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Multiple Sclerosis, Oxidative Stress and Nrf2: What you Need to Know!
Multiple Sclerosis is an autoimmune disease that damages the nerves in the brain and spinal cord. This damage causes loss of muscle control, tingling of the nerves or numbness in the body. Vision and balance can also be negatively impacted. Sclerosis means the creation or buildup of scar tissue in the brain and spine. This buildup destroys the protective covering (myelin) around the nerves. This in turn interrupts the communications between the brain, spinal cord and other areas of the body.
MS Nrf2

What is Multiple Sclerosis?

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Multiple Sclerosis is an autoimmune disease that damages the nerves in the brain and spinal cord. This damage causes loss of muscle control, tingling of the nerves or numbness in the body. Vision and balance can also be negatively impacted. Sclerosis means the creation or buildup of scar tissue in the brain and spine. This buildup destroys the protective covering (myelin) around the nerves. This in turn interrupts the communications between the brain, spinal cord and other areas of the body.

Secondarily, the disease generates inflammatory-mediated reactive oxygen and nitrogen species within the body. Those that study Nuclear factor-erythroid 2-related factor 2 (Nrf2) know this has a negative impact on the production of protective antioxidant and detoxication enzymes within the cells.

The disease affects 400,000 plus Americans according to the WebMD website. Statistically more females are impacted by the disease than males. Prime ages for risk are between 20 and 50 years old.

Multiple Sclerosis Symptoms:

  1. Vision problems: Blurred and or double vision
  2. Eye pain
  3. Muscle weakness
  4. Coordination problems
  5. Muscle stiffness
  6. Bladder control problems

NRF2, Oxidative Stress and Multiple Sclerosis Studies

NRF2 activation or balancing may help MS patients in the following ways.

  1. Reduction or slowdown of scar tissue creation. NRF2 activation has been shown to reduce fibrosis in the body.
  2. Increased production of protective antioxidant and detoxication enzymes
  3. Nrf2 can modulate an autoimmune neuroinflammatory response
  4. A study published in Pharmacogenomics Journal (June 2012) showed NRF2 treatment worked best when consistently applied as opposed to once off “boost” treatments.
  5. Production of antioxidant genes regulate inflammatory cytokines and endogenous anti-oxidants which are variables affecting disease progression in multiple sclerosis (MS). In addition they exert neuroprotective effects directly.(See Sci Rep. 2011;1:201. Epub 2011 Dec 19)

Information provided on this site is for educational purposes only. Do your own research, and consult with a medical professional about your findings.


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Oxidative Stress
New Protandim Study – International Formula Impact on Oxidative Stress
There are numerous studies about the USA Protandim formula. This one is about the International formulation.
Augusta Nrf2 Study
Augusta University Discovers How Nrf2 Activator Preserves Sight in Retinal Degeneration Model
“We are very, very pleased that we can now explore the mechanisms,”, mentioned Dr. Sylvia Smith, chair of the Department of Cellular Biology and Anatomy at the Medical College of Georgia at Augusta University and co-director of the James and Jean Culver Vision Discovery Institute at AU.
persistent fibrosis
Reversal of persistent fibrosis in aging by targeting nox4-Nrf2 redox imbalance – Sciencemag.org
This is a promising study because the current treatments of pathological and cystic fibrosis are costly and very time consuming. Persistent fibrosis in lungs of aged mice was caused by the loss of cellular redox balance. The mice in the study with low NRF2 expression had a higher incidence of progressive lung disease. Tissues from human lung samples demonstrated this same Nox4-Nrf2 imbalance.

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