Michael J. Fox Foundation Awards an Additional Grant for Nrf2 Research

Michael J. Fox Foundation Awards an Additional Grant for Nrf2 Research

Our original article highlighting the Michael J. Fox Foundation’s interest in NRF2 activation solutions for Parkinson’s disease met with a lot of interest, so we decided to do a follow up piece highlighting an additional study that is currently underway.

This time, the Michael J. Fox Foundation has provided a grant in its search for a Parkinson’s Disease (PD) cure to Dr. Martin Martinov, PhD. His research project is entitled “Identification of Nrf2 Activators Using an In Silico Modeling Platform, Followed by Evaluation of These Compounds in an Alpha-Synuclein Model of PD”.

End-in-Mind:
As demonstrated in numerous medical studies, Oxidative stress plays a crucial role in the advancement of many disease conditions. This includes Parkinson’s disease (PD). The aim of this study is to determine whether the transcription factor NF-E2-related factor (Nrf2) induces antioxidant protection and phase II detoxification enzymes. Numerous studies have been published on Pubmed which suggests protection to vulnerable neurons through the NRF2/ARE pathway. This neuronal Nrf2 up-regulation study is considered an attractive therapeutic strategy for PD by the Michael J. Fox Foundation.

Project Description:
Gradient Biomodeling, LLC claims to have identified two new potent non-toxic Nrf2 pathway activators. Their approach claims to have higher modulators than two other NRF2 activators, BHQ and Sulforaphane. Their preliminary experiments show evidence of blood brain barrier penetration.. The main objective is to determine whether these Nrf2 activators will result in neuroprotection in  pre-clinical Parkinson’s disease conditions.

Progress Report:
Thus far the experiments prove that blood brain barrier penetration takes place. Furthermore, the compounds offer protection of dopaminergic neurons in vitro. The researchers are continuing to explore methods to improve solubility of GB822 in the gut, or to bypass the gut via alternative delivery of the compound.

Nrf2 Research Moving Forward:
Nrf2 research studies will continue to be the topic of study not just for treatment of Parkinson’s Disease, but also for the other hundreds of diseases associated with Oxidative Stress as well. The recent FDA’s approval of the NRF2 activator, Tecfidera for the treatment of MS symptoms will further the interest in using NRF2 activators to treat disease conditions. It is estimated that more than 4 million people have Parkinson’s Disease. Those impacted by the disease including patients, families, care providers and medical practitioners are interested in finding a solution to slow down or eradicate the disease.

This article is educational purposes only, consult with a medical professional to discuss your own medical conditions.

Visit the Michael J Fox Foundation for more information or to become more involved in finding a cure for Parkinson’s. The NRF2 Study details are on the Michael J. Fox Foundation’s web site.

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Multiple Sclerosis: Tecfidera (BG-12), tBHQ, SFN and Protandim Compared

Multiple Sclerosis: Tecfidera (BG-12), tBHQ, SFN and Protandim Compared

 

English: This slide shows the global prevalenc...

English: This slide shows the global prevalence of multiple sclerosis. Deutsch: Geographische Verteilung der Multiple Sklerose Česky: Geografické rozšíření roztroušené sklerózy (Photo credit: Wikipedia)

 

In a previous post entitled,  “Multiple Sclerosis, Oxidative Stress and NRF2: What you Need to Know!” The potential benefits of NRF2 activation on Multiple Sclerosis (MS) were examined.

 

This post updates the previous post to include findings from a paper presented to 5th Joint triennial congress of the European and Americas Committees for Treatment and Research in Multiple Sclerosis (Amsterdam, The Netherlands 2011)

 

The study by J. Lim, S. van der Pol, J. Drexhage, E. de Vries, J. van Horssen (Amsterdam, NL) investigates the potential that four different Nrf2 activators (BG-12, tBHQ, SFN and protandim) had to boost antioxidant enzyme expression in oligodendrocytes and protect them from reactive oxygen species (ROS)-mediated cell death. View the MS & NRF2 study summary.

 

To quote from the summary, “BG-12, tBHQ, SFN and protandim are well-tolerated and strongly induce Nrf2-driven antioxidant enzyme production in oligodendrocytes, with protandim showing the most potent induction.”

 

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How Long Should I Continue Taking My Nrf2 Activation Supplement?

How Long Should I Continue Taking My Nrf2 Activation Supplement?

As a consumer of numerous vitamins and supplements over the years I would frequently start and stop consuming various supplements based on the recommendations of a Herbologist friend of mine.  I used to suffer from seasonal allergies and was constantly looking for a “cure” or at least an effective means of reducing the effects of the allergies. My mindset was that I’d give the various supplements “a try” and if they did not work, meaning stop my allergy symptoms, I would stop using them. I would finish off my 30 day supply before deciding whether to continue or relegate that “treatment” to the list of “been there done that” list of supplements.

A few years ago I was introduced to a supplement that could activate NRF2 in the body. I was educated then and have continued to receive further health updates on the benefits of NRF2 activation. Here is what I have discovered.

1. The benefits of NRF2 activation are achieved more like an exercise regimen than a painkiller.

When you take a painkiller to treat pain, you would not want it to take effect in 6 months time! It is designed to treat the pain immediately. Although NRF2 activation does begin to work within a few hours after consuming a NRF2 activation ingredient, it’s effects are more gradual and long term.

Consider someone expecting to be in shape after one visit to the gym, or even one month’s visits?  If I had followed my previous “methodology” of deciding whether supplements worked or didn’t work, I would have probably stopped using my Nrf2 activation supplement after 30 days, and missed out on the long term benefits that I have gained for being a consistent user of the product.

2. Nrf2 activation increases enzyme production gradually.

The below graph is taken from a study on the NRF2 product called Protandim. It shows the gradual increase in two of the numerous enzymes that get “turned back on” after NRF2 activation. Levels of these enzymes are more favorable after 120 days than they are after 30 days.

Plasma T-bars are an indicator of oxidative stress in the cells. Oxidative stress is associated with hundreds of disease states. The below graph shows how NRF2 activation is able to reduce oxidative stress in a body over time.

 

3. A good NRF2 activation supplement  will reduce oxidative stress, reduce inflammation and fibrosis (scar tissue) in the body over a period of time.

We live in an “instant society” and expect results immediately. Microwave meals, drive through windows for coffee and banking, instant music and book downloads have changed our lives dramatically over the past few years. Many times we expect health results to be as instant as the examples listed above. It seems illogical, however, to expect an immediate reversal of the damage caused by many years of wear and tear on our bodies through malfunction, aging and disease to be reversed within a few days, weeks or months.  Some people may feel improvements short term, however it is probably more the exception than the rule. Oxidative stress, inflammation and fibrosis improvements generally will take time to improve.

4. Will you “feel” the difference?

Perhaps! It all depends on a number of factors and the conditions of each person involved. However, if you do not feel a difference it doesn’t mean that your NRF2 product is not generating positive effects in the body. Compare this reasoning to whether you can feel the blood pressure and cholesterol changes in the body on a daily basis. Those are changes that largely go unnoticed. The same is true for feeling the changes to your levels of your antioxidant survival genes.

A healthy person taking the product for largely preventative reasons may not feel a noticeable change compared to someone who has been feeling the effects of a disease. Continuous consumption of a NRF2 activator each day will have more of an impact on the cells than eating a bowl of strawberries once every few months, and will probably have more chance of you noticing changes in your body. Become aware of the subtle changes occurring in the body. Some less obvious changes may be more energy, improved sleep, the strengthening of nails, the improvement in overall health and condition of your hair or darkening of hair as the catalase production increases.

In summary, expect a gradual change and improvement in your general health and wellness. The benefits may or may not be immediately noticed, but that does not mean the body is not experiencing positive results. Every body is unique and may observe different results to a friend or family member taking the same product.

This article is for educational purposes. As always, consult with a medical professional if you have any questions or need advice for your personal circumstances.

 

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We welcome the involvement of those who have published peer review studies in this field. 

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