Multiple Sclerosis is an autoimmune disease that damages the nerves in the brain and spinal cord. This damage causes loss of muscle control, tingling of the nerves or numbness in the body. Vision and balance can also be negatively impacted. Sclerosis means the creation or buildup of scar tissue in the brain and spine. This buildup destroys the protective covering (myelin) around the nerves. This in turn interrupts the communications between the brain, spinal cord and other areas of the body.
Secondarily, the disease generates inflammatory-mediated reactive oxygen and nitrogen species within the body. Those that study Nuclear factor-erythroid 2-related factor 2 (Nrf2) know this has a negative impact on the production of protective antioxidant and detoxication enzymes within the cells.
The disease affects 400,000 plus Americans according to the WebMD website. Statistically more females are impacted by the disease than males. Prime ages for risk are between 20 and 50 years old.
NRF2 activation or balancing may help MS patients in the following ways.
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