Sondey C, Sriraman V, Tucker TJ, Walji A, Wan H, Yue Y, Stoeck A and DiMauro EF. Discovery and characterization of novel peptide inhibitors of the NRF2/MAFG/DNA ternary complex for the treatment of cancer. (2021) Eur J Med Chem. 224, 113686 Pubmed Eur J Med Chem
Julián-Serrano S, Yuan F, Wheeler W, Benyamin B, Machiela MJ, Arslan AA, Beane-Freeman LE, Bracci PM, Duell EJ, Du M, Gallinger S, Giles GG, Goodman PJ, Kooperberg C, Marchand LL, Neale RE, Shu XO, Van Den Eeden SK, Visvanathan K, Zheng W, Albanes D, Andreotti G, Ardanaz E, Babic A, Berndt SI, Brais LK, Brennan P, Bueno-de-Mesquita B, Buring JE, Chanock SJ, Childs EJ, Chung CC, Fabiánová E, Foretová L, Fuchs CS, Gaziano JM, Gentiluomo M, Giovannucci EL, Goggins MG, Hackert T, Hartge P, Hassan MM, Holcátová I, Holly EA, Hung RI, Janout V, Kurtz RC, Lee IM, Malats N, McKean D, Milne RL, Newton CC, Oberg AL, Perdomo S, Peters U, Porta M, Rothman N, Schulze MB, Sesso HD, Silverman DT, Thompson IM, Wactawski-Wende J, Weiderpass E, Wenstzensen N, White E, Wilkens LR, Yu H, Zeleniuch-Jacquotte A, Zhong J, Kraft P, Li D, Campbell PT, Petersen GM, Wolpin BM, Risch HA, Amundadottir LT, Klein AP, Yu K and Stolzenberg-Solomon RZ. Hepcidin-regulating iron metabolism genes and pancreatic ductal adenocarcinoma: a pathway analysis of genome-wide association studies. (2021) Am J Clin Nutr. Pubmed Am J Clin Nutr
Javadinia SA, Nazeminezhad N, Ghahramani-Asl R, Soroosh D, Fazilat-Panah D, PeyroShabany B, Saberhosseini SN, Mehrabian A, Taghizadeh-Hesary F, Nematshahi M, Dhawan G, Welsh JS, Calabrese EJ and Kapoor R. Low-dose radiation therapy for osteoarthritis and enthesopathies: a review of current data. (2021) Int J Radiat Biol. 1-16 Pubmed Int J Radiat Biol
Santo SGE, Romualdo GR, Santos LAD, Grassi TF and Barbisan LF. Modifying effects of menthol against benzo(a)pyrene-induced forestomach carcinogenesis in female Swiss mice. (2021) Environ Toxicol. Pubmed Environ Toxicol
Akaishi R, Fujishima F, Ishida H, Tsunokake J, Yamauchi T, Gokon Y, Ueki S, Fukutomi T, Okamoto H, Takaya K, Sato C, Taniyama Y, Nakamura T, Nakaya N, Kamei T and Sasano H. HO-1 in lymph node metastasis predicted overall survival in patients with esophageal squamous cell carcinoma receiving neoadjuvant chemoradiation therapy. (2021) Cancer Rep (Hoboken). e1477 Pubmed Cancer Rep (Hoboken)
Maina S, Ryu DH, Cho JY, Jung DS, Park JE, Nho CW, Bakari G, Misinzo G, Jung JH, Yang SH and Kim HY. Exposure to Salinity and Light Spectra Regulates Glucosinolates, Phenolics, and Antioxidant Capacity of L. Microgreens. (2021) Antioxidants (Basel). 10, Pubmed Antioxidants (Basel) PMC Article
Kim M, Kim JY, Yang HS, Choe JS and Hwang IG. Nepetoidin B from R. Br. Inhibits Inflammation by Modulating the NF-κB and Nrf2/HO-1 Signaling Pathways in Macrophage Cells. (2021) Antioxidants (Basel). 10, Pubmed Antioxidants (Basel) PMC Article
Zhang N, Zhao W, Hu ZJ, Ge SM, Huo Y, Liu LX and Gao BL. Protective effects and mechanisms of high-dose vitamin C on sepsis-associated cognitive impairment in rats. (2021) Sci Rep. 11, 14511 Pubmed Sci Rep PMC Article
Petkovic M, Leal EC, Alves I, Bose C, Palade PT, Singh P, Awasthi S, Børsheim E, Dalgaard LT, Singh SP and Carvalho E. Dietary supplementation with sulforaphane ameliorates skin aging through activation of the Keap1-Nrf2 pathway. (2021) J Nutr Biochem. 98, 108817 Pubmed J Nutr Biochem
Singh G, Haileselassie Y, Ji AR, Maecker HT, Sinha SR, Brim H, Habtezion A and Ashktorab H. Protective Effect of Saffron in Mouse Colitis Models Through Immune Modulation. (2021) Dig Dis Sci. Pubmed Dig Dis Sci
Wang YZ, Fei DD, Zhang Y, Zhang XG, Wang Y and Wang QT. [Role and mechanism of low-dose lipopolysaccharide-treated human periodontal ligament stem cells on the expression of macrophage pro-inflammatory factors]. (2021) Zhonghua Kou Qiang Yi Xue Za Zhi. 56, 672-678 Pubmed Zhonghua Kou Qiang Yi Xue Za Zhi
Turan I, Demir S, Yaman SO, Canbolat D, Mentese A and Aliyazicioglu Y. An Investigation of the Antiproliferative Effect of Extract on Cervical Cancer (HeLa) Cells via Nrf2 Signaling Pathway. (2021) Nutr Cancer. 1-12 Pubmed Nutr Cancer
Wang XH, Ao QG and Cheng QL. Caloric restriction inhibits renal artery ageing by reducing endothelin-1 expression. (2021) Ann Transl Med. 9, 979 Pubmed Ann Transl Med PMC Article
Storz L, Walther P, Chemnitzer O, Lyros O, Niebisch S, Mehdorn M, Jansen-Winkeln B, Moulla Y, Büch T, Gockel I and Thieme R. Nrf2/Keap1-Pathway Activation and Reduced Susceptibility to Chemotherapy Treatment by Acidification in Esophageal Adenocarcinoma Cells. (2021) Cancers (Basel). 13, Pubmed Cancers (Basel) PMC Article
Tsakonas G, Martín-Bernabé A, Rounis K, Moreno-Ruiz P, Botling J, De Petris L, Ylipää A, Mezheyeuski A, Micke P, Östman A and Ekman S. High Density of NRF2 Expression in Malignant Cells Is Associated with Increased Risk of CNS Metastasis in Early-Stage NSCLC. (2021) Cancers (Basel). 13, Pubmed Cancers (Basel) PMC Article
Jiao Y, Wang G, Li D, Li H, Liu J, Yang X and Yang W. Okadaic Acid Exposure Induced Neural Tube Defects in Chicken () Embryos. (2021) Mar Drugs. 19, Pubmed Mar Drugs PMC Article
Jenkins T and Gouge J. Nrf2 in Cancer, Detoxifying Enzymes and Cell Death Programs. (2021) Antioxidants (Basel). 10, Pubmed Antioxidants (Basel) PMC Article
Wu X, Xu J, Cai Y, Yang Y, Liu Y and Cao S. Cytoprotection against Oxidative Stress by Methylnissolin-3--β-d-glucopyranoside from Mainly via the Activation of the Nrf2/HO-1 Pathway. (2021) Molecules. 26, Pubmed Molecules PMC Article
D'Amico R, Genovese T, Cordaro M, Siracusa R, Gugliandolo E, Peritore AF, Interdonato L, Crupi R, Cuzzocrea S, Di Paola R, Fusco R and Impellizzeri D. Palmitoylethanolamide/Baicalein Regulates the Androgen Receptor Signaling and NF-κB/Nrf2 Pathways in Benign Prostatic Hyperplasia. (2021) Antioxidants (Basel). 10, Pubmed Antioxidants (Basel) PMC Article
Ito A, Nasako H, Akizuki R, Takashina Y, Eguchi H, Matsunaga T, Yoshino Y, Endo S and Ikari A. Elevation of Chemosensitivity of Lung Adenocarcinoma A549 Spheroid Cells by Claudin-2 Knockdown through Activation of Glucose Transport and Inhibition of Nrf2 Signal. (2021) Int J Mol Sci. 22, Pubmed Int J Mol Sci PMC Article
Bischoff-Kont I and Fürst R. Benefits of Ginger and Its Constituent 6-Shogaol in Inhibiting Inflammatory Processes. (2021) Pharmaceuticals (Basel). 14, Pubmed Pharmaceuticals (Basel) PMC Article
Fujihara KM, Zhang BZ and Clemons NJ. Opportunities for Ferroptosis in Cancer Therapy. (2021) Antioxidants (Basel). 10, Pubmed Antioxidants (Basel) PMC Article
Chen LY, Cheng HL, Kuan YH, Liang TJ, Chao YY and Lin HC. Therapeutic Potential of Luteolin on Impaired Wound Healing in Streptozotocin-Induced Rats. (2021) Biomedicines. 9, Pubmed Biomedicines PMC Article
Zhang H and Fu L. The role of ALDH2 in tumorigenesis and tumor progression: Targeting ALDH2 as a potential cancer treatment. (2021) Acta Pharm Sin B. 11, 1400-1411 Pubmed Acta Pharm Sin B PMC Article
El-Shahawy AAG, Abdel-Moneim A, Ebeid ASM, Eldin ZE and Zanaty MI. A novel layered double hydroxide-hesperidin nanoparticles exert antidiabetic, antioxidant and anti-inflammatory effects in rats with diabetes. (2021) Mol Biol Rep. 48, 5217-5232 Pubmed Mol Biol Rep
Mingione A, Pivari F, Plotegher N, Dei Cas M, Zulueta A, Bocci T, Trinchera M, Albi E, Maglione V, Caretti A, Bubacco L, Paroni R, Bottai D, Ghidoni R and Signorelli P. Inhibition of Ceramide Synthesis Reduces α-Synuclein Proteinopathy in a Cellular Model of Parkinson's Disease. (2021) Int J Mol Sci. 22, Pubmed Int J Mol Sci PMC Article
Oh JH, Kim J, Karadeniz F, Kim HR, Park SY, Seo Y and Kong CS. Santamarine Shows Anti-Photoaging Properties via Inhibition of MAPK/AP-1 and Stimulation of TGF-β/Smad Signaling in UVA-Irradiated HDFs. (2021) Molecules. 26, Pubmed Molecules PMC Article
Hennig P, Fenini G, Di Filippo M, Karakaya T and Beer HD. The Pathways Underlying the Multiple Roles of p62 in Inflammation and Cancer. (2021) Biomedicines. 9, Pubmed Biomedicines PMC Article
Davuljigari CB, Ekuban FA, Zong C, Fergany AAM, Morikawa K and Ichihara G. Nrf2 Activation Attenuates Acrylamide-Induced Neuropathy in Mice. (2021) Int J Mol Sci. 22, Pubmed Int J Mol Sci PMC Article
Arunachalam S, Nagoor Meeran MF, Azimullah S, Sharma C, Goyal SN and Ojha S. Nerolidol Attenuates Oxidative Stress, Inflammation, and Apoptosis by Modulating Nrf2/MAPK Signaling Pathways in Doxorubicin-Induced Acute Cardiotoxicity in Rats. (2021) Antioxidants (Basel). 10, Pubmed Antioxidants (Basel) PMC Article
Đurašević S, Pejić S, Grigorov I, Nikolić G, Mitić-Ćulafić D, Dragićević M, Đorđević J, Todorović Vukotić N, Đorđević N, Todorović A, Drakulić D, Veljković F, Pajović SB and Todorović Z. Effects of C60 Fullerene on Thioacetamide-Induced Rat Liver Toxicity and Gut Microbiome Changes. (2021) Antioxidants (Basel). 10, Pubmed Antioxidants (Basel) PMC Article
Ahmadi M, Saberianpour S, Heidarzadeh M and Rezaie J. Diabetes mellitus can cause cardiomyopathy disorders by inducing the aging pathway. (2021) Iran J Basic Med Sci. 24, 636-640 Pubmed Iran J Basic Med Sci PMC Article
Payandeh Z, Pirpour Tazehkand A, Mansoori B, Khaze V, Asadi M, Baradaran B and Samadi N. The Impact of Nrf2 Silencing on Nrf2-PD-L1 Axis to Overcome Oxaliplatin Resistance and Migration in Colon Cancer Cells. Avicenna J Med Biotechnol. 13, 116-122 Pubmed Avicenna J Med Biotechnol PMC Article
Gao L, Morine Y, Yamada S, Saito Y, Ikemoto T, Tokuda K, Takasu C, Miyazaki K and Shimada M. Nrf2 signaling promotes cancer stemness, migration, and expression of ABC transporter genes in sorafenib-resistant hepatocellular carcinoma cells. (2021) PLoS One. 16, e0256755 Pubmed PLoS One PMC Article
Xu S, Huang H, Tang D, Xing M, Zhao Q, Li J, Si J, Gan L, Mao A and Zhang H. Diallyl Disulfide Attenuates Ionizing Radiation-Induced Migration and Invasion by Suppressing Nrf2 Signaling in Non-small-Cell Lung Cancer. Dose Response. 19, 15593258211033114 Pubmed Dose Response PMC Article
Gao P, Peng T, Lin S, Zhi W, Cao C, Wu P, Xi L, Wu P, Yang Q and Ding W. Key Role of MCUR1 in Malignant Progression of Breast Cancer. (2021) Onco Targets Ther. 14, 4163-4175 Pubmed Onco Targets Ther PMC Article
Chaisit S and Jianmongkol S. Apoptosis Inducing Activity of Rhinacanthin-C in Doxorubicin-Resistant Breast Cancer MCF-7 Cells. (2021) Biol Pharm Bull. 44, 1239-1246 Pubmed Biol Pharm Bull
Liu H, Xu X, Wu R, Bi L, Zhang C, Chen H and Yang Y. Antioral Squamous Cell Carcinoma Effects of Carvacrol via Inhibiting Inflammation, Proliferation, and Migration Related to Nrf2/Keap1 Pathway. (2021) Biomed Res Int. 2021, 6616547 Pubmed Biomed Res Int PMC Article
Jia X, He Q, Zeng M, Chen Y and Liu Y. Activation of MEK1/2/Nrf-2 Signaling Pathway by Epstein-Barr Virus-Latent Membrane Protein 1 Enhances Autophagy and Cisplatin Resistance in T-Cell Lymphoma. (2021) Anal Cell Pathol (Amst). 2021, 6668947 Pubmed Anal Cell Pathol (Amst) PMC Article
Liu M, Wu N, Xu K, Saaoud F, Vasilopoulos E, Shao Y, Zhang R, Wang J, Shen H, Yang WY, Lu Y, Sun Y, Drummer C, Liu L, Li L, Hu W, Yu J, Praticò D, Sun J, Jiang X, Wang H and Yang X. Organelle Crosstalk Regulators Are Regulated in Diseases, Tumors, and Regulatory T Cells: Novel Classification of Organelle Crosstalk Regulators. (2021) Front Cardiovasc Med. 8, 713170 Pubmed Front Cardiovasc Med PMC Article
Li R, Yang W, Yin Y, Zhang P, Wang Y and Tao K. Protective Role of 4-Octyl Itaconate in Murine LPS/D-GalN-Induced Acute Liver Failure via Inhibiting Inflammation, Oxidative Stress, and Apoptosis. (2021) Oxid Med Cell Longev. 2021, 9932099 Pubmed Oxid Med Cell Longev PMC Article
Zhang X, Liu X, Zhang Y, Yang A, Zhang Y, Tong Z, Wang Y and Qiu Y. Wan-Nian-Qing, a Herbal Composite Prescription, Suppresses the Progression of Liver Cancer in Mice by Regulating Immune Response. (2021) Front Oncol. 11, 696282 Pubmed Front Oncol PMC Article
Zhang L and Tew KD. Reductive stress in cancer. (2021) Adv Cancer Res. 152, 383-413 Pubmed Adv Cancer Res
Kang C, Song CH, Kim N, Nam RH, Choi SI, Yu JE, Nho H, Choi JA, Kim JW, Na HY, Lee HN and Surh YJ. The Enhanced Inhibitory Effect of Estrogen on PD-L1 Expression Following Nrf2 Deficiency in the AOM/DSS Model of Colitis-Associated Cancer. (2021) Front Oncol. 11, 679324 Pubmed Front Oncol PMC Article
Bu X, Qu X, Guo K, Meng X, Yang X, Huang Q, Dou W, Feng L, Wei X, Gao J, Sun W, Chao M, Han L, Hu Y, Shen L, Zhang J and Wang L. CD147 confers temozolomide resistance of glioma cells via the regulation of β-TrCP/Nrf2 pathway. (2021) Int J Biol Sci. 17, 3013-3023 Pubmed Int J Biol Sci PMC Article
Fu H, Ni X, Ni F, Li D, Sun H, Kong H, Shan Y and Dai S. Study of the Mechanism by Which Curcumin Cooperates with Sestrin2 to Inhibit the Growth of Pancreatic Cancer. (2021) Gastroenterol Res Pract. 2021, 7362233 Pubmed Gastroenterol Res Pract PMC Article
Lu J, Liu SY, Zhang J, Yang GM, Gao GB, Yu NN, Li YP, Li YX, Ma ZQ, Wang Y and Lu CH. Inhibition of BAG3 enhances the anticancer effect of shikonin in hepatocellular carcinoma. (2021) Am J Cancer Res. 11, 3575-3593 Pubmed Am J Cancer Res PMC Article
Li X, Wang X, Miao L, Guo Y, Yuan R, Ren J, Huang Y and Tian H. Design, Synthesis, and Biological Evaluation of a Novel Aminothiol Compound as Potential Radioprotector. (2021) Oxid Med Cell Longev. 2021, 4714649 Pubmed Oxid Med Cell Longev PMC Article
Simms L, Mason E, Berg EL, Yu F, Rudd K, Czekala L, Trelles Sticken E, Brinster O, Wieczorek R, Stevenson M and Walele T. Use of a rapid human primary cell-based disease screening model, to compare next generation products to combustible cigarettes. (2021) Curr Res Toxicol. 2, 309-321 Pubmed Curr Res Toxicol PMC Article
Li Y, Jia Y, Xu Y and Li K. DMF Activates to Inhibit the Pro-Invasion Ability of TAMs in Breast Cancer. (2021) Front Oncol. 11, 706448 Pubmed Front Oncol PMC Article
Yue L, Ren Y, Yue Q, Ding Z, Wang K, Zheng T, Chen G, Chen X, Li M and Fan L. -Lipoic Acid Targeting PDK1/NRF2 Axis Contributes to the Apoptosis Effect of Lung Cancer Cells. (2021) Oxid Med Cell Longev. 2021, 6633419 Pubmed Oxid Med Cell Longev PMC Article
Noh JK, Woo SR, Yun M, Lee MK, Kong M, Min S, Kim SI, Lee YC, Eun YG and Ko SG. SOD2- and NRF2-associated Gene Signature to Predict Radioresistance in Head and Neck Cancer. Cancer Genomics Proteomics. 18, 675-684 Pubmed Cancer Genomics Proteomics
Kalinichenko SV, Korobko IV and Shepelev MV. [Combination of ARE and HRE cis- Regulatory Elements Elevates the Activity of Tumor-Specific hTERT Promoter]. Mol Biol (Mosk). 55, 606-616 Pubmed Mol Biol (Mosk)
Jalali A, Mahmoudi S, Larki Harchegani A, Mohammadiasl J and Ahmadzadeh A. Evaluation of Nrf2, Keap1 and Apoptotic Pathway Genes Expression in Acute Myeloid Leukemia Patients. (2021) Iran J Pharm Res. 20, 398-407 Pubmed Iran J Pharm Res PMC Article
Wei R, Zhao Y, Wang J, Yang X, Li S, Wang Y, Yang X, Fei J, Hao X, Zhao Y, Gui L and Ding X. Tagitinin C induces ferroptosis through PERK-Nrf2-HO-1 signaling pathway in colorectal cancer cells. (2021) Int J Biol Sci. 17, 2703-2717 Pubmed Int J Biol Sci PMC Article
Chen YC, Chen JH, Tsai CF, Wu CT, Wu MH, Chang PC and Yeh WL. Nicardipine Inhibits Breast Cancer Migration Nrf2/HO-1 Axis and Matrix Metalloproteinase-9 Regulation. (2021) Front Pharmacol. 12, 710978 Pubmed Front Pharmacol PMC Article
Zhu Z, Zheng Z and Liu J. Comparison of COVID-19 and Lung Cancer Reactive Oxygen Species Signaling. (2021) Front Oncol. 11, 708263 Pubmed Front Oncol PMC Article
Alvi AM, Al Kury LT, Alattar A, Ullah I, Muhammad AJ, Alshaman R, Shah FA, Khan AU, Feng J and Li S. Carveol Attenuates Seizure Severity and Neuroinflammation in Pentylenetetrazole-Kindled Epileptic Rats by Regulating the Signaling Pathway. (2021) Oxid Med Cell Longev. 2021, 9966663 Pubmed Oxid Med Cell Longev PMC Article
Shao Y, Saredy J, Xu K, Sun Y, Saaoud F, Drummer C, Lu Y, Luo JJ, Lopez-Pastrana J, Choi ET, Jiang X, Wang H and Yang X. Endothelial Immunity Trained by Coronavirus Infections, DAMP Stimulations and Regulated by Anti-Oxidant NRF2 May Contribute to Inflammations, Myelopoiesis, COVID-19 Cytokine Storms and Thromboembolism. (2021) Front Immunol. 12, 653110 Pubmed Front Immunol PMC Article
Ye H, Luo J, Hu D, Yang S, Zhang A, Qiu Y, Ma X, Wang J, Hou J and Bai J. Total Flavonoids of Petals Release -Butyl Hydroperoxide-Induced Oxidative Stress in BRL-3A Cells. (2021) Oxid Med Cell Longev. 2021, 5453047 Pubmed Oxid Med Cell Longev PMC Article
Arbab AAI, Lu X, Abdalla IM, Idris AA, Chen Z, Li M, Mao Y, Xu T and Yang Z. Metformin Inhibits Lipoteichoic Acid-Induced Oxidative Stress and Inflammation Through AMPK/NRF2/NF-κB Signaling Pathway in Bovine Mammary Epithelial Cells. (2021) Front Vet Sci. 8, 661380 Pubmed Front Vet Sci PMC Article
Song CH, Kim N, Nam RH, Choi SI, Yu JE, Nho H and Surh YJ. Changes in Microbial Community Composition Related to Sex and Colon Cancer by Nrf2 Knockout. (2021) Front Cell Infect Microbiol. 11, 636808 Pubmed Front Cell Infect Microbiol PMC Article
Rutland CS, Cockcroft JM, Lothion-Roy J, Harris AE, Jeyapalan JN, Simpson S, Alibhai A, Bailey C, Ballard-Reisch AC, Rizvanov AA, Dunning MD, de Brot S and Mongan NP. Immunohistochemical Characterisation of GLUT1, MMP3 and NRF2 in Osteosarcoma. (2021) Front Vet Sci. 8, 704598 Pubmed Front Vet Sci PMC Article
Wang M, Ren Y, Hu S, Liu K, Qiu L and Zhang Y. TCF11 Has a Potent Tumor-Repressing Effect Than Its Prototypic Nrf1α by Definition of Both Similar Yet Different Regulatory Profiles, With a Striking Disparity From Nrf2. (2021) Front Oncol. 11, 707032 Pubmed Front Oncol PMC Article
Kim JE, Kim HR, Kim JC, Lee ES, Chung CH, Lee EY and Chung BY. Tetrahydrocurcumin Ameliorates Skin Inflammation by Modulating Autophagy in High-Fat Diet-Induced Obese Mice. (2021) Biomed Res Int. 2021, 6621027 Pubmed Biomed Res Int PMC Article
Gao H, Li Y, Sun J, Xu H, Wang M, Zuo X, Fu Q, Guo Y, Chen Z, Zhang P, Li X, Wang N, Ye T and Yao Y. Ameliorates Dextran Sulfate Sodium-Induced Ulcerative Colitis in Mice by Regulating NF-B and Nrf2 Signaling Pathways. (2021) Oxid Med Cell Longev. 2021, 1622375 Pubmed Oxid Med Cell Longev PMC Article
Johnston ME and Timchenko N. Molecular signatures of aggressive pediatric liver cancer. (2021) Arch Stem Cell Ther. 2, 1-4 Pubmed Arch Stem Cell Ther PMC Article
Lu Y, Zhang W, Zhang B, Heinemann SH, Hoshi T, Hou S and Zhang G. Bilirubin Oxidation End Products (BOXes) Induce Neuronal Oxidative Stress Involving the Nrf2 Pathway. (2021) Oxid Med Cell Longev. 2021, 8869908 Pubmed Oxid Med Cell Longev PMC Article
Wu R, Zuo W, Xu X, Bi L, Zhang C, Chen H and Liu H. MCU That Is Transcriptionally Regulated by Nrf2 Augments Malignant Biological Behaviors in Oral Squamous Cell Carcinoma Cells. (2021) Biomed Res Int. 2021, 6650791 Pubmed Biomed Res Int PMC Article
Liu J, Lin H, Yuan L, Wang D, Wang C, Sun J, Zhang C, Chen J, Li H and Jing S. Protective Effects of Anwulignan against HCl/Ethanol-Induced Acute Gastric Ulcer in Mice. (2021) Evid Based Complement Alternat Med. 2021, 9998982 Pubmed Evid Based Complement Alternat Med PMC Article
Malcare WordPress Security