Clinical Trials & Research

English: Graph of Nrf2 publications (pubmed se...

English: Graph of Nrf2 publications (pubmed search) by year (Photo credit: Wikipedia)

There are currently over 2300 articles (peer reviewed clinical reviews and studies) on on the topic of NRF2 Activation.

There are a ton of companies claiming they have scientific studies showing that their products are NRF2 Activators. Go to and type in the name of their product.

Pubmed is a website operated by the National Institute of Health (NIH).  PubMed comprises over 21 million citations for biomedical literature from MEDLINE, life science journals, and online books. PubMed citations and abstracts include the fields of biomedicine and health, covering portions of the life sciences, behavioral sciences, chemical sciences, and bioengineering. PubMed also provides access to additional relevant web sites and links to the other NCBI molecular biology resources.

Last 200 NRF-2 Studies published on Pubmed

Kalvala AK, Yerra VG and Kumar A. LONP1 induction by SRT1720 attenuates mitochondrial dysfunction against high glucose induced neurotoxicity in PC12 cells. (2020) Toxicol In Vitro. 62, 104695 Pubmed Toxicol In Vitro
Li LH, Peng WN, Deng Y, Li JJ and Tian XR. Action of trichostatin A on Alzheimer's disease-like pathological changes in SH-SY5Y neuroblastoma cells. (2020) Neural Regen Res. 15, 293-301 Pubmed Neural Regen Res
Hu L, Li H, Lee ED, Grandis JR, Bauman JE and Johnson DE. Gene targets of sulforaphane in head and neck squamous cell carcinoma. (2019) Mol Med Rep. 20, 5335-5344 Pubmed Mol Med Rep
Kandasamy M, Mak KK, Devadoss T, Thanikachalam PV, Sakirolla R, Choudhury H and Pichika MR. Construction of a novel quinoxaline as a new class of Nrf2 activator. (2019) BMC Chem. 13, 117 Pubmed BMC Chem PMC Article
Hammad A, Zheng ZH, Gao Y, Namani A, Shi HF and Tang X. Identification of novel Nrf2 target genes as prognostic biomarkers in colitis-associated colorectal cancer in Nrf2-deficient mice. (2019) Life Sci.. 238, 116968 Pubmed Life Sci.
Hammad A, Namani A, Elshaer M, Wang XJ and Tang X. "NRF2 addiction" in lung cancer cells and its impact on cancer therapy. (2019) Cancer Lett.. 467, 40-49 Pubmed Cancer Lett.
Han H, Wang H, Du Y and Gao L. Grape Seed Procyanidins Attenuates Cisplatin-induced Human Embryonic Renal Cell Cytotoxicity by Modulating Heme Oxygenase-1 in Vitro. (2019) Cell Biochem. Biophys.. 77, 367-377 Pubmed Cell Biochem. Biophys.
Dhar R, Zhang L, Li Y, Rana MN, Hu Z, Li Z, Cui H and Tang H. Electroacupuncture ameliorates cardiopulmonary bypass induced apoptosis in lung via ROS/Nrf2/NLRP3 inflammasome pathway. (2019) Life Sci.. 238, 116962 Pubmed Life Sci.
El-Shitany NA and Eid BG. Icariin modulates carrageenan-induced acute inflammation through HO-1/Nrf2 and NF-kB signaling pathways. (2019) Biomed. Pharmacother.. 120, 109567 Pubmed Biomed. Pharmacother.
Huang XT, Liu W, Zhou Y, Hao CX, Zhou Y, Zhang CY, Sun CC, Luo ZQ and Tang SY. Dihydroartemisinin attenuates lipopolysaccharide‑induced acute lung injury in mice by suppressing NF‑κB signaling in an Nrf2‑dependent manner. (2019) Int. J. Mol. Med.. 44, 2213-2222 Pubmed Int. J. Mol. Med. PMC Article
Li Y, Darwish WS, Chen Z, Hui T, Wu Y, Hirotaka S, Chiba H and Hui SP. Identification of lead-produced lipid hydroperoxides in human HepG2 cells and protection using rosmarinic and ascorbic acids with a reference to their regulatory roles on Nrf2-Keap1 antioxidant pathway. (2019) Chem. Biol. Interact.. 314, 108847 Pubmed Chem. Biol. Interact.
Jaafaru MS, Nordin N, Rosli R, Shaari K, Bako HY, Saad N, Noor NM and Abdull Razis AF. Neuroprotective effects of glucomoringin-isothiocyanate against HO-Induced cytotoxicity in neuroblastoma (SH-SY5Y) cells. (2019) Neurotoxicology. 75, 89-104 Pubmed Neurotoxicology
Wu C, Zhang H, Zhang J, Zhang H, Zeng Y, Fang S, Li P, Zhang Y, Lin X, Wang L, Xue Y and Guan M. Increased oxidative stress, inflammation and fibrosis in perirenal adipose tissue of patients with cortisol-producing adenoma. (2019) Adipocyte. 8, 347-356 Pubmed Adipocyte
Guo H, Xu J, Zheng Q, He J, Zhou W, Wang K, Huang X, Fan Q, Ma J, Cheng J, Mei W, Xing R and Cai R. NRF2 SUMOylation promotes de novo serine synthesis and maintains HCC tumorigenesis. (2019) Cancer Lett.. 466, 39-48 Pubmed Cancer Lett.
Zhang J, Zhang Q, Liu G and Zhang N. Therapeutic potentials and mechanisms of the Chinese traditional medicine Danshensu. (2019) Eur. J. Pharmacol.. 864, 172710 Pubmed Eur. J. Pharmacol.
Peng N, Jin L, He A, Deng C and Wang X. Effect of sulphoraphane on newborn mouse cardiomyocytes undergoing ischaemia/reperfusion injury. (2019) Pharm Biol. 57, 753-759 Pubmed Pharm Biol PMC Article
Yu Q, Xia Z, Liong EC and Tipoe GL. Chronic aerobic exercise improves insulin sensitivity and modulates Nrf2 and NF‑κB/IκBα pathways in the skeletal muscle of rats fed with a high fat diet. (2019) Mol Med Rep. 20, 4963-4972 Pubmed Mol Med Rep
Zhang Z, Jiang D, Wang C, Garzotto M, Kopp R, Wilmot B, Thuillier P, Dang A, Palma A, Farris PE and Shannon J. Polymorphisms in oxidative stress pathway genes and prostate cancer risk. (2019) Cancer Causes Control. 30, 1365-1375 Pubmed Cancer Causes Control
Wu XX, Huang XL, Chen RR, Li T, Ye HJ, Xie W, Huang ZM and Cao GZ. Paeoniflorin Prevents Intestinal Barrier Disruption and Inhibits Lipopolysaccharide (LPS)-Induced Inflammation in Caco-2 Cell Monolayers. (2019) Inflammation. 42, 2215-2225 Pubmed Inflammation
Mizumura K, Maruoka S, Shimizu T and Gon Y. Role of Nrf2 in the pathogenesis of respiratory diseases. (2019) Respir Investig. Pubmed Respir Investig
Lu Y, Hu P, Zhou H, Yang Z, Sun YU, Hoffman RM and Chen J. Double-negative T Cells Inhibit Proliferation and Invasion of Human Pancreatic Cancer Cells in Co-culture. (2019) Anticancer Res.. 39, 5911-5918 Pubmed Anticancer Res.
Vaghefinezhad N, Farsani SF and Gharaghani S. In Silico Drug-Designing Studies on Sulforaphane Analogues: Pharmacophore Mapping, Molecular Docking and QSAR Modeling. (2019) Curr Drug Discov Technol. Pubmed Curr Drug Discov Technol
Yu H, Wu CL, Wang X, Ban Q, Quan C, Liu M, Dong H, Li J, Kim GY, Choi YH, Wang Z and Jin CY. SP600125 enhances C-2-induced cell death by the switch from autophagy to apoptosis in bladder cancer cells. (2019) J. Exp. Clin. Cancer Res.. 38, 448 Pubmed J. Exp. Clin. Cancer Res. PMC Article
Ho CJ and Gorski SM. Molecular Mechanisms Underlying Autophagy-Mediated Treatment Resistance in Cancer. (2019) Cancers (Basel). 11, Pubmed Cancers (Basel)
Li R, Jia Z and Zhu H. Regulation of Nrf2 Signaling. (2019) React Oxyg Species (Apex). 8, 312-322 Pubmed React Oxyg Species (Apex) PMC Article
Wang J, Lu Q, Cai J, Wang Y, Lai X, Qiu Y, Huang Y, Ke Q, Zhang Y, Guan Y, Wu H, Wang Y, Liu X, Shi Y, Zhang K, Wang M and Peng Xiang A. Nestin regulates cellular redox homeostasis in lung cancer through the Keap1-Nrf2 feedback loop. (2019) Nat Commun. 10, 5043 Pubmed Nat Commun PMC Article
Panigrahi DP, Bhol CS, R N, Nagini S, Patil S, Maiti TK and Bhutia SK. Abrus agglutinin inhibits oral carcinogenesis through inactivation of NRF2 signaling pathway. (2019) Int. J. Biol. Macromol.. Pubmed Int. J. Biol. Macromol.
Zimta AA, Cenariu D, Irimie A, Magdo L, Nabavi SM, Atanasov AG and Berindan-Neagoe I. The Role of Nrf2 Activity in Cancer Development and Progression. (2019) Cancers (Basel). 11, Pubmed Cancers (Basel)
Lee SM, Kim NH, Lee S, Kim YN, Heo JD, Jeong EJ and Rho JR. Deacetylphylloketal, a New Phylloketal Derivative from a Marine Sponge, Genus , with Potent Anti-Inflammatory Activity in In Vitro Co-Culture Model of Intestine. (2019) Mar Drugs. 17, Pubmed Mar Drugs
Badshah H, Ikram M, Ali W, Ahmad S, Hahm JR and Kim MO. Caffeine May Abrogate LPS-Induced Oxidative Stress and Neuroinflammation by Regulating Nrf2/TLR4 in Adult Mouse Brains. (2019) Biomolecules. 9, Pubmed Biomolecules
Yao B, He J, Yin X, Shi Y, Wan J and Tian Z. The protective effect of lithocholic acid on the intestinal epithelial barrier is mediated by the vitamin D receptor via a SIRT1/Nrf2 and NF-κB dependent mechanism in Caco-2 cells. (2019) Toxicol. Lett.. 316, 109-118 Pubmed Toxicol. Lett.
Zhang X, Chu X, Gong X, Zhou H and Cai C. The expression of miR-125b in Nrf2-silenced A549 cells exposed to hyperoxia and its relationship with apoptosis. (2019) J. Cell. Mol. Med.. Pubmed J. Cell. Mol. Med.
Luo J, Long Y, Ren G, Zhang Y, Chen J, Huang R and Yang L. Punicalagin Reversed the Hepatic Injury of Tetrachloromethane by Antioxidation and Enhancement of Autophagy. (2019) J Med Food. Pubmed J Med Food
Zhang Z, Li H, Liang Z, Li C, Yang Z, Li Y, Cao L, She Y, Wang W, Liu C and Chen L. Vaporized perfluorocarbon inhalation attenuates primary blast lung injury in canines by inhibiting mitogen-activated protein kinase/nuclear factor-κB activation and inducing nuclear factor, erythroid 2 like 2 pathway. (2019) Toxicol. Lett.. 319, 49-57 Pubmed Toxicol. Lett.
Qu H, Gao X, Wang ZY and Yi JJ. Comparative study on hepatoprotection of pine nut (Pinus koraiensis Sieb. et Zucc.) polysaccharide against different types of chemical-induced liver injury models in vivo. (2019) Int. J. Biol. Macromol.. Pubmed Int. J. Biol. Macromol.
Ooi A. Advances in hereditary leiomyomatosis and renal cell carcinoma (HLRCC) research. (2019) Semin. Cancer Biol.. Pubmed Semin. Cancer Biol.
Schultrich K, Henderson CJ, Braeuning A and Buhrke T. Correlation between 3-MCPD-induced organ toxicity and oxidative stress response in male mice. (2019) Food Chem. Toxicol.. 110957 Pubmed Food Chem. Toxicol.
Szade A, Szade K, Nowak WN, Bukowska-Strakova K, Muchova L, Gońka M, Żukowska M, Cieśla M, Kachamakova-Trojanowska N, Rams-Baron M, Ratuszna A, Dulak J and Józkowicz A. Cobalt protoporphyrin IX increases endogenous G-CSF and mobilizes HSC and granulocytes to the blood. (2019) EMBO Mol Med. e09571 Pubmed EMBO Mol Med
Geng X, Yang B, Li R, Teng T, Ladu MJ, Sun GY, Greenlief CM and Lee JC. Effects of Docosahexaenoic Acid and Its Peroxidation Product on Amyloid-β Peptide-Stimulated Microglia. (2019) Mol. Neurobiol.. Pubmed Mol. Neurobiol.
Luk ST, Ng KY, Zhou L, Tong M, Wong TL, Yu H, Lo CM, Man K, Guan XY, Lee TK and Ma S. Deficiency in embryonic stem cell marker REX1 activates MKK6-dependent p38 MAPK signaling to drive hepatocarcinogenesis. (2019) Hepatology. Pubmed Hepatology
Londhe AM, Gadhe CG, Lim SM and Pae AN. Investigation of Molecular Details of Keap1-Nrf2 Inhibitors Using Molecular Dynamics and Umbrella Sampling Techniques. (2019) Molecules. 24, Pubmed Molecules
Khiatah B, Qi M, Du W, T-Chen K, van Megen KM, Perez RG, Isenberg JS, Kandeel F, Roep BO, Ku HT and Al-Abdullah IH. Intra-pancreatic tissue-derived mesenchymal stromal cells: a promising therapeutic potential with anti-inflammatory and pro-angiogenic profiles. (2019) Stem Cell Res Ther. 10, 322 Pubmed Stem Cell Res Ther
Yang C, Gong J, Xu W, Liu Z and Cui D. Next-generation sequencing identified somatic alterations that may underlie the etiology of Chinese papillary thyroid carcinoma. (2019) Eur. J. Cancer Prev.. Pubmed Eur. J. Cancer Prev.
Kim DH, Jang JH, Kwon OS, Cha HJ, Chun KS and Surh YJ. Nrf2-induced reductive stress favours self-renewal of breast cancer stem-like cells via the FoxO3a-Bmi-1 axis. (2019) Antioxid. Redox Signal.. Pubmed Antioxid. Redox Signal.
Zhu T, Fang F, Sun D, Yang S, Zhang X, Yu X and Yang L. Piceatannol Inhibits P. acnes-Induced Keratinocyte Proliferation and Migration by Downregulating Oxidative Stress and the Inflammatory Response. (2019) Inflammation. Pubmed Inflammation
Cho JH, Lee YM, Bae SH and Chou JY. Activation of tumor-promoting pathways implicated in hepatocellular adenoma/carcinoma, a long-term complication of glycogen storage disease type Ia. (2019) Biochem. Biophys. Res. Commun.. Pubmed Biochem. Biophys. Res. Commun.
Nam LB and Keum YS. Binding partners of NRF2: Functions and regulatory mechanisms. (2019) Arch. Biochem. Biophys.. 108184 Pubmed Arch. Biochem. Biophys.
Sun Y, Zhou S, Guo H, Zhang J, Ma T, Zheng Y, Zhang Z and Cai L. Protective effects of sulforaphane on type 2 diabetes-induced cardiomyopathy via AMPK-mediated activation of lipid metabolic pathways and NRF2 function. (2019) Metab. Clin. Exp.. 154002 Pubmed Metab. Clin. Exp.
Towers CG and Thorburn A. Circumventing autophagy inhibition. (2019) Cell Cycle. 1-11 Pubmed Cell Cycle
Nadal E, Palmero R and Muñoz-Pinedo C. Mutations in the Antioxidant KEAP1/NRF2 Pathway Define an Aggressive Subset of NSCLC Resistant to Conventional Treatments. (2019) J Thorac Oncol. 14, 1881-1883 Pubmed J Thorac Oncol
Wang J, Gao Y, Lin F, Han K and Wang X. Omentin-1 attenuates lipopolysaccharide (LPS)-induced U937 macrophages activation by inhibiting the TLR4/MyD88/NF-κB signaling. (2019) Arch. Biochem. Biophys.. 108187 Pubmed Arch. Biochem. Biophys.
Montesano A, Senesi P, Vacante F, Mollica G, Benedini S, Mariotti M, Luzi L and Terruzzi I. L-Carnitine counteracts in vitro fructose-induced hepatic steatosis through targeting oxidative stress markers. (2019) J. Endocrinol. Invest.. Pubmed J. Endocrinol. Invest.
Murray JR, de la Vega L, Hayes JD, Duan L and Penning TM. Induction of the Antioxidant Response by the Transcription Factor NRF2 Increases Bioactivation of the Mutagenic Air Pollutant 3-Nitrobenzanthrone in Human Lung Cells. (2019) Chem. Res. Toxicol.. Pubmed Chem. Res. Toxicol.
Jabbarzadeh Kaboli P, Afzalipour Khoshkbejari M, Mohammadi M, Abiri A, Mokhtarian R, Vazifemand R, Amanollahi S, Yazdi Sani S, Li M, Zhao Y, Wu X, Shen J, Cho CH and Xiao Z. Targets and mechanisms of sulforaphane derivatives obtained from cruciferous plants with special focus on breast cancer - contradictory effects and future perspectives. (2019) Biomed. Pharmacother.. 121, 109635 Pubmed Biomed. Pharmacother.
Yu J, Chen J, Yang H, Chen S and Wang Z. Overexpression of miR‑200a‑3p promoted inflammation in sepsis‑induced brain injury through ROS‑induced NLRP3. (2019) Int. J. Mol. Med.. 44, 1811-1823 Pubmed Int. J. Mol. Med. PMC Article
Dai P, Shen D, Shen J, Tang Q, Xi M, Li Y and Li C. The roles of Nrf2 and autophagy in modulating inflammation mediated by TLR4 - NFκB in A549 cell exposed to layer house particulate matter 2.5 (PM). (2019) Chemosphere. 235, 1134-1145 Pubmed Chemosphere
Zarei M, Du H, Nassar AH, Yan RE, Giannikou K, Johnson SH, Lam HC, Henske EP, Wang Y, Zhang T, Asara J and Kwiatkowski DJ. Tumors with TSC mutations are sensitive to CDK7 inhibition through NRF2 and glutathione depletion. (2019) J. Exp. Med.. 216, 2635-2652 Pubmed J. Exp. Med. PMC Article
Yu H, Liang H, Ren M, Ji K, Yang Q, Ge X, Xi B and Pan L. Effects of dietary fenugreek seed extracts on growth performance, plasma biochemical parameters, lipid metabolism, Nrf2 antioxidant capacity and immune response of juvenile blunt snout bream (Megalobrama amblycephala). (2019) Fish Shellfish Immunol.. 94, 211-219 Pubmed Fish Shellfish Immunol.
Wang Y, Chen Q, Shi C, Jiao F and Gong Z. Mechanism of glycyrrhizin on ferroptosis during acute liver failure by inhibiting oxidative stress. (2019) Mol Med Rep. 20, 4081-4090 Pubmed Mol Med Rep PMC Article
Zhou Y, Jiang Z, Lu H, Xu Z, Tong R, Shi J and Jia G. Recent Advances of Natural Polyphenols Activators for Keap1-Nrf2 Signaling Pathway. (2019) Chem. Biodivers.. 16, e1900400 Pubmed Chem. Biodivers.
Iqubal A, Sharma S, Najmi AK, Syed MA, Ali J, Alam MM and Haque SE. Nerolidol ameliorates cyclophosphamide-induced oxidative stress, neuroinflammation and cognitive dysfunction: Plausible role of Nrf2 and NF- κB. (2019) Life Sci.. 236, 116867 Pubmed Life Sci.
Bai T, Lei P, Zhou H, Liang R, Zhu R, Wang W, Zhou L and Sun Y. Sigma-1 receptor protects against ferroptosis in hepatocellular carcinoma cells. (2019) J. Cell. Mol. Med.. 23, 7349-7359 Pubmed J. Cell. Mol. Med. PMC Article
Almeida M, Soares M, Ramalhinho AC, Moutinho JF, Breitenfeld L and Pereira L. The prognostic value of NRF2 in breast cancer patients: a systematic review with meta-analysis. (2019) Breast Cancer Res. Treat.. Pubmed Breast Cancer Res. Treat.
Zimta AA, Schitcu V, Gurzau E, Stavaru C, Manda G, Szedlacsek S and Berindan-Neagoe I. Biological and molecular modifications induced by cadmium and arsenic during breast and prostate cancer development. (2019) Environ. Res.. 178, 108700 Pubmed Environ. Res.
Liu X, Bai J, Jiang C, Song Z, Zhao Y, Nauwynck H and Jiang P. Therapeutic effect of Xanthohumol against highly pathogenic porcine reproductive and respiratory syndrome viruses. (2019) Vet. Microbiol.. 238, 108431 Pubmed Vet. Microbiol.
Chu Q, Jia R, Chen W, Liu Y, Li Y, Ye X, Jiang Y and Zheng X. Purified Tetrastigma hemsleyanum vines polysaccharide attenuates EC-induced toxicity in Caco-2 cells and Caenorhabditis elegans via DAF-16/FOXO pathway. (2019) Int. J. Biol. Macromol.. Pubmed Int. J. Biol. Macromol.
Kobayashi A and Waku T. New addiction to the NRF2-related factor NRF3 in cancer cells: Ubiquitin-independent proteolysis via the 20S proteasome. (2019) Cancer Sci.. Pubmed Cancer Sci.
Kiesslich T, Mayr C and Neureiter D. NRF2: The key to tumor- and patient-dependent chemosensitivity in biliary tract cancer?. (2019) EBioMedicine. 49, 9-10 Pubmed EBioMedicine
Bernardo PS, Guimarães GHC, De Faria FCC, Longo GMDC, Lopes GPF, Netto CD, Costa PRR and Maia RC. LQB‑118 compound inhibits migration and induces cell death in glioblastoma cells. (2019) Oncol. Rep.. Pubmed Oncol. Rep.
Lian W, Liu X and Chen W. TNFα Induces Multidrug Resistance-Associated Protein 4 Expression through p38-E2F1-Nrf2 Signaling in Obstructive Cholestasis. (2019) Yonsei Med. J.. 60, 1045-1053 Pubmed Yonsei Med. J. PMC Article
Kabel AM, Estfanous RS and Alrobaian MM. Targeting oxidative stress, proinflammatory cytokines, apoptosis and toll like receptor 4 by empagliflozin to ameliorate bleomycin-induced lung fibrosis. (2019) Respir Physiol Neurobiol. 273, 103316 Pubmed Respir Physiol Neurobiol
Lipponen A, Natunen T, Hujo M, Ciszek R, Hämäläinen E, Tohka J, Hiltunen M, Paananen J, Poulsen D, Kansanen E, Ekolle Ndode-Ekane X, Levonen AL and Pitkänen A. In Vitro and In Vivo Pipeline for Validation of Disease-Modifying Effects of Systems Biology-Derived Network Treatments for Traumatic Brain Injury-Lessons Learned. (2019) Int J Mol Sci. 20, Pubmed Int J Mol Sci
Dash S, Aydin Y and Moroz K. Chaperone-Mediated Autophagy in the Liver: Good or Bad?. (2019) Cells. 8, Pubmed Cells
Vabeiryureilai M, Lalrinzuali K and Jagetia GC. Chemopreventive effect of hesperidin, a citrus bioflavonoid in two stage skin carcinogenesis in Swiss albino mice. (2019) Heliyon. 5, e02521 Pubmed Heliyon PMC Article
Yagishita Y, Fahey JW, Dinkova-Kostova AT and Kensler TW. Broccoli or Sulforaphane: Is It the Source or Dose That Matters?. (2019) Molecules. 24, Pubmed Molecules PMC Article
Ali J, Khan AU, Shah FA, Ali H, Islam SU, Kim YS and Khan S. Mucoprotective effects of Saikosaponin-A in 5-fluorouracil-induced intestinal mucositis in mice model. (2019) Life Sci.. 239, 116888 Pubmed Life Sci.
Stenvinkel P, Painer J, Johnson RJ and Natterson-Horowitz B. Biomimetics - Nature's roadmap to insights and solutions for burden of lifestyle diseases. (2019) J. Intern. Med.. Pubmed J. Intern. Med.
Tang KK, Liu XY, Wang ZY, Qu KC and Fan RF. Trehalose alleviates cadmium-induced brain damage by ameliorating oxidative stress, autophagy inhibition, and apoptosis. (2019) Metallomics. Pubmed Metallomics
Zhang HB, Tu XK, Chen Q and Shi SS. Propofol Reduces Inflammatory Brain Injury after Subarachnoid Hemorrhage: Involvement of PI3K/Akt Pathway. (2019) J Stroke Cerebrovasc Dis. 104375 Pubmed J Stroke Cerebrovasc Dis
Jiang S, Yang Z, Huang L, Yang W, Song D, Liu F, Ge J, Wang Y and Jiang S. Effect of Illicium verum or Eucommia ulmoides leaf extracts on the anti-stress ability, and mRNA and protein expression of Nrf2 and TNF-α in Duroc × Landrace × Yorkshire and Chinese native Licha-black nursery piglets. (2019) J Anim Physiol Anim Nutr (Berl). Pubmed J Anim Physiol Anim Nutr (Berl)
Yi J, Huang WZ, Wen YQ and Yi YC. Effect of miR-101 on proliferation and oxidative stress-induced apoptosis of breast cancer cells via Nrf2 signaling pathway. (2019) Eur Rev Med Pharmacol Sci. 23, 8931-8939 Pubmed Eur Rev Med Pharmacol Sci
Kushwaha P, Gupta S, Singh AK, Prajapati KS, Shuaib M and Kumar S. MicroRNA Targeting NADPH Oxidases in Cancer. (2019) Antioxid. Redox Signal.. Pubmed Antioxid. Redox Signal.
Kim W, Lee H, Kim S, Joo S, Jeong S, Yoo JW and Jung Y. Sofalcone, a gastroprotective drug, covalently binds to KEAP1 to activate Nrf2 resulting in anti-colitic activity. (2019) Eur. J. Pharmacol.. 865, 172722 Pubmed Eur. J. Pharmacol.
Shi Y, Fan S, Wu M, Zuo Z, Li X, Jiang L, Shen Q, Xu P, Zeng L, Zhou Y, Huang Y, Yang Z, Zhou J, Gao J, Zhou H, Xu S, Ji H, Shi P, Wu DD, Yang C and Chen Y. YTHDF1 links hypoxia adaptation and non-small cell lung cancer progression. (2019) Nat Commun. 10, 4892 Pubmed Nat Commun PMC Article
Cheleschi S, Gallo I, Barbarino M, Giannotti S, Mondanelli N, Giordano A, Tenti S and Fioravanti A. MicroRNA Mediate Visfatin and Resistin Induction of Oxidative Stress in Human Osteoarthritic Synovial Fibroblasts Via NF-κB Pathway. (2019) Int J Mol Sci. 20, Pubmed Int J Mol Sci PMC Article
Lee JE, Zhong X, Lee JY, Surh YJ and Na HK. 15-Keto prostaglandin E induces heme oxygenase-1 expression through activation of Nrf2 in human colon epithelial CCD 841 CoN cells. (2019) Arch. Biochem. Biophys.. 108162 Pubmed Arch. Biochem. Biophys.
Foglia B and Parola M. Of FACT complex and oxidative stress response: a KEAP1/NRF2-dependent novel mechanism sustaining hepatocellular carcinoma progression. (2019) Gut. Pubmed Gut
Kyung S, Lim JW and Kim H. α-Lipoic Acid Inhibits IL-8 Expression by Activating Nrf2 Signaling in -infected Gastric Epithelial Cells. (2019) Nutrients. 11, Pubmed Nutrients
Si L, Fu J, Liu W, Hayashi T, Nie Y, Mizuno K, Hattori S, Fujisaki H, Onodera S and Ikejima T. Silibinin inhibits migration and invasion of breast cancer MDA-MB-231 cells through induction of mitochondrial fusion. (2019) Mol. Cell. Biochem.. Pubmed Mol. Cell. Biochem.
Wang L, Tang W, Yang S, He P, Wang J, Gaedcke J, Ströbel P, Azizian A, Ried T, Gaida MM, Yfantis HG, Lee DH, Lal A, Van den Eynde BJ, Alexander HR, Ghadimi BM, Hanna N and Hussain SP. NO /RUNX3/kynurenine metabolic signaling enhances disease aggressiveness in pancreatic cancer. (2019) Int. J. Cancer. Pubmed Int. J. Cancer
Salim H, Song J, Sahni A and Pei D. Development of a Cell-Permeable Cyclic Peptidyl Inhibitor against the Keap1-Nrf2 Interaction. (2019) J. Org. Chem.. Pubmed J. Org. Chem.
El-Naggar AM, Somasekharan SP, Wang Y, Cheng H, Negri GL, Pan M, Wang XQ, Delaidelli A, Rafn B, Cran J, Zhang F, Zhang H, Colborne S, Gleave M, Mandinova A, Kedersha N, Hughes CS, Surdez D, Delattre O, Wang Y, Huntsman DG, Morin GB and Sorensen PH. Class I HDAC inhibitors enhance YB-1 acetylation and oxidative stress to block sarcoma metastasis. (2019) EMBO Rep.. e48375 Pubmed EMBO Rep.
Ashrafizadeh M, Fekri HS, Ahmadi Z, Farkhondeh T and Samarghandian S. Therapeutic and biological activities of berberine: The involvement of Nrf2 signaling pathway. (2019) J. Cell. Biochem.. Pubmed J. Cell. Biochem.
Nazari Soltan Ahmad S, Sanajou D, Kalantary-Charvadeh A, Hosseini V, Roshangar L, Khojastehfard M, Haiaty S and Mesgari-Abbasi M. β-LAPachone ameliorates doxorubicin-induced cardiotoxicity via regulating autophagy and Nrf2 signalling pathways in mice. (2019) Basic Clin. Pharmacol. Toxicol.. Pubmed Basic Clin. Pharmacol. Toxicol.
Su R, Su W and Jiao Q. NGF protects neuroblastoma cells against β-amyloid-induced apoptosis via the Nrf2/HO-1 pathway. (2019) FEBS Open Bio. Pubmed FEBS Open Bio
Carota G, Raffaele M, Sorrenti V, Salerno L, Pittalà V and Intagliata S. Ginseng and heme oxygenase-1: The link between an old herb and a new protective system. (2019) Fitoterapia. 139, 104370 Pubmed Fitoterapia
Kahroba H, Shirmohamadi M, Hejazi MS and Samadi N. The Role of Nrf2 signaling in cancer stem cells: from stemness and self-renewal to tumorigenesis and chemoresistance. (2019) Life Sci.. 116986 Pubmed Life Sci.
Jamil MU, Kim J, Yum HW, Kim S, Kim SJ, Kim DH, Cho NC, Na HK and Surh YJ. 17-Oxo-docosahexaenoic acid induces Nrf2-mediated expression of heme oxygenase-1 in mouse skin in vivo and in cultured murine epidermal cells. (2019) Arch. Biochem. Biophys.. 108156 Pubmed Arch. Biochem. Biophys.
Wang Z, Yu K, Hu Y, Su F, Gao Z, Hu T, Yang Y, Cao X and Qian F. Schisantherin A induces cell apoptosis through ROS/JNK signaling pathway in human gastric cancer cells. (2019) Biochem. Pharmacol.. 113673 Pubmed Biochem. Pharmacol.
Qian X, Li X, Shi Z, Bai X, Xia Y, Zheng Y, Xu D, Chen F, You Y, Fang J, Hu Z, Zhou Q and Lu Z. KDM3A Senses Oxygen Availability to Regulate PGC-1α-Mediated Mitochondrial Biogenesis. (2019) Mol. Cell. Pubmed Mol. Cell
Luzón-Toro B, Fernández RM, Martos-Martínez JM, Rubio-Manzanares-Dorado M, Antiñolo G and Borrego S. LncRNA LUCAT1 as a novel prognostic biomarker for patients with papillary thyroid cancer. (2019) Sci Rep. 9, 14374 Pubmed Sci Rep PMC Article
Badamjav R, Sonom D, Wu Y, Zhang Y, Kou J, Yu B and Li F. The protective effects of Thalictrum minus L. on lipopolysaccharide-induced acute lung injury. (2019) J Ethnopharmacol. 112355 Pubmed J Ethnopharmacol
Zhan M, Wang H, Xu SW, Yang LH, Chen W, Zhao SX, Shen H, Liu Q, Yang RM and Wang J. Variants in oxidative stress-related genes affect the chemosensitivity through Nrf2-mediated signaling pathway in biliary tract cancer. (2019) EBioMedicine. 48, 143-160 Pubmed EBioMedicine PMC Article
Bailly C. Potential use of edaravone to reduce specific side effects of chemo-, radio- and immuno-therapy of cancers. (2019) Int. Immunopharmacol.. 77, 105967 Pubmed Int. Immunopharmacol.
Mao C, Xu Y, Shi L, Guo S, Jin X, Yan S and Shi B. Effects of Photoperiod Change on Melatonin Secretion, Immune Function and Antioxidant Status of Cashmere Goats. (2019) Animals (Basel). 9, Pubmed Animals (Basel) PMC Article
Song Y, Jeong HY, Lee JK, Choi YS, Kim DO, Jang D, Park CS, Maeng S and Kang H. Enzyme Treatment Alters the Anti-Inflammatory Activity of the Water Extract of Wheat Germ In Vitro and In Vivo. (2019) Nutrients. 11, Pubmed Nutrients
Li C, Fan K, Qu Y, Zhai W, Huang A, Sun X and Xing S. Deregulation of UCA1 expression may be involved in the development of chemoresistance to cisplatin in the treatment of non-small-cell lung cancer via regulating the signaling pathway of microRNA-495/NRF2. (2019) J. Cell. Physiol.. Pubmed J. Cell. Physiol.
Sun Q, Zhang Z, Lu Y, Liu Q, Xu X, Xu J, Liu Y, Yu H, Yu D and Sun B. Loss of Xanthine Oxidoreductase Potentiates Propagation of Hepatocellular Carcinoma Stem Cells. (2019) Hepatology. Pubmed Hepatology
Haley JA, Ruiz CF, Montal ED, Wang D, Haley JD and Girnun GD. Decoupling of Nrf2 Expression Promotes Mesenchymal State Maintenance in Non-Small Cell Lung Cancer. (2019) Cancers (Basel). 11, Pubmed Cancers (Basel) PMC Article
Bao L, Festa F, Freet CS, Lee JP, Hirschler-Laszkiewicz IM, Chen SJ, Keefer KA, Wang HG, Patterson AD, Cheung JY and Miller BA. The Human Transient Receptor Potential Melastatin 2 Ion Channel Modulates ROS Through Nrf2. (2019) Sci Rep. 9, 14132 Pubmed Sci Rep PMC Article
Ashrafizadeh M, Ahmadi Z, Mohamamdinejad R, Farkhondeh T and Samarghandian S. Curcumin activates the Nrf2 pathway and induces cellular protection against oxidative injury. (2019) Curr. Mol. Med.. Pubmed Curr. Mol. Med.
Akın-Balı DF, Aktas SH, Unal MA and Kankılıc T. Identification of novel Nrf2/Keap1 pathway mutations in pediatric acute lymphoblastic leukemia. (2019) Pediatr Hematol Oncol. 1-18 Pubmed Pediatr Hematol Oncol
Das U, Manna K, Adhikary A, Mishra S, Saha KD, Sharma RD, Majumder B and Dey S. Ferulic acid enhances the radiation sensitivity of lung and liver carcinoma cells by collapsing redox homeostasis: mechanistic involvement of Akt/p38 MAPK signalling pathway. (2019) Free Radic. Res.. 53, 944-967 Pubmed Free Radic. Res.
Bartolini D, Tew KD, Marinelli R, Galli F and Wang GY. Nrf2-modulation by seleno-hormetic agents and its potential for radiation protection. (2019) Biofactors. Pubmed Biofactors
Zhang L, Wu P, Zhang L, SreeHarsha N, Mishra A and Su X. Ameliorative effect of rosiglitazone, a peroxisome proliferator gamma agonist on adriamycin-induced cardio toxicity via suppressing oxidative stress and apoptosis. (2019) IUBMB Life. Pubmed IUBMB Life
Li J, Wang Q, Yang Y, Lei C, Yang F, Liang L, Chen C, Xia J, Wang K and Tang N. GSTZ1 deficiency promotes hepatocellular carcinoma proliferation via activation of the KEAP1/NRF2 pathway. (2019) J. Exp. Clin. Cancer Res.. 38, 438 Pubmed J. Exp. Clin. Cancer Res. PMC Article
Skowron MA, Petzsch P, Hardt K, Wagner N, Beier M, Stepanow S, Drechsler M, Rieder H, Köhrer K, Niegisch G, Hoffmann MJ and Schulz WA. Distinctive mutational spectrum and karyotype disruption in long-term cisplatin-treated urothelial carcinoma cell lines. (2019) Sci Rep. 9, 14476 Pubmed Sci Rep PMC Article
Shi W, Zhang D, Wang L, Sreeharsha N and Ning Y. Curcumin synergistically potentiates the protective effect of sitagliptin against chronic deltamethrin nephrotoxicity in rats: Impact on pro-inflammatory cytokines and Nrf2/Ho-1 pathway. (2019) J. Biochem. Mol. Toxicol.. 33, e22386 Pubmed J. Biochem. Mol. Toxicol.
Zhou ZY, Zhao WR, Zhang J, Chen XL and Tang JY. Sodium tanshinone IIA sulfonate: A review of pharmacological activity and pharmacokinetics. (2019) Biomed. Pharmacother.. 118, 109362 Pubmed Biomed. Pharmacother.
Lin P, Hwang E, Ngo HTT, Seo SA and Yi TH. Sambucus nigra L. ameliorates UVB-induced photoaging and inflammatory response in human skin keratinocytes. (2019) Cytotechnology. 71, 1003-1017 Pubmed Cytotechnology PMC Article
Zaghloul MS, Said E, Suddek GM and Salem HA. Crocin attenuates lung inflammation and pulmonary vascular dysfunction in a rat model of bleomycin-induced pulmonary fibrosis. (2019) Life Sci.. 235, 116794 Pubmed Life Sci.
Verma N, Singh H, Khanna D, Rana PS and Bhadada SK. Classification of drug molecules for oxidative stress signalling pathway. (2019) IET Syst Biol. 13, 243-250 Pubmed IET Syst Biol
Zhang H, Sun H, Peng A, Guo S, Wang M, Loor JJ and Wang H. N-carbamylglutamate and l-arginine promote intestinal function in suckling lambs with intrauterine growth restriction by regulating antioxidant capacity via a nitric oxide-dependent pathway. (2019) Food Funct. 10, 6374-6384 Pubmed Food Funct
Jung J, Zhang Y, Celiku O, Zhang W, Song H, Williams BJ, Giles AJ, Rich JN, Abounader R, Gilbert MR and Park DM. Mitochondrial NIX Promotes Tumor Survival in the Hypoxic Niche of Glioblastoma. (2019) Cancer Res.. 79, 5218-5232 Pubmed Cancer Res. PMC Article
Wu J, Zhang L, Li H, Wu S and Liu Z. Nrf2 induced cisplatin resistance in ovarian cancer by promoting CD99 expression. (2019) Biochem. Biophys. Res. Commun.. 518, 698-705 Pubmed Biochem. Biophys. Res. Commun.
Opichka M, Shute R, Marshall K and Slivka D. Effects of exercise in a cold environment on gene expression for mitochondrial biogenesis and mitophagy. (2019) Cryobiology. 90, 47-53 Pubmed Cryobiology PMC Article
Burgener AV, Bantug GR, Meyer BJ, Higgins R, Ghosh A, Bignucolo O, Ma EH, Loeliger J, Unterstab G, Geigges M, Steiner R, Enamorado M, Ivanek R, Hunziker D, Schmidt A, Müller-Durovic B, Grählert J, Epple R, Dimeloe S, Lötscher J, Sauder U, Ebnöther M, Burger B, Heijnen I, Martínez-Cano S, Cantoni N, Brücker R, Kahlert CR, Sancho D, Jones RG, Navarini A, Recher M and Hess C. SDHA gain-of-function engages inflammatory mitochondrial retrograde signaling via KEAP1-Nrf2. (2019) Nat. Immunol.. 20, 1311-1321 Pubmed Nat. Immunol.
Ghareeb MA, Sobeh M, El-Maadawy WH, Mohammed HS, Khalil H, Botros S and Wink M. Chemical Profiling of Polyphenolics in and Evaluation of Its Hepato-Renal Protective Potential Against Cyclophosphamide Induced Toxicity in Mice. (2019) Antioxidants (Basel). 8, Pubmed Antioxidants (Basel) PMC Article
Bender D and Hildt E. Effect of Hepatitis Viruses on the Nrf2/Keap1-Signaling Pathway and Its Impact on Viral Replication and Pathogenesis. (2019) Int J Mol Sci. 20, Pubmed Int J Mol Sci PMC Article
Resendez A, Tailor D, Graves E and Malhotra SV. Radiosensitization of Head and Neck Squamous Cell Carcinoma (HNSCC) by a Podophyllotoxin. (2019) ACS Med Chem Lett. 10, 1314-1321 Pubmed ACS Med Chem Lett PMC Article
Xu W, Wang M, Cui G, Li L, Jiao D, Yao B, Xu K, Chen Y, Long M, Yang S and He J. Astaxanthin Protects OTA-Induced Lung Injury in Mice through the Nrf2/NF-κB Pathway. (2019) Toxins (Basel). 11, Pubmed Toxins (Basel) PMC Article
Liu SH and Zhang YC. Effect of levocarnitine on cerebral ischemia-reperfusion rats via activating Nrf2/ARE signaling pathway. (2019) Eur Rev Med Pharmacol Sci. 23, 8168-8174 Pubmed Eur Rev Med Pharmacol Sci
Celentano S, Capolongo G and Pollastro RM. [Bardoxolone: a new potential therapeutic agent in the treatment of autosomal dominant polycystic kidney disease?]. (2019) G Ital Nefrol. 36, Pubmed G Ital Nefrol
Bose P, Siddique MUM, Acharya R, Jayaprakash V, Sinha BN, Lapenna A and Pattanayak SP. Quinazolinone derivative BNUA-3 ameliorated [NDEA+2-AAF]-induced liver carcinogenesis in SD rats by modulating AhR-CYP1B1-Nrf2-Keap1 pathway. (2019) Clin. Exp. Pharmacol. Physiol.. Pubmed Clin. Exp. Pharmacol. Physiol.
Lauricella M, Lo Galbo V, Cernigliaro C, Maggio A, Palumbo Piccionello A, Calvaruso G, Carlisi D, Emanuele S, Giuliano M and D'Anneo A. The Anti-Cancer Effect of L. Peel Extract is Associated to γH2AX-mediated Apoptosis in Colon Cancer Cells. (2019) Antioxidants (Basel). 8, Pubmed Antioxidants (Basel) PMC Article
Wan ZH, Jiang TY, Shi YY, Pan YF, Lin YK, Ma YH, Yang C, Feng XF, Huang LF, Kong XN, Ding ZW, Tan YX, Dong LW and Wang HY. RPB5-mediating protein promotes cholangiocarcinoma tumorigenesis and drug resistance by competing with NRF2 for KEAP1 binding. (2019) Hepatology. Pubmed Hepatology
Lee SM, Kim NH, Lee S, Kim YN, Heo JD, Rho JR and Jeong EJ. (10)-Debromohymenialdisine from Marine Sponge sp. Regulates Intestinal Inflammatory Responses in Co-Culture Model of Epithelial Caco-2 Cells and THP-1 Macrophage Cells. (2019) Molecules. 24, Pubmed Molecules PMC Article
Albert AE, Adua SJ, Cai WL, Arnal-Estapé A, Cline GW, Liu Z, Zhao M, Cao PD, Mariappan M and Nguyen DX. Adaptive Protein Translation by the Integrated Stress Response Maintains the Proliferative and Migratory Capacity of Lung Adenocarcinoma Cells. (2019) Mol. Cancer Res.. Pubmed Mol. Cancer Res.
Yang Y, Liu L, Zhang X, Jiang X and Wang L. Tanshinone IIA prevents rifampicin-induced liver injury by regulating BSEP/NTCP expression via epigenetic activation of NRF2. (2019) Liver Int.. Pubmed Liver Int.
Gai C, Yu M, Li Z, Wang Y, Ding D, Zheng J, Lv S, Zhang W and Li W. Acetaminophen sensitizing erastin-induced ferroptosis via modulation of Nrf2/heme oxygenase-1 signaling pathway in non-small-cell lung cancer. (2019) J. Cell. Physiol.. Pubmed J. Cell. Physiol.
Tang X, Fu X, Liu Y, Yu D, Cai SJ and Yang C. Blockade of glutathione metabolism in IDH1-mutated glioma. (2019) Mol. Cancer Ther.. Pubmed Mol. Cancer Ther.
Kwon DH, Lee H, Park C, Hong SH, Hong SH, Kim GY, Cha HJ, Kim S, Kim HS, Hwang HJ and Choi YH. Glutathione Induced Immune-Stimulatory Activity by Promoting M1-Like Macrophages Polarization via Potential ROS Scavenging Capacity. (2019) Antioxidants (Basel). 8, Pubmed Antioxidants (Basel) PMC Article
Castrejón-Jiménez NS, Leyva-Paredes K, Baltierra-Uribe SL, Castillo-Cruz J, Campillo-Navarro M, Hernández-Pérez AD, Luna-Angulo AB, Chacón-Salinas R, Coral-Vázquez RM, Estrada-García I, Sánchez-Torres LE, Torres-Torres C and García-Pérez BE. Ursolic and Oleanolic Acids Induce Mitophagy in A549 Human Lung Cancer Cells. (2019) Molecules. 24, Pubmed Molecules PMC Article
Bousquet MS, Ratnayake R, Pope JL, Chen QY, Zhu F, Chen S, Carney TJ, Gharaibeh RZ, Jobin C, Paul VJ and Luesch H. Seaweed natural products modify the host inflammatory response via Nrf2 signaling and alter colon microbiota composition and gene expression. (2019) Free Radic. Biol. Med.. Pubmed Free Radic. Biol. Med.
Wang LY, Huang CS, Chen YH, Chen CC, Chen CC and Chuang CH. Anti-Inflammatory Effect of Erinacine C on NO Production Through Down-Regulation of NF-κB and Activation of Nrf2-Mediated HO-1 in BV2 Microglial Cells Treated with LPS. (2019) Molecules. 24, Pubmed Molecules PMC Article
Ke Y, Yu K, Zeng W and Lian G. Protective roles of Pyracantha fortuneana extract on acute renal toxicity induced by cadmium chloride in rats. (2019) Acta Cir Bras. 34, e201900706 Pubmed Acta Cir Bras PMC Article
Aydin Y, Kurt R, Song K, Lin D, Osman H, Youngquist B, Scott JW, Shores NJ, Thevenot P, Cohen A and Dash S. Hepatic Stress Response in HCV Infection Promotes STAT3-Mediated Inhibition of HNF4A- Feedback Loop in Liver Fibrosis and Cancer Progression. (2019) Cancers (Basel). 11, Pubmed Cancers (Basel) PMC Article
Kim MJ, Park H, Choi SH, Kong MJ, Kim JE and Kang TC. CDDO-Me Attenuates Vasogenic Edema and Astroglial Death by Regulating NF-κB p65 Phosphorylations and Nrf2 Expression Following Status Epilepticus. (2019) Int J Mol Sci. 20, Pubmed Int J Mol Sci PMC Article
Chen LH, Liao CY, Lai LC, Tsai MH and Chuang EY. Semaphorin 6A Attenuates the Migration Capability of Lung Cancer Cells via the NRF2/HMOX1 Axis. (2019) Sci Rep. 9, 13302 Pubmed Sci Rep PMC Article
Zou Y, Wang Y, Cai Y and Ma D. [Effects of equol on proliferation of colorectal cancer HCT-15 cell]. (2019) Wei Sheng Yan Jiu. 48, 803-806 Pubmed Wei Sheng Yan Jiu
Zhou JW, Wang M, Sun NX, Qing Y, Yin TF, Li C and Wu D. Sulforaphane-induced epigenetic regulation of Nrf2 expression by DNA methyltransferase in human Caco-2 cells. (2019) Oncol Lett. 18, 2639-2647 Pubmed Oncol Lett PMC Article
Afridi R, Khan AU, Khalid S, Shal B, Rasheed H, Ullah MZ, Shehzad O, Kim YS and Khan S. Anti-hyperalgesic properties of a flavanone derivative Poncirin in acute and chronic inflammatory pain models in mice. (2019) BMC Pharmacol Toxicol. 20, 57 Pubmed BMC Pharmacol Toxicol PMC Article
de Oliveira MR, de Souza ICC and Fürstenau CR. Mitochondrial Protection Promoted by the Coffee Diterpene Kahweol in Methylglyoxal-Treated Human Neuroblastoma SH-SY5Y Cells. (2019) Neurotox Res. Pubmed Neurotox Res
Zhang Z, Zhang Y and Zhou R. Loss of Annexin A5 expression attenuates the lipopolysaccharide-induced inflammatory response of rat alveolar macrophages. (2019) Cell Biol. Int.. Pubmed Cell Biol. Int.
Ostrand-Rosenberg S, Beury DW, Parker KH and Horn LA. Survival of the fittest: how myeloid-derived suppressor cells survive in the inhospitable tumor microenvironment. (2019) Cancer Immunol. Immunother.. Pubmed Cancer Immunol. Immunother.
Tauffenberger A, Fiumelli H, Almustafa S and Magistretti PJ. Lactate and pyruvate promote oxidative stress resistance through hormetic ROS signaling. (2019) Cell Death Dis. 10, 653 Pubmed Cell Death Dis PMC Article
Kim HG, Kim CW, Lee DH, Lee JS, Oh ET and Park HJ. Quinacrine-Mediated Inhibition of Nrf2 Reverses Hypoxia-Induced 5-Fluorouracil Resistance in Colorectal Cancer. (2019) Int J Mol Sci. 20, Pubmed Int J Mol Sci PMC Article
Cho HY and Kleeberger SR. Mitochondrial biology in airway pathogenesis and the role of NRF2. (2019) Arch. Pharm. Res.. Pubmed Arch. Pharm. Res.
Rajib SA and Sharif Siam MK. Characterization and Analysis of Mammalian AKR7A Gene Promoters: Implications for Transcriptional Regulation. (2019) Biochem. Genet.. Pubmed Biochem. Genet.
Qin JJ, Cheng XD, Zhang J and Zhang WD. Dual roles and therapeutic potential of Keap1-Nrf2 pathway in pancreatic cancer: a systematic review. (2019) Cell Commun. Signal. 17, 121 Pubmed Cell Commun. Signal PMC Article
Ferraro SA, Domingo MG, Etcheverrito A, Olmedo DG and Tasat DR. Neurotoxicity mediated by oxidative stress caused by titanium dioxide nanoparticles in human neuroblastoma (SH-SY5Y) cells. (2019) J Trace Elem Med Biol. 126413 Pubmed J Trace Elem Med Biol
Lee JH, Rangappa S, Mohan CD, , Sethi G, Lin ZX, Rangappa KS and Ahn KS. Brusatol, a Nrf2 Inhibitor Targets STAT3 Signaling Cascade in Head and Neck Squamous Cell Carcinoma. (2019) Biomolecules. 9, Pubmed Biomolecules
Wang N, Song L, Xu Y, Zhang L, Wu Y, Guo J, Ji W, Li L, Zhao J, Zhang X and Zhan L. Loss of Scribble confers cisplatin resistance during NSCLC chemotherapy via Nox2/ROS and Nrf2/PD-L1 signaling. (2019) EBioMedicine. 47, 65-77 Pubmed EBioMedicine PMC Article
Pljesa-Ercegovac M, Savic-Radojevic A, Coric V, Radic T and Simic T. Glutathione transferase genotypes may serve as determinants of risk and prognosis in renal cell carcinoma. (2019) Biofactors. Pubmed Biofactors
Best SA, Ding S, Kersbergen A, Dong X, Song JY, Xie Y, Reljic B, Li K, Vince JE, Rathi V, Wright GM, Ritchie ME and Sutherland KD. Distinct initiating events underpin the immune and metabolic heterogeneity of KRAS-mutant lung adenocarcinoma. (2019) Nat Commun. 10, 4190 Pubmed Nat Commun PMC Article
Sha JY, Zhou YD, Yang JY, Leng J, Li JH, Hu JN, Liu W, Jiang S, Wang YP, Chen C and Li W. Maltol (3-Hydroxy-2-methyl-4-pyrone) Slows d-Galactose-Induced Brain Aging Process by Damping the Nrf2/HO-1-Mediated Oxidative Stress in Mice. (2019) J. Agric. Food Chem.. 67, 10342-10351 Pubmed J. Agric. Food Chem.
Wang W, Yuhai , Wang H, Chasuna and Bagenna . Astilbin reduces ROS accumulation and VEGF expression through Nrf2 in psoriasis-like skin disease. (2019) Biol. Res.. 52, 49 Pubmed Biol. Res. PMC Article
Leung CH, Zhang JT, Yang GJ, Liu H, Han QB and Ma DL. Emerging Screening Approaches in the Development of Nrf2-Keap1 Protein-Protein Interaction Inhibitors. (2019) Int J Mol Sci. 20, Pubmed Int J Mol Sci PMC Article
Gao X, Guo N, Xu H, Pan T, Lei H, Yan A, Mi Y and Xu L. Ibuprofen induces ferroptosis of glioblastoma cells via downregulation of nuclear factor erythroid 2-related factor 2 signaling pathway. (2019) Anticancer Drugs. Pubmed Anticancer Drugs
Liu CF, Zhang JX, Li YQ, Li C, Zhu XX, Jia KX, Wang JX, Wang JX, Fan YF, Xu Y, Wang T and Lin N. [Effects of Tripterygium Glycosides Tablets from 6 different manufacturers on acute liver injury of normal mice]. (2019) Zhongguo Zhong Yao Za Zhi. 44, 3494-3501 Pubmed Zhongguo Zhong Yao Za Zhi
Passero FC, Ravi D, McDonald JT, Beheshti A, David KA and Evens AM. Combinatorial ixazomib and belinostat therapy induces NFE2L2-dependent apoptosis in Hodgkin and T-cell lymphoma. (2019) Br. J. Haematol.. Pubmed Br. J. Haematol.
Milković L, Tomljanović M, Čipak Gašparović A, Novak Kujundžić R, Šimunić D, Konjevoda P, Mojzeš A, Đaković N, Žarković N and Gall Trošelj K. Nutritional Stress in Head and Neck Cancer Originating Cell Lines: The Sensitivity of the NRF2-NQO1 Axis. (2019) Cells. 8, Pubmed Cells PMC Article
Jin J, Qiu S, Wang P, Liang X, Huang F, Wu H, Zhang B, Zhang W, Tian X, Xu R, Shi H and Wu X. Cardamonin inhibits breast cancer growth by repressing HIF-1α-dependent metabolic reprogramming. (2019) J. Exp. Clin. Cancer Res.. 38, 377 Pubmed J. Exp. Clin. Cancer Res. PMC Article
Kadıoğlu E, Tekşen Y, Koçak C and Koçak FE. Beneficial effects of bardoxolone methyl, an Nrf2 activator, on crush-related acute kidney injury in rats. (2019) Eur J Trauma Emerg Surg. Pubmed Eur J Trauma Emerg Surg
Packer JR, Hirst AM, Droop AP, Adamson R, Simms MS, Mann VM, Frame FM, O'Connell D and Maitland NJ. Notch signalling is a potential resistance mechanism of progenitor cells within patient-derived prostate cultures following ROS-inducing treatments. (2019) FEBS Lett.. Pubmed FEBS Lett.
Kheiry M, Dianat M, Badavi M, Mard SA and Bayati V. p-Coumaric acid protects cardiac function against lipopolysaccharide-induced acute lung injury by attenuation of oxidative stress. (2019) Iran J Basic Med Sci. 22, 949-955 Pubmed Iran J Basic Med Sci PMC Article
Jia Q, Wang Y, Liu X, Ma S and Yang R. [Effects of genistein on Nrf2/HO-1 pathway in myocardial tissues of diabetic rats]. (2019) Zhong Nan Da Xue Xue Bao Yi Xue Ban. 44, 850-856 Pubmed Zhong Nan Da Xue Xue Bao Yi Xue Ban
Zhou J, Zhang S, Xu Y, Ye W, Li Z, Chen Z and He Z. Cullin 3 overexpression inhibits lung cancer metastasis and is associated with survival of lung adenocarcinoma. (2019) Clin. Exp. Metastasis. Pubmed Clin. Exp. Metastasis
Kovács P, Csonka T, Kovács T, Sári Z, Ujlaki G, Sipos A, Karányi Z, Szeőcs D, Hegedűs C, Uray K, Jankó L, Kiss M, Kiss B, Laoui D, Virág L, Méhes G, Bai P and Mikó E. Lithocholic Acid, a Metabolite of the Microbiome, Increases Oxidative Stress in Breast Cancer. (2019) Cancers (Basel). 11, Pubmed Cancers (Basel) PMC Article
Zeng TT, Yao TW, Li XZ and Tang CL. [Electroacupuncture intervention increases testosterone level of aged rats by activating ERK/Nrf2/HO-1 signaling of Leydig cells]. (2019) Zhen Ci Yan Jiu. 44, 566-70 Pubmed Zhen Ci Yan Jiu
Ji L, Zhang R, Chen J, Xue Q, Moghal N and Tsao MS. PIDD interaction with KEAP1 as a new mutation-independent mechanism to promote NRF2 stabilization and chemoresistance in NSCLC. (2019) Sci Rep. 9, 12437 Pubmed Sci Rep PMC Article
Yan TT, Xu GC, Peng Q, Wu WD, Yi XW and Zhao YZ. [Renal Injury and Its Mechanisms in Mice]. (2019) Sichuan Da Xue Xue Bao Yi Xue Ban. 50, 334-338 Pubmed Sichuan Da Xue Xue Bao Yi Xue Ban
Zhou S, Jin J, Wang J, Zhang Z, Huang S, Zheng Y and Cai L. Effects of Breast Cancer Genes 1 and 2 on Cardiovascular Diseases. (2019) Curr Probl Cardiol. 100421 Pubmed Curr Probl Cardiol
Mohamed MZ, Hafez HM, Mohamed HH and Zenhom NM. STAT3 and Nrf2 pathways modulate the protective effect of verapamil on lung injury of diabetic rats. (2018) Endocr Regul. 52, 192-198 Pubmed Endocr Regul
Chen M, Samuel VP, Wu Y, Dang M, Lin Y, Sriramaneni R, Sah SK, Chinnaboina GK and Zhang G. Nrf2/HO-1 Mediated Protective Activity of Genistein Against Doxorubicin-Induced Cardiac Toxicity. (2019) J. Environ. Pathol. Toxicol. Oncol.. 38, 143-152 Pubmed J. Environ. Pathol. Toxicol. Oncol.
Sun X, Wang S, Gai J, Guan J, Li J, Li Y, Zhao J, Zhao C, Fu L and Li Q. SIRT5 Promotes Cisplatin Resistance in Ovarian Cancer by Suppressing DNA Damage in a ROS-Dependent Manner via Regulation of the Nrf2/HO-1 Pathway. (2019) Front Oncol. 9, 754 Pubmed Front Oncol PMC Article
Khezri R and Rusten TE. Autophagy and Tumorigenesis in Drosophila. (2019) Adv. Exp. Med. Biol.. 1167, 113-127 Pubmed Adv. Exp. Med. Biol.
Li X, Yao Q, Huang J, Jin Q, Xu B, Chen F and Tu C. Morin Hydrate Inhibits TREM-1/TLR4-Mediated Inflammatory Response in Macrophages and Protects Against Carbon Tetrachloride-Induced Acute Liver Injury in Mice. (2019) Front Pharmacol. 10, 1089 Pubmed Front Pharmacol PMC Article
Czogalla B, Kahaly M, Mayr D, Schmoeckel E, Niesler B, Hester A, Zeder-Göß C, Kolben T, Burges A, Mahner S, Jeschke U and Trillsch F. Correlation of NRF2 and progesterone receptor and its effects on ovarian cancer biology. (2019) Cancer Manag Res. 11, 7673-7684 Pubmed Cancer Manag Res PMC Article
Gunderstofte C, Iversen MB, Peri S, Thielke A, Balachandran S, Holm CK and Olagnier D. Nrf2 Negatively Regulates Type I Interferon Responses and Increases Susceptibility to Herpes Genital Infection in Mice. (2019) Front Immunol. 10, 2101 Pubmed Front Immunol PMC Article
Wang N, Xin H, Xu P, Yu Z and Shou D. Erxian Decoction Attenuates TNF-α Induced Osteoblast Apoptosis by Modulating the Akt/Nrf2/HO-1 Signaling Pathway. (2019) Front Pharmacol. 10, 988 Pubmed Front Pharmacol PMC Article
Quinn TJ, Ding X, Li X, Wilson GD, Buelow K, Sivananthan A, Thermozier S, Henderson A, Epperly MW, Franicola D, Wipf P, Greenberger JS, Stevens CW and Kabolizadeh P. Amelioration of Mucositis in Proton Therapy of Fanconi Anemia Fanca Mice by JP4-039. In Vivo. 33, 1757-1766 Pubmed In Vivo
Kobaisi F, Fayyad N, Rezvani HR, Fayyad-Kazan M, Sulpice E, Badran B, Fayyad-Kazan H, Gidrol X and Rachidi W. Signaling Pathways, Chemical and Biological Modulators of Nucleotide Excision Repair: The Faithful Shield against UV Genotoxicity. (2019) Oxid Med Cell Longev. 2019, 4654206 Pubmed Oxid Med Cell Longev PMC Article
Varmazyar R, Noori-Zadeh A, Abbaszadeh HA, Hamidabadi HG, Rajaei F, Darabi S, Rezaie MJ, Abdollahifar MA, Zafari F and Bakhtiyari S. Neural stem cells neuroprotection by simvastatin via autophagy induction and apoptosis inhibition. (2019) Bratisl Lek Listy. 120, 744-751 Pubmed Bratisl Lek Listy
Yu Y, Tian ZQ, Liang L, Yang X, Sheng DD, Zeng JX, Li XY, Shi RY, Han ZP and Wei LX. Babao Dan attenuates acute ethanol-induced liver injury via Nrf2 activation and autophagy. (2019) Cell Biosci. 9, 80 Pubmed Cell Biosci PMC Article
Michel M, Hollenbach M, Pohl S, Ripoll C and Zipprich A. Inhibition of Glyoxalase-I Leads to Reduced Proliferation, Migration and Colony Formation, and Enhanced Susceptibility to Sorafenib in Hepatocellular Carcinoma. (2019) Front Oncol. 9, 785 Pubmed Front Oncol PMC Article
Song S, Chu L, Liang H, Chen J, Liang J, Huang Z, Zhang B and Chen X. Protective Effects of Dioscin Against Doxorubicin-Induced Hepatotoxicity Regulation of Sirt1/FOXO1/NF-κb Signal. (2019) Front Pharmacol. 10, 1030 Pubmed Front Pharmacol PMC Article
Hämäläinen M, Teppo HR, Skarp S, Haapasaari KM, Porvari K, Vuopala K, Kietzmann T and Karihtala P. NRF1 and NRF2 mRNA and Protein Expression Decrease Early during Melanoma Carcinogenesis: An Insight into Survival and MicroRNAs. (2019) Oxid Med Cell Longev. 2019, 2647068 Pubmed Oxid Med Cell Longev PMC Article
Wu Y, Wei G, Yu J, Chen Z, Xu Z, Shen R, Liang T, Zheng L, Wang K, Sun X and Li X. Danhong Injection Alleviates Postoperative Intra-abdominal Adhesion in a Rat Model. (2019) Oxid Med Cell Longev. 2019, 4591384 Pubmed Oxid Med Cell Longev PMC Article
Zhou Y, Wang X, Ying W, Wu D and Zhong P. Cryptotanshinone Attenuates Inflammatory Response of Microglial Cells via the Nrf2/HO-1 Pathway. (2019) Front Neurosci. 13, 852 Pubmed Front Neurosci PMC Article