Notice: Undefined index: id in /var/www/html/wp-content/plugins/seo-by-rank-math/includes/opengraph/class-image.php on line 130
Parkinson’s and Nrf2: New Research
A new study has been published in the journal Antioxidants and Redox Signaling by Dr. Bobby Thomas who is a neuroscientist with the Medical College of Georgia at Georgia Health Sciences University. His study shows that NRF2 activation in an animal model boosts the cell’s production of its own antioxidant enzymes and manages inflammation at the same time. This helps the cells recover from the damaging effects of high oxidative stress associated with Parkinson’s disease.
Parkinsons-nrf2

A new study has been published in the journal Antioxidants and Redox Signaling by Dr. Bobby Thomas who is a neuroscientist with the Medical College of Georgia at Georgia Health Sciences University. His study shows that NRF2 activation in an animal model boosts the cell’s production of its own antioxidant enzymes and manages inflammation at the same time. This helps the cells recover from the damaging effects of high oxidative stress associated with Parkinson’s disease.

More specifically, Thomas and his fellow researchers proved that they were able to block the death of dopamine-producing brain cells that occurs in Parkinson’s by activating Nrf2, a natural antioxidant and inflammation fighter.

Parkinson’s Disease Symptoms Include:

  • Tremors
  • Slowed movement (bradykinesia).
  • Rigid muscles/Muscle stiffness
  • Loss of automatic movements including blinking, smiling or swinging your arms when you walk.
  •  Speech changes

This is not the first study to have been completed on NRF-2 and Parkinson’s. Pubmed has the following additional studies.

  • The Nrf2-ARE Pathway: A Valuable Therapeutic Target for the Treatment of Neurodegenerative Diseases.
  • 15-Deoxy-Δ12,14-prostaglandin J₂ modulates manganese-induced activation of the NF-κB, Nrf2, and PI3K pathways in astrocytes.
  • Molecular mechanism underlying the cerebral effect of Gly-Pro-Glu tripeptide bound to L: -dopa in a Parkinson‘s animal model.
  • Genetic activation of Nrf2 signaling is sufficient to ameliorate neurodegenerative phenotypes in a Drosophila model of Parkinson‘s disease.
  • Maneb and paraquat-mediated neurotoxicity: involvement of peroxiredoxin/thioredoxin system.
  • Regulation of dopaminergic neuronal death by endogenous dopamine and proteasome activity].
  • Controlled enzymatic production of astrocytic hydrogen peroxide protects neurons from oxidative stress via an Nrf2-independent pathway.
  • Different susceptibility to the Parkinson‘s toxin MPTP in mice lacking the redox master regulator Nrf2 or its target gene heme oxygenase-1.
  • Decaffeinated coffee and nicotine-free tobacco provide neuroprotection in Drosophila models of Parkinson‘s disease through an NRF2-dependent mechanism.
  • Association of Nrf2-encoding NFE2L2 haplotypes with Parkinson‘s disease.
  • Therapeutic approaches to mitochondrial dysfunction in Parkinson‘s disease.
  • Genome-wide microarray analysis of the differential neuroprotective effects of antioxidants in neuroblastoma cells overexpressing the familial Parkinson‘s disease alpha-synuclein A53T mutation.
  • Nrf2-mediated neuroprotection in the MPTP mouse model of Parkinson‘s disease: Critical role for the astrocyte.
  • Transcribe to survive: transcriptional control of antioxidant defense programs for neuroprotection in Parkinson‘s disease.
  • Bromocriptine activates NQO1 via Nrf2-PI3K/Akt signaling: novel cytoprotective mechanism against oxidative damage.
  • Expression of Nrf2 in neurodegenerative diseases.
  • Proteasome inhibition induces glutathione synthesis and protects cells from oxidative stress: relevance to Parkinson disease.The Nrf2-ARE Signalling pathway: promising drug target to combat oxidative stress in neurodegenerative disorders.

Information provided on this site is for educational purposes only. Do your own research, and consult with a medical professional about your findings.


Sign Up for Our Newsletter



Read More

Oxidative Stress
New Protandim Study – International Formula Impact on Oxidative Stress
There are numerous studies about the USA Protandim formula. This one is about the International formulation.
Augusta Nrf2 Study
Augusta University Discovers How Nrf2 Activator Preserves Sight in Retinal Degeneration Model
“We are very, very pleased that we can now explore the mechanisms,”, mentioned Dr. Sylvia Smith, chair of the Department of Cellular Biology and Anatomy at the Medical College of Georgia at Augusta University and co-director of the James and Jean Culver Vision Discovery Institute at AU.
persistent fibrosis
Reversal of persistent fibrosis in aging by targeting nox4-Nrf2 redox imbalance – Sciencemag.org
This is a promising study because the current treatments of pathological and cystic fibrosis are costly and very time consuming. Persistent fibrosis in lungs of aged mice was caused by the loss of cellular redox balance. The mice in the study with low NRF2 expression had a higher incidence of progressive lung disease. Tissues from human lung samples demonstrated this same Nox4-Nrf2 imbalance.

Next Steps

Get Our Free Newsletter

View Resources

Take Our Quiz

0

PROJECTS COMPLETED

0

ACTIVE CLIENTS

0

CUPS OF COFFEE

0

HAPPY CLIENTS

TESTIMONIALS

What They Say?

SEND US YOUR FEEDBACK

Get a face-to-face appoinment with our qualified specialists

PHONE NUMBER

+ 924 888 0250

EMAIL ADDRESS

hello@spirit.health

OUR LOCATION

Crown Rd. 14b, San Diego, California


© 2021 / Spirit Health / All rights reserved

Malcare WordPress Security