Reversal of persistent fibrosis in aging by targeting nox4-Nrf2 redox imbalance – Sciencemag.org
This is a promising study because the current treatments of pathological and cystic fibrosis are costly and very time consuming. Persistent fibrosis in lungs of aged mice was caused by the loss of cellular redox balance. The mice in the study with low NRF2 expression had a higher incidence of progressive lung disease. Tissues from human lung samples demonstrated this same Nox4-Nrf2 imbalance.
persistent fibrosis

A brand new article in Sciencemag.org presents a study demonstrating how pathological fibrosis increases with age, but how NRF2 activation in mice was able to reverse the damage and repair lung capacity and fibrosis (scar tissue) resolution.

This is a promising study because the current treatments of pathological and cystic fibrosis are costly and very time consuming. Persistent fibrosis in lungs of aged mice was caused by the loss of cellular redox balance. The mice in the study with low NRF2 expression had a higher incidence of progressive lung disease. Tissues from human lung samples demonstrated this same Nox4-Nrf2 imbalance.

The abstract concludes with the following promising statement. “The studies suggest that restoration of Nox4-Nrf2 redox balance in myofibroblasts may be a therapeutic strategy in age-associated fibrotic disorders, potentially able to resolve persistent fibrosis or even reverse its progression.”


Sign Up for Our Newsletter



Read More

Oxidative Stress
New Protandim Study – International Formula Impact on Oxidative Stress
There are numerous studies about the USA Protandim formula. This one is about the International formulation.
Augusta Nrf2 Study
Augusta University Discovers How Nrf2 Activator Preserves Sight in Retinal Degeneration Model
“We are very, very pleased that we can now explore the mechanisms,”, mentioned Dr. Sylvia Smith, chair of the Department of Cellular Biology and Anatomy at the Medical College of Georgia at Augusta University and co-director of the James and Jean Culver Vision Discovery Institute at AU.
persistent fibrosis
Reversal of persistent fibrosis in aging by targeting nox4-Nrf2 redox imbalance – Sciencemag.org
This is a promising study because the current treatments of pathological and cystic fibrosis are costly and very time consuming. Persistent fibrosis in lungs of aged mice was caused by the loss of cellular redox balance. The mice in the study with low NRF2 expression had a higher incidence of progressive lung disease. Tissues from human lung samples demonstrated this same Nox4-Nrf2 imbalance.

Next Steps

Get Our Free Newsletter

View Resources

Take Our Quiz

0

PROJECTS COMPLETED

0

ACTIVE CLIENTS

0

CUPS OF COFFEE

0

HAPPY CLIENTS

TESTIMONIALS

What They Say?

SEND US YOUR FEEDBACK

Get a face-to-face appoinment with our qualified specialists

PHONE NUMBER

+ 924 888 0250

EMAIL ADDRESS

hello@spirit.health

OUR LOCATION

Crown Rd. 14b, San Diego, California


© 2021 / Spirit Health / All rights reserved

Malcare WordPress Security